{"id":632711,"date":"2025-07-02T15:42:50","date_gmt":"2025-07-02T19:42:50","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=632711"},"modified":"2026-01-28T14:10:51","modified_gmt":"2026-01-28T19:10:51","slug":"anti-inflammatory-with-xarelto","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/anti-inflammatory-with-xarelto\/","title":{"rendered":"What anti-inflammatory can you take with Xarelto?"},"content":{"rendered":"

Xarelto<\/span><\/a> is the brand name for rivaroxaban, an anticoagulant (blood thinner). It\u2019s a<\/span> factor Xa inhibitor<\/span><\/a>, which helps decrease blood clot production in the body. Xarelto is FDA-approved to prevent and treat clots in numerous conditions, such as stroke, nonvalvular atrial fibrillation, and deep vein thrombosis.\u00a0\u00a0<\/span><\/p>\n

Unfortunately, combining Xarelto with most common anti-inflammatory medications is not safe, because it can increase your risk of bleeding. That said, there are other pain medications you can take, and some anti-inflammatory medications that are safer than others.<\/span><\/p>\n

Here, we\u2019ll discuss which anti-inflammatory medications you can take with Xarelto and which ones you should avoid.<\/span><\/p>\n

What anti-inflammatory drugs can you take with Xarelto?<\/span>\u00a0<\/b><\/h2>\n

The most common anti-inflammatory medications are<\/span> nonsteroidal anti-inflammatory drugs <\/span><\/a>(NSAIDs), which are pain relievers that can also decrease inflammation in the body. Common NSAIDs include <\/span>Advil<\/span><\/a>, <\/span>Motrin<\/span><\/a>, and <\/span>Aleve<\/span><\/a>. It\u2019s important to be very cautious when it comes to taking Xarelto and NSAIDs, as well as other anti-inflammatory medications.<\/span>\u00a0<\/span><\/p>\n

\u201cThe big concern when taking anti-inflammatory medications\u2014like ibuprofen or naproxen\u2014along with Xarelto is the risk of bleeding,\u201d Sean Ormond, MD, dual board-certified in anesthesiology and interventional pain management physician at Atlas Pain Specialists, explains. \u201cXarelto already makes your blood less likely to clot (which is good if you’re at risk for strokes or clots), but NSAIDs can add to that risk by irritating your stomach lining and affecting how your platelets work.\u201d<\/span><\/p>\n

At the same time, some non-anti-inflammatory pain medications are safe to take with Xarelto. Additionally, some anti-inflammatory medications carry a lower risk of bleeding when combined with Xarelto. Still, these medications should be used cautiously and only under a healthcare provider\u2019s supervision.<\/span><\/p>\n

Over-the-counter medications that are safe to take with Tylenol<\/span><\/h3>\n

While you have to be cautious when it comes to most over-the-counter anti-inflammatory pain relievers like <\/span>non-steroidal anti-inflammatory drugs<\/span> (<\/span>NSAIDs), other over-the-counter pain relievers are generally safe to take.\u00a0\u00a0<\/span><\/p>\n

Tylenol<\/span><\/h3>\n

Tylenol<\/span><\/a> and Xarelto are typically a safe combination. \u201cAcetaminophen (Tylenol) is generally considered the safest over-the-counter pain reliever to use with Xarelto and other anticoagulants since it does not impair platelet function or increase bleeding risk in the same way NSAIDs do,\u201d Erika Gray, Pharm.D., founder and chief medical officer at MyToolBox Genomics, says. But even Tylenol should be used in moderation, she says, especially in patients with liver disease or who consume more than two alcoholic drinks per day.<\/span><\/p>\n

Low-dose aspirin<\/span><\/h3>\n

Xarelto is indicated for use in combination with low-dose aspirin<\/span><\/a> to decrease the risk of serious heart issues, heart attacks, and strokes in people with coronary artery disease. It\u2019s also indicated to decrease the risk of reduced blood flow to your legs, amputation, heart issues, and stroke in people with peripheral artery disease. However, it\u2019s vital that you seek medical advice from a healthcare provider before you take low-dose aspirin with Xarelto.<\/span><\/p>\n

Prescription medications safe to take with Xarelto<\/span><\/h3>\n

There are certain prescription pain relievers, and even certain prescription anti-inflammatory medications, that may be safer to take with Xarelto. Again, it\u2019s important to consult with a healthcare provider before combining any prescription medications with Xarelto.<\/span><\/p>\n

Celebrex<\/span><\/h3>\n

Celebrex (celecoxib)<\/span><\/a> is an NSAID. Nevertheless, as <\/span>Matthew L. Holt, Pharm.D., assistant professor of pharmacology at PCOM (Philadelphia College of Osteopathic Medicine), notes it\u2019s a newer NSAID, and is less likely to cause unwanted bleeding, such as stomach bleeding. Yet while the risk of stomach bleeding is lower with Celebrex than other NSAIDs, the risk still exists, Dr. Holt notes.<\/span>\u00a0<\/span><\/p>\n

As such, if <\/span>Celebrex is combined with anticoagulants like Xarelto, caution should be taken. \u201cIt\u2019s a bit gentler on the stomach than others, but still not something I\u2019d recommend casually with Xarelto,\u201d Dr. Ormond says. \u201cIf it’s absolutely needed, it should be used short-term and under close supervision.\u201d<\/span><\/p>\n

Voltaren gel<\/span><\/h3>\n

If you are looking for a safe anti-inflammatory to combine with Xarelto,<\/span> Voltaren gel<\/span><\/a> is a good option. \u201cDiclofenac (Voltaren) gel ranks among the safest anti-inflammatory to take with anticoagulants such as Xarelto, as the medication is applied onto the skin, and absorption is often limited to the affected painful area,\u201d Dr. Holt explains. \u201cThis aspect of diclofenac gel decreases the risk of bleeding that usually accompanies other NSAIDs taken by mouth.\u201d<\/span><\/p>\n

At the same time, some caution is advised. \u201cThere is some degree of absorption so prolonged use can potentially increase bleeding risk and should be used with caution under medical supervision,\u201d Dr. Gray says.<\/span><\/p>\n\t\t

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What anti-inflammatory medications should be avoided while on Xarelto?<\/span><\/h2>\n

Most oral NSAIDs should be avoided while taking Xarelto, unless they are strictly prescribed by your healthcare provider, Dr. Gray explains. These include:<\/span><\/p>\n