{"id":632403,"date":"2025-06-02T11:40:29","date_gmt":"2025-06-02T15:40:29","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=632403"},"modified":"2026-01-28T14:13:06","modified_gmt":"2026-01-28T19:13:06","slug":"zepbound-interactions","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/zepbound-interactions\/","title":{"rendered":"Zepbound interactions to avoid"},"content":{"rendered":"

Zepbound<\/span><\/a> (tirzepatide) is a prescription medication used for weight loss, weight management, and obstructive sleep apnea. The weekly injection belongs to the drug class of dual glucose-dependent insulinotropic (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonists. Like any medication, the Zepbound treatment can interact with other drugs, such as oral birth control and antidiabetic drugs. The weight loss medication isn\u2019t known to interact with certain foods, but alcohol and caffeine could increase your chances of side effects. Knowing Zepbound\u2019s interactions can prevent unwanted and potentially serious side effects while using this drug.<\/span><\/p>\n

Zepbound drug interactions<\/span><\/h2>\n

Here\u2019s a look at known drug interactions with Zepbound and potential side effects that may occur:<\/span><\/p>\n\n\n\n\n\n\n\n\n
Drug class or group name<\/b><\/td>\nDrug name<\/b><\/td>\nInteractions\/side effects<\/b><\/td>\n<\/tr>\n
Sulfonylureas<\/span><\/td>\n\n
    \n
  • Diabeta, Glynasen (glyburide)<\/span><\/li>\n
  • Amaryl (glimepiride)<\/span><\/li>\n
  • Glucotrol XL (glipizide<\/span>)<\/span><\/li>\n<\/ul>\n<\/td>\n
Can lower blood sugar<\/span><\/td>\n<\/tr>\n
Oral contraceptives<\/span><\/td>\n\n
    \n
  • Aurovela, Blisovi, Hailey Fe, etc. (ethinyl estradiol\/norethindrone acetate)<\/span><\/li>\n
  • Yasmin, Yaz, and Syeda (ethinyl estradiol\/drospirenone)<\/span><\/li>\n
  • Estaylla, Vylibra, Tri-Mili, etc. (ethinyl estradiol\/norgestimate)<\/span><\/li>\n<\/ul>\n<\/td>\n
Decreased efficacy<\/span><\/td>\n<\/tr>\n
Insulin<\/span><\/td>\n\n
    \n
  • Fiasp, NovoLog (insulin aspart)<\/span><\/li>\n
  • Levemir (insulin detemir)<\/span><\/li>\n
  • Lantus, Toujeo (insulin glargine)<\/span><\/li>\n<\/ul>\n<\/td>\n
Can lower blood sugar<\/span><\/td>\n<\/tr>\n
Meglitinides<\/span><\/td>\n\n
    \n
  • Repaglinide<\/span><\/li>\n
  • Starlix (nateglinide)<\/span><\/li>\n<\/ul>\n<\/td>\n
Can lower blood sugar<\/span><\/td>\n<\/tr>\n
Any oral medications<\/span><\/td>\n\n
    \n
  • Jantoven (warfarin)<\/span><\/li>\n
  • Gengraf, Neoral, and Sandimmune (cyclosporine)<\/span><\/li>\n<\/ul>\n<\/td>\n
Decreased efficacy<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Sulfonylureas<\/span><\/h3>\n

Sulfonylureas are a class of medications used to <\/span>manage blood sugar levels<\/span><\/a> in people with Type 2 diabetes. Taking the antidiabetic drug with Zepbound may lower blood sugar (known as hypoglycemia). \u201cThis doesn\u2019t necessarily mean that Zepbound is off the table for these patients, but it does mean that it\u2019ll need to be added under close medical supervision,\u201d says Marlee Bruno, MMS, PA-C, a board-certified physician assistant and founder of <\/span>Mind Body & Soul Medical<\/span><\/a> in Pensacola, Florida. \u201cI\u2019ve had patients try to white-knuckle their way through hypoglycemia episodes because no one explained that the combination could hit that hard.\u201d<\/span><\/p>\n

The types of sulfonylureas healthcare providers may prescribe include the following:<\/span><\/p>\n