{"id":633115,"date":"2025-08-07T14:54:16","date_gmt":"2025-08-07T18:54:16","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=633115"},"modified":"2026-01-27T18:10:28","modified_gmt":"2026-01-27T23:10:28","slug":"ondansetron-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/ondansetron-alternatives\/","title":{"rendered":"Ondansetron alternatives: What can I take instead of Zofran"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Ondansetron is a prescription antiemetic medication approved by the Food and Drug Administration (FDA) to prevent nausea and vomiting. The brand-name Zofran is no longer available in the U.S., but the generic version, ondansetron, is commonly prescribed for patients undergoing cancer treatments such as chemotherapy or radiation, or those who have recently undergone surgery. It\u2019s also prescribed <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/off-label-prescription-drugs\/\"><span style=\"font-weight: 400;\">off-label<\/span><\/a><span style=\"font-weight: 400;\"> as an add-on therapy to reduce symptoms of some mental health conditions, such as obsessive-compulsive disorder (OCD) and schizophrenia. Ondansetron is a powerful medication to prevent nausea and vomiting, but some patients are unable to take it due to its side effects or interactions with other medications.\u00a0<\/span><\/p>\n<h2 id=\"what-can-you-take-instead-of-ondansetron\"><span style=\"font-weight: 400;\">What can you take instead of ondansetron?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If you are unable to take ondansetron or find that it doesn\u2019t provide sufficient nausea relief, there are other options you can explore. <\/span><a href=\"https:\/\/www.cancer.org\/cancer\/managing-cancer\/side-effects\/eating-problems\/nausea-and-vomiting\/medicines.html\"><span style=\"font-weight: 400;\">Other antiemetics<\/span><\/a><span style=\"font-weight: 400;\"> that can help with chemotherapy-induced nausea include:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Other <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/serotonin-antagonists\"><span style=\"font-weight: 400;\">serotonin (5-HT3) antagonists<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">NK-1 receptor antagonists (such as aprepitant)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antihistamines (promethazine, meclizine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anticholinergics (scopolamine, dimenhydrinate)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Phenothiazines (<\/span><span style=\"font-weight: 400;\">prochlorperazine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gastrointestinal stimulants (metoclopramide)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Olanzapine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Benzodiazepines\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cannabinoids<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Certain steroids\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">A variety of medicines may be used to treat nausea in different ways, and not all patients will find the same medication to be the right fit. \u201cOne option is Promethazine (phenergan), a first-generation antihistamine that blocks histamine receptors to promote strong anti-nausea and sedative effects, similar to Zofran,\u201d says <\/span><a href=\"https:\/\/www.integrative-psych.org\/experts\/dr-ryan-sultan\"><span style=\"font-weight: 400;\">Ryan Sultan<\/span><\/a><span style=\"font-weight: 400;\">, MD, a double board\u2011certified psychiatrist and the founder and medical director of Integrative Psych in Chelsea, New York. \u201cAprepitant (Emend) is another, typically used for chemotherapy nausea. It\u2019s typically used alongside ondansetron to produce an effect better than using either medication individually. When used by itself, aprepitant stays active in the body longer than ondansetron to offer extended relief.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The best choice of medication will also depend on the underlying cause of your nausea. There are many reasons you might be experiencing nausea or vomiting, such as morning sickness from the first trimester of pregnancy, migraine headaches, cancer treatment, postoperative nausea, or other health conditions. Figuring out why you\u2019re experiencing nausea will help you and your healthcare team identify the best anti-nausea medication for you.<\/span><\/p>\n<table class=\" singlecare-table\" role=\"table\">\n<thead>\n<tr>\n<th class=\"title\" role=\"columnheader\" colspan=\"4\" scope=\"col\">\n<h3 id=\"compare-ondansetron-alternatives\"><span style=\"font-weight: 400;\">Compare ondansetron alternatives<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><b>Drug name<\/b><\/td>\n<td><b>Price without insurance<\/b><\/td>\n<td><b>SingleCare price<\/b><\/td>\n<td><b>Savings options<\/b><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/zofran\/dosage\"><span style=\"font-weight: 400;\">Zofran<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ondansetron\/what-is\"><span style=\"font-weight: 400;\">ondansetron<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$409 for 30, 4 mg tablets\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$8 for 10, 4 mg tablets at Walmart<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/ondansetron-hcl\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Phenergan (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/promethazine-hcl\/dosage\"><span style=\"font-weight: 400;\">promethazine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$24 for 30, 20 mg tablets\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$8 for 30, 20 mg tablets at Kroger<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/promethazine-hcl\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Emend (aprepitant)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$301 per 1, 40 mg capsule\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$46 per 1, 40 mg capsule at CVS<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/emend\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Antivert (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/meclizine-hcl\/dosage\"><span style=\"font-weight: 400;\">meclizine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$25 for 30, 25 mg tablets of generic meclizine<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$9 for 30, 25 mg tablets at Walmart<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/meclizine-hcl\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Reglan (metoclopramide)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$144 for 30, 10 mg tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$4 for 30, 10 mg tablets at Walmart<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/reglan#coupons\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/scopolamine\/what-is\"><span style=\"font-weight: 400;\">Scopolamine<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">$136 per 1, 4 patch 72-hour box\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$17 for 1, 4 patch 72-hour box at Kroger<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/scopolamine\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Compro (prochlorperazine)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$177 per 1, 12-suppository box\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$38 per 1, 12-suppository box at CVS<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/compro#coupons\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Driminate (dimenhydrinate)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$8 per 30, 50 mg tablets\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$6 for 30, 50 mg tablets at Kroger<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/driminate\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><small><i><span style=\"font-weight: 400;\">Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of Jan. 27, 2026. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available.<\/span><\/i><small><\/small><\/small><\/p>\n<h2 id=\"top-5-ondansetron-alternatives\"><span style=\"font-weight: 400;\">Top 5 ondansetron alternatives<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Here are some of the most common alternatives to ondansetron:<\/span><\/p>\n<h3 id=\"1-promethazine\"><span style=\"font-weight: 400;\">1. Promethazine<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Promethazine is an antiemetic medication often used as an alternative to ondansetron. It was previously available as brand-name Phenergan, which has been discontinued in the U.S. Both <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/phenergan-vs-zofran\/\"><span style=\"font-weight: 400;\">promethazine (Phenergan) and ondansetron (Zofran)<\/span><\/a><span style=\"font-weight: 400;\"> are used to treat nausea and vomiting, but they contain different active ingredients and mechanisms of action. While Zofran contains ondansetron, a serotonin receptor antagonist, Phenergan contains promethazine, an antihistamine. Promethazine can be taken as an oral tablet, solution, injection, or suppository, and your healthcare provider will prescribe the proper dose, typically between 12.5 and 25 milligrams (mg) every four to six hours, not exceeding 100 mg per day.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cPr<\/span><span style=\"font-weight: 400;\">omethazine helps stop the feeling of nausea by calming the part of the brain that causes vomiting,\u201d says <\/span><a href=\"https:\/\/www.linkedin.com\/in\/jessicairoanya\/\"><span style=\"font-weight: 400;\">Jessica Iroanya, <\/span><\/a><span style=\"font-weight: 400;\">Pharm.D.,<\/span><span style=\"font-weight: 400;\"> a registered pharmacist and medication therapy management specialist in San Antonio, Texas. <\/span><span style=\"font-weight: 400;\">\u201cIt works well, but it can make you drowsy, so it\u2019s best to take it when you are able to comfortably rest.\u201d<\/span><\/p>\n<h3 id=\"2-emend\"><span style=\"font-weight: 400;\">2. Emend<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">While ondansetron is used to prevent nausea and vomiting in a wide range of cases, Emend (aprepitant) is an NK-1 receptor antagonist specifically used to <\/span><a href=\"https:\/\/www.mayoclinic.org\/drugs-supplements\/aprepitant-oral-route\/description\/drg-20066897\"><span style=\"font-weight: 400;\">treat nausea and vomiting triggered by cancer treatments<\/span><\/a><span style=\"font-weight: 400;\"> like chemotherapy. It works by blocking a receptor in the brain that can cause vomiting. Unlike ondansetron, it\u2019s rarely taken alone and is instead paired with another anti-nausea medication for better efficacy. It\u2019s typically taken as a capsule, with a dosage of anywhere from 80 to 125 mg.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Common side effects of aprepitant include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tiredness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Loss of appetite<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dehydration<\/span><\/li>\n<\/ul>\n<h3 id=\"3-reglan\"><span style=\"font-weight: 400;\">3. Reglan<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Reglan (metoclopramide) is a gastrointestinal stimulant sometimes used for patients with<\/span><a href=\"https:\/\/my.clevelandclinic.org\/health\/drugs\/18008-metoclopramide-tablets\"><span style=\"font-weight: 400;\"> gastroesophageal reflux (GERD)<\/span><\/a><span style=\"font-weight: 400;\"> after other drugs have been ineffective. It\u2019s also used to treat patients with gastroparesis who are unable to empty their stomach due to paralysis of the GI tract. However, it\u2019s also prescribed by healthcare providers <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/off-label-prescription-drugs\/\"><span style=\"font-weight: 400;\">off-label<\/span><\/a><span style=\"font-weight: 400;\"> to treat nausea and vomiting. It\u2019s a medication best taken short-term and should not be taken for more than twelve weeks at a time, as severe side effects become more likely with prolonged use. A serious movement disorder called tardive dyskinesia may be more likely in older patients who take it for longer periods of time.<\/span><\/p>\n<h3 id=\"4-antivert\"><span style=\"font-weight: 400;\">4. Antivert<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Antivert (meclizine) is a popular antihistamine used to <\/span><a href=\"https:\/\/www.mayoclinic.org\/drugs-supplements\/meclizine-oral-route\/description\/drg-20075849\"><span style=\"font-weight: 400;\">prevent nausea.<\/span><\/a><span style=\"font-weight: 400;\"> It blocks the effects of histamines in the body. The medication is frequently prescribed for people with extreme dizziness from vertigo or Meniere\u2019s disease. It\u2019s sold as 25 mg tablets and can be taken several times throughout the day. It\u2019s also commonly recommended to prevent motion sickness.<\/span><\/p>\n<h3 id=\"5-scopolamine\"><span style=\"font-weight: 400;\">5. Scopolamine<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Scopolamine is a prescription anticholinergic drug primarily used to <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK554397\/\"><span style=\"font-weight: 400;\">treat motion sickness and postoperative nausea and vomiting<\/span><\/a><span style=\"font-weight: 400;\">. Unlike many nausea medications that come in tablet form, scopolamine is available exclusively as an extended-release transdermal patch, which is worn behind the ear. It should only be used for up to three days at a time, and side effects such as dry mouth may occur as long as the medication remains in the bloodstream. The FDA has not approved Scopolamine for use by children under 18.<\/span><\/p>\n<h2 id=\"natural-alternatives-to-ondansetron\"><span style=\"font-weight: 400;\">Natural alternatives to ondansetron<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">For people seeking to relieve nausea without medication, there are natural alternatives to ondansetron that can be safe and effective.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cThere\u2019s a growing interest in simple ingredients and non-toxic products when it comes to wellness,\u201d Dr. Iroanya says. \u201cFor people traveling by air or on cruise ships, I also suggest Sea-Bands, which are acupressure wristbands that help prevent motion sickness. I\u2019ve personally tried the ginger version of Dramamine and had a good experience with it.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, she warns that natural remedies may not be as effective as <\/span><span style=\"font-weight: 400;\">ondansetron<\/span><span style=\"font-weight: 400;\">, especially for severe nausea. \u201cIt\u2019s best to check with your provider to make sure the new option will help manage your symptoms properly.\u201d<\/span><\/p>\n<p><a href=\"https:\/\/www.gipsychology.com\/\"><span style=\"font-weight: 400;\">Ali Navidi<\/span><\/a><span style=\"font-weight: 400;\">, PsyD<\/span><span style=\"font-weight: 400;\">, an expert in <\/span><span style=\"font-weight: 400;\">effective gut-brain therapies<\/span><span style=\"font-weight: 400;\"> of GI Psychology in Virginia, says he\u2019s had clinical experience supporting the use of hypnosis for nausea relief in chemotherapy, hyperemesis gravidarum (excessive vomiting in pregnancy), cyclic vomiting syndrome, anxiety, and more. \u201cI can remember working with a young lady who had endured years of nausea, finding relief and transitioning off medication only after she learned how to use se<\/span><span style=\"font-weight: 400;\">lf-hypnosis.&#8221; While some <\/span><a href=\"https:\/\/www.cghjournal.org\/article\/S1542-3565(21)01142-3\/fulltext\"><span style=\"font-weight: 400;\">studies<\/span><\/a><span style=\"font-weight: 400;\"> suggest that mind-body techniques may be effective for nausea in some circumstances, they may not work for everyone.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ultimately, it&#8217;s crucial to consult with a healthcare provider to determine whether a natural alternative to ondansetron will be sufficient or if you should consider the use of prescription drugs in the treatment of nausea.<\/span><\/p>\n<h2 id=\"how-to-switch-to-an-ondansetron-alternative\"><span style=\"font-weight: 400;\">How to switch to an ondansetron alternative<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Switching to an ondansetron alternative is possible, but it should be done carefully. Dr. Sultan says it&#8217;s key to work through the transition with the help of your healthcare provider.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cYou can safely switch to a Zofran alternative by first working with your clinician to accurately address the cause of the nausea, as different causes may respond better to specific alternatives,\u201d Dr. Sultan says. From there, your healthcare provider will determine an effective transition plan.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Sometimes, healthcare providers will consider a dual approach. \u201cFor conditions like chemotherapy-induced nausea, a combination of pharmaceutical and natural treatments may be more effective than monotherapy,\u201d Dr. Sultan adds.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Your healthcare provider will likely recommend a treatment plan that\u2019s slow and steady, as abruptly switching from ondansetron may cause nausea and vomiting to return. If you have any questions or concerns about the medication, please seek medical advice from your healthcare provider.<\/span><\/p>\n<h2 id=\"frequently-asked-questions-about-zofran-ondansetron\"><span style=\"font-weight: 400;\">Frequently asked questions about Zofran (ondansetron)<\/span><\/h2>\n<h3 id=\"is-zofran-over-the-counter\"><span style=\"font-weight: 400;\">Is Zofran over the counter?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">No. Zofran is not available over the counter. It is a prescription medication, and you need a prescription from your healthcare provider in order to purchase it.<\/span><\/p>\n<h3 id=\"what-is-similar-to-zofran-over-the-counter\"><span style=\"font-weight: 400;\">What is similar to Zofran over the counter?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">There is no direct OTC alternative to Zofran, since it is a prescription medication, but there are OTC options that can help with certain types of nausea. <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/otc-antiemetic\/\"><span style=\"font-weight: 400;\">OTC antiemetic medications<\/span><\/a><span style=\"font-weight: 400;\"> to ask your healthcare provider about include Dramamine, Pepto-Bismol, and other affordable alternatives.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ondansetron is a prescription antiemetic medication approved by the Food and Drug Administration (FDA) to prevent nausea and vomiting. The brand-name Zofran is no longer available in the U.S., but the generic version, ondansetron, is commonly prescribed for patients undergoing cancer treatments such as chemotherapy or radiation, or those who have recently undergone surgery. It\u2019s [&hellip;]<\/p>\n","protected":false},"author":154,"featured_media":633117,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[16414,3418],"coauthors":[20975],"class_list":["post-633115","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-digestive-health","tag-generic-drugs","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Top ondansetron alternatives and how to switch your Rx<\/title>\n<meta name=\"description\" content=\"Phenergan, Emend, Reglan, Antivert, and scopolamine are some ondansetron alternatives. Get the full list here, including natural alternatives.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/ondansetron-alternatives\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ondansetron alternatives: What can I take instead of Zofran\" \/>\n<meta property=\"og:description\" content=\"Phenergan, Emend, Reglan, Antivert, and scopolamine are some ondansetron alternatives. 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