{"id":633740,"date":"2025-10-02T14:42:13","date_gmt":"2025-10-02T18:42:13","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=633740"},"modified":"2026-09-10T20:37:56","modified_gmt":"2026-09-11T00:37:56","slug":"jardiance-10-mg-vs-25-mg","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/jardiance-10-mg-vs-25-mg\/","title":{"rendered":"Jardiance 10 mg vs 25 mg: Which dose is right for you?"},"content":{"rendered":"

Jardiance<\/a> is the brand name for empagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor. It\u2019s FDA approved to treat Type 2 diabetes in adults and children who are at least 10 years of age, in conjunction with diet and exercise. Jardiance<\/a> is also approved to reduce the risk of cardiovascular death in adults with Type 2 diabetes and cardiovascular disease, to reduce the risk of worsening kidney function in adults with chronic kidney disease, and to reduce the risk of hospitalization and cardiovascular death in adults with heart failure or chronic kidney disease. Jardiance works by removing excess glucose (sugar) from the body through the kidneys.<\/p>\n

Jardiance is taken orally once per day at either a 10 mg or 25 mg dose. Wondering what the difference is between Jardiance 10 mg vs. 25 mg? Most people who take Jardiance take a 10 mg dose, but a 25 mg dose is sometimes used in patients with Type 2 diabetes who need more help reducing their blood sugar.<\/p>\n\t\t\t

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What\u2019s the difference between Jardiance 10 mg versus 25 mg?<\/h2>\n

The 10 mg dose of Jardiance is the typical starting dose, says Linda Khoshaba, NMD, naturopathic endocrinologist and founder of Natural Endocrinology Specialists (NES)<\/a>. \u201cIt\u2019s sort of a \u2018let\u2019s see how your body does with this\u2019 approach,\u201d she says. If your blood sugar levels aren\u2019t being lowered sufficiently with the 10 mg dose, your healthcare provider may bump you up to 25 mg for a more potent effect. \u201cThe higher dose isn\u2019t automatically better for everyone\u2014it\u2019s usually reserved for when the smaller dose isn\u2019t enough,\u201d says Dr. Khoshaba.<\/p>\n

According to the prescribing information<\/a>, 10 mg once daily is the recommended dose for all four approved uses of Jardiance. An increased dosage of 25 mg per day is listed as an option for those who need additional glycemic control.<\/p>\n

Here\u2019s what to know about conditions that Jardiance treats and 10 mg vs. 25 mg dosing.<\/p>\n\n\n\n\n\n\n\n\n\n
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Conditions treated by Jardiance 10 mg and 25 mg<\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

Condition<\/b><\/td>\n10 mg once daily<\/b><\/td>\n25 mg once daily<\/b><\/td>\n<\/tr>\n
Reduction in the risk of cardiovascular death and hospitalization in adults with heart failure<\/td>\nYes<\/td>\nNot recommended for added heart failure benefit<\/td>\n<\/tr>\n
Reduction in the risk of kidney failure, hospitalization, and death in adults with chronic kidney disease<\/td>\nYes<\/td>\nNot recommended for added kidney benefit<\/td>\n<\/tr>\n
Reduction in the risk of cardiovascular death in adults with Type 2 diabetes and cardiovascular disease<\/td>\nYes<\/td>\nNot recommended for added heart disease benefit<\/td>\n<\/tr>\n
Blood glucose control in people with Type 2 diabetes<\/td>\nYes<\/td>\nYes, if well tolerated and if further glycemic control is needed<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Jardiance dosage for Type 2 diabetes<\/h2>\n

When it comes to diabetes management, research has shown that higher doses of Jardiance can be more effective for glycemic control. For example, a study published in the Journal of Clinical Pharmacy and Therapeutics<\/i><\/a> found that higher doses of empagliflozin (the active ingredient in Jardiance) result in more substantial decreases in hemoglobin A1C<\/a>, a blood test that measures your average glucose level from the past three months. Over 12 weeks, empagliflozin doses of 10, 25, and 50 mg were more effective at lowering A1C than 1, 2.5, and 5 mg. Among these doses, 25 mg performed the best overall when both efficacy and side effects were considered.<\/p>\n

According to the drug label<\/a>, the 25 mg dose is typically reserved for offering extra support to patients with Type 2 diabetes. Most people start with 10 mg once daily in the morning, with or without food. The dosage may be increased in people who tolerate the lower dose and need more blood sugar control.<\/p>\n

Jardiance dosage for heart failure and chronic kidney disease<\/h2>\n

For people with heart failure and chronic kidney disease, the recommended dose is 10 mg once daily. In practice, 10 mg per day is also the maximum effective dosage for these conditions.<\/p>\n

The EMPEROR-Reduced<\/a> and EMPEROR-Preserved<\/a> heart failure trials both used a once-daily dose of 10 mg. In addition, the EMPA-KIDNEY<\/a> trial in people with chronic kidney disease found a 28% lower risk of kidney disease progression or cardiovascular death with 10 mg of empagliflozin than with placebo.<\/p>\n

The 25 mg dose comes into play for people with heart failure or chronic kidney disease who also have Type 2 diabetes. In this case, a higher dosage may be prescribed if blood sugar levels remain uncontrolled at the lower dose.<\/p>\n

Does the dose affect weight loss?<\/h2>\n

The different doses may slightly affect weight loss. In monotherapy trials<\/a>, people taking Jardiance 10 mg lost an average of 2.8% of their body weight, while those on the 25 mg dose lost 3.2% of their body weight. When Jardiance was taken with metformin, the figures were 2.5% on the lower dose versus 2.9% on the higher one. For someone weighing 200 pounds, that difference between doses works out to roughly one pound over the study period.<\/p>\n

Jardiance is not a weight-loss medication and is not FDA approved for this purpose. If weight loss is a specific goal of your treatment plan, you may want to consider discussing other medications with a healthcare provider, not a different dose.<\/p>\n

Are side effects different between the 10 mg and 25 mg dose?<\/h2>\n

Like all medications, Jardiance can have side effects. The most common side effects of Jardiance<\/a> are:<\/p>\n