{"id":632818,"date":"2025-07-10T11:09:41","date_gmt":"2025-07-10T15:09:41","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=632818"},"modified":"2026-02-24T13:59:56","modified_gmt":"2026-02-24T18:59:56","slug":"zepbound-vs-wegovy-cost","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/zepbound-vs-wegovy-cost\/","title":{"rendered":"Is Zepbound cheaper than Wegovy?"},"content":{"rendered":"

Zepbound<\/span><\/a> (tirzepatide) and <\/span>Wegovy<\/span><\/a> (semaglutide) are brand-name prescription drugs that help people lose weight. These drugs are injected under the skin once weekly. There is no generic form of either drug, although compounded versions of tirzepatide and semaglutide were temporarily permitted during drug shortages. One drug may be more expensive than the other, but the price you ultimately pay for Wegovy or Zepbound depends on several factors, such as whether your health insurance covers it and your reason for taking it.\u00a0\u00a0<\/span><\/p>\n

What\u2019s the difference between Zepbound and Wegovy?<\/span><\/h2>\n

Wegovy<\/span><\/a> (semaglutide) was approved by the Food and Drug Administration (FDA) in June 2021 for chronic weight management in people ages 12 and older with <\/span>obesity<\/span><\/a> and in adults who are overweight with at least one weight-related condition, such as <\/span>high blood pressure<\/span><\/a>, <\/span>Type 2 diabetes<\/span><\/a>, or <\/span>high cholesterol<\/span><\/a>. In 2024, the FDA also approved Wegovy <\/span>for reducing the risk of cardiovascular death<\/span><\/a>, heart attack, and stroke in adults with cardiovascular disease and either obesity or a BMI of 27 or higher. Wegovy is made by Novo Nordisk and available in five dose strengths: 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, and 2.4 mg.\u00a0<\/span><\/p>\n

\u00a0<\/span>Zepbound<\/span><\/a> (tirzepatide) is FDA approved to reduce excess body weight and maintain weight reduction long-term in adults with obesity or who are overweight and who have at least one weight-related comorbid condition. It is also <\/span>approved to treat moderate to severe obstructive sleep apnea (OSA)<\/span><\/a> in adults with obesity. Zepbound is made by Lilly and is available in six dose strengths: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, or 15 mg per 0.5 mL single-dose pen.<\/span><\/p>\n

Zepbound and Wegovy mimic hormones in the gut that help with blood sugar regulation and digestion, suppressing appetite and helping people feel fuller longer. Both medications are intended to be used as part of a healthy diet and exercise plan. \u201cThe primary difference between Wegovy and Zepbound is that Zepbound is a glucose-dependent insulinotropic polypeptide (GIP)\/glucagon-like peptide (GLP-1) receptor agonist, while Wegovy is only a GLP-1 receptor agonist,\u201d says <\/span>Gianna R. D\u2019Angelo<\/span><\/a>, Pharm.D., a clinical assistant professor in the Department of Pharmacy Practice at the D\u2019Youville School of Pharmacy in Buffalo, New York.\u201d<\/span><\/p>\n

A study published in the <\/span>New England Journal of Medicine<\/span><\/i><\/a> comparing the two drugs found that the active ingredient in Zepbound (tirzepatide) was more effective than the active ingredient in Wegovy (semaglutide). The researchers observed that while both drugs are highly effective for obesity management, people who took tirzepatide lost an average of 20.2% of their body weight at 72 weeks, while people who took semaglutide lost an average of 13.7% of their body weight. Also, participants who took tirzepatide lost an average of 18.4 centimeters (cm) from their waist circumference, while participants who took semaglutide lost an average of 13 cm.<\/span><\/p>\n

RELATED: <\/b>Zepbound vs. Wegovy for weight loss<\/b><\/a><\/p>\n

How much does Zepbound cost without insurance?<\/span><\/h2>\n

The average retail price of Zepbound is $1,520 per 4, 0.5 mL of 5 mg\/0.5 mL pens. Costs can vary by pharmacy and location. With a <\/span>SingleCare coupon for Zepbound<\/span><\/a>, you could pay $950 for 4, 5 mg\/0.5 mL pens, saving close to $600.\u00a0<\/span><\/p>\n

How much does Wegovy cost without insurance?<\/span><\/h2>\n

The average retail price of Wegovy is $1,821 per 4, 0.75 mL of 2.4 mg\/0.75 mL pens, but you can pay $1,225 with a <\/span>SingleCare coupon for Wegovy<\/span><\/a>, depending on your choice of pharmacy.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n
\n

Zepbound vs. Wegovy cost comparison<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

<\/td>\nZepbound pen<\/b><\/td>\nWegovy pen<\/b><\/td>\n<\/tr>\n
Typically covered by insurance?<\/b><\/td>\nVaries<\/span><\/td>\nVaries<\/span><\/td>\n<\/tr>\n
Typically covered by Medicare Part D?<\/b><\/td>\nNot for weight loss<\/span><\/td>\nNot for weight loss<\/span><\/td>\n<\/tr>\n
Cost without insurance*<\/b><\/td>\n $1,520 per 4, 0.5 mL of 5 mg\/0.5 mL pens<\/span><\/td>\n $1,821 for 4, 5 mg\/0.5 mL pens<\/span><\/td>\n<\/tr>\n
SingleCare cost*<\/b><\/td>\n $937 at Publix<\/span><\/td>\n $1,210 at Publix<\/span><\/td>\n<\/tr>\n
Savings<\/b><\/td>\nGet coupon<\/span><\/a><\/td>\nGet coupon<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of Feb. 24, 2026. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available.<\/small><\/em><\/p>\n

Does insurance cover Zepbound?<\/span><\/h2>\n

Whether or not your insurance covers Zepbound depends on why you are taking it and what type of insurance you have.\u00a0<\/span><\/p>\n

Medicare Part D plans typically do not provide coverage for Zepbound if taken for weight loss but may be more likely to cover it for obstructive sleep apnea. Contact your plan provider for more information.<\/span><\/p>\n

Medicaid coverage of Zepbound varies by state. In July 2023, only nine states covered GLP-1s for obesity. As of August 2024, the <\/span>number of state Medicaid programs covering GLP-1s<\/span><\/a> increased to 13: California, Delaware, Kansas, Massachusetts, Michigan, Minnesota, Mississippi, New Hampshire, North Carolina, Pennsylvania, Rhode Island, Vermont, and Virginia. With coverage increasing, be sure to check with your <\/span>state\u2019s Medicaid office<\/span><\/a> to monitor and verify coverage.\u00a0<\/span><\/p>\n

Does insurance cover Wegovy?<\/span><\/h2>\n

As is the case with Zepbound, insurance coverage for Wegovy varies. Coverage is always changing, so be sure to check with your plan provider for specifics. If your insurance plan doesn\u2019t cover Wegovy for weight loss, it may be more likely to cover it for reducing cardiovascular risk. The Wegovy website has <\/span>a tool that allows you to check your coverage<\/span><\/a>.\u00a0<\/span><\/p>\n

Medicare<\/span><\/a> also isn\u2019t likely to cover Wegovy for weight loss but may cover it to reduce cardiovascular risk in adults with established heart disease and a BMI of 27 or higher.<\/span><\/p>\n

Medicaid coverage for Wegovy<\/span><\/a> is similar to that of Zepbound: It is more likely to cover both drugs for their approved indications other than weight loss, but coverage varies by state.\u00a0<\/span><\/p>\n

Monitoring insurance coverage for GLP-1s<\/span><\/h2>\n

Insurance coverage for GIP and GLP-1 drugs like Zepbound and Wegovy is complex and constantly changing. Coverage can vary significantly from one plan to another. Although the <\/span>American Medical Association classifies obesity as a chronic disease<\/span><\/a>, some insurance companies and <\/span>Medicare<\/span><\/a> don\u2019t cover weight loss medications, and Medicaid coverage is limited. Until obesity is more widely recognized as a chronic disease, people are more likely to get coverage for weight-related conditions such as Type 2 diabetes, cardiovascular risk reduction, and obstructive sleep apnea than they are for weight loss itself.\u00a0<\/span><\/p>\n

How to get coverage for GLP-1s<\/span><\/h2>\n

There may be ways to <\/span>get insurance to cover Wegovy<\/span><\/a> and Zepbound, even if your insurance company initially denies coverage. For example, you could ask your healthcare provider to submit a request asking the insurance company to reconsider benefits, or you may send an appeal to your insurance company to document that you meet the FDA requirements for either drug.\u00a0<\/span><\/p>\n

Although not many insurance companies cover medications specifically for weight loss, Cigna has <\/span>recently announced<\/span><\/a> that it will cap out-of-pocket costs for both Zepbound and Wegovy at $200 per month for certain plans. If you have private insurance, check with your insurance company for specific drug coverage and copay details.\u00a0<\/span><\/p>\n

Bottom line<\/span><\/h2>\n

If you can\u2019t get coverage for either drug, remember that SingleCare coupons for <\/span>Wegovy<\/span><\/a> and <\/span>Zepbound<\/span><\/a> can help you save close to $600 per month. They\u2019re free and accepted at pharmacies across the country.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Zepbound (tirzepatide) and Wegovy (semaglutide) are brand-name prescription drugs that help people lose weight. These drugs are injected under the skin once weekly. There is no generic form of either drug, although compounded versions of tirzepatide and semaglutide were temporarily permitted during drug shortages. One drug may be more expensive than the other, but the […]<\/p>\n","protected":false},"author":149,"featured_media":632819,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8313],"tags":[15103,21067,9825],"coauthors":[21058],"class_list":["post-632818","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-vs-drug","tag-drug-pricing","tag-glp-1-drugs","tag-weight-loss","wpautop"],"acf":[],"yoast_head":"\nZepbound vs. Wegovy cost comparison<\/title>\n<meta name=\"description\" content=\"Zepbound costs over $1,500 without insurance, while Wegovy costs over $1,800 per month. 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