{"id":632790,"date":"2025-07-08T17:31:22","date_gmt":"2025-07-08T21:31:22","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=632790"},"modified":"2026-03-27T15:45:07","modified_gmt":"2026-03-27T19:45:07","slug":"linzess-statistics","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/news\/linzess-statistics\/","title":{"rendered":"Linzess statistics and facts"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Few things can ruin a date, a night out with friends, or even a quiet evening like a bout of<\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/ibs-treatment-and-medications\"> <span style=\"font-weight: 400;\">irritable bowel syndrome<\/span><\/a><span style=\"font-weight: 400;\"> or<\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/constipation-treatment-and-medications\"> <span style=\"font-weight: 400;\">constipation<\/span><\/a><span style=\"font-weight: 400;\">. The symptoms can be a gauntlet of discomfort, from constipation to <\/span><span style=\"font-weight: 400;\">abdominal pain<\/span><span style=\"font-weight: 400;\">, <\/span><span style=\"font-weight: 400;\">bloating<\/span><span style=\"font-weight: 400;\">, <\/span><span style=\"font-weight: 400;\">abdominal distension<\/span><span style=\"font-weight: 400;\">, <\/span><span style=\"font-weight: 400;\">hard stools<\/span><span style=\"font-weight: 400;\">, and <\/span><span style=\"font-weight: 400;\">flatulence<\/span><span style=\"font-weight: 400;\">, and can leave you in desperate need of relief. Fortunately, medications like<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/linzess\"> <span style=\"font-weight: 400;\">Linzess<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><span style=\"font-weight: 400;\">linaclotide<\/span><span style=\"font-weight: 400;\">) can help. From a class of drugs called <\/span><span style=\"font-weight: 400;\">guanylate cyclase-C agonists<\/span><span style=\"font-weight: 400;\"> (<\/span><span style=\"font-weight: 400;\">GC-C<\/span><span style=\"font-weight: 400;\">), it calms pain-sensing nerves and accelerates bowel movements to help treat constipation associated with IBS or <\/span><span style=\"font-weight: 400;\">CIC<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">That effectiveness has made it extremely popular in the U.S., with millions of prescriptions already written. How many people use it? What makes it so widespread? How effective is it? We\u2019ve got plenty of facts and statistics on <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> use below.<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Linzess with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tLinzess 145 mcg (30 capsules)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$252.26<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/linzess#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/linzess#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-harristeeter.svg\" alt=\"Harris Teeter Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$252.26<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/linzess#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/linzess#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/linzess#blog-cta\" class=\"coupon-see-all-btn\">See Linzess prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"how-many-people-have-ibs-or-cic\"><span style=\"font-weight: 400;\">How many people have IBS or <\/span><span style=\"font-weight: 400;\">CIC<\/span><span style=\"font-weight: 400;\">?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">IBS and <\/span><span style=\"font-weight: 400;\">CIC<\/span><span style=\"font-weight: 400;\"> are common conditions. More specifically:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Experts estimate that around 10\u201315% of Americans have IBS, yet only 5\u20137% have been diagnosed. (<\/span><a href=\"https:\/\/gi.org\/topics\/irritable-bowel-syndrome\/\"><span style=\"font-weight: 400;\">American College of <\/span><span style=\"font-weight: 400;\">Gastroenterology<\/span><\/a><span style=\"font-weight: 400;\">, 2024)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Approximately 8\u201312% of U.S. adults have <\/span><span style=\"font-weight: 400;\">CIC<\/span><span style=\"font-weight: 400;\"> (aka <\/span><span style=\"font-weight: 400;\">functional constipation<\/span><span style=\"font-weight: 400;\">). (<\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10542656\/\"><i><span style=\"font-weight: 400;\">Gastroenterology<\/span><\/i><\/a><i><span style=\"font-weight: 400;\">, <\/span><\/i><span style=\"font-weight: 400;\">2024)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">In the U.S., one-third of people with IBS have constipation as the predominant symptom. (<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37595647\/\"><i><span style=\"font-weight: 400;\">Gastroenterology<\/span><\/i><\/a><span style=\"font-weight: 400;\">, 2023)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">IBS is reported around twice as often in women as in men. (<\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0953620524001055\"><i><span style=\"font-weight: 400;\">European Journal of Internal Medicine<\/span><\/i><\/a><span style=\"font-weight: 400;\">, 2024)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chronic idiopathic constipation affects 10-11% of people around the world, and is about twice as common in women. (<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34090581\/\"><i><span style=\"font-weight: 400;\">Lancet Gastroenterology<\/span><\/i><\/a><span style=\"font-weight: 400;\">, 2021)\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">IBS appears to be more common at younger ages. One study showed a prevalence of 45% for ages 18\u201329, 29% for ages 30\u201349, and 26% for ages 50 and older. (<\/span><a href=\"https:\/\/www.nature.com\/articles\/s44355-024-00010-y\"><i><span style=\"font-weight: 400;\">NPJ Gut and Liver<\/span><\/i><\/a><i><span style=\"font-weight: 400;\">, <\/span><\/i><span style=\"font-weight: 400;\">2024)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">CIC is more prevalent in older adults, with an incidence of 33.5% in adults aged 60 101, versus an average of 16% across adults in general. (<\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6829047\/\"><span style=\"font-weight: 400;\">Mayo Clin Proc.<\/span><\/a><span style=\"font-weight: 400;\">, 2020)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The prevalence of functional constipation in children aged 0-18 is 9.5%, and geographical location, lifestyle factors, and stressful life events influence it. (<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29656863\/\"><span style=\"font-weight: 400;\">The Journal of pediatrics<\/span><\/a><span style=\"font-weight: 400;\">, 2018).<\/span><\/li>\n<\/ul>\n<h2 id=\"how-many-people-use-linzess\"><span style=\"font-weight: 400;\">How many people use <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\">?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Hundreds of thousands of <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> prescriptions are written and filled each year. While it\u2019s hard to say how many people are using <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> right now, here\u2019s what we know:<\/span><\/p>\n<ul>\n<li><span style=\"font-weight: 400;\">Between 2012 and 2017, more than seven million prescriptions were filled for <\/span><span style=\"font-weight: 400;\">Linzess by 1.5 million unique patients<\/span><span style=\"font-weight: 400;\">. (<\/span><a href=\"https:\/\/investor.ironwoodpharma.com\/press-releases\/press-release-details\/2017\/US-Food-and-Drug-Administration-Approves-72-mcg-Dose-of-LINZESS-linaclotide-for-Adults-with-Chronic-Idiopathic-Constipation\/default.aspx\"><span style=\"font-weight: 400;\">Ironwood Pharmaceutical <\/span><span style=\"font-weight: 400;\">Inc.<\/span><\/a><span style=\"font-weight: 400;\">,<\/span><span style=\"font-weight: 400;\"> 2017)<\/span><\/li>\n<li><span style=\"font-weight: 400;\">In 2022 alone, there were an estimated 534,890 people in the U.S. using <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/clincalc.com\/DrugStats\/Drugs\/Linaclotide\"><span style=\"font-weight: 400;\">ClinCalc<\/span><\/a><span style=\"font-weight: 400;\">, 2022)<\/span><\/li>\n<li><span style=\"font-weight: 400;\">By 2024, more than 5 million people had been prescribed <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> since its approval. (<\/span><a href=\"https:\/\/www.linzesshcp.com\/linzess-insurance-coverage\"><span style=\"font-weight: 400;\">IQVIA Total Patient Tracker<\/span><\/a><span style=\"font-weight: 400;\">, 2024)<\/span><\/li>\n<\/ul>\n<h2 id=\"why-is-linzess-so-popular\"><span style=\"font-weight: 400;\">Why is <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> so popular?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u201c<\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> is widely used because it addresses two major complaints: constipation and discomfort,\u201d says <\/span><a href=\"https:\/\/drtelx.com\/our-experts\/\"><span style=\"font-weight: 400;\">Dr. Martina Ambardjieva, MD<\/span><\/a><span style=\"font-weight: 400;\">, a urologist at Dr. Telx. \u201cIt\u2019s also convenient\u2014taken once daily on an empty stomach\u2014and acts locally in the gut with very little systemic absorption, which lowers the risk of broader side effects.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0The popularity of Linzess for people with IBS and CIC has been increasing since it was approved.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Approximately 212 million <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> capsules were dispensed in 2024, an 11% increase from 2023. (<\/span><a href=\"https:\/\/investor.ironwoodpharma.com\/press-releases\/press-release-details\/2025\/Ironwood-Pharmaceuticals-Reports-Fourth-Quarter-and-Full-Year-2024-Results-Achieves-2024-Financial-Guidance\/default.aspx\"><span style=\"font-weight: 400;\">Ironwood Pharmaceuticals<\/span><\/a><span style=\"font-weight: 400;\">, Inc.<\/span><span style=\"font-weight: 400;\">, 2025)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">From 2022 to 2023, <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> saw an increase in prescription demand of 10%. (<\/span><a href=\"https:\/\/www.investing.com\/news\/stock-market-news\/earnings-call-ironwood-pharmaceuticals-reports-growth-and-pipeline-progress-93CH-3305702\"><span style=\"font-weight: 400;\">Ironwood Pharmaceuticals<\/span><\/a><span style=\"font-weight: 400;\">, Inc.<\/span><span style=\"font-weight: 400;\">, 2024)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> and Constellation comprised 37.3% of the IBS treatment market in 2024, the most of any IBS drugs. (<\/span><a href=\"https:\/\/www.grandviewresearch.com\/industry-analysis\/irritable-bowel-syndrome-ibs-treatment-market\"><span style=\"font-weight: 400;\">Grand View Research<\/span><\/a><span style=\"font-weight: 400;\">, 2025)<\/span><\/li>\n<\/ul>\n<h2 id=\"how-effective-is-linzess-for-ibs-and-cic\"><span style=\"font-weight: 400;\">How effective is <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> for IBS and <\/span><span style=\"font-weight: 400;\">CIC<\/span><span style=\"font-weight: 400;\">?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">According to <\/span><a href=\"https:\/\/www.ketchum.edu\/directory\/genene-salman\"><span style=\"font-weight: 400;\">Dr. Genene Salman, Pharm.D, BCCCP, BCPS, CNSC<\/span><\/a><span style=\"font-weight: 400;\">, an associate professor in the <\/span><a href=\"https:\/\/www.ketchum.edu\"><span style=\"font-weight: 400;\">Marshall B. Ketchum University<\/span><\/a><span style=\"font-weight: 400;\"> College of Pharmacy, <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> \u201cfunctions as a secretagogue by drawing ions and water into the <\/span><span style=\"font-weight: 400;\">gastrointestinal<\/span><span style=\"font-weight: 400;\"> tract. <\/span><span style=\"font-weight: 400;\">Linaclotide<\/span><span style=\"font-weight: 400;\"> and its active metabolite bind to and activate <\/span><span style=\"font-weight: 400;\">GC-C<\/span><span style=\"font-weight: 400;\"> on the luminal surface of intestinal epithelial cells.\u201d Activating the protein <\/span><span style=\"font-weight: 400;\">GC-C<\/span><span style=\"font-weight: 400;\"> leads to increased intestinal <\/span><span style=\"font-weight: 400;\">fluid secretion<\/span><span style=\"font-weight: 400;\">, improving <\/span><span style=\"font-weight: 400;\">stool consistency<\/span><span style=\"font-weight: 400;\"> and movement.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Research has shown its efficacy for reliably treating the symptoms of both IBS with constipation (IBS-C) and <\/span><span style=\"font-weight: 400;\">CIC<\/span><span style=\"font-weight: 400;\">. Dr. Salman cites a few studies as particularly convincing:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A 2012 study by Chey and colleagues, which studied 804 patients with IBS-C over a 26-week <\/span><span style=\"font-weight: 400;\">treatment period<\/span><span style=\"font-weight: 400;\">, found that approximately 34% of trial participants who received <\/span><span style=\"font-weight: 400;\">linaclotide<\/span><span style=\"font-weight: 400;\"> met the <\/span><span style=\"font-weight: 400;\">FDA<\/span><span style=\"font-weight: 400;\"> definition for effectiveness compared to 13.9% who received a placebo. (<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22986437\/\"><i><span style=\"font-weight: 400;\">The American College of <\/span><\/i><i><span style=\"font-weight: 400;\">Gastroenterology<\/span><\/i><\/a><i><span style=\"font-weight: 400;\">, <\/span><\/i><span style=\"font-weight: 400;\">2012)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A network meta-analysis conducted by Black and colleagues in 2018 identified <\/span><span style=\"font-weight: 400;\">linaclotide<\/span><span style=\"font-weight: 400;\"> as the most effective agent among other <\/span><span style=\"font-weight: 400;\">IBS-C<\/span><span style=\"font-weight: 400;\"> prescription medications available at that time. (<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30144426\/\"><i><span style=\"font-weight: 400;\">Gastroenterology<\/span><\/i><\/a><i><span style=\"font-weight: 400;\">, <\/span><\/i><span style=\"font-weight: 400;\">2018)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">In a 2021 study consisting of 614 patients with IBS-C, Chang and colleagues reported that 40.5% of those treated with <\/span><span style=\"font-weight: 400;\">linaclotide<\/span><span style=\"font-weight: 400;\"> experienced significant improvement in weekly <\/span><span style=\"font-weight: 400;\">abdominal symptoms<\/span><span style=\"font-weight: 400;\"> (<\/span><span style=\"font-weight: 400;\">bloating<\/span><span style=\"font-weight: 400;\">, discomfort, and pain) for at least 6 out of 12 weeks, compared to 23.4% in the placebo group. (<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34465695\/\"><i><span style=\"font-weight: 400;\">The American College of <\/span><\/i><i><span style=\"font-weight: 400;\">Gastroenterology<\/span><\/i><\/a><i><span style=\"font-weight: 400;\">, <\/span><\/i><span style=\"font-weight: 400;\">2021)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Yet those aren\u2019t the only studies that have shown the effectiveness of <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> for IBS and <\/span><span style=\"font-weight: 400;\">CIC<\/span><span style=\"font-weight: 400;\">:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">In a 2023 study, <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> reduced <\/span><span style=\"font-weight: 400;\">abdominal pain<\/span><span style=\"font-weight: 400;\">, discomfort, or <\/span><span style=\"font-weight: 400;\">bloating<\/span><span style=\"font-weight: 400;\"> associated with <\/span><span style=\"font-weight: 400;\">IBS-C<\/span><span style=\"font-weight: 400;\"> by \u226530% for over 50% of 2,350 <\/span><span style=\"font-weight: 400;\">adult patients<\/span><span style=\"font-weight: 400;\">. (<\/span><a href=\"https:\/\/journals.lww.com\/ajg\/fulltext\/2023\/05000\/linaclotide_reduced_response_time_for_irritable.24.aspx\"><i><span style=\"font-weight: 400;\">The American Journal of <\/span><\/i><i><span style=\"font-weight: 400;\">Gastroenterology<\/span><\/i><\/a><span style=\"font-weight: 400;\">, 2023)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">In <\/span><span style=\"font-weight: 400;\">clinical trials<\/span><span style=\"font-weight: 400;\">, 49% of patients who took <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> for <\/span><span style=\"font-weight: 400;\">IBS-C<\/span><span style=\"font-weight: 400;\"> reported improved <\/span><span style=\"font-weight: 400;\">abdominal pain<\/span><span style=\"font-weight: 400;\"> and more frequent <\/span><span style=\"font-weight: 400;\">complete spontaneous bowel movements<\/span><span style=\"font-weight: 400;\"> (<\/span><span style=\"font-weight: 400;\">CSBMs<\/span><span style=\"font-weight: 400;\">) in six out of twelve weeks, compared to 30% for <\/span><span style=\"font-weight: 400;\">placebo-treated patients<\/span><span style=\"font-weight: 400;\">. (<\/span><a href=\"https:\/\/www.linzesshcp.com\/linzess-ibs-c-efficacy\"><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> website<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Clinical trials<\/span><span style=\"font-weight: 400;\"> also showed that <\/span><span style=\"font-weight: 400;\">IBS-C patients<\/span><span style=\"font-weight: 400;\"> taking <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> experienced a mean 28.9% reduction in <\/span><span style=\"font-weight: 400;\">bloating<\/span><span style=\"font-weight: 400;\">, compared to 18.8% with a placebo. (<\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> website)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">For <\/span><span style=\"font-weight: 400;\">CIC patients<\/span><span style=\"font-weight: 400;\">, <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> improved patients\u2019 <\/span><span style=\"font-weight: 400;\">CSBM<\/span><span style=\"font-weight: 400;\"> frequency after twelve weeks by an average of 1.5 more <\/span><span style=\"font-weight: 400;\">CSBMs<\/span><span style=\"font-weight: 400;\"> than the <\/span><span style=\"font-weight: 400;\">placebo-controlled<\/span><span style=\"font-weight: 400;\"> group. (<\/span><a href=\"https:\/\/www.linzesshcp.com\/linzess-cic-efficacy\"><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> website<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<\/ul>\n<h2 id=\"how-much-do-americans-spend-on-linzess\"><span style=\"font-weight: 400;\">How much do Americans spend on <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\">?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Since its <\/span><span style=\"font-weight: 400;\">FDA approval<\/span><span style=\"font-weight: 400;\"> in 2012, the total money spent on <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> has increased drastically. Today, Americans spend around $1 billion per year on the drug.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">In 2024, net revenue from <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> purchases totaled $913.3 million. In 2023, net revenue was over $1 billion. (<\/span><span style=\"font-weight: 400;\">Ironwood Pharmaceuticals<\/span><span style=\"font-weight: 400;\">, 2025)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">On average, a 30-day supply of <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> costs around $731.30. (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/linzess\"><span style=\"font-weight: 400;\">SingleCare<\/span><\/a><span style=\"font-weight: 400;\">, 2025)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Around 91% of <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> prescriptions have an out-of-pocket cost of $0-$50 per month for people with private health insurance. (<\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> website, 2025)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">For people with Medicare Part D prescription drug coverage, about 84% of <\/span><span style=\"font-weight: 400;\">LINZESS<\/span><span style=\"font-weight: 400;\"> prescriptions have an out-of-pocket cost between $0-$50 per month. (<\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> website, 2025)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nearly 100% of people who have Medicaid pay $0\u2013$10 per month out of pocket for their <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> prescription. (<\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> website)<\/span><\/li>\n<\/ul>\n<h3 id=\"how-many-americans-use-insurance-for-linzess\"><span style=\"font-weight: 400;\">How many Americans use insurance for <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\">?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The exact percentage is unknown, but according to <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\">\u2019 manufacturer, more than 98% of commercial plans cover <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\">. (<\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> website, 2024)<\/span><\/p>\n<h3 id=\"how-many-americans-pay-for-linzess-out-of-pocket\"><span style=\"font-weight: 400;\">How many Americans pay for <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> out of pocket?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The exact percentage is unknown, but as of 2024, around 8.2% of Americans were uninsured. (<\/span><a href=\"https:\/\/aspe.hhs.gov\/sites\/default\/files\/documents\/ee0475e44e27daef00155e95a24fd023\/nhis-q1-2024-datapoint.pdf\"><span style=\"font-weight: 400;\">U.S. Department of Health and Human Services<\/span><\/a><span style=\"font-weight: 400;\">, 2025)<\/span><\/p>\n<h2 id=\"linzess-side-effects\"><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">For anyone weathering the daily trials of living with IBS or <\/span><span style=\"font-weight: 400;\">CIC<\/span><span style=\"font-weight: 400;\">, <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> offers some enticing benefits. And while its <\/span><span style=\"font-weight: 400;\">tolerability<\/span><span style=\"font-weight: 400;\"> is generally pretty good, those benefits<\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=09beda19-56d6-4a56-afdc-9a77b70b2ef3\"> <span style=\"font-weight: 400;\">may come with <\/span><span style=\"font-weight: 400;\">adverse effects<\/span><\/a><span style=\"font-weight: 400;\">. Most of these <\/span><span style=\"font-weight: 400;\">adverse events<\/span><span style=\"font-weight: 400;\"> are <\/span><span style=\"font-weight: 400;\">gastrointestinal<\/span><span style=\"font-weight: 400;\">, and they include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gas<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bloating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Viral gastroenteritis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headaches<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u201cThat\u2019s why it\u2019s important to start the medication as directed\u2014on an empty stomach at least 30 minutes before a meal\u2014and to monitor how patients respond, especially during the first two weeks,\u201d Dr. Ambardjieva says.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Additionally, in rare cases, <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> may cause more<\/span><a href=\"https:\/\/www.singlecare.com\/blog\/linzess-side-effects\/\"> <span style=\"font-weight: 400;\">serious side effects<\/span><\/a><span style=\"font-weight: 400;\">, which require medical attention. These include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weight loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe diarrhea<\/span><span style=\"font-weight: 400;\">, increasing the <\/span><span style=\"font-weight: 400;\">risk of serious dehydration<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Allergic reactions<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Per the <\/span><span style=\"font-weight: 400;\">FDA<\/span><span style=\"font-weight: 400;\">, <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\">\u2019 <\/span><span style=\"font-weight: 400;\">contraindications<\/span><span style=\"font-weight: 400;\"> include <\/span><span style=\"font-weight: 400;\">pediatric patients<\/span><span style=\"font-weight: 400;\"> under two <\/span><span style=\"font-weight: 400;\">years of age<\/span><span style=\"font-weight: 400;\"> and people who have a known or suspected intestinal obstruction. It may also have <\/span><span style=\"font-weight: 400;\">drug interactions<\/span><span style=\"font-weight: 400;\"> with other medications, so always inform a <\/span><span style=\"font-weight: 400;\">healthcare<\/span><span style=\"font-weight: 400;\"> provider about other drugs or supplements you\u2019re taking.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Patients should also inform a <\/span><span style=\"font-weight: 400;\">healthcare<\/span><span style=\"font-weight: 400;\"> provider about any side effects they experience. The prescribing doctor may adjust the dosage, discontinue the prescription, or consider<\/span><a href=\"https:\/\/www.singlecare.com\/blog\/linzess-alternatives\/\"> <span style=\"font-weight: 400;\">other <\/span><span style=\"font-weight: 400;\">treatment options<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Few things can ruin a date, a night out with friends, or even a quiet evening like a bout of irritable bowel syndrome or constipation. The symptoms can be a gauntlet of discomfort, from constipation to abdominal pain, bloating, abdominal distension, hard stools, and flatulence, and can leave you in desperate need of relief. Fortunately, [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":632794,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4114],"tags":[20947,16413],"coauthors":[8861],"class_list":["post-632790","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-constipation","tag-singlecare-stats","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Linzess statistics and facts 2026<\/title>\n<meta name=\"description\" content=\"Linzess is a popular treatment for IBS and CIC. 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