{"id":632780,"date":"2025-07-21T09:30:08","date_gmt":"2025-07-21T13:30:08","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=632780"},"modified":"2025-08-11T14:19:20","modified_gmt":"2025-08-11T18:19:20","slug":"why-take-aripiprazole-in-the-morning","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/why-take-aripiprazole-in-the-morning\/","title":{"rendered":"When is the best time to take aripiprazole?"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/aripiprazole\"><span style=\"font-weight: 400;\">Aripiprazole<\/span><\/a><span style=\"font-weight: 400;\"> is an FDA-approved medication used to treat mental health conditions, such as bipolar disorder, irritability associated with autism spectrum disorder, major depressive disorder (MDD), schizophrenia, and Tourette&#8217;s Syndrome. Also known by the brand name <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/abilify\"><span style=\"font-weight: 400;\">Abilify<\/span><\/a><span style=\"font-weight: 400;\">, this atypical antipsychotic medication balances dopamine and serotonin levels in the brain to help regulate mood, behavior, and thoughts.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It\u2019s sometimes used <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/off-label-prescription-drugs\/\"><span style=\"font-weight: 400;\">off-label<\/span><\/a><span style=\"font-weight: 400;\"> to treat a range of other anxiety disorders, agitation from dementia, attention-deficit hyperactivity disorder (ADHD), and eating disorders. \u201cIn clinical practice, it\u2019s sometimes prescribed as an adjunct for treatment-resistant depression,\u201d says Daniel Tan, MD, MPH, founder of ADHD ONE. Aripiprazole is most commonly prescribed as a once-daily oral tablet, available in low doses of 2 mg up to higher doses of 30 mg. There is also a long-acting injectable formulation, sold under the brand name Abilify Maintena, that is given once a month. Oral aripiprazole has mild stimulating properties, so taking this drug in the morning could help reduce the risk of insomnia later in the day.<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Aripiprazole with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tAripiprazole 5 mg (30 Tablets)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23663 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-food-lion.svg\" alt=\"Food Lion\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$11.30<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/aripiprazole#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/aripiprazole#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart-nbh-market.svg\" alt=\"Walmart Neighborhood Market\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$12.93<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/aripiprazole#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/aripiprazole#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/aripiprazole#blog-cta\" class=\"coupon-see-all-btn\">See Aripiprazole prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"when-is-the-best-time-to-take-aripiprazole\"><span style=\"font-weight: 400;\">When is the best time to take aripiprazole?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Everyone has a unique brain chemistry that can affect what time of day it is best to take a medication, says Jared Heathman, MD, a Houston-based psychiatrist. Here\u2019s what to consider when you\u2019re discussing why to take aripiprazole in the morning versus at night with your provider:\u00a0<\/span><\/p>\n<h3 id=\"morning\"><span style=\"font-weight: 400;\">Morning<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Aripiprazole can have energizing effects. If you feel invigorated after your daily dose, morning is likely best for you. \u201cSome patients experience energy and motivation from aripiprazole, which could cause insomnia if taken at night,\u201d <\/span><a href=\"https:\/\/www.yourfamilypsychiatrist.com\/child-psychiatrists.html\"><span style=\"font-weight: 400;\">Dr. Heathman<\/span><\/a><span style=\"font-weight: 400;\"> explains.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cIt\u2019s not a hard-and-fast rule, but if someone\u2019s feeling wired or agitated after taking it at night, switching to a morning schedule often improves tolerance,\u201d <\/span><a href=\"https:\/\/adhdone.com\/daniel-tan\/\"><span style=\"font-weight: 400;\">Dr. Tan<\/span><\/a><span style=\"font-weight: 400;\"> agrees.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nausea is a common side effect of this medication. If it affects you, taking it with a light breakfast of toast or yogurt can help alleviate that queasy feeling, Dr. Tan says.\u00a0<\/span><\/p>\n<h3 id=\"night\"><span style=\"font-weight: 400;\">Night<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">For some, the same medication can have the opposite effect. Drowsiness is a possible reaction to aripiprazole. If you feel lethargic, rather than alert, timing your dose before bed makes the most sense. \u201cIf it makes you sleepy, take it at night,\u201d Dr. Heathman says.\u00a0<\/span><\/p>\n<h2 id=\"what-if-i-miss-a-dose-of-aripiprazole\"><span style=\"font-weight: 400;\">What if I miss a dose of aripiprazole?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Life happens. When your daily routine is interrupted, it\u2019s easy to miss a dose of aripiprazole. If you accidentally forget your daily pill, it\u2019s important to take it as soon as you remember\u2014unless it is almost time for your next dose.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cIf you are close to the next scheduled dose, skip the missed dose and continue with your regular schedule,\u201d says <\/span><a href=\"https:\/\/able2changerecovery.com\/staff\/meet-the-medical-director-randall-turner-do\/\"><span style=\"font-weight: 400;\">Randall Turner<\/span><\/a><span style=\"font-weight: 400;\">, DO, psychiatrist and medical director with Able to Change Recovery in California. \u201cDo not double up. Taking two doses at once can increase the risk of side effects, such as restlessness or feeling jittery.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you frequently miss doses, simple tools like alarm reminders on your phone can help you stay on track with your medication schedule.<\/span><\/p>\n<h2 id=\"how-long-does-it-take-for-aripiprazole-to-start-working\"><span style=\"font-weight: 400;\">How long does it take for aripiprazole to start working?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">For most people, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/how-long-does-abilify-take-to-work\/\"><span style=\"font-weight: 400;\">aripiprazole<\/span><\/a><span style=\"font-weight: 400;\"> starts to take effect within one to three weeks. However, it can take several weeks, sometimes up to six, to reach its full benefits.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cPeople with depression who are using it as an add-on to antidepressants might notice mood improvements sooner than those being treated for psychosis, but everyone responds a little differently,\u201d Dr. Turner says. Several factors can affect how quickly the drug starts working or how quickly you begin to feel better.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our mental health newsletter<\/span>\n\t\t\t<form class=\"form-wrapper\" data-newsletter-form=\"1\" data-subsource=\"Mental Health Newsletter\">\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<label for=\"dynamic-email\">Email<\/label>\n\t\t\t\t\t<input type=\"email\" id=\"dynamic-email\" class=\"email\" required>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<input class=\"submit-form-btn\" type=\"submit\" value=\"Click to sign up\">\n\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t\t<p class=\"success-message\" aria-live=\"polite\"><\/p>\n\t\t<\/div>\n\t<\/span><\/p>\n<h3 id=\"metabolism\"><span style=\"font-weight: 400;\">Metabolism<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u201cGenetics and liver metabolism play a significant role, particularly in how your body processes enzymes such as CYP2D6 and CYP3A4,\u201d Dr. Turner says.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">These enzymes are primarily responsible for breaking down aripiprazole in the liver to its active metabolite, <\/span><span style=\"font-weight: 400;\">dehydroaripiprazole<\/span><span style=\"font-weight: 400;\">. <\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0278584624002021\"><span style=\"font-weight: 400;\">One study<\/span><\/a><span style=\"font-weight: 400;\"> found that individual variations in these enzymes can lead to differences in how quickly or slowly patients metabolize the drug and start to feel the beneficial effects.<\/span><\/p>\n<h3 id=\"medications\"><span style=\"font-weight: 400;\">Medications<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Additionally, these same liver enzymes metabolize many common prescriptions, such as carbamazepine, alprazolam, and amiodarone. \u201cIf you are taking other medications that <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/aripiprazole-interactions\/\"><span style=\"font-weight: 400;\">interact<\/span><\/a><span style=\"font-weight: 400;\"> with these enzymes, it may affect how aripiprazole is broken down,\u201d Dr. Turner says. \u201cThat, in turn, might change how quickly you start to feel better.\u201d<\/span><\/p>\n<h3 id=\"supplements-and-vitamins\"><span style=\"font-weight: 400;\">Supplements and vitamins<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">There are a few over-the-counter vitamins and supplements that block the effectiveness of aripiprazole, though timing matters.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Iron and magnesium: <\/b><span style=\"font-weight: 400;\">Avoid taking iron and magnesium supplements too close to dosing since they can reduce absorption, Dr. Tan says.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>St. John\u2019s wort: <\/b><span style=\"font-weight: 400;\">Herbal supplements that are sometimes used to treat mild depression, such as <\/span><a href=\"https:\/\/www.mayoclinic.org\/drugs-supplements-st-johns-wort\/art-20362212\"><span style=\"font-weight: 400;\">St. John\u2019s Wort<\/span><\/a><span style=\"font-weight: 400;\">, can impact medication levels in the body as well, Dr. Heathman says. St. John\u2019s wort is an inducer of the CYP3A4 enzyme, meaning it can increase the metabolism of aripiprazole.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">This is not a complete list of all possible interactions. Always share any supplements you take with your pharmacist and healthcare team.<\/span><\/p>\n<h2 id=\"how-do-i-get-the-most-out-of-my-aripiprazole\"><span style=\"font-weight: 400;\">How do I get the most out of my aripiprazole?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">When taking any medication, there are steps you can take to minimize side effects and maximize benefits. To get the most out of aripiprazole, try these strategies:<\/span><\/p>\n<ul>\n<li><b>Take aripiprazole at the same time every day,<\/b><span style=\"font-weight: 400;\"> whether morning or evening works better for you. Consistency is key, Dr. Turner says.<\/span><\/li>\n<li><b>Avoid alcohol<\/b><span style=\"font-weight: 400;\"> while starting or adjusting psychiatric medications, since <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/aripiprazole-and-alcohol\/\"><span style=\"font-weight: 400;\">drinking alcohol<\/span><\/a><span style=\"font-weight: 400;\"> can worsen side effects like drowsiness or mood swings, Dr. Heathman says.<\/span><\/li>\n<li><b>Make healthy lifestyle changes. <\/b><span style=\"font-weight: 400;\">\u201cPatients do better when they understand this med isn\u2019t a knockout punch,\u201d Dr. Tan suggests. \u201cIt\u2019s more of a dial adjuster. Medication is just one spoke in the recovery wheel. Routine, therapy, and lifestyle matter just as much.\u201d\u00a0<\/span><\/li>\n<li><b>Report any shifts in mood or new side effects<\/b><span style=\"font-weight: 400;\"> to your healthcare provider. Small timing or dose tweaks can help smooth out the entire regimen. Common side effects of aripiprazole include nausea, constipation, restlessness, and weight gain. Rare but serious side effects include a drop in blood pressure, which can cause lightheadedness when standing up, as well as uncontrollable movements called <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK534115\/\"><span style=\"font-weight: 400;\">extrapyramidal symptoms<\/span><\/a><span style=\"font-weight: 400;\"> (EPS) and <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/tardive-dyskinesia-symptoms\"><span style=\"font-weight: 400;\">tardive dyskinesia <\/span><\/a><span style=\"font-weight: 400;\">(TD).<\/span><\/li>\n<li><b>Don\u2019t panic<\/b><span style=\"font-weight: 400;\"> in the first few days if your body feels off, Dr. Turner says. You may feel a little drowsy or wired at first, but this may fade as the body adjusts.<\/span><\/li>\n<li aria-level=\"1\"><b>Partner with your provider to optimize your dose. <\/b><span style=\"font-weight: 400;\">When Dr. Heathman treated a patient who struggled for years with agitation, unable to tolerate the first few medications she tried, he says she felt discouraged and wanted to give up. \u201cWe worked together over several visits, slowly adjusting the dose of aripiprazole,\u201d he says. \u201cWithin a couple of weeks, she started feeling calmer at work and told me, \u2018I finally feel like myself again.\u2019\u201d\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">That kind of transformation is why personalized care matters and why it\u2019s important to work with a healthcare provider to choose the right medication, monitor for common and serious side effects, and adjust the dose based on how you\u2019re responding.\u00a0<\/span><\/p>\n<h2 id=\"the-bottom-line\"><span style=\"font-weight: 400;\">The bottom line\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">While it is common to take aripiprazole in the morning to avoid trouble sleeping at night, some patients may prefer to take the drug in the evening if they experience drowsiness as a side effect. Timing aripiprazole doses isn\u2019t a one-size-fits-all process, Dr. Heathman says.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Getting the most out of any medication begins with establishing a trusted relationship with a healthcare provider who can provide medical advice. \u201cIf you think you might have symptoms of a mental health condition, don\u2019t wait to seek help,\u201d Dr. Heathman says. \u201cMental health conditions are increasingly common, treatable, and nothing to be ashamed of.\u201d<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Aripiprazole is an FDA-approved medication used to treat mental health conditions, such as bipolar disorder, irritability associated with autism spectrum disorder, major depressive disorder (MDD), schizophrenia, and Tourette&#8217;s Syndrome. Also known by the brand name Abilify, this atypical antipsychotic medication balances dopamine and serotonin levels in the brain to help regulate mood, behavior, and thoughts.\u00a0 [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":632620,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[12752,450,8905],"coauthors":[21050],"class_list":["post-632780","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-medication-side-effects","tag-mental-health","tag-seasonal","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Why take aripiprazole in the morning?<\/title>\n<meta name=\"description\" content=\"You may want to take aripiprazole in the morning if it causes insomnia at bedtime, but it affects everyone differently, and you can take it any time of day.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/why-take-aripiprazole-in-the-morning\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Morning doses, better days? Why timing matters on aripiprazole\" \/>\n<meta property=\"og:description\" content=\"Taking it early may avoid sleep issues and keep a steady routine\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.singlecare.com\/blog\/why-take-aripiprazole-in-the-morning\/\" \/>\n<meta property=\"og:site_name\" content=\"The Checkup\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/singlecare\" \/>\n<meta property=\"article:published_time\" content=\"2025-07-21T13:30:08+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-08-11T18:19:20+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2025\/06\/Blog_072125_Why_take_aripiprazole_in_the_morning-copy.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"Christine Bryant\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"Morning doses, better days? 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