{"id":633890,"date":"2025-10-09T13:10:06","date_gmt":"2025-10-09T17:10:06","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=633890"},"modified":"2025-10-09T13:10:06","modified_gmt":"2025-10-09T17:10:06","slug":"linzess-290-mcg","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/linzess-290-mcg\/","title":{"rendered":"Understanding Linzess 290 mcg"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/linzess\"><span style=\"font-weight: 400;\">Linzess<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><span style=\"font-weight: 400;\">linaclotide<\/span><span style=\"font-weight: 400;\">) is an <\/span><span style=\"font-weight: 400;\">FDA-approved<\/span><span style=\"font-weight: 400;\"> prescription medication used to treat different types of <\/span><span style=\"font-weight: 400;\">chronic constipation<\/span><span style=\"font-weight: 400;\">, including <\/span><span style=\"font-weight: 400;\">irritable bowel syndrome<\/span><span style=\"font-weight: 400;\"> with constipation (<\/span><span style=\"font-weight: 400;\">IBS-C<\/span><span style=\"font-weight: 400;\">), <\/span><span style=\"font-weight: 400;\">chronic idiopathic constipation<\/span><span style=\"font-weight: 400;\"> (<\/span><span style=\"font-weight: 400;\">CIC<\/span><span style=\"font-weight: 400;\">), and <\/span><span style=\"font-weight: 400;\">functional constipation<\/span><span style=\"font-weight: 400;\"> (FC). The guanylate cyclase-C (<\/span><span style=\"font-weight: 400;\">GC-C<\/span><span style=\"font-weight: 400;\">) helps soften stool, encourage more frequent and complete <\/span><span style=\"font-weight: 400;\">bowel movements<\/span><span style=\"font-weight: 400;\">, and alleviate <\/span><span style=\"font-weight: 400;\">abdominal pain<\/span><span style=\"font-weight: 400;\">. The typical dosage strengths of <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> are 72 <\/span><span style=\"font-weight: 400;\">mcg<\/span><span style=\"font-weight: 400;\">, 145 <\/span><span style=\"font-weight: 400;\">mcg<\/span><span style=\"font-weight: 400;\">, and 290 <\/span><span style=\"font-weight: 400;\">mcg<\/span><span style=\"font-weight: 400;\"> taken orally once daily. Your prescribed dosage strength will depend on the condition being treated.\u00a0<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Linzess with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tLinzess 145 mcg (30 capsules)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$252.26<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/linzess#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/linzess#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-harristeeter.svg\" alt=\"Harris Teeter Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$252.26<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/linzess#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/linzess#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/linzess#blog-cta\" class=\"coupon-see-all-btn\">See Linzess prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"what-is-linzess-290-mcg-used-for\"><span style=\"font-weight: 400;\">What is <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> 290 <\/span><span style=\"font-weight: 400;\">mcg<\/span><span style=\"font-weight: 400;\"> used for?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The maximum <\/span><span style=\"font-weight: 400;\">dose of Linzess<\/span><span style=\"font-weight: 400;\"> is 290 micrograms (<\/span><span style=\"font-weight: 400;\">mcg<\/span><span style=\"font-weight: 400;\">) taken once daily. This high dose is typically prescribed for adults with <\/span><span style=\"font-weight: 400;\">irritable bowel syndrome<\/span><span style=\"font-weight: 400;\"> with <\/span><span style=\"font-weight: 400;\">chronic constipation<\/span><span style=\"font-weight: 400;\"> (<\/span><span style=\"font-weight: 400;\">IBS-C<\/span><span style=\"font-weight: 400;\">) to relieve <\/span><span style=\"font-weight: 400;\">abdominal pain<\/span><span style=\"font-weight: 400;\"> and constipation.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other <\/span><a href=\"https:\/\/www.linzess.com\/understanding-constipation\/what-is-ibs-c\"><span style=\"font-weight: 400;\">common symptoms of <\/span><span style=\"font-weight: 400;\">IBS-C<\/span><\/a><span style=\"font-weight: 400;\"> include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hard, dry, or lumpy stools<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Incomplete <\/span><span style=\"font-weight: 400;\">bowel movements<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Straining during <\/span><span style=\"font-weight: 400;\">bowel movements<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bloating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Flatulence<\/span><span style=\"font-weight: 400;\"> (gas)\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u201cI consider it when patients haven\u2019t responded to standard <\/span><span style=\"font-weight: 400;\">laxatives<\/span><span style=\"font-weight: 400;\"> or fiber,\u201d says <\/span><a href=\"https:\/\/www.linkedin.com\/in\/drsarahbonza\/\"><span style=\"font-weight: 400;\">Sarah Bonza, MD, MPH, FAAFP<\/span><\/a><span style=\"font-weight: 400;\">, a family medicine physician, founder of <\/span><a href=\"https:\/\/www.bonzahealth.com\/\"><span style=\"font-weight: 400;\">Bonza Health<\/span><\/a><span style=\"font-weight: 400;\">, and hospitalist physician at Fairfield Medical Center in Lancaster, Ohio. \u201cIt\u2019s not usually the first-line drug, but it can be helpful for those with persistent symptoms.\u201d<\/span><\/p>\n<p><a href=\"https:\/\/www.linkedin.com\/in\/omarkhokhar\/\"><span style=\"font-weight: 400;\">Omar Khokhar, MD<\/span><\/a><span style=\"font-weight: 400;\">, a gastroenterologist at <\/span><a href=\"http:\/\/illinoisgastrohealth.com\/\"><span style=\"font-weight: 400;\">Illinois GastroHealth<\/span><\/a><span style=\"font-weight: 400;\"> in Bloomington, Illinois, also adds that in addition to fiber, he typically prescribes <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> when traditional methods like eating more fruits and engaging in exercise have been unsuccessful. \u201cPrescribing <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> over others depends on a number of factors,\u201d he says. \u201cIn my experience, insurance coverage usually determines which agent is used.\u201d<\/span><\/p>\n<h2 id=\"what-to-expect-when-taking-it\"><span style=\"font-weight: 400;\">What to expect when taking it<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Like any medication, <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> can cause mild to severe <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Below are the most <\/span><span style=\"font-weight: 400;\">common side effects<\/span><span style=\"font-weight: 400;\"> of the anti-constipation drug:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Swelling or feeling of fullness or pressure in the abdominal area<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gas<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Some patients claim to experience rapid weight loss while <\/span><span style=\"font-weight: 400;\">taking Linzess<\/span><span style=\"font-weight: 400;\">. However, Dr. Bonza says this isn\u2019t quite the case. \u201cWhile patients may claim to lose some weight, it&#8217;s due to fluid shifts from diarrhea, so what they are actually losing is water weight,\u201d she says. \u201cIt is not a weight loss medication.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">More <\/span><span style=\"font-weight: 400;\">serious side effects<\/span><span style=\"font-weight: 400;\"> include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Unusual or severe <\/span><span style=\"font-weight: 400;\">abdominal pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Black sticky or bright red stools<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness or fainting spells<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe <\/span><span style=\"font-weight: 400;\">allergic reactions<\/span><span style=\"font-weight: 400;\">, including <\/span><span style=\"font-weight: 400;\">hives<\/span><span style=\"font-weight: 400;\">, rash, itching, swelling of the lips, throat, or tongue, shortness of breath, or difficulty breathing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fast heartbeat<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Extreme thirst<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth or skin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sunken eyes<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If you experience any of these symptoms, seek immediate evaluation with your <\/span><span style=\"font-weight: 400;\">healthcare provider<\/span><span style=\"font-weight: 400;\"> or at the emergency room.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> 290 <\/span><span style=\"font-weight: 400;\">mcg<\/span><span style=\"font-weight: 400;\"> is very effective in treating symptoms of <\/span><span style=\"font-weight: 400;\">IBS-C<\/span><span style=\"font-weight: 400;\">. A <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22986437\/\"><span style=\"font-weight: 400;\">randomized, double-blind, <\/span><span style=\"font-weight: 400;\">placebo<\/span><span style=\"font-weight: 400;\">-controlled trial<\/span><\/a><span style=\"font-weight: 400;\"> found that a daily <\/span><span style=\"font-weight: 400;\">dose of Linzess<\/span><span style=\"font-weight: 400;\"> 290 over 26 weeks significantly reduced abdominal and bowel symptoms associated with the chronic condition.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Another <\/span><a href=\"https:\/\/journals.lww.com\/ajg\/fulltext\/2021\/09000\/efficacy_of_linaclotide_in_reducing_abdominal.24.aspx\"><span style=\"font-weight: 400;\">randomized, double-blind, <\/span><span style=\"font-weight: 400;\">placebo<\/span><span style=\"font-weight: 400;\">-controlled trial<\/span><\/a><span style=\"font-weight: 400;\"> had similar results, with patients with <\/span><span style=\"font-weight: 400;\">IBS-C<\/span><span style=\"font-weight: 400;\"> reporting less <\/span><span style=\"font-weight: 400;\">abdominal pain<\/span><span style=\"font-weight: 400;\"> and discomfort after taking 290 <\/span><span style=\"font-weight: 400;\">mcg<\/span><span style=\"font-weight: 400;\"> of <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> daily for 12 weeks.<\/span><\/p>\n<h2 id=\"linzess-145-mcg-vs-290-mcg\"><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> 145 <\/span><span style=\"font-weight: 400;\">mcg<\/span><span style=\"font-weight: 400;\"> vs. 290 <\/span><span style=\"font-weight: 400;\">mcg<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">While there\u2019s currently no research that compares the different strengths, <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> 145 <\/span><span style=\"font-weight: 400;\">mcg<\/span><span style=\"font-weight: 400;\"> is prescribed to treat <\/span><span style=\"font-weight: 400;\">chronic idiopathic constipation<\/span><span style=\"font-weight: 400;\"> (<\/span><span style=\"font-weight: 400;\">CIC<\/span><span style=\"font-weight: 400;\">), while <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> 290 <\/span><span style=\"font-weight: 400;\">mcg<\/span><span style=\"font-weight: 400;\"> is prescribed for <\/span><span style=\"font-weight: 400;\">IBS-C<\/span><span style=\"font-weight: 400;\">. <\/span><span style=\"font-weight: 400;\">CIC<\/span><span style=\"font-weight: 400;\"> is a <\/span><a href=\"https:\/\/www.ajmc.com\/view\/update-on-the-management-of-chronic-idiopathic-constipati\"><span style=\"font-weight: 400;\">long-term constipation<\/span><\/a><span style=\"font-weight: 400;\"> that is not caused by an underlying <\/span><span style=\"font-weight: 400;\">medical condition<\/span><span style=\"font-weight: 400;\">. While some people may be able to take the lower dose of 72 <\/span><span style=\"font-weight: 400;\">mcg<\/span><span style=\"font-weight: 400;\"> to treat <\/span><span style=\"font-weight: 400;\">CIC<\/span><span style=\"font-weight: 400;\">, those with <\/span><span style=\"font-weight: 400;\">IBS-C<\/span><span style=\"font-weight: 400;\"> must take the highest or maximum dose of the anti-constipation medication\u2014290 <\/span><span style=\"font-weight: 400;\">mcg<\/span><span style=\"font-weight: 400;\">\u2014to relieve symptoms. It is the only recommended dose to treat <\/span><span style=\"font-weight: 400;\">IBS-C<\/span><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you have questions or concerns about the best <\/span><span style=\"font-weight: 400;\">dose of Linzess<\/span><span style=\"font-weight: 400;\"> for your symptoms, please consult your <\/span><span style=\"font-weight: 400;\">healthcare provider<\/span><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<h2 id=\"how-to-take-linzess-290-mcg\"><span style=\"font-weight: 400;\">How to <\/span><span style=\"font-weight: 400;\">take Linzess<\/span><span style=\"font-weight: 400;\"> 290 <\/span><span style=\"font-weight: 400;\">mcg<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Follow your <\/span><span style=\"font-weight: 400;\">healthcare provider<\/span><span style=\"font-weight: 400;\">\u2019s instructions when <\/span><span style=\"font-weight: 400;\">taking Linzess<\/span><span style=\"font-weight: 400;\"> 290 <\/span><span style=\"font-weight: 400;\">mcg to get the best results<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Below are some <\/span><a href=\"https:\/\/my.clevelandclinic.org\/health\/drugs\/19230-linaclotide-capsules\"><span style=\"font-weight: 400;\">tips and best practices<\/span><\/a><span style=\"font-weight: 400;\"> for <\/span><span style=\"font-weight: 400;\">taking Linzess<\/span><span style=\"font-weight: 400;\"> 290 <\/span><span style=\"font-weight: 400;\">mcg<\/span><span style=\"font-weight: 400;\">:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Take pill on <\/b><b>empty stomach<\/b><b> with <\/b><b>bottled water<\/b><b>: <\/b><span style=\"font-weight: 400;\">\u201cI advise my patients to take it on an <\/span><span style=\"font-weight: 400;\">empty stomach<\/span><span style=\"font-weight: 400;\">, at least 30 minutes before the first meal,\u201d Dr. Bonza says. If you take the medication with food\u2014particularly fatty or greasy foods\u2014you may increase the risk of gastrointestinal (GI) <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\">, such as gas, <\/span><span style=\"font-weight: 400;\">abdominal pain<\/span><span style=\"font-weight: 400;\">, and diarrhea. If you have trouble swallowing the capsule, you can take it apart and mix the drug with a teaspoon of <\/span><span style=\"font-weight: 400;\">applesauce<\/span><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Don\u2019t alter the medication:<\/b><span style=\"font-weight: 400;\"> \u201cI encourage taking the medication as it is, and that there is no need for crushing or chewing the pill,\u201d Dr. Bonza says. Exceptions apply if you have a <\/span><span style=\"font-weight: 400;\">nasogastric<\/span> <span style=\"font-weight: 400;\">feeding tube<\/span><span style=\"font-weight: 400;\">, as <\/span><span style=\"font-weight: 400;\">Linzess capsules<\/span><span style=\"font-weight: 400;\"> can be administered by emptying their contents into the tubing.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Avoid double-dosing: <\/b><span style=\"font-weight: 400;\">If you miss a dose, it\u2019s best to skip it and take the <\/span><span style=\"font-weight: 400;\">next dose<\/span><span style=\"font-weight: 400;\"> at the regular time. Don\u2019t double-up on pills to make up for the <\/span><span style=\"font-weight: 400;\">missed dose<\/span><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Monitor your symptoms: <\/b><span style=\"font-weight: 400;\">Keep track of your <\/span><span style=\"font-weight: 400;\">IBS-C<\/span><span style=\"font-weight: 400;\"> symptoms while <\/span><span style=\"font-weight: 400;\">taking Linzess<\/span><span style=\"font-weight: 400;\">. If you\u2019re not seeing any improvement, notify your <\/span><span style=\"font-weight: 400;\">healthcare provider<\/span><span style=\"font-weight: 400;\">. A benefit of <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> is that no tapering (process of medication withdrawal) is required. \u201cIt can be stopped if not tolerated (e.g., having diarrhea or more than three watery loose <\/span><span style=\"font-weight: 400;\">bowel movements<\/span><span style=\"font-weight: 400;\"> in 24 hours),\u201d Dr. Bonza says.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Prepare for <\/b><b>possible side effects<\/b><b>: <\/b><span style=\"font-weight: 400;\">As previously mentioned, <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> may cause <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\">, such as <\/span><span style=\"font-weight: 400;\">bloating<\/span><span style=\"font-weight: 400;\">, diarrhea, gas, and stomach pain. While these are typical, if you experience <\/span><span style=\"font-weight: 400;\">allergic reactions<\/span><span style=\"font-weight: 400;\"> or other severe <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\">, please notify your <\/span><span style=\"font-weight: 400;\">healthcare provider<\/span><span style=\"font-weight: 400;\"> or seek immediate medical attention if it\u2019s an emergency.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Store <\/b><b>Linzess capsules<\/b><b> properly: <\/b><span style=\"font-weight: 400;\">They should be stored at <\/span><span style=\"font-weight: 400;\">room temperature<\/span><span style=\"font-weight: 400;\">, in a tightly closed original prescription bottle, and in a <\/span><span style=\"font-weight: 400;\">dry place<\/span><span style=\"font-weight: 400;\">. Keep the dessicant (drying agent) packet in the bottle.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Be aware of <\/b><b>drug interactions<\/b><b> or <\/b><b>contraindications<\/b><b>:<\/b><span style=\"font-weight: 400;\"> Medications like anticholinergics and antidiarrheals may decrease the effectiveness of <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\">. <\/span><span style=\"font-weight: 400;\">Breastfeeding<\/span><span style=\"font-weight: 400;\">, pregnancy, GI obstruction, hypersensitivity to active ingredients, and children under 2 <\/span><span style=\"font-weight: 400;\">years of age<\/span><span style=\"font-weight: 400;\"> are <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2023\/202811s021lbl.pdf\"><span style=\"font-weight: 400;\">contraindications<\/span><\/a><span style=\"font-weight: 400;\"> for the prescription drug.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u201cIt&#8217;s important to know that the results aren&#8217;t instant,\u201d Dr. Khokhar says. \u201cTaking it daily results in the best overall impact.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Because <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> 290 <\/span><span style=\"font-weight: 400;\">mcg<\/span><span style=\"font-weight: 400;\"> is the only dose for <\/span><span style=\"font-weight: 400;\">IBS-C<\/span><span style=\"font-weight: 400;\">, you won\u2019t need to titrate or gradually adjust your dose over time.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">When you pick up your prescription from the pharmacy, you should receive a <\/span><span style=\"font-weight: 400;\">Medication Guide<\/span><span style=\"font-weight: 400;\"> (MedGuide), which provides instructions on how to <\/span><span style=\"font-weight: 400;\">take Linzess<\/span><span style=\"font-weight: 400;\"> 290 <\/span><span style=\"font-weight: 400;\">mcg<\/span><span style=\"font-weight: 400;\">. If you still have questions about how and when to <\/span><span style=\"font-weight: 400;\">take Linzess<\/span><span style=\"font-weight: 400;\">, please consult your pharmacist or <\/span><span style=\"font-weight: 400;\">healthcare provider<\/span><span style=\"font-weight: 400;\"> for <\/span><span style=\"font-weight: 400;\">medical advice<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h2 id=\"how-much-does-linzess-290-mcg-cost\"><span style=\"font-weight: 400;\">How much does <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> 290 <\/span><span style=\"font-weight: 400;\">mcg<\/span><span style=\"font-weight: 400;\"> cost?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If you don\u2019t have <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/linzess-without-insurance\/\"><span style=\"font-weight: 400;\">insurance<\/span><\/a><span style=\"font-weight: 400;\"> or are underinsured, <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> can cost about $750 per month for 30 capsules. With a SingleCare coupon, you could get the anti-constipation medication for as low as $515 per 30, 290 <\/span><span style=\"font-weight: 400;\">mcg<\/span><span style=\"font-weight: 400;\"> capsules.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">According to the drug\u2019s manufacturer, AbbVie, <\/span><a href=\"https:\/\/www.linzesshcp.com\/linzess-insurance-coverage\"><span style=\"font-weight: 400;\">98% of Americans with commercial insurance are covered for <\/span><span style=\"font-weight: 400;\">Linzess<\/span><\/a><span style=\"font-weight: 400;\">, with many patients paying only $30 for a 30-day, 60-day, or 90-day prescription. Medicaid recipients may receive <\/span><a href=\"https:\/\/www.linzess.com\/cost-and-savings\"><span style=\"font-weight: 400;\">100% coverage for <\/span><span style=\"font-weight: 400;\">Linzess<\/span><\/a><span style=\"font-weight: 400;\">, with typical out-of-pocket costs ranging from $0 to $10 per month. Approximately 84% of Medicare Part D beneficiaries pay $0 to $50 per month for their prescription.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While most commercial and federal health insurance plans cover <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\">, processes such as <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/prior-authorization\/\"><span style=\"font-weight: 400;\">prior authorization<\/span><\/a><span style=\"font-weight: 400;\"> are typically required by insurance companies. \u201cThey usually want to see documentation of previously failed therapies,\u201d Dr. Khokhar says. \u201cBe sure to tell your doctor everything you&#8217;ve tried.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Prior authorization is a health insurance company\u2019s approval process that\u2019s required before covering certain medications, medical services, treatments, or equipment. This process helps insurers determine whether a treatment is medically necessary, safe, and cost-effective.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you need assistance paying for <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> 290 <\/span><span style=\"font-weight: 400;\">mcg<\/span><span style=\"font-weight: 400;\">, AbbVie\u2019s <\/span><a href=\"https:\/\/www.abbvie.com\/patients\/patient-support\/patient-assistance\/available-programs.html\"><span style=\"font-weight: 400;\">myAbbVie Assist Program<\/span><\/a><span style=\"font-weight: 400;\"> is available to people who are uninsured, underinsured, or have coverage through Medicare. If you are eligible, you may be able to receive the medication at no cost.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">You can also consult your <\/span><span style=\"font-weight: 400;\">healthcare provider<\/span><span style=\"font-weight: 400;\"> to explore other savings options on <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> 290 <\/span><span style=\"font-weight: 400;\">mcg<\/span><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<h2 id=\"linzess-290-mcg-alternatives\"><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> 290 <\/span><span style=\"font-weight: 400;\">mcg<\/span><span style=\"font-weight: 400;\"> alternatives<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If you\u2019re unable to get coverage for <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\"> 290 <\/span><span style=\"font-weight: 400;\">mcg<\/span><span style=\"font-weight: 400;\"> or can\u2019t tolerate the dosage strength, you and your <\/span><span style=\"font-weight: 400;\">healthcare provider<\/span><span style=\"font-weight: 400;\"> can explore <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/linzess-alternatives\/\"><span style=\"font-weight: 400;\">alternative options<\/span><\/a><span style=\"font-weight: 400;\"> for treating <\/span><span style=\"font-weight: 400;\">IBS-C<\/span><span style=\"font-weight: 400;\">, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/amitiza\"><b>Amitiza<\/b><\/a><b> (lubiprostone): <\/b><span style=\"font-weight: 400;\">A chloride channel activator approved to treat <\/span><span style=\"font-weight: 400;\">IBS-C<\/span><span style=\"font-weight: 400;\"> in women 18 years and older.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/ibsrela\"><b>Israel<\/b><\/a><b> (tenapanor): <\/b><span style=\"font-weight: 400;\">A sodium\/hydrogen exchanger 3 (NHE3) inhibitor that treats <\/span><span style=\"font-weight: 400;\">IBS-C<\/span><span style=\"font-weight: 400;\"> in adults.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/trulance\"><b>Trulance<\/b><\/a><b> (plecanatide):<\/b><span style=\"font-weight: 400;\"> A <\/span><span style=\"font-weight: 400;\">guanylate cyclase-C agonist<\/span><span style=\"font-weight: 400;\"> approved to treat <\/span><span style=\"font-weight: 400;\">IBS-C<\/span><span style=\"font-weight: 400;\"> in adults, but is unsafe for <\/span><span style=\"font-weight: 400;\">pediatric patients<\/span><span style=\"font-weight: 400;\"> under 6 <\/span><span style=\"font-weight: 400;\">years of age<\/span><span style=\"font-weight: 400;\"> due to the serious risk of dehydration.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Because there\u2019s no need to taper off <\/span><span style=\"font-weight: 400;\">Linzess<\/span><span style=\"font-weight: 400;\">, once you and your <\/span><span style=\"font-weight: 400;\">healthcare provider<\/span><span style=\"font-weight: 400;\"> decide on an alternative, you can easily switch over without experiencing any adverse reactions.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cI advise going back to your provider and communicating the <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> you feel so you can be given alternatives,\u201d Dr. Bonza says. \u201cThe choice depends on tolerance and insurance coverage.\u201d<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Linzess (linaclotide) is an FDA-approved prescription medication used to treat different types of chronic constipation, including irritable bowel syndrome with constipation (IBS-C), chronic idiopathic constipation (CIC), and functional constipation (FC). The guanylate cyclase-C (GC-C) helps soften stool, encourage more frequent and complete bowel movements, and alleviate abdominal pain. The typical dosage strengths of Linzess are [&hellip;]<\/p>\n","protected":false},"author":137,"featured_media":633891,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[20947,20956],"coauthors":[20975],"class_list":["post-633890","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-constipation","tag-ibs","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Linzess 290 mcg: Uses, side effects, and cost<\/title>\n<meta name=\"description\" content=\"Linzess 290 mcg treats IBS-C by easing constipation and pain. 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