{"id":633326,"date":"2025-08-26T15:29:24","date_gmt":"2025-08-26T19:29:24","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=633326"},"modified":"2026-01-28T13:43:03","modified_gmt":"2026-01-28T18:43:03","slug":"xyzal-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/xyzal-alternatives\/","title":{"rendered":"Xyzal alternatives: What can I take instead of Xyzal?"},"content":{"rendered":"

Xyzal<\/span><\/a> is the brand name for levocetirizine dihydrochloride, an <\/span>antihistamine<\/span> medication<\/span> (H1 blocker) that offers <\/span>24-hour relief<\/span> from <\/span>allergy symptoms<\/span> like <\/span>allergic rhinitis<\/span>, <\/span>runny<\/span> nose<\/span>, sneezing, itchy, watery eyes, throat irritation, and <\/span>skin rash<\/span> symptoms<\/span> like hives. It\u2019s available in both <\/span>prescription<\/span> and over-the-counter (<\/span>OTC<\/span>) forms.<\/span><\/p>\n

Although <\/span>Xyzal<\/span> is usually well tolerated, it can have unwanted <\/span>side effects<\/span><\/a> like <\/span>dry mouth<\/span>, diarrhea, <\/span>sleepiness<\/span>, and dose adjustment is required in kidney impairment<\/span>. <\/span>If you are dealing with negative <\/span>side effects<\/span> after taking <\/span>Xyzal<\/span>, you may be looking for <\/span>Xyzal<\/span> alternatives.<\/span><\/p>\n

What can I take instead of <\/span>Xyzal<\/span>?<\/span><\/h2>\n

If you\u2019re looking for alternatives to <\/span>Xyzal<\/span>, you likely want a <\/span>medication<\/span> that effectively treats your <\/span>allergy symptoms<\/span>, but that has <\/span>fewer side effects<\/span> for you. The <\/span>medications<\/span> that are most similar to <\/span>Xyzal<\/span> in terms of what <\/span>symptoms<\/span> they treat and how they <\/span>work<\/span> are second-generation <\/span>antihistamines, such as<\/span> Allegra<\/span> (fexofenadine), <\/span>Zyrtec<\/span> (cetirizine), or <\/span>Claritin<\/span> (loratadine). These all treat <\/span>hay fever<\/span> symptoms<\/span> like <\/span>runny nose<\/span>, sneezing, watery, itchy eyes, and other common <\/span>allergy symptoms<\/span><\/a>.<\/span><\/p>\n

Other <\/span>Xyzal<\/span> alternatives to consider, says Morris Nejat, MD, allergist and owner of <\/span>New York <\/span>Allergy<\/span> and Sinus Centers<\/span><\/a>, are <\/span>medications<\/span> applied directly to the <\/span>skin<\/span> (topical). \u201cTo treat topical <\/span>allergies<\/span>, you can also <\/span>use<\/span> antihistamine<\/span> eye drops such as Pataday (olopatadine) and <\/span>nasal sprays<\/span> like Flonase (fluticasone) and Astepro (azelastine),\u201d Dr. Nejat recommends.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n
\n

Compare Xyzal alternatives<\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n

Drug name<\/b><\/th>\nPrice without insurance<\/b><\/th>\nSingleCare price<\/b><\/th>\nSavings options<\/b><\/th>\n<\/tr>\n
Allegra (fexofenadine)<\/span><\/th>\n$33 for 30, 180mg tablets<\/span><\/th>\n$4 for 30, 180 mg tablets of generic Allegra<\/span><\/th>\nAllegra coupons<\/span><\/a><\/th>\n<\/tr>\n
Zyrtec<\/span><\/a>
\n<\/span>(<\/span>cetirizine<\/span><\/a>)<\/span><\/td>\n		$30 for 1, 10mg, 24 tablets chewable box<\/span><\/td>\n$59 for 1, 10 mg, 30 tablets chewable box<\/span> of brand-name Zyrtec<\/span><\/td>\nZyrtec coupons<\/span><\/a><\/td>\n<\/tr>\n
Claritin (<\/span>loratadine<\/span><\/a>)<\/span><\/td>\n $34 for 30, 10mg tablets<\/span><\/td>\n $5 for 30, 10 mg tablets of generic Claritin<\/span><\/td>\nClaritin coupons<\/span><\/a><\/td>\n<\/tr>\n
Flonase (<\/span>fluticasone<\/span><\/a>)<\/span><\/td>\n$24 for 1, 9.9ml of 50mcg\/act bottle<\/span><\/td>\n$12 for 1, 16 gm of 50mcg\/act bottle<\/span> of brand name Flonase<\/span><\/td>\nFlonase coupons<\/span><\/a><\/td>\n<\/tr>\n
Astepro (azelastine)<\/span><\/td>\n$34 per 1, 23ml of 205.5mcg\/spray spray bottle<\/span><\/td>\n$18 for 1, 23 ml of 205.5mcg\/spray spray bottle of generic Astepro\u00a0<\/span><\/td>\nAstepro<\/span> coupons<\/span><\/a><\/td>\n<\/tr>\n
Pataday (olopatadine)<\/span><\/td>\n$25 for 1, 2.5ml of 0.2% bottle<\/span><\/td>\n$9 for 1, 2.5 ml of 0.2% bottle of brand-name Pataday<\/span><\/td>\nPataday coupons<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Prescription drug prices often change. These are the most accurate medication prices at the time of publishing. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available. Click the link under \u201cSavings options\u201d to see the latest drug prices.<\/span><\/i><\/p>\n

Top 5 <\/span>Xyzal<\/span> alternatives<\/span><\/h2>\n

The following are some of the most common alternatives to <\/span>Xyzal<\/span>.<\/span><\/p>\n

Zyrtec<\/span> (cetirizine)<\/span><\/h3>\n

Zyrtec<\/span> and <\/span>Xyzal<\/span><\/a> are both <\/span>oral antihistamines<\/span> used to treat <\/span>allergic rhinitis<\/span> (sneezing, <\/span>runny nose<\/span>, itchy throat, teary eyes associated with <\/span>allergies<\/span>) as well as chronic hives. Both <\/span>Zyrtec<\/span> and <\/span>Xyzal<\/span> cause less <\/span>drowsiness<\/span> than <\/span>older antihistamines<\/span> and <\/span>first-generation antihistamines<\/span> like<\/span> Benadryl<\/span><\/a>, but <\/span>Xyzal<\/span> may cause even less <\/span>drowsiness<\/span> than <\/span>Zyrtec<\/span>. Both <\/span>medications<\/span> have generic counterparts. While <\/span>Xyzal<\/span> is offered as both an over-the-counter (<\/span>OTC<\/span>) and <\/span>prescription<\/span> antihistamine<\/span>, <\/span>Zyrtec<\/span> is only available over the counter.<\/span><\/p>\n

Claritin<\/span> (loratadine)<\/span><\/h3>\n

Both <\/span>Claritin<\/span> and <\/span>Xyzal<\/span><\/a> are <\/span>antihistamines<\/span> (H1 blockers) used to treat seasonal <\/span>allergy symptoms<\/span> and chronic hives. However, while <\/span>Xyzal<\/span> is indicated to treat both perennial (<\/span>year-round allergies<\/span>) and seasonal <\/span>allergies<\/span>, <\/span>Claritin is FDA approved for both seasonal allergic rhinitis and chronic urticaria (hives)<\/span>. There are generic versions available of both these <\/span>drugs<\/span>. <\/span>Xyzal<\/span> is available as both an over-the-counter <\/span>medication<\/span> and a <\/span>prescription<\/span> medication<\/span>. Claritin was once a prescription but is now available only over-the-counter.\u00a0<\/span><\/p>\n

Flonase (fluticasone)<\/span><\/h3>\n

Flonase<\/span><\/a> is a <\/span>nasal spray<\/span><\/a> that can be used to treat some of the same <\/span>allergy symptoms<\/span> Xyzal<\/span> does, including sneezing, <\/span>nasal congestion<\/span>, and <\/span>runny nose<\/span> associated with seasonal <\/span>allergies<\/span>. Flonase is a corticosteroid and not an <\/span>antihistamine<\/span>. Only inhaled fluticasone (different formulation) is indicated for asthma, topical forms are used for eczema\/dermatitis, and a separate nasal formulation (e.g., Xhance) may be used for nasal polyps. Flonase nasal spray is FDA-approved for allergic and non-allergic rhinitis only. Unlike <\/span>Xyzal<\/span>, Flonase can\u2019t treat hives. Flonase won\u2019t make you sleepy like <\/span>Xyzal<\/span> can, but it can have unwanted <\/span>side effects<\/span> like an <\/span>itchy nose <\/span>and <\/span>sore throat<\/span>.<\/span><\/p>\n

Astepro (azelastine)<\/span><\/h3>\n

Astepro<\/span><\/a> is an <\/span>antihistamine<\/span> nasal spray<\/span> that can treat some of the <\/span>allergy symptoms<\/span> that <\/span>Xyzal<\/span> does, such as <\/span>nasal congestion<\/span>, <\/span>runny nose<\/span>, sneezing, and <\/span>itchy nose<\/span>. Astepro doesn\u2019t treat hives, whereas <\/span>Xyzal<\/span> can. It works faster than <\/span>Xyzal<\/span>, <\/span>usually within 30 minutes<\/span><\/a>. Astepro is only available over-the-counter, but <\/span>Xyzal<\/span> is available both over-the-counter and by <\/span>prescription<\/span>.<\/span><\/p>\n

Natural alternatives to <\/span>Xyzal<\/span><\/h2>\n

The <\/span>best way<\/span> to treat <\/span>allergies<\/span> naturally is to avoid exposure to the things you\u2019re allergic to. If you haven\u2019t done so already, Dr. Nejat recommends <\/span>allergy<\/span> testing<\/span><\/a>. \u201c<\/span>Allergy<\/span> testing can identify your <\/span>allergens,<\/span> and there are avoidance measures to avoid exposure based on your specific <\/span>allergies<\/span>,\u201d he explains.<\/span><\/p>\n

Avoiding <\/span>allergens<\/span> can be tricky when your <\/span>allergies<\/span> include pollen and other outdoor <\/span>allergens<\/span>, because you can\u2019t stay inside all the time. Still, there are things you can do to minimize your exposure, including staying indoors during dry, windy <\/span>days<\/span>.<\/span><\/p>\n

Kara Wada, MD, founder, CEO, and physician at the <\/span>Immune Confident Institute<\/span><\/a>, recommends keeping your windows closed during high pollen season. And what if your <\/span>allergies<\/span> include <\/span>pet dander<\/span>? \u201cFor pet <\/span>allergies<\/span>, using an indoor air purifier in the bedroom and main living spaces can be helpful along with vacuuming regularly,\u201d Dr. Wada describes.<\/span><\/p>\n

Dietary changes can\u2019t cure <\/span>allergies<\/span>, but Dr. Wada suggests eating foods that contain natural antioxidants like quercetin (onions, apples, pears, berries, green tea) and luteolin (celery, bell peppers, herbs like thyme, oregano, and rosemary), which may decrease allergic response.\u00a0<\/span><\/p>\n

How to switch to an <\/span>Xyzal<\/span> alternative<\/span><\/h2>\n

In general, it\u2019s usually okay to stop one oral <\/span>allergy medication<\/span><\/a> and start the new one the next <\/span>day<\/span>, says Dr. Wada. This means that switching from <\/span>Xyzal<\/span> to a <\/span>medication<\/span> like <\/span>Allegra<\/span>, <\/span>Claritin<\/span>, or <\/span>Zyrtec<\/span> can be as simple as switching to the new <\/span>medication<\/span> at the same time that you\u2019d normally take <\/span>Xyzal<\/span>.<\/span><\/p>\n

However, the <\/span>FDA has warned<\/span><\/a> that stopping <\/span>Xyzal<\/span> suddenly can sometimes result in increased itching, which may be severe for some <\/span>people<\/span>. \u201cOccasionally, patients may notice an increase in itching when they come off <\/span>Xyzal,<\/span> but often this is lessened by using the alternative <\/span>antihistamine<\/span>,\u201d Dr. Wada says. \u201cIf they are struggling with itching due to withdrawal, they should reach out to their <\/span>allergy<\/span> physician.\u201d<\/span><\/p>\n

Choosing the right path for allergy treatment<\/span><\/h2>\n

People<\/span> who are looking for <\/span>Xyzal<\/span> alternatives usually want <\/span>medications<\/span> that <\/span>work<\/span> as well for them as <\/span>Xyzal<\/span>, but which have <\/span>fewer side effects<\/span>. The most common <\/span>Xyzal<\/span> alternatives to try are <\/span>Allegra<\/span>, <\/span>Claritin<\/span>, and <\/span>Zyrtec<\/span>. As for which <\/span>Xyzal<\/span> alternative is best for you, \u201cthere is no one best <\/span>antihistamine<\/span> from this list, but often patients will notice that one might <\/span>work<\/span> better for them or cause fewer <\/span>side effects<\/span>,\u201d Dr. Wada shares.<\/span><\/p>\n

As you navigate <\/span>Xyzal<\/span> alternatives, be sure to stay in touch with your <\/span>healthcare provider<\/span>, who can offer you <\/span>medical advice<\/span> about the <\/span>best <\/span>allergy medication<\/span> for you<\/span><\/a> and put together an individualized <\/span>allergy<\/span> treatment plan.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Xyzal is the brand name for levocetirizine dihydrochloride, an antihistamine medication (H1 blocker) that offers 24-hour relief from allergy symptoms like allergic rhinitis, runny nose, sneezing, itchy, watery eyes, throat irritation, and skin rash symptoms like hives. It\u2019s available in both prescription and over-the-counter (OTC) forms. Although Xyzal is usually well tolerated, it can have […]<\/p>\n","protected":false},"author":85,"featured_media":633327,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[554,802],"coauthors":[20899],"class_list":["post-633326","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-allergies","tag-seasonal-allergies","wpautop"],"acf":[],"yoast_head":"\nTop Xyzal alternatives and how to switch your Rx<\/title>\n<meta name=\"description\" content=\"Allegra, Zyrtec, Claritin, Flonase, and Astepro are some Xyzal alternatives. 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Allegra<\/span> (fexofenadine)<\/span><\/h3>\n

Both<\/span> Xyzal<\/span> and <\/span>Allegra<\/span><\/a> are <\/span>oral antihistamines<\/span> that treat <\/span>hay fever allergy symptoms<\/span> like <\/span>runny nose<\/span>, sneezing, itchiness, and hives. <\/span>Allegra<\/span> is less likely to cause <\/span>drowsiness<\/span> than <\/span>Xyzal<\/span>, whereas <\/span>Xyzal<\/span> tends to offer longer-lasting relief from <\/span>allergies<\/span>. Both <\/span>medications<\/span> are available in both <\/span>prescription<\/span> and over-the-counter (<\/span>OTC<\/span>) versions, and both have generic options.<\/span><\/p>\n