{"id":633419,"date":"2025-09-04T09:41:57","date_gmt":"2025-09-04T13:41:57","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=633419"},"modified":"2026-04-09T19:11:40","modified_gmt":"2026-04-09T23:11:40","slug":"generic-keppra","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/generic-keppra\/","title":{"rendered":"Generic Keppra (levetiracetam): Cost, coverage, and side effects"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/keppra\"><span style=\"font-weight: 400;\">Keppra<\/span><\/a><span style=\"font-weight: 400;\"> is an antiepileptic or anticonvulsant medication approved by the U.S. Food and Drug Administration (FDA) to treat seizures (epilepsy) in adults and children. It may be prescribed by itself or together with other medications to control seizures. A generic version, levetiracetam, has been available in the U.S. since 2008.<\/span><\/p>\n<table class=\" singlecare-table\" role=\"table\">\n<thead>\n<tr>\n<th colspan=\"2\">\n<h2 id=\"keppra-generic-availability\"><span style=\"font-weight: 400;\">Keppra generic availability<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><b>Generic name<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Levetiracetam<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>FDA approval date of the generic version<\/b><\/td>\n<td><span style=\"font-weight: 400;\">2008<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Is there a generic available for sale in the U.S.?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"is-there-a-generic-for-keppra\"><span style=\"font-weight: 400;\">Is there a generic for Keppra?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The generic for Keppra is <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/levetiracetam\"><span style=\"font-weight: 400;\">levetiracetam<\/span><\/a><span style=\"font-weight: 400;\"> (levetiracetam ER is the generic for Keppra ER). While the brand-name version was approved in 1999, it wasn\u2019t until 2008 that the FDA approved a generic form.<\/span><\/p>\n<h2 id=\"what-are-the-differences-between-generic-vs-brand-name-keppra\"><span style=\"font-weight: 400;\">What are the differences between generic vs. brand-name Keppra?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Keppra and levetiracetam are almost identical medications. \u201cFundamentally, there is no difference between brand and generic medications,\u201d says <\/span><a href=\"https:\/\/www.linkedin.com\/in\/erikaigray\/\"><span style=\"font-weight: 400;\">Erika Gray, <\/span><\/a><span style=\"font-weight: 400;\">Pharm.D., founder and Chief Medical Officer of <\/span><a href=\"https:\/\/www.mytoolboxgenomics.com\/about-us\/erika-gray\/\"><span style=\"font-weight: 400;\">Toolbox Genomics<\/span><\/a><span style=\"font-weight: 400;\"> and clinical pharmacist at Zuckerberg San Francisco General Hospital and Trauma Center in San Francisco, California. \u201cIn this case, levetiracetam\/Keppra has the same active ingredient. In fact, for a medication to be accepted as a generic, the company has to prove its medication is bioequivalent to the brand medication.\u201d<\/span><\/p>\n<h3 id=\"dosage-form\"><span style=\"font-weight: 400;\">Dosage form<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Keppra and its generic version are available in several forms, including oral tablets (immediate-release), extended-release (XR) oral tablets, oral solution (liquid), and intravenous (IV) injection.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Keppra and levetiracetam pills are oblong tablets in various colors. They can vary in terms of their inactive ingredients and manufacturer.\u00a0<\/span><\/p>\n<h3 id=\"strength\"><span style=\"font-weight: 400;\">Strength<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">While dosing varies depending on a person\u2019s needs, Keppra and its generic version have the same dosage forms.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Here\u2019s a look at the <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/levetiracetam\/dosage\"><span style=\"font-weight: 400;\">strengths<\/span><\/a><span style=\"font-weight: 400;\"> based on form:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Immediate-release tablets: <\/b><span style=\"font-weight: 400;\">250 mg, 500 mg, 750 mg, and 1,000 mg<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Extended-release tablets: <\/b><span style=\"font-weight: 400;\">500 mg and 750 mg<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Tablets for suspension: <\/b><span style=\"font-weight: 400;\">250 mg and 500 mg<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Oral solution (liquid): <\/b><span style=\"font-weight: 400;\">100 mg\/mL<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Injection (IV): <\/b><span style=\"font-weight: 400;\">100 mg\/mL<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Dosages can vary based on age. For younger children, dosage may vary based on body weight.<\/span><\/p>\n<h3 id=\"inactive-ingredients\"><span style=\"font-weight: 400;\">Inactive ingredients<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u201cThe place where Keppra and levetiracetam could differ is what type of inactive ingredients were used,\u201d Dr. Gray says. \u201cOccasionally, I have had patients who have had sensitivities to the excipients or dyes.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Talk to your healthcare provider about any allergic reactions you&#8217;ve had to medications. And avoid taking medications with active or inactive ingredients that may be the source of the allergy or adverse effect.<\/span><\/p>\n<h2 id=\"how-much-does-generic-keppra-cost\"><span style=\"font-weight: 400;\">How much does generic Keppra cost?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Keppra and its generic counterpart can also differ in pricing. Without insurance, the average cost of Keppra is around $765 for 60, 500 mg tablets. The cost of the same amount of generic Keppra can be as low as $6 with a SingleCare coupon. Still, the cost can vary based on factors such as the pharmacy, location, and the quantity prescribed.<\/span><\/p>\n<table class=\" singlecare-table\" role=\"table\">\n<thead>\n<tr>\n<th colspan=\"3\">\n<h3 id=\"brand-vs-generic-keppra-prices\"><span style=\"font-weight: 400;\">Brand vs. generic Keppra prices<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td><b>Brand-name Keppra<\/b><\/td>\n<td><b>Keppra generic (levetiracetam)<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Average cost without insurance<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$765 for 60, 500 mg tablets of Keppra<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$153 for 60, 500 mg tablets of levetiracetam\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">SingleCare\u2019s lowest price<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$611 for 60, 500 mg tablets of Keppra at Kroger<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$6 for 60, 500 mg tablets of levetiracetam at Kroger<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Free coupons<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/keppra\"><span style=\"font-weight: 400;\">Keppra coupons<\/span><\/a><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/levetiracetam\"><span style=\"font-weight: 400;\">Levetiracetam coupons<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><small><i><span style=\"font-weight: 400;\">Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of Mar. 23, 2026. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available.\u00a0<\/span><\/i><\/small><\/p>\n<h2 id=\"is-keppra-covered-by-insurance\"><span style=\"font-weight: 400;\">Is Keppra covered by insurance?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Brand-name Keppra is usually <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/keppra-without-insurance\/\"><span style=\"font-weight: 400;\">not covered<\/span><\/a><span style=\"font-weight: 400;\"> by health insurance plans. \u201cInsurance companies typically cover levetiracetam, and they will be reluctant to cover Keppra unless there is a very specific documented reason that the patient cannot tolerate levetiracetam,\u201d Dr. Gray says. Even with insurance coverage, your out-of-pocket costs may vary depending on copays, coinsurance, deductibles, and coverage gaps.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">You can check your plan\u2019s formulary (a list of covered drugs) or call your plan directly to see which specific drugs are covered.<\/span><\/p>\n<h2 id=\"how-do-you-get-keppra-covered-by-insurance\"><span style=\"font-weight: 400;\">How do you get Keppra covered by insurance?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Because brand-name Keppra is rarely covered by insurance, the most reliable way to get coverage is to ask your healthcare provider to prescribe generic levetiracetam, which most plans will cover. If coverage is still denied, your prescriber can submit a prior authorization showing that the brand name is medically necessary. If you are uninsured or your plan does not cover the medication, a SingleCare discount may help reduce the out-of-pocket cost of generic Keppra.<\/span><\/p>\n<h2 id=\"generic-alternatives-to-keppra\"><span style=\"font-weight: 400;\">Generic alternatives to Keppra<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If Keppra or its generic version is not safe for you to take due to certain inactive ingredients or other medical concerns, you and your healthcare provider can explore other generic anti-seizure drugs.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">These include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/topiramate\"><span style=\"font-weight: 400;\">Topiramate<\/span><\/a><span style=\"font-weight: 400;\"> (Topamax)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/lamotrigine\"><span style=\"font-weight: 400;\">Lamotrigine<\/span><\/a><span style=\"font-weight: 400;\"> (Lamictal)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/gabapentin\"><span style=\"font-weight: 400;\">Gabapentin<\/span><\/a><span style=\"font-weight: 400;\"> (Neurontin, Gralise)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/divalproex-sodium\"><span style=\"font-weight: 400;\">Divalproex sodium<\/span><\/a><span style=\"font-weight: 400;\"> (Depakote)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/phenytoin\"><span style=\"font-weight: 400;\">Phenytoin<\/span><\/a><span style=\"font-weight: 400;\"> (Dilantin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/carbamazepine\"><span style=\"font-weight: 400;\">Carbamazepine<\/span><\/a><span style=\"font-weight: 400;\"> (Tegretol)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Keppra is FDA-approved to treat partial-onset seizures, myoclonic seizures in juvenile myoclonic epilepsy, and primary generalized tonic-clonic seizures in people with idiopathic generalized epilepsy. However, some healthcare providers may prescribe it off-label to manage <\/span><a href=\"https:\/\/www.researchgate.net\/publication\/312186559_Keppra_a_magical_antiepileptic_medication\"><span style=\"font-weight: 400;\">other seizure disorders<\/span><\/a><span style=\"font-weight: 400;\"> like status epilepticus and seizure prophylaxis. One <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8405400\/\"><span style=\"font-weight: 400;\">study review<\/span><\/a><span style=\"font-weight: 400;\"> also found that the anticonvulsant drug may reduce headache frequency, severity, and duration in people with migraines.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Although generic Keppra is the go-to for many healthcare providers and insurance plans, there are a few instances where the brand-name may be the better option for patients. \u201cA healthcare provider might recommend brand-name Keppra over generic levetiracetam if the patient loses seizure control after switching or if a patient reacts poorly to generic fillers,\u201d says <\/span><a href=\"https:\/\/www.linkedin.com\/in\/james-lyons-755129340\/\"><span style=\"font-weight: 400;\">James Lyons, MD<\/span><\/a><span style=\"font-weight: 400;\">, a hospitalist, family medicine and emergency room physician, and medical consultant at <\/span><a href=\"https:\/\/synergyhouses.com\/\"><span style=\"font-weight: 400;\">Synergy Houses<\/span><\/a><span style=\"font-weight: 400;\"> in West Chester, Pennsylvania.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">He adds that if a person receives a prescription for Keppra but prefers the generic version for reasons such as cost or allergic reactions to the inactive ingredients, a pharmacist may be able to make the switch, depending on local pharmacy and insurance rules. \u201cIf a doctor writes a prescription for Keppra, the pharmacist can usually dispense the generic levetiracetam instead,\u201d he explains. \u201cHowever, if the prescriber specifically writes \u2018DAW\u2019 (dispense as written) or checks the \u2018no substitution box&#8217; on the prescription, then the pharmacist must provide the brand Keppra.\u201d<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Keppra is an antiepileptic or anticonvulsant medication approved by the U.S. Food and Drug Administration (FDA) to treat seizures (epilepsy) in adults and children. It may be prescribed by itself or together with other medications to control seizures. A generic version, levetiracetam, has been available in the U.S. since 2008. Keppra generic availability Generic name [&hellip;]<\/p>\n","protected":false},"author":87,"featured_media":633420,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[790,15103],"coauthors":[20975],"class_list":["post-633419","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-chronic-disease","tag-drug-pricing","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Keppra vs. generic levetiracetam: Uses, dosage, side effects, and costs<\/title>\n<meta name=\"description\" content=\"Learn the differences between Keppra and its generic version, levetiracetam. 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