{"id":633066,"date":"2025-08-06T12:42:03","date_gmt":"2025-08-06T16:42:03","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=633066"},"modified":"2026-03-28T19:02:41","modified_gmt":"2026-03-28T23:02:41","slug":"zofran-generic","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/zofran-generic\/","title":{"rendered":"Zofran generic: Availability, cost, and dosage"},"content":{"rendered":"

Zofran (<\/span>ondansetron<\/span><\/a>) is a prescription antiemetic medication used to treat and prevent nausea and vomiting in people undergoing treatment for cancer, as well as postoperative nausea and vomiting. Zofran was approved in 1991 by the Food and Drug Administration, but was eventually discontinued as a brand-name drug. However, it\u2019s still available in generic form as ondansetron. Here\u2019s what to know about taking this common anti-nausea medication.<\/span><\/p>\n\n\n\n\n\n\n\n
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\u00a0 Zofran generic availability<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n

Generic name<\/b><\/td>\nOndansetron<\/span><\/td>\n<\/tr>\n
FDA approval date of generic version<\/b><\/td>\n2006<\/span><\/td>\n<\/tr>\n
Is there a generic available for sale in the U.S.?<\/b><\/td>\nYes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Why was Zofran discontinued?\u00a0<\/span><\/h2>\n

Various forms of Zofran have been discontinued over the years for different reasons. In 2012, high intravenous (IV) doses of the drug were taken off the market because they posed a cardiac risk, potentially causing an irregular heart rhythm called QT interval prolongation. By 2023, all other forms of brand-name Zofran were discontinued, but not for safety or efficacy reasons. The dissolvable tablets were discontinued because the packaging didn\u2019t meet federal regulations for safety (the tablets themselves were safe), and other forms of the drug were no longer profitable once generic versions became widely available.<\/span><\/p>\n

What are the differences between generic and brand-name Zofran?<\/span><\/h2>\n

Brand-name drugs and generic drugs are <\/span>largely the same<\/span><\/a>. They contain identical active ingredients and have the same safety and effectiveness. \u201cWhen brand-name Zofran was still on the market, there were no meaningful differences between it and ondansetron,\u201d says <\/span>Erika Gray<\/span><\/a>, Pharm.D., cofounder of Toolbox Genomics.\u00a0<\/span><\/p>\n

\u201cGeneric ondansetron is held to strict FDA standards for bioequivalence, ensuring it delivers the same therapeutic effect as the original brand,\u201d she explains. \u201cWhile some patients may have perceived differences based on pill appearance, taste, or tolerability, especially with orally disintegrating tablets, these variations are due to inactive ingredients rather than any change in efficacy and safety.\u201d Currently, only generic ondansetron products are available: oral tablets, oral disintegrating tablets, oral solution (liquid), and injections.\u00a0<\/span><\/p>\n

How much does generic Zofran cost?<\/span><\/h2>\n

Without insurance<\/span><\/a>, generic Zofran (ondansetron) costs about $409 for 30, 4 mg tablets. Using a <\/span>SingleCare discount card<\/span><\/a>, your cost could be lowered to as low as $12 for 30, 4 mg tablets.<\/span><\/p>\n

Orally disintegrating tablets of ondansetron are slightly more expensive, costing about $474 for 30, 4 mg orally disintegrating tablets. A SingleCare discount or coupon can lower that cost to about $14.<\/span><\/p>\n\n\n\n\n\n\n\n\n
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\u00a0 Generic Zofran prices<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n

Cost details<\/b><\/td>\nZofran generic oral tablets (ondansetron)<\/b><\/td>\nZofran generic orally disintegrating tablets (ondansetron)<\/b><\/td>\n<\/tr>\n
Average cost without insurance<\/b><\/td>\n$409 for 30, 4 mg tablets of ondansetron oral tablets<\/span><\/td>\n$474 for 30, 4 mg tablets of ondansetron orally disintegrating tablets (ODT)<\/span><\/td>\n<\/tr>\n
SingleCare\u2019s lowest price<\/b><\/td>\n$12 for 30, 4 mg tablets of ondansetron oral tablets at Food Lion<\/span><\/td>\n$14 for 30, 4 mg tablets of ondansetron ODT at Kroger or Harris Teeter<\/span><\/td>\n<\/tr>\n
Free coupons<\/b><\/td>\nOndansetron coupons<\/span><\/a><\/td>\nOndansetron ODT coupons<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of March 17, 2026. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available.\u00a0<\/span><\/i><\/small><\/small><\/p>\n

Is Zofran covered by insurance?<\/span><\/h2>\n

Brand-name Zofran is no longer available, but generic ondansetron is often covered by insurance plans, including commercial plans and Medicare and Medicaid plans. However, coverage and out-of-pocket costs may vary widely. To know for sure if your plan covers ondansetron, you can contact your health insurance company or check the most recent <\/span>formulary<\/span><\/a> online.\u00a0<\/span><\/p>\n

Generic alternatives to Zofran<\/span><\/h2>\n

Since brand-name Zofran is no longer available, generic ondansetron would be the primary option. Generic ondansetron is available in several forms, including oral tablets (tablets that you swallow), orally disintegrating tablets (tablets that dissolve on the tongue), liquid, and injection. If generic ondansetron does not work for you or you cannot take or tolerate it, there are other generic medications used for nausea and vomiting that you can discuss with your healthcare provider, such as:<\/span><\/p>\n