{"id":633577,"date":"2025-09-23T09:30:26","date_gmt":"2025-09-23T13:30:26","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=633577"},"modified":"2025-12-03T13:09:32","modified_gmt":"2025-12-03T18:09:32","slug":"how-long-does-azstarys-last","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/how-long-does-azstarys-last\/","title":{"rendered":"How long does Azstarys last?"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/azstarys\"><span style=\"font-weight: 400;\">Azstarys<\/span><\/a><span style=\"font-weight: 400;\"> is a brand-name medication that is FDA approved to treat attention-deficit hyperactivity disorder (ADHD). ADHD is the most commonly diagnosed behavioral disorder in children, which also affects an estimated 15.5 million adults in the United States. Azstarys belongs to a group of medicines called central nervous system (CNS) stimulants and helps improve attention, focus, and impulsiveness by increasing certain neurotransmitters, such as dopamine and norepinephrine, in the brain. The drug is a once-daily pill that works for up to 13 hours to help manage ADHD symptoms.<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Azstarys with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tAzstarys 39.2-7.8 mg (30 Capsules)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$385.07<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/azstarys#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/azstarys#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-harristeeter.svg\" alt=\"Harris Teeter Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$385.07<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/azstarys#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/azstarys#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/azstarys#blog-cta\" class=\"coupon-see-all-btn\">See Azstarys prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"how-long-does-azstarys-last\"><span style=\"font-weight: 400;\">How long does Azstarys last?<\/span><\/h2>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/azstarys-without-insurance\/\"><span style=\"font-weight: 400;\">Azstarys<\/span><\/a><span style=\"font-weight: 400;\"> is designed to last up to 13 hours, giving people with ADHD all-day symptom relief. It contains two active ingredients: a short-acting medication (immediate-release dexmethylphenidate) that starts working quickly, and a long-acting medication (extended-release serdexmethylphenidate) that\u2019s gradually converted in the body to extend its effects.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cLiving with ADHD is hard. It\u2019s like driving a car with a flat tire and wondering why everyone else is speeding past you,\u201d says <a href=\"https:\/\/www.linkedin.com\/in\/cooper-stone-a476b6373\">Cooper Stone, DO<\/a>, <a href=\"https:\/\/www.med.upenn.edu\/apps\/faculty\/index.php\/g275\/p9866808\">Clinical Assistant Professor of Psychiatry<\/a> at Perelman School of Medicine at the University of Pennsylvania<\/span><span style=\"font-weight: 400;\">. \u201cFor many, medications like Azstarys can help level the playing field by keeping symptoms under control throughout the day.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Unlike many drugs, Azstarys isn\u2019t broken down by the liver\u2019s CYP system, which means it has fewer drug-to-drug interactions for most patients..<\/span><\/p>\n<h3 id=\"what-factors-can-impact-the-duration-of-action\"><span style=\"font-weight: 400;\">What factors can impact the duration of action?\u00a0\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The good news is that most people experience steady coverage, regardless of age, gender, or even common health conditions. Research shows that kidney or liver issues don\u2019t significantly change how long Azstarys remains effective, says Allison Hinkle, Pharm.D., clinical pharmacy manager with <\/span><a href=\"https:\/\/www.hcafloridahealthcare.com\/\"><span style=\"font-weight: 400;\">HCA Florida Healthcare<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">That said, certain situations may shorten or reduce its effect:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Absorption issues: <\/b><span style=\"font-weight: 400;\">Conditions that speed up digestion or reduce absorption, such as severe diarrhea, Crohn\u2019s disease, or celiac disease, can limit how much of the medication your body is able to process.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Tachyphylaxis: <\/b><span style=\"font-weight: 400;\">Like other stimulants, Azstarys may become less effective over time if your body adapts to repeated use, Dr. Stone explains.<\/span><\/li>\n<\/ul>\n<h3 id=\"how-long-does-it-take-azstarys-to-wear-off\"><span style=\"font-weight: 400;\">How long does it take Azstarys to wear off?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Azstarys usually reaches peak effect about two hours after taking it, then tapers off gradually. Unlike some short-acting stimulants, it doesn\u2019t typically cause a sudden \u201ccrash.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cIt\u2019s not sedating, it\u2019s a stimulant,\u201d notes <\/span><a href=\"https:\/\/sleepopolis.com\/experts\/dr-raj-dasgupta\/\"><span style=\"font-weight: 400;\">Raj Dasgupta, MD<\/span><\/a><span style=\"font-weight: 400;\">, clinical researcher and associate professor at the University of Southern California. \u201cIf taken first thing in the morning, most people don\u2019t notice trouble falling asleep. Problems arise mainly if it\u2019s taken too late in the day, since it can keep the mind active.\u201d<\/span><\/p>\n<h2 id=\"how-long-does-azstarys-take-to-work\"><span style=\"font-weight: 400;\">How long does Azstarys take to work?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Most people begin to notice the effects of Azstarys within 30 to 60 minutes, with the full benefit building over the next one to two hours, says <\/span><a href=\"https:\/\/recovered.org\/about-us\/medical-advisors\/dr-matt-glowiak\"><span style=\"font-weight: 400;\">Matt Glowiak, Ph.D.<\/span><\/a><span style=\"font-weight: 400;\">, LCPC, chief addiction specialist with Recovered.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cThere isn\u2019t an immediate, all-or-nothing sensation,\u201d Glowiak explains. \u201cEffectiveness is usually observed as improved focus and task completion in real-life activities.\u201d\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Azstarys can be taken with or without food, depending on preference. For those who have trouble swallowing Azstarys capsules, the medication can be opened and sprinkled into 2 ounces of water or onto 2 tablespoons of applesauce. The mixture should be taken right away, within 10 minutes, and not saved for later.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If someone doesn\u2019t notice meaningful improvements, their healthcare provider may adjust the dose or treatment plan.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our mental health newsletter<\/span>\n\t\t\t<form class=\"form-wrapper\" data-newsletter-form=\"1\" data-subsource=\"Mental Health Newsletter\">\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<label for=\"dynamic-email\">Email<\/label>\n\t\t\t\t\t<input type=\"email\" id=\"dynamic-email\" class=\"email\" required>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<input class=\"submit-form-btn\" type=\"submit\" value=\"Click to sign up\">\n\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t\t<p class=\"success-message\" aria-live=\"polite\"><\/p>\n\t\t<\/div>\n\t<\/span><\/p>\n<h2 id=\"what-are-the-side-effects-of-azstarys\"><span style=\"font-weight: 400;\">What are the side effects of Azstarys?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Like any medication, Azstarys can have side effects. The most common side effects of Azstarys are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Decreased appetite or weight loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Trouble sleeping (insomnia)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach upset, nausea, or vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Irritability or nervousness<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Less common but possible side effects:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased sweating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness or blurred vision<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anxiety<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Serious side effects:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chest pain or trouble breathing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased risk of heart problems, including fast, pounding, or irregular heart rate<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased blood pressure\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hallucinations, confusion, or false beliefs (psychosis-like symptoms)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle weakness or sudden problems speaking\/moving<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Slowed growth in children and adolescents\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Raynaud&#8217;s phenomenon, a condition that causes reduced blood flow and circulation problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Priapism (sustained or painful erections)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Worsening Tourette\u2019s Syndrome, including increased motor and verbal tics<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased intraocular pressure (fluid pressure inside the eye) and glaucoma<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Manic episode in patients with bipolar disorder<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If you experience any of these, seek medical attention from a healthcare professional for medical advice immediately.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The <\/span><a href=\"https:\/\/www.corium.com\/products\/AZSTARYS\/AZSTARYS_PI_ENGLISH_US.pdf\"><span style=\"font-weight: 400;\">safety<\/span><\/a><span style=\"font-weight: 400;\"> of Azstarys during pregnancy and breastfeeding is unknown, but the medication passes into breast milk, so be sure to seek guidance from your healthcare provider. Additionally, you should discuss preexisting medical conditions and medications or dietary supplements you are taking with your provider.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Azstarys has a boxed warning, the highest safety precaution issued by the FDA, due to its high potential for abuse and substance use disorder. Abuse of CNS stimulants like Azstarys, which are controlled substances, can cause overdose and death.<\/span><\/p>\n<h2 id=\"how-long-should-you-take-azstarys\"><span style=\"font-weight: 400;\">How long should you take Azstarys?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Azstarys can be used long-term under careful supervision by the prescribing provider with ongoing monitoring, Glowiak says.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cRegular follow-up visits help assess effects on sleep, appetite, growth in children, cardiovascular parameters, and mood over time,\u201d he explains. \u201cIf the response wanes or adverse effects become problematic, clinicians may adjust the dose of Azstarys, switch formulations, or add non-stimulant options.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If your provider decides to discontinue your Azstarys treatment, Dr. Stone says it would take approximately 60 hours for the medicine to completely wash out of your system, based on the half-life of the active drug, which is just under 12 hours. Depending on how long you\u2019ve been taking the medication, your provider may taper your dose gradually to avoid rebound ADHD symptoms.<\/span><\/p>\n<h2 id=\"azstarys-alternatives\"><span style=\"font-weight: 400;\">Azstarys alternatives<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There are three main categories of alternative treatment options to Azstarys:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Other types of CNS stimulants:<\/b><span style=\"font-weight: 400;\"> Common stimulant medications that may be used in place of Azstarys include <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/adderall\"><span style=\"font-weight: 400;\">Adderall (amphetamine dextroamphetamine)<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ritalin\"><span style=\"font-weight: 400;\">Ritalin (methylphenidate)<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/concerta\"><span style=\"font-weight: 400;\">Concerta (methylphenidate)<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/focalin\"><span style=\"font-weight: 400;\">Focalin (dexmethylphenidate)<\/span><\/a><span style=\"font-weight: 400;\">, and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vyvanse\"><span style=\"font-weight: 400;\">Vyvanse (lisdexamfetamine)<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Non-stimulants:<\/b><span style=\"font-weight: 400;\"> Examples of non-stimulant ADHD medications include <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/clonidine\"><span style=\"font-weight: 400;\">clonidine<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/guanfacine-hcl\"><span style=\"font-weight: 400;\">guanfacine<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/atomoxetine-hcl\"><span style=\"font-weight: 400;\">atomoxetine<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/bupropion-hcl\"><span style=\"font-weight: 400;\">bupropion<\/span><\/a><span style=\"font-weight: 400;\">, and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/qelbree-without-insurance\/\"><span style=\"font-weight: 400;\">viloxazine<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Therapy: <\/b><span style=\"font-weight: 400;\">Cognitive behavioral therapy, dialectical behavioral therapy, behavior therapy, parent\/family training, and social skills training can also help.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u201cThe best approach combines medication with lifestyle strategies &#8211; structured routines, good sleep habits, exercise, and coaching or counseling,\u201d Dr. Dasgupta says.\u201d The key is finding an ADHD treatment routine that works for you and sticking with it.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Azstarys is a brand-name medication that is FDA approved to treat attention-deficit hyperactivity disorder (ADHD). ADHD is the most commonly diagnosed behavioral disorder in children, which also affects an estimated 15.5 million adults in the United States. Azstarys belongs to a group of medicines called central nervous system (CNS) stimulants and helps improve attention, focus, [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":633541,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[15107,12752,8905],"coauthors":[21050],"class_list":["post-633577","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-adhd","tag-medication-side-effects","tag-seasonal","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>How long does Azstarys last?<\/title>\n<meta name=\"description\" content=\"Azstarys can last up to 13 hours, which is why patients are advised to take it in the morning for control of ADHD symptoms. 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What to know about Azstarys\" \/>\n<meta property=\"og:description\" content=\"It can help you stay focused for up to 13 hours\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.singlecare.com\/blog\/how-long-does-azstarys-last\/\" \/>\n<meta property=\"og:site_name\" content=\"The Checkup\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/singlecare\" \/>\n<meta property=\"article:published_time\" content=\"2025-09-23T13:30:26+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-03T18:09:32+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2025\/09\/Blog_092325_How_long_does_Azstarys_last-copy.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"Christine Bryant\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"Living with ADHD? 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