{"id":632770,"date":"2025-07-07T19:06:55","date_gmt":"2025-07-07T23:06:55","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=632770"},"modified":"2025-07-07T19:06:55","modified_gmt":"2025-07-07T23:06:55","slug":"tradjenta-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/tradjenta-alternatives\/","title":{"rendered":"Tradjenta alternatives: What can I take instead of Tradjenta?"},"content":{"rendered":"

An oral tablet, taken once daily, with minimal <\/span>side effects<\/span>, <\/span>Tradjenta<\/span> is an effective treatment to lower <\/span>blood sugar levels<\/span> in the treatment of <\/span>Type 2 diabetes mellitus<\/span>. Despite all of those glowing characteristics, it is not unusual to need to find an alternative to prescription <\/span>Tradjenta<\/span>. The price may be too high, considering there is no generic <\/span>linagliptin<\/span> available yet, or your insurance formulary does not cover it. Maybe it is not potent enough to bring <\/span>blood glucose levels<\/span> under control. Whatever the reason, you will be happy to know that plenty of alternatives are available, and you are in the right place to read about them.<\/span><\/p>\n\t\t

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Save up to 80% on Tradjenta with SingleCare<\/p>\n\t\t\t

Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t

\n\t\t\t\t
\n\t\t\t\t\tTradjenta 5 mg (30 Tablets)\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t
\n\t\t\t\"Kroger\t\t\t<\/div>\n\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t$515.53\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\tGet free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\"Harris\t\t\t<\/div>\n\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t$515.53\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\tGet free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\tSee Tradjenta prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n

What can I take instead of <\/span>Tradjenta<\/span>?<\/span><\/h2>\n

Tradjenta<\/span><\/a> belongs to the <\/span>dipeptidyl peptidase-4<\/span> inhibitor<\/span> (<\/span>DPP-4 inhibitor<\/span>) family of drugs for diabetes. They all increase the levels of <\/span>incretin<\/span> hormones like <\/span>glucagon<\/span>-like <\/span>peptide-1<\/span> (<\/span>GLP-1<\/span>), thereby increasing insulin and decreasing <\/span>glucagon<\/span> levels. Switching to a different <\/span>DPP-4 inhibitor<\/span> may allow you to get the same <\/span>glucose<\/span>-lowering effects but at a better price.<\/span><\/p>\n

Fortunately, a plethora of different <\/span>drug classes<\/span> provide effective <\/span>Type 2 diabetes<\/span> therapy<\/span><\/a>. <\/span>GLP-1<\/span> agonists<\/span><\/a>, such as <\/span>Ozempic<\/span><\/a>, <\/span>Mounjaro<\/span><\/a>, <\/span>Trulicity<\/span><\/a>, and <\/span>Victoza<\/span><\/a>, are options with growing popularity. Another new and popular pick, <\/span>sodium-<\/span>glucose<\/span> cotransporter-2 <\/span>inhibitors<\/span> (<\/span>SGLT-2 inhibitors<\/span>)<\/span><\/a>, could be a better option, and <\/span>Jardiance<\/span><\/a>, <\/span>Farxiga<\/span><\/a>, and <\/span>Invokana<\/span><\/a> are some of the <\/span>brand names<\/span> in the group. <\/span>Biguanides<\/span><\/a>, namely <\/span>metformin<\/span><\/a>, have remained a foundational treatment for years. Also long-tenured, <\/span>sulfonylureas<\/span><\/a>, like <\/span>glimepiride<\/span><\/a> and <\/span>glipizide<\/span><\/a>, and <\/span>Actos<\/span><\/a>, a <\/span>thiazolidinedione<\/span><\/a>, continue to play a role in <\/span>Type 2 diabetes management<\/span>. <\/span>Insulins<\/span><\/a> are a well-known option too.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Compare Tradjenta alternatives<\/span><\/th>\n<\/tr>\n<\/thead>\n
Drug name<\/b><\/td>\nUses<\/b><\/td>\nDosage<\/b><\/td>\nSavings options<\/b><\/td>\n<\/tr>\n
Tradjenta<\/span> (<\/span>linagliptin<\/span>)<\/span><\/td>\nType 2 diabetes mellitus<\/span><\/td>\n5 mg once daily<\/span><\/td>\nTradjenta<\/span> coupons<\/span><\/a><\/td>\n<\/tr>\n
Januvia<\/span> (<\/span>sitagliptin<\/span>)<\/span><\/td>\nType 2 diabetes mellitus<\/span><\/td>\n100 mg once daily<\/span><\/td>\nJanuvia<\/span> coupons<\/span><\/a><\/td>\n<\/tr>\n
Onglyza (<\/span>saxagliptin<\/span>)<\/span><\/td>\nType 2 diabetes mellitus<\/span><\/td>\n2.5-5 mg once daily<\/span><\/td>\nOnglyza coupons<\/span><\/a><\/td>\n<\/tr>\n
Metformin<\/span><\/td>\nType 2 diabetes mellitus<\/span>, polycystic ovarian syndrome (<\/span>off-label<\/span><\/a>)<\/span><\/td>\n500-1000 mg twice daily<\/span><\/td>\nMetformin<\/span> coupons<\/span><\/a><\/td>\n<\/tr>\n
Metformin<\/span> ER (<\/span>extended-release<\/span>)<\/span><\/td>\nType 2 diabetes mellitus<\/span>, polycystic ovarian syndrome (off-label)<\/span><\/td>\n500-1000 mg once or twice daily<\/span><\/td>\nMetformin<\/span> ER coupons<\/span><\/a><\/td>\n<\/tr>\n
Jentadueto XR (<\/span>linagliptin<\/span>\/<\/span>metformin<\/span> extended-release<\/span>)<\/span><\/td>\nType 2 diabetes mellitus<\/span><\/td>\n5 mg\/1000 mg once daily<\/span><\/td>\nJentadueto XR coupons<\/span><\/a><\/td>\n<\/tr>\n
Trulicity (dulaglutide)<\/span><\/td>\nType 2 diabetes mellitus<\/span>, cardiovascular event risk reduction in those with <\/span>type 2 diabetes<\/span> and cardiovascular disease or multiple risk factors<\/span><\/td>\n0.75-4.5 mg subcutaneous (under the skin) injection once weekly<\/span><\/td>\nTrulicity coupons<\/span><\/a><\/td>\n<\/tr>\n
Ozempic<\/span> (<\/span>semaglutide<\/span>)<\/span><\/td>\nType 2 diabetes mellitus<\/span>, cardiovascular event risk reduction in those with <\/span>type 2 diabetes<\/span> and cardiovascular disease<\/span><\/td>\n0.5-2 mg subcutaneous injection once weekly<\/span><\/td>\nOzempic<\/span> coupons<\/span><\/a><\/td>\n<\/tr>\n
Rybelsus (<\/span>semaglutide<\/span>)<\/span><\/td>\nType 2 diabetes mellitus<\/span><\/td>\n7-14 mg once daily<\/span><\/td>\nRybelsus coupons<\/span><\/a><\/td>\n<\/tr>\n
Victoza (liraglutide)<\/span><\/td>\nType 2 diabetes mellitus<\/span>, cardiovascular event risk reduction in those with <\/span>type 2 diabetes<\/span> and cardiovascular disease<\/span><\/td>\n1.2-1.8 mg subcutaneous injection once daily<\/span><\/td>\nVictoza coupons<\/span><\/a><\/td>\n<\/tr>\n
Mounjaro (tirzepatide)<\/span><\/td>\nType 2 diabetes mellitus<\/span><\/td>\n5-15 mg subcutaneous injection once weekly<\/span><\/td>\nMounjaro coupons<\/span><\/a><\/td>\n<\/tr>\n
Farxiga (dapagliflozin)<\/span><\/td>\nType 2 diabetes mellitus<\/span>, <\/span>heart failure<\/span> risk reduction in <\/span>type 2 diabetes mellitus<\/span> with heart disease or multiple cardiovascular risk factors, <\/span>heart failure<\/span> risk reduction in those with <\/span>heart failure<\/span>, and <\/span>heart failure<\/span> and <\/span>kidney disease<\/span> progression risk reduction in those with chronic renal disease<\/span><\/td>\n5-10 mg once daily<\/span><\/td>\nFarxiga coupons<\/span><\/a><\/td>\n<\/tr>\n
Jardiance<\/span> (empagliflozin)<\/span><\/td>\nType 2 diabetes mellitus<\/span>, cardiovascular event risk reduction in <\/span>type 2 diabetes mellitus<\/span>, <\/span>heart failure<\/span> risk reduction in those with heart failure, cardiovascular death, and <\/span>kidney disease<\/span> progression risk reduction in those with chronic renal disease<\/span><\/td>\n10-25 mg once daily<\/span><\/td>\nJardiance<\/span> coupons<\/span><\/a><\/td>\n<\/tr>\n
Glipizide<\/span><\/td>\nType 2 diabetes mellitus<\/span><\/td>\n2.5-20 mg twice daily<\/span><\/td>\nGlipizide<\/span> coupons<\/span><\/a><\/td>\n<\/tr>\n
Actos (<\/span>pioglitazone<\/span>)<\/span><\/td>\nType 2 diabetes mellitus<\/span><\/td>\n15-30 mg once daily<\/span><\/td>\nActos coupons<\/span><\/a><\/td>\n<\/tr>\n
Lantus Solostar (insulin glargine)<\/span><\/td>\nType 2 diabetes mellitus<\/span>, <\/span>type 1 diabetes<\/span> mellitus<\/span><\/td>\nIndividualized dose injected subcutaneously once daily<\/span><\/td>\nLantus Solostar coupons<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Top 5 <\/span>Tradjenta<\/span> alternatives<\/span><\/h2>\n

The following are some of the most common alternatives to <\/span>Tradjenta<\/span>.<\/span><\/p>\n

1. <\/span>Januvia<\/span><\/h3>\n

As a fellow <\/span>DPP-4 inhibitor<\/span>, <\/span>Januvia<\/span> is closely related to <\/span>Tradjenta<\/span>. They have similar efficacy and <\/span>side effects<\/span><\/a>, including nasal or throat irritation and a warning about <\/span>pancreatitis<\/span> risk. Unlike <\/span>Tradjenta<\/span>, <\/span>Januvia<\/span> must be dosed differently for patients with kidney function impairment. The only reason to favor <\/span>Januvia<\/span> over <\/span>Tradjenta<\/span> is usually insurance coverage and lower <\/span>copays<\/span><\/a> due to the availability of <\/span>sitagliptin<\/span>, the generic form of <\/span>Januvia<\/span>.<\/span><\/p>\n

2. <\/span>Metformin<\/span> ER<\/span><\/h3>\n

Metformin<\/span>, regular and <\/span>extended release<\/span>, is often the <\/span>first-line medication<\/span><\/a> for <\/span>Type 2 diabetes<\/span>. Its long history and proven benefits for lowering blood sugar and slowing disease progression have kept it in a favored status for years. Being relatively cheap as a generic is a bonus. It is also conveniently manufactured in combination tablets with numerous other <\/span>anti-diabetic<\/span> drugs, including <\/span>linagliptin<\/span> in the form of Jentadueto XR.<\/span><\/p>\n

The downfall of <\/span>metformin<\/span> is most often its gastrointestinal <\/span>side effects,<\/span> like diarrhea and nausea. The <\/span>extended-release<\/span> version has less risk of these adverse reactions, but it does not completely avoid them. Nonetheless, it is typically a medication that must be tried first before other options are approved by <\/span>insurance plans<\/span> utilizing <\/span>step-therapy<\/span><\/a> in their <\/span>prior authorization process<\/span><\/a>.<\/span><\/p>\n

3. <\/span>Ozempic<\/span><\/h3>\n

Although it <\/span>gained notoriety<\/span><\/a> for off-label use in assisting with <\/span>weight loss<\/span>, <\/span>Ozempic<\/span> is a well-proven option for treating <\/span>Type 2 diabetes mellitus<\/span>, the use that it actually has <\/span>Food and Drug Administration<\/span> (<\/span>FDA<\/span>) approval<\/span><\/a> for. The <\/span>GLP-1<\/span> agonist<\/span> has a similar <\/span>incretin<\/span>-based mechanism as <\/span>Tradjenta<\/span> but is more potent and long-lasting. As a result, <\/span>Ozempic<\/span> is favored when needing help with <\/span>glucose<\/span> control.\u00a0<\/span><\/p>\n

Keep in mind that <\/span>Ozempic<\/span> is a weekly injection rather than an oral pill. For those who are injection-averse, Rybelus has the same active ingredient, <\/span>semaglutide<\/span>, in a pill form taken daily. Either form carries a sizable price tag. Neither <\/span>semaglutide<\/span> product nor any <\/span>GLP-1<\/span> agonist,<\/span> for that matter, should be used alongside <\/span>Tradjenta<\/span> or other <\/span>DPP-4 inhibitors<\/span> due to their overlapping mechanisms of action.<\/span><\/p>\n

4. Mounjaro<\/span><\/h3>\n

Coupling <\/span>GLP-1<\/span> agonist<\/span> activity with <\/span>glucose<\/span>-dependent insulinotropic polypeptide (GIP) receptor activity gives Mounjaro a dual action in combating <\/span>Type 2 diabetes<\/span>. The double <\/span>incretin<\/span> mechanism may also explain why it tends to lead to <\/span>more <\/span>weight loss<\/span> than <\/span>Ozempic<\/span><\/a>. By themselves, the <\/span>GLP-1<\/span>\/GIP <\/span>agonists<\/span><\/a> and <\/span>DPP-4 inhibitors<\/span> do not cause <\/span>hypoglycemia<\/span> (excessively <\/span>low blood sugars<\/span>) unless they are combined with other diabetes meds like insulins or <\/span>sulfonylureas<\/span>. Once again, the price and injectable format could be seen as detractors to Mounjaro compared to <\/span>Tradjenta<\/span>.<\/span><\/p>\n

5. <\/span>Jardiance<\/span><\/h3>\n

Like <\/span>GLP-1<\/span> agonists<\/span>, the <\/span>SGLT-2 inhibitors<\/span> have gained favor in recent years due to their additional benefits. In the case of <\/span>SGLT-2 inhibitors<\/span>, like <\/span>Jardiance<\/span>, they have clinical study data demonstrating better <\/span>kidney<\/span><\/a> and <\/span>heart disease outcomes<\/span><\/a>. Achieving this and controlling blood sugar in the setting of diabetes can be a compelling reason to choose them over a <\/span>DPP-4 inhibitor<\/span>. A heightened <\/span>risk of urinary tract infection and genitourinary yeast infection<\/span><\/a> is an unfortunate feature of <\/span>Jardiance<\/span> and other members of the <\/span>drug class<\/span> that could dissuade you.<\/span><\/p>\n

Natural alternatives to <\/span>Tradjenta<\/span><\/h2>\n

Getting to the goal with <\/span>Type 2 diabetes mellitus<\/span> management often requires multiple measures. A healthy <\/span>diet<\/span><\/a> and individualized <\/span>exercise<\/span><\/a> regimen are essential for all. Oftentimes, multiple <\/span>diabetes medications<\/span> may be necessary. Dietary supplements and herbal remedies may be of interest, but one\u2019s healthcare provider should vet them to ensure they are both effective and safe. Two prime examples are <\/span>cinnamon<\/span><\/a> and <\/span>fiber<\/span><\/a> supplements. They both have evidence from clinical studies showing positive results without untoward risk.<\/span><\/p>\n

How to switch to a <\/span>Tradjenta<\/span> alternative<\/span><\/h2>\n

Before making a change, get the <\/span>medical advice<\/span> of your doctor. Explain your concerns with <\/span>Tradjenta<\/span> and why you are interested in switching. The two of you can review the other options, highlighting the pros and cons of each. Ultimately, your insurance\u2019s drug <\/span>formulary<\/span><\/a> may have a large say in what options are available. If <\/span>Tradjenta<\/span>\u2019s price is a factor<\/span><\/a>, get a <\/span>SingleCare discount card<\/span><\/a> and show it to your pharmacist to see your savings on <\/span>Tradjenta<\/span> and alternatives. Changing from <\/span>Tradjenta<\/span> requires careful consideration and planning, but if it is agreed that it is best to move on, the drug does not need to be weaned off.<\/span><\/p>\n

Choosing the right path for diabetes treatment<\/span><\/h2>\n

There is a lot to consider when choosing the optimal diabetes treatment strategy. Drug <\/span>side effects<\/span> and costs must be considered, as well as <\/span>glucose<\/span>-lowering efficacy and <\/span>additional benefits<\/span><\/a>. The other medications on your list and health conditions in your past could impact choosing the right regimen, too. As a result, you should lean on your team of <\/span>healthcare<\/span> professionals in the doctor\u2019s office and pharmacy to ensure your diabetes treatment is optimized.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

An oral tablet, taken once daily, with minimal side effects, Tradjenta is an effective treatment to lower blood sugar levels in the treatment of Type 2 diabetes mellitus. Despite all of those glowing characteristics, it is not unusual to need to find an alternative to prescription Tradjenta. The price may be too high, considering there […]<\/p>\n","protected":false},"author":137,"featured_media":632771,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[10298],"coauthors":[20732],"class_list":["post-632770","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-diabetes","wpautop"],"acf":[],"yoast_head":"\nTop Tradjenta alternatives and how to switch your Rx<\/title>\n<meta name=\"description\" content=\"Januvia, metformin ER, Ozempic, Mounjaro, and Jardiance are some Tradjenta alternatives. 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