{"id":633725,"date":"2025-10-01T15:22:01","date_gmt":"2025-10-01T19:22:01","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=633725"},"modified":"2026-01-28T14:06:47","modified_gmt":"2026-01-28T19:06:47","slug":"valtrex-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/valtrex-alternatives\/","title":{"rendered":"Valtrex alternatives: Prescription, OTC, and natural option"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/valtrex\"><span style=\"font-weight: 400;\">Valtrex<\/span><\/a><span style=\"font-weight: 400;\"> (valacyclovir) is a brand-name prescription medication approved by the Food and Drug Administration (FDA) to treat viral infections caused by the herpes simplex virus (HSV) and varicella zoster virus (VZV). These viruses cause infections such as <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/how-to-get-rid-of-cold-sores\/\"><span style=\"font-weight: 400;\">cold sores<\/span><\/a><span style=\"font-weight: 400;\">, genital <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/herpes-treatment-and-medications\"><span style=\"font-weight: 400;\">herpes<\/span><\/a><span style=\"font-weight: 400;\">, herpes zoster (<\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/shingles-treatment-and-medications\"><span style=\"font-weight: 400;\">shingles<\/span><\/a><span style=\"font-weight: 400;\">), and chickenpox. As an <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antivirals\"><span style=\"font-weight: 400;\">antiviral drug<\/span><\/a><span style=\"font-weight: 400;\">, Valtrex is classified as a purine nucleoside analog and works by blocking viruses from multiplying (spreading) in the body.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Although Valtrex is an effective treatment option, not everyone is a candidate for Valtrex. The good news is that there are several alternatives you can discuss with your healthcare provider.\u00a0<\/span><\/p>\n<h2 id=\"what-can-i-take-instead-of-valtrex\"><span style=\"font-weight: 400;\">What can I take instead of Valtrex?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Whether <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/fda\/fdaDrugXsl.cfm?setid=1f338cd7-3520-337b-e063-6294a90aa45d&amp;type=display\"><span style=\"font-weight: 400;\">Valtrex<\/span><\/a><span style=\"font-weight: 400;\"> is causing side effects or you aren\u2019t a candidate for it, there are other options available that can treat viral infections like the herpes virus. These alternative prescription medications include other types of oral antiviral drugs and topical antiviral medications. One of these options may be more suitable for your needs as they each have different uses, side effect profiles, and dosages.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The following table highlights some of the common alternatives to Valtrex.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th colspan=\"4\">\n<h3 id=\"compare-valtrex-alternatives\"><span style=\"font-weight: 400;\">Compare Valtrex alternatives<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><b>Drug name<\/b><\/td>\n<td><b>Price without insurance<\/b><\/td>\n<td><b>SingleCare price<\/b><\/td>\n<td><b>Savings options<\/b><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/valtrex\/what-is\"><span style=\"font-weight: 400;\">Valtrex<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">(<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/valacyclovir-hcl\/what-is\"><span style=\"font-weight: 400;\">valacylovir<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$512 for 30, 500 mg tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$11 for 30, 500 mg tablets of generic Valtrex<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/valtrex\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/zovirax\/what-is\"><span style=\"font-weight: 400;\">Zovirax<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">(<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/acyclovir\/what-is\"><span style=\"font-weight: 400;\">acyclovir<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$595 for 1, 5gm of 5% tube of cream<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$42 for 1, 5gm of 5% tube of cream of generic Zovirax<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/zovirax#coupons\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Famvir\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">(<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/famciclovir\/what-is\"><span style=\"font-weight: 400;\">famciclovir<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$241 for 21, 500 mg tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$24 for 21, 500 mg tablets of generic Famvir<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/famciclovir\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/denavir\/what-is\"><span style=\"font-weight: 400;\">Denavir<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">(<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/penciclovir\/what-is\"><span style=\"font-weight: 400;\">penciclovir<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$1052 for 1, 5gm of 1% tube of cream<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$161 for 1, 5gm of 1% tube of cream of generic Denavir<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/denavir\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><i><span style=\"font-weight: 400;\">Prescription drug prices often change. These are the most accurate medication prices at the time of publishing. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available. Click the link under \u201cSavings options\u201d to see the latest drug prices.<\/span><\/i><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Valtrex with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tValtrex 500 mg (29 Tablet)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$11.14<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/valtrex#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/valtrex#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-harristeeter.svg\" alt=\"Harris Teeter Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$11.14<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/valtrex#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/valtrex#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/valtrex#blog-cta\" class=\"coupon-see-all-btn\">See Valtrex prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"top-3-valtrex-alternatives\"><span style=\"font-weight: 400;\">Top 3 Valtrex alternatives<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The following are some of the most common alternatives to Valtrex.<\/span><\/p>\n<h3 id=\"1-zovirax-acyclovir\"><span style=\"font-weight: 400;\">1. Zovirax (acyclovir)<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Like Valtrex, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/acyclovir-vs-valacyclovir\/\"><span style=\"font-weight: 400;\">Zovirax<\/span><\/a><span style=\"font-weight: 400;\"> is a prescription antiviral medication <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/fda\/fdaDrugXsl.cfm?setid=8cd22728-34b4-4e55-8339-580138fe46d8&amp;type=display\"><span style=\"font-weight: 400;\">FDA-approved<\/span><\/a><span style=\"font-weight: 400;\"> to treat genital herpes, shingles, and chickenpox. It is available in multiple dosage forms, including oral tablets, oral capsules, creams, ointments, and injections. Compared to Zovirax, Valtrex is better absorbed in the body and requires less frequent dosing. However, both medications are generally covered by commercial and Medicare insurance plans.\u00a0<\/span><\/p>\n<h3 id=\"2-famvir-famciclovir\"><span style=\"font-weight: 400;\">2. Famvir (famciclovir)<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Famvir, also known as <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/fda\/fdaDrugXsl.cfm?setid=08c58224-5920-4853-8c59-ec5fbb66c2f6&amp;type=display\"><span style=\"font-weight: 400;\">famciclovir<\/span><\/a><span style=\"font-weight: 400;\">, is another prescription antiviral medication. Like Valtrex, it is prescribed to treat cold sores, genital herpes, and shingles. It has one additional indication, which is for the treatment of orolabial (mouth and lip) herpes and genital herpes in adults with human immunodeficiency virus (HIV). It comes as a tablet that is taken two to three times daily, depending on the condition being treated. In comparison, Valtrex is prescribed one to three times daily. Both cause similar adverse effects, such as headache and nausea.\u00a0<\/span><\/p>\n<h3 id=\"3-denavir-penciclovir\"><span style=\"font-weight: 400;\">3. Denavir (penciclovir)<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Another alternative to Valtrex is <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/fda\/fdaDrugXsl.cfm?setid=61229829-55a0-4d6f-a423-4b48a2b4d8e5&amp;type=display\"><span style=\"font-weight: 400;\">Denavir<\/span><\/a><span style=\"font-weight: 400;\">, which is a prescription antiviral cream used to treat cold sores in adults and children aged 12 years and older. It needs to be applied every two hours while awake for four days, so it requires more frequent dosing than Valtrex. Because it is a cream, the potential side effects of Denavir include reactions at the site of application, whereas common side effects of Valtrex include headache, nausea, and abdominal pain.\u00a0<\/span><\/p>\n<h2 id=\"over-the-counter-treatments\"><span style=\"font-weight: 400;\">Over-the-counter treatments<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There are a few OTC options that can be used for cold sores. Keep in mind, these are not curative treatments like Valtrex. Instead, they provide symptom relief only. OTC options for cold sores include Abreva (docosanol), numbing agents, like Orajel, and pain relievers, like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/tylenol\"><span style=\"font-weight: 400;\">Tylenol<\/span><\/a><span style=\"font-weight: 400;\"> (acetaminophen) and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/advil\"><span style=\"font-weight: 400;\">Advil<\/span><\/a><span style=\"font-weight: 400;\"> (ibuprofen). While these options are more easily accessible and sometimes cheaper than Valtrex, you should always consult a healthcare provider before starting any new medications.\u00a0<\/span><\/p>\n<h2 id=\"natural-alternatives-to-valtrex\"><span style=\"font-weight: 400;\">Natural alternatives to Valtrex<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Certain lifestyle changes may help manage symptoms of cold sores, shingles, genital herpes, and chickenpox. According to the <\/span><a href=\"https:\/\/www.aad.org\/public\/diseases\/a-z\/cold-sores-self-care\"><span style=\"font-weight: 400;\">American Academy of Dermatology Association<\/span><\/a><span style=\"font-weight: 400;\"> (AAD), stress reduction, sun protection for your lips, maintaining lip moisture, and getting adequate sleep can all help reduce the likelihood of another cold sore. For shingles, the <\/span><a href=\"https:\/\/www.aad.org\/public\/diseases\/a-z\/shingles-self-care\"><span style=\"font-weight: 400;\">AAD<\/span><\/a><span style=\"font-weight: 400;\"> recommends keeping the skin cool by applying a clean, cool, and damp washcloth, soaking in an oatmeal bath, or applying calamine lotion. They also recommend getting plenty of rest, stress reduction, and eating healthy, well-balanced meals. For <\/span><a href=\"https:\/\/www.aad.org\/public\/everyday-care\/itchy-skin\/rash\/chicken-pox\"><span style=\"font-weight: 400;\">chickenpox<\/span><\/a><span style=\"font-weight: 400;\">, you can try colloidal oatmeal baths, calamine lotion, and petroleum jelly.\u00a0<\/span><\/p>\n<h2 id=\"how-to-switch-to-a-valtrex-alternative\"><span style=\"font-weight: 400;\">How to switch to a Valtrex alternative<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Before switching to a Valtrex alternative, consult your healthcare provider. While there aren\u2019t any withdrawal effects noted in the Valtrex\u2019s prescribing information, stopping antiviral medications earlier than prescribed can cause your infection to worsen or come back. So, if Valtrex is causing side effects, or you feel it isn\u2019t working, talk to a healthcare professional. They can provide medical advice on whether an alternative is a good idea and, if so, which one is best suited for you. Lastly, it is also important to consider the cost when switching medications. Contact your insurance provider to understand the financial implications of switching to a Valtrex alternative.\u00a0<\/span><\/p>\n<h2 id=\"choosing-the-right-path-for-antiviral-treatment\"><span style=\"font-weight: 400;\">Choosing the right path for antiviral treatment<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Viral infections are often painful and disruptive to your everyday life. Antivirals, such as Valtrex, can help treat your infection. If you aren\u2019t a candidate for Valtrex, talk to your health care provider about an alternative. Common alternatives include Zovirax, Famvir, and Denavir. <\/span><span style=\"font-weight: 400;\">They will take into account your <\/span><span style=\"font-weight: 400;\">medical history<\/span><span style=\"font-weight: 400;\"> and other <\/span><span style=\"font-weight: 400;\">medications<\/span><span style=\"font-weight: 400;\"> to help choose the right medication.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Valtrex (valacyclovir) is a brand-name prescription medication approved by the Food and Drug Administration (FDA) to treat viral infections caused by the herpes simplex virus (HSV) and varicella zoster virus (VZV). These viruses cause infections such as cold sores, genital herpes, herpes zoster (shingles), and chickenpox. As an antiviral drug, Valtrex is classified as a [&hellip;]<\/p>\n","protected":false},"author":87,"featured_media":633727,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[790,15103],"coauthors":[20969],"class_list":["post-633725","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-chronic-disease","tag-drug-pricing","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Best Valtrex alternatives with prices, side effects, and treatment guidance<\/title>\n<meta name=\"description\" content=\"Discover the top Valtrex alternatives, including Zovirax, Famvir, and Denavir, plus OTC and lifestyle remedies for relief.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/valtrex-alternatives\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Valtrex alternatives: Prescription, OTC, and natural option\" \/>\n<meta property=\"og:description\" content=\"Discover the top Valtrex alternatives, including Zovirax, Famvir, and Denavir, plus OTC and lifestyle remedies for relief.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.singlecare.com\/blog\/valtrex-alternatives\/\" \/>\n<meta property=\"og:site_name\" content=\"The Checkup\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/singlecare\" \/>\n<meta property=\"article:published_time\" content=\"2025-10-01T19:22:01+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-01-28T19:06:47+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2025\/10\/Valtrex-alternatives.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Ashley Wong, Pharm. 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