{"id":632956,"date":"2025-08-05T09:30:56","date_gmt":"2025-08-05T13:30:56","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=632956"},"modified":"2025-09-03T15:11:59","modified_gmt":"2025-09-03T19:11:59","slug":"azstarys-and-caffeine","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/azstarys-and-caffeine\/","title":{"rendered":"Can you drink coffee on Azstarys?"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/blog\/adhd-facts-myths\/\"><span style=\"font-weight: 400;\">Attention deficit hyperactivity disorder (ADHD)<\/span><\/a><span style=\"font-weight: 400;\"> is commonly associated with children. However, an estimated <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/news\/adhd-statistics\/\"><span style=\"font-weight: 400;\">15.5 million adults in the United States<\/span><\/a><span style=\"font-weight: 400;\"> currently have an ADHD diagnosis, half of whom were diagnosed in adulthood, according to the CDC. All that to say, there are plenty of people taking medication for ADHD who also start their day with a cup of coffee.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">One commonly prescribed drug for ADHD is <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/azstarys\"><span style=\"font-weight: 400;\">Azstarys<\/span><\/a><span style=\"font-weight: 400;\">, which is a combination of serdexmethylphenidate and dexmethylphenidate. <\/span><a href=\"https:\/\/azstarys.com\/how-azstarys-works\"><span style=\"font-weight: 400;\">Azstarys<\/span><\/a><span style=\"font-weight: 400;\"> is a central nervous system (CNS) stimulant that\u2019s meant to increase attention and reduce impulsiveness and hyperactivity in people with <\/span><a href=\"https:\/\/www.singlecare.com\/resources\/adhd\"><span style=\"font-weight: 400;\">ADHD<\/span><\/a><span style=\"font-weight: 400;\">. It\u2019s recommended to take this medication in the morning (read: the same time as your daily joe), so its benefits last throughout the day.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While coffee won\u2019t hinder the effectiveness of Azstarys, you should be mindful of the amount you consume while taking this medication. Here\u2019s why.<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Azstarys with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tAzstarys 39.2-7.8 mg (30 Capsules)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$385.07<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/azstarys#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/azstarys#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-harristeeter.svg\" alt=\"Harris Teeter Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$385.07<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/azstarys#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/azstarys#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/azstarys#blog-cta\" class=\"coupon-see-all-btn\">See Azstarys prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"can-you-drink-coffee-on-azstarys\"><span style=\"font-weight: 400;\">Can you drink coffee on Azstarys?\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u201cIt\u2019s generally advised to limit or avoid caffeine while taking any stimulant medications,\u201d says <\/span><a href=\"https:\/\/www.hotelcaliforniabythesea.com\/dr-jason-kellogg\/\"><span style=\"font-weight: 400;\">Jason Kellogg, MD<\/span><\/a><span style=\"font-weight: 400;\">, psychiatrist and Medical Director of Hotel California by the Sea in Orange County, California. The reason? Caffeine is also a stimulant, so combining the two could exacerbate the side effects of Azstarys.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cThis could potentially lead to effects like increased heart rate, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/anxiety-vs-depression\/\"><span style=\"font-weight: 400;\">anxiety<\/span><\/a><span style=\"font-weight: 400;\">, insomnia, or jitteriness, particularly in sensitive individuals,\u201d explains <\/span><a href=\"https:\/\/telapsychiatry.com\/ozan-toy-md-mph\/\"><span style=\"font-weight: 400;\">Ozan Toy, MD<\/span><\/a><span style=\"font-weight: 400;\">, psychiatrist and Chief Medical Officer with Telapsychiatry, a virtual mental health practice. That\u2019s because \u201cboth substances cause these effects directly,\u201d Dr. Toy continues. Additionally, both Azstarys and coffee cause decreased appetite, which could result in unintended weight loss when combined.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In other words, while there\u2019s not a direct interaction between coffee and Azstarys, the two together can exacerbate their common side effects. So if you\u2019re prone to getting jitters or <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/medications-that-cause-insomnia\/\"><span style=\"font-weight: 400;\">having trouble sleeping<\/span><\/a><span style=\"font-weight: 400;\"> from drinking coffee alone, there\u2019s a strong chance you\u2019ll experience these side effects from combining it with Azstarys. That said, there are some important considerations:<\/span><\/p>\n<ul>\n<li><b>The amount of caffeine:<\/b><span style=\"font-weight: 400;\"> Stick with the FDA-recommended limits of less than 400 mg daily, which is about two to three 12-ounce cups of coffee daily, depending on how strong your brew. Avoid large amounts of caffeine, such as from caffeine pills or energy drinks. If your standard two cups of coffee are making your side effects worse, you can drop your intake to one cup or switch the second to decaf.\u00a0<\/span><\/li>\n<li aria-level=\"1\"><b>The <a href=\"https:\/\/www.singlecare.com\/prescription\/azstarys\/dosage\">dose<\/a> of Azstarys:<\/b><span style=\"font-weight: 400;\"> Higher doses of stimulant medication carry a greater risk of side effects, which could increase when combined with caffeine. Dr. Kellogg suggests spacing out your medication and your coffee to reduce symptoms, such as waiting at least an hour after taking your Azstarys before drinking your first cup of coffee.<\/span><\/li>\n<li aria-level=\"1\"><b>The preexisting medical conditions: <\/b><span style=\"font-weight: 400;\">The most serious side effects of combining these two stimulants are increased heart rate and high blood pressure. People with a personal or family history of circulation problems, heart disease, or other heart problems may need to avoid caffeine completely if taking a stimulant medication.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If you don\u2019t experience any side effects from caffeine, you should be okay to consume some while taking the ADHD medication. \u201cEveryone is different, and some may be more susceptible to the effects of caffeine combined with ADHD medications than others,\u201d Dr. Toy notes. The safest bet is to seek medical advice from your provider and then try a trial period to determine how exactly the two are affecting you.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cIf ADHD makes it difficult for you to recognize or recall, keeping a log of symptoms and comparing when you had caffeine and refrained would be beneficial for reviewing,\u201d Dr. Kellogg adds.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our mental health newsletter<\/span>\n\t\t\t<form class=\"form-wrapper\" data-newsletter-form=\"1\" data-subsource=\"Mental Health Newsletter\">\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<label for=\"dynamic-email\">Email<\/label>\n\t\t\t\t\t<input type=\"email\" id=\"dynamic-email\" class=\"email\" required>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<input class=\"submit-form-btn\" type=\"submit\" value=\"Click to sign up\">\n\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t\t<p class=\"success-message\" aria-live=\"polite\"><\/p>\n\t\t<\/div>\n\t<\/span><\/p>\n<h2 id=\"does-coffee-taste-different-while-on-azstarys\"><span style=\"font-weight: 400;\">Does coffee taste different while on Azstarys?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If your go-to coffee drink tastes a little different after taking Azstarys, it\u2019s not in your head. In fact, it\u2019s likely a result of dry mouth, which is a common side effect of most stimulant medications used to treat ADHD, including Azstarys.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cDry mouth may change the oral balance of the mouth, especially the taste buds\u2019 capabilities,\u201d Dr. Kellogg explains. \u201cIndividuals will try to eat their favorite foods after saliva hasn\u2019t been properly produced, and they often notice a difference (even a metallic taste).\u201d<\/span><\/p>\n<h2 id=\"does-coffee-interact-with-other-cns-stimulants\"><span style=\"font-weight: 400;\">Does coffee interact with other CNS stimulants?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There are many <\/span><a href=\"https:\/\/my.clevelandclinic.org\/health\/treatments\/11766-adhd-medication\"><span style=\"font-weight: 400;\">different treatment options<\/span><\/a><span style=\"font-weight: 400;\"> for ADHD, including both stimulant and nonstimulant medications. In general, coffee will interact with any stimulants the same way as Azstarys, potentially worsening or exacerbating side effects like anxiety and changes in blood pressure or heart rate. Common stimulants that could interact with coffee include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/adderall\"><span style=\"font-weight: 400;\">Adderall<\/span><\/a><span style=\"font-weight: 400;\"> (amphetamine\/dextroamphetamine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/ritalin\"><span style=\"font-weight: 400;\">Ritalin<\/span><\/a><span style=\"font-weight: 400;\"> (methylphenidate)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/vyvanse\"><span style=\"font-weight: 400;\">Vyvanse<\/span><\/a><span style=\"font-weight: 400;\"> (lisdexamfetamine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/focalin\"><span style=\"font-weight: 400;\">Focalin<\/span><\/a><span style=\"font-weight: 400;\"> (dexmethylphenidate)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Nonstimulant options are less likely to interact with and are thought to be safer to combine with caffeine, such as:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/atomoxetine-hcl\"><span style=\"font-weight: 400;\">Strattera<\/span><\/a><span style=\"font-weight: 400;\"> (atomoxetine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/qelbree\"><span style=\"font-weight: 400;\">Qelbree<\/span><\/a><span style=\"font-weight: 400;\"> (viloxazine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/clonidine-hcl-er\"><span style=\"font-weight: 400;\">Kapvay<\/span><\/a><span style=\"font-weight: 400;\"> (clonidine extended-release)\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/intuniv\"><span style=\"font-weight: 400;\">Intuniv<\/span><\/a><span style=\"font-weight: 400;\"> (guanfacine extended-release)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u201cNon-stimulant replacement medications may have a lower likelihood of interaction and are thought to be safer taken with caffeine,\u201d Dr. Kellogg says.\u00a0<\/span><\/p>\n<h2 id=\"best-practices-for-taking-azstarys\"><span style=\"font-weight: 400;\">Best practices for taking Azstarys<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">To get the most benefits with the fewest side effects, experts recommend the following strategies for taking Azstarys:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Take it in the morning:<\/b><span style=\"font-weight: 400;\"> \u201cTo maximize the efficacy of Azstarys, take it in the morning, as directed, to align with the medication\u2019s peak effectiveness during daytime hours,\u201d Dr. Toy says.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Be consistent:<\/b><span style=\"font-weight: 400;\"> Azstarys can be taken <\/span><a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a621026.html\"><span style=\"font-weight: 400;\">with or without food<\/span><\/a><span style=\"font-weight: 400;\">, and should be taken around the same time every day.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Prioritize sleep: <\/b><span style=\"font-weight: 400;\">\u201cMaintain a consistent sleep schedule and avoid late-day dosing of Azstarys and\/or caffeine to ensure quality rest,\u201d Dr. Toy adds.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Drink lots of water:<\/b><span style=\"font-weight: 400;\"> \u201cStay hydrated to avoid dehydration and minimize dry mouth.\u201d<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Avoid certain foods close to your dose:<\/b><span style=\"font-weight: 400;\"> \u201cCoffee, soda, and even <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/vitamin-c-and-adderall\/\"><span style=\"font-weight: 400;\">vitamin C supplements<\/span><\/a><span style=\"font-weight: 400;\"> have an acidity that interferes with stimulant absorption,\u201d Dr. Kellogg says. \u201cHigh-fat foods may also delay medication\u2019s immediate release.\u201d You don\u2019t have to eliminate them from your diet; just eat them later in the day.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Share a complete list of all prescription medicines and over-the-counter supplements with your healthcare team: <\/b><span style=\"font-weight: 400;\">Azstarys has some drug interactions, such as with monoamine oxidase inhibitors (<\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/maois\"><span style=\"font-weight: 400;\">MAOIs<\/span><\/a><span style=\"font-weight: 400;\">) and certain antihypertensive drugs (medicines used for high blood pressure).\u00a0<\/span><\/li>\n<\/ul>\n<h2 id=\"the-bottom-line\"><span style=\"font-weight: 400;\">The bottom line<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Ultimately, it is generally safe to drink coffee or other caffeinated beverages while taking Azstarys for ADHD. Caffeine won\u2019t hurt the drug\u2019s ability to do its job. But if you tend to react strongly to caffeine, experiencing side effects like jitters, anxiety, or a quickened heart rate from a cup or two, there\u2019s a good chance that combining coffee with Azstarys (or any of the other stimulant medications frequently prescribed to treat ADHD) is going to make these symptoms worse and you might want to shift your habits accordingly.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">That said, every person is different. It\u2019s important to listen to your body and maintain active communication with your healthcare provider to develop a personalized ADHD treatment plan that fits you and your lifestyle.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Attention deficit hyperactivity disorder (ADHD) is commonly associated with children. However, an estimated 15.5 million adults in the United States currently have an ADHD diagnosis, half of whom were diagnosed in adulthood, according to the CDC. All that to say, there are plenty of people taking medication for ADHD who also start their day with [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":632947,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[15107,450,8905],"coauthors":[20980],"class_list":["post-632956","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-adhd","tag-mental-health","tag-seasonal","franchise-the-jolt","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Azstarys and caffeine: What to know<\/title>\n<meta name=\"description\" content=\"Azstarys and caffeine are both stimulants. 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