{"id":632510,"date":"2025-06-09T18:17:49","date_gmt":"2025-06-09T22:17:49","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=632510"},"modified":"2025-06-10T13:56:01","modified_gmt":"2025-06-10T17:56:01","slug":"trintellix-nausea","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/trintellix-nausea\/","title":{"rendered":"Does Trintellix cause nausea?"},"content":{"rendered":"

Trintellix<\/span> (<\/span>vortioxetine<\/span>) is a <\/span>brand-name<\/span> antidepressant<\/span> in the <\/span>selective serotonin reuptake inhibitor<\/span>\/5-HT1A receptor partial agonist drug class and is an important contribution to the armamentarium of <\/span>mental health<\/span> prescription drugs<\/span>. It is approved by the Food and Drug Administration (<\/span>FDA<\/span>) for the management of <\/span>major depressive disorder<\/span> (<\/span>MDD<\/span>). <\/span>Trintellix<\/span> may be more desirable to some afflicted with depression over other drug classes since it is associated with reduced risk of <\/span>weight gain<\/span> and <\/span>sexual dysfunction<\/span> in comparison to more traditional <\/span>antidepressants<\/span> like <\/span>SSRIs<\/span> and <\/span>SNRIs<\/span>. Unfortunately, up to 30% of patients can suffer from nausea due to <\/span>Trintellix<\/span>. The <\/span>dose of Trintellix<\/span> seems to have an impact, such that higher doses are associated with <\/span>worsening<\/span> nausea.<\/span><\/p>\n\t\t

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Can <\/span>Trintellix<\/span> cause nausea?<\/span><\/h2>\n

Nausea<\/span><\/a> is a well-known and well-described <\/span>side effect<\/span> of <\/span>Trintellix<\/span><\/a> (<\/span>vortioxetine<\/span>), especially when someone first starts taking this medication to manage their depression. The nausea is described as at its worst in the <\/span>first week<\/span> of therapy and can last up to 2 weeks before it begins to subside. Some, however, are afflicted for weeks after initiation. Nausea associated with <\/span>Trintellix<\/span> is also <\/span>linked to dose<\/span><\/a>, such that higher doses are associated with higher rates of nausea. In many analyses, the nausea caused by <\/span>Trintellix<\/span> is the <\/span>most common side effect<\/span> leading to withdrawal of the medication<\/span><\/a>. If the <\/span>side effect<\/span> of nausea is too intense for a patient and they wish to stop it, they should only do so under the supervision of a medical professional, given the risk of <\/span>discontinuation syndrome<\/span> and <\/span>withdrawal symptoms<\/span><\/a> like anxiety, agitation, confusion, and irritability.\u00a0<\/span><\/p>\n

Why does <\/span>Trintellix<\/span> cause nausea?<\/span><\/h2>\n

Serotonin is a fundamental player in the gastrointestinal tract<\/span><\/a> related to motility, nausea, and vomiting. In fact, almost 90-95% of the body\u2019s serotonin is in the gut. The increased circulating serotonin from <\/span>Trintellix<\/span> and other <\/span>antidepressants<\/span> like <\/span>Zoloft<\/span><\/a> (<\/span>sertraline<\/span>), <\/span>Lexapro<\/span><\/a> (<\/span>escitalopram<\/span>), and <\/span>Celexa<\/span><\/a> (<\/span>citalopram<\/span>) stimulates the serotonin receptors throughout the gut, resulting in nausea. Other gastrointestinal <\/span>side effects<\/span>, like <\/span>constipation<\/span> or diarrhea, can also occur. Adaptation to the altered serotonin levels should occur after the first couple of weeks of therapy, and this <\/span>common side effect of Trintellix<\/span> should resolve over that period.\u00a0<\/span><\/p>\n

How to avoid nausea with <\/span>Trintellix<\/span>\u00a0<\/span><\/h2>\n

Limiting nausea associated with <\/span>Trintellix<\/span> includes taking it with food, taking the medication at night so that the symptom of nausea is masked during sleeping, and starting with a lower dose. The nausea improves over time, usually resolving after about 2 weeks of therapy as the body adapts to the new serotonin levels. If nausea is really interfering with your daily activities, consider speaking with a <\/span>healthcare professional<\/span> about additional medications that you can take to help manage this <\/span>side effect<\/span>. Some typical antinausea medications, such as Zofran, can result in <\/span>drug interactions,<\/span> which can increase the risk of a <\/span>life-threatening<\/span> phenomenon known as <\/span>serotonin syndrome<\/span><\/a>. More homeopathic approaches, like <\/span>ginger <\/span>supplements<\/span> to settle the stomach<\/span><\/a>, may be a safer option. Initiation of any remedy\u2014prescription or <\/span>over-the-counter<\/span>\u2014should always be reviewed with a <\/span>healthcare professional,<\/span> as it may also interfere with other medications one may be taking.\u00a0<\/span><\/p>\n

Trintellix<\/span> alternatives<\/span><\/h2>\n

Examples of other medications used to <\/span>treat depression<\/span> but with lower nausea risks include:<\/span><\/p>\n