{"id":632779,"date":"2025-07-18T09:30:31","date_gmt":"2025-07-18T13:30:31","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=632779"},"modified":"2025-07-09T14:49:16","modified_gmt":"2025-07-09T18:49:16","slug":"does-ubrelvy-work-on-all-headaches","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/does-ubrelvy-work-on-all-headaches\/","title":{"rendered":"Does Ubrelvy work on all headaches?"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/ubrelvy\"><span style=\"font-weight: 400;\">Ubrelvy<\/span><\/a><span style=\"font-weight: 400;\"> (ubrogepant) is a brand-name medication that is approved by the U.S. Food and Drug Administration (FDA) for the acute treatment of migraine, with or without aura, in adults. Ubrelvy is very effective at stopping a migraine headache in its tracks. The ACHIEVE I and II clinical trials found that a significantly higher proportion of people taking ubrogepant felt better and were able to function normally within two hours of taking the medication, compared to a placebo (inactive treatment).\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ubrelvy belongs to a drug class called calcitonin gene-related peptide (CGRP) receptor antagonists, also known as gepants. Drugs in this class work by blocking receptors involved in migraine pain. Ubrelvy is a tablet taken by mouth at the first symptoms of an oncoming migraine attack. It is not used to prevent migraine or treat other types of headaches. Here\u2019s why.<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Ubrelvy with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tUbrelvy 100 mg (10 Tablets)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$1032.29<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/ubrelvy#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/ubrelvy#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-harristeeter.svg\" alt=\"Harris Teeter Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$1032.29<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/ubrelvy#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/ubrelvy#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/ubrelvy#blog-cta\" class=\"coupon-see-all-btn\">See Ubrelvy prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"does-ubrelvy-work-on-all-headaches\"><span style=\"font-weight: 400;\">Does Ubrelvy work on all headaches?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">&#8220;It\u2019s only approved and effective for migraines,&#8221; explains Kimberly Idoko, MD, a board-certified neurologist and medical director at Everwell Neuro. &#8220;It hasn\u2019t been studied for other <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/types-of-headaches\/\"><span style=\"font-weight: 400;\">headache types<\/span><\/a><span style=\"font-weight: 400;\">, so it shouldn\u2019t be used for those.&#8221; In other words, it hasn\u2019t been studied for tension, sinus, cluster, caffeine, exertion, or hormonal headaches. These types of headaches have different underlying causes from migraine.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For example, a <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/headache-in-back-of-head\/\"><span style=\"font-weight: 400;\">tension headache<\/span><\/a><span style=\"font-weight: 400;\"> is a tightening in the neck and scalp caused by stress, poor posture, or lack of sleep. <\/span><span style=\"font-weight: 400;\">Medication, such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ibuprofen\"><span style=\"font-weight: 400;\">ibuprofen<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/acetaminophen\"><span style=\"font-weight: 400;\">acetaminophen<\/span><\/a><span style=\"font-weight: 400;\">, can alleviate pain<\/span><span style=\"font-weight: 400;\">. A <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/migraine-definition\/\"><span style=\"font-weight: 400;\">migraine<\/span><\/a><span style=\"font-weight: 400;\"> is a neurological condition <\/span><span style=\"font-weight: 400;\">thought to be caused in part by the CGRP protein triggering inflammation in the brain. Migraine medication targets blood vessels and chemicals in the brain.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There are several types of medications used to treat and prevent migraine. <\/span><span style=\"font-weight: 400;\">Preventive medications are taken daily and stop a migraine headache before it starts. They can include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Beta blockers such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/propranolol-hcl\"><span style=\"font-weight: 400;\">Inderal (propranolol)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anticonvulsants\u2014also used to treat epilepsy\u2014such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/depakote\"><span style=\"font-weight: 400;\">Depakote (divalproex sodium)<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/topiramate\"><span style=\"font-weight: 400;\">Topamax (topiramate)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antidepressants such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/amitriptyline-hcl\"><span style=\"font-weight: 400;\">Elavil (amitriptyline)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Calcitonin gene-related peptide (CGRP) antagonists such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/emgality\"><span style=\"font-weight: 400;\">Emgality (galcanezumab-gnlm)<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/aimovig\"><span style=\"font-weight: 400;\">Aimovig<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><span style=\"font-weight: 400;\">erenumab-aooe<\/span><span style=\"font-weight: 400;\">).<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/botox\"><span style=\"font-weight: 400;\">Botox (botulinum toxin)<\/span><\/a><span style=\"font-weight: 400;\"> injections<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Abortive medications are designed to stop migraine pain after its onset. These prescriptions can include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Triptans such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/imitrex\"><span style=\"font-weight: 400;\">Imitrex (sumatriptan)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ergotamines such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/migranal\"><span style=\"font-weight: 400;\">Migranal (dihydroergotamine nasal spray)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">CGRP antagonists such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ubrelvy\"><span style=\"font-weight: 400;\">Ubrelvy (ubrogepant)<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/nurtec\"><span style=\"font-weight: 400;\">Nurtec ODT (rimegepant)<\/span><\/a><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Each type of medication works slightly differently. For example, triptans cause vasoconstriction, or narrow blood vessels, to relieve migraine headaches. \u201cGepants inhibit the CGRP receptor responsible for pain transmission but have no effect on blood vessels,\u201d explains <\/span><a href=\"https:\/\/drsono.com\/author-bio\/\"><span style=\"font-weight: 400;\">Charles Carlsen, MD<\/span><\/a><span style=\"font-weight: 400;\">, Chief Technology Officer with Dr. Sono. <\/span><span style=\"font-weight: 400;\">&#8220;If you have a headache that doesn\u2019t meet the criteria of a migraine, be sure to talk to your healthcare professional so that you receive a proper diagnosis and treatment.\u201d<\/span><\/p>\n<h2 id=\"how-to-take-ubrelvy\"><span style=\"font-weight: 400;\">How to take Ubrelvy<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Ubrelvy is an oral tablet available in <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ubrelvy\/dosage\"><span style=\"font-weight: 400;\">two different strengths<\/span><\/a><span style=\"font-weight: 400;\">: 50 mg or 100 mg. &#8220;It\u2019s meant to be taken when a migraine has already started, so you can take it once the pain begins,&#8221; Dr. Idoko says.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If one dose is not working to treat your migraine symptoms, a second dose of Ubrelvy may be taken as directed by your healthcare provider. &#8220;As needed, a repeat dose is taken after a period of two hours, but no more than 200 mg should be consumed over a 24-hour period,&#8221; Dr. Carlsen says.\u00a0<\/span><\/p>\n<h2 id=\"how-long-does-ubrelvy-take-to-work\"><span style=\"font-weight: 400;\">How long does Ubrelvy take to work?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Ubrelvy should provide migraine pain relief within about two hours. However, a few factors affect how quickly it works:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Timing: <\/b><span style=\"font-weight: 400;\">You can take Ubrelvy at any time during a migraine headache, but the sooner you take it at the onset of symptoms, the faster it should work to relieve your migraine pain and discomfort.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Diet: <\/b><span style=\"font-weight: 400;\">A high-fat meal can slow its absorption. You should not take a second tablet within 24 hours if you consume grapefruit or grapefruit juice. can interact with Ubrelvy.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Drug interactions: <\/b><span style=\"font-weight: 400;\">&#8220;Ubrelvy is metabolized by CYP3A4, so strong inhibitors (like certain antifungals or antivirals) can increase its levels, and strong inducers (like some seizure medications) can reduce its effect,&#8221; Dr. Idoko says.\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Be sure to share a list of all over-the-counter medications, supplements, and prescription drugs you take with your pharmacist and healthcare provider. Many different <\/span><a href=\"https:\/\/www.ubrelvy.com\/important-safety-information\"><span style=\"font-weight: 400;\">medications<\/span><\/a><span style=\"font-weight: 400;\"> can interact with Ubrelvy, such as verapamil, cyclosporine, ciprofloxacin, fluconazole, fluvoxamine, ketoconazole, clarithromycin, itraconazole, phenytoin, and rifampin. St. John&#8217;s wort is also a strong CYP3A4 inducer and should be avoided when using Ubrelvy.<\/span><\/p>\n<h2 id=\"ubrelvy-side-effects\"><span style=\"font-weight: 400;\">Ubrelvy side effects<\/span><\/h2>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/ubrelvy-side-effects\/\"><span style=\"font-weight: 400;\">Ubrelvy side effects<\/span><\/a><span style=\"font-weight: 400;\"> are minimal and usually mild and short-lived, according to Dr. Carlsen. The most common side effects include:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sleepiness<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Less common but more serious <\/span><a href=\"https:\/\/www.rxabbvie.com\/pdf\/ubrelvy_pi.pdf\"><span style=\"font-weight: 400;\">side effects<\/span><\/a><span style=\"font-weight: 400;\"> of Ubrelvy include:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Raynaud&#8217;s phenomenon, which is a circulation problem that can lead to feelings of numbness, cold, and pain in the fingers and toes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">An allergic reaction, which could cause difficulty breathing, hives, and swelling of the face, lips, tongue, or throat<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Seek emergency medical treatment immediately if you experience signs of an allergic reaction. If you experience any unexpected side effects from taking Ubrelvy, be sure to seek medical advice from a healthcare provider. If you are pregnant or breastfeeding, check in with your healthcare provider as well.<\/span><\/p>\n<h2 id=\"what-can-i-take-instead-of-ubrelvy\"><span style=\"font-weight: 400;\">What can I take instead of Ubrelvy?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If Ubrelvy doesn\u2019t work well to alleviate your migraine, there are several other options for acute migraine treatment. The most common <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/ubrelvy-alternatives\/\"><span style=\"font-weight: 400;\">Ubrelvy alternatives <\/span><\/a><span style=\"font-weight: 400;\">include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/imitrex\"><span style=\"font-weight: 400;\">Imitrex (sumatriptan)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/diclofenac-sodium\"><span style=\"font-weight: 400;\">Cambia (diclofenac)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/zavzpret\"><span style=\"font-weight: 400;\">Zavzpret (zavegepant nasal spray)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/reyvow\"><span style=\"font-weight: 400;\">Reyvow (lasmiditan)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/trudhesa\"><span style=\"font-weight: 400;\">Trudhesa (dihydroergotamine)<\/span><\/a><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Additionally, your healthcare team may add preventive medication if you have frequent migraines or rescue treatments for specific symptoms, such as pain relief medication (such as ibuprofen) or anti-nausea medication (such as ondansetron).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Certain <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8105190\/#\"><span style=\"font-weight: 400;\">supplements<\/span><\/a><span style=\"font-weight: 400;\"> may also help reduce the frequency and length of migraine attacks, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/coenzyme-q10\"><span style=\"font-weight: 400;\">Coenzyme Q10<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/magnesium\"><span style=\"font-weight: 400;\">Magnesium<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/riboflavin\"><span style=\"font-weight: 400;\">Riboflavin<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/feverfew\"><span style=\"font-weight: 400;\">Feverfew<\/span><\/a><\/li>\n<\/ul>\n<h2 id=\"the-bottom-line\"><span style=\"font-weight: 400;\">The bottom line<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Ubrelvy is used exclusively to treat migraine headaches. It is not known to be effective and has not been studied for treating other types of headaches. Always seek advice from a healthcare provider before making decisions about which medication to take for your migraine headaches. If the medication you are using isn&#8217;t working, whether it&#8217;s Ubrelvy or another type of migraine treatment, consult your healthcare provider to figure out the next step.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ubrelvy (ubrogepant) is a brand-name medication that is approved by the U.S. Food and Drug Administration (FDA) for the acute treatment of migraine, with or without aura, in adults. Ubrelvy is very effective at stopping a migraine headache in its tracks. The ACHIEVE I and II clinical trials found that a significantly higher proportion of [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":632619,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[4316,8905],"coauthors":[21054],"class_list":["post-632779","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-migraine","tag-seasonal","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Ubrelvy for headaches: Optimal use and side effects<\/title>\n<meta name=\"description\" content=\"Ubrelvy (ubrogepant) won\u2019t work on tension, cluster, or other types of headaches. 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