{"id":634121,"date":"2025-10-30T10:23:23","date_gmt":"2025-10-30T14:23:23","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=634121"},"modified":"2026-01-28T14:05:35","modified_gmt":"2026-01-28T19:05:35","slug":"ketoconazole-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/ketoconazole-alternatives\/","title":{"rendered":"Ketoconazole alternatives: Top prescription and OTC antifungal options"},"content":{"rendered":"

Ketoconazole<\/span><\/a>, a medication also known by the brand names Nizoral, Xolegel, and Extina, is a generic medication that is approved by the US Food and Drug Administration (FDA) to treat certain types of fungal infections. It is an azole antifungal medication that works by killing or stopping the growth of fungi causing the infection. While it is an effective medication, ketoconazole isn\u2019t right for everyone. Some people may need a ketoconazole alternative due to drug interactions, contraindications, or allergies.\u00a0<\/span><\/p>\n

Read on to learn more about alternatives to ketoconazole.\u00a0<\/span><\/p>\n

What can I take instead of ketoconazole?<\/span><\/h2>\n

There are several other options available to treat fungal infections. However, alternatives depend on the specific type of infection, your other medications, and your medical history. These alternative medications include other types of azole antifungals and over-the-counter (OTC) <\/span>topical medications<\/span><\/a> or shampoos. Each of these alternatives has its unique uses, side effect profiles, and dosages.\u00a0<\/span><\/p>\n

The following table highlights the most common alternatives to ketoconazole. <\/span>
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Compare ketoconazole alternatives<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

Drug name<\/b><\/td>\nPrice without insurance<\/b><\/td>\nSingleCare price<\/b><\/td>\nSavings options<\/b><\/td>\n<\/tr>\n
Ketodan <\/span><\/a>(<\/span>ketoconazole<\/span><\/a>)<\/span><\/td>\n$831 for 1, 100 gm of 2% can<\/span><\/td>\n$147 for 1, 50 gm of 2% can of generic Ketodan at CVS<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Diflucan<\/span><\/a> (<\/span>fluconazole<\/span><\/a>)<\/span><\/td>\n$215 for 1, 35 ml of 40mg\/ml bottle<\/span><\/td>\n$22 for 1, 35 ml of 40 mg\/ml bottle of generic Diflucan at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Sporanox<\/span><\/a> (<\/span>itraconazole<\/span><\/a>)<\/span><\/td>\n$1,926 for 60, 100 mg capsules<\/span><\/td>\n$50 for 60, 10 mg capsules of generic Sporanox at CVS<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Vfend<\/span><\/a>\u00a0<\/span><\/p>\n

(<\/span>voriconazole<\/span><\/a>)<\/span><\/td>\n

$3,249 for 60, 200 mg tablets<\/span><\/td>\n$71 for 60, 200 mg tablets of generic Vfend at CVS<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Lotrimin AF<\/span><\/a> (<\/span>clotrimazole<\/span><\/a>)\u00a0<\/span><\/td>\n$149 for 1, 90 gm of 1% bottle<\/span><\/td>\n$12 for 1, 30 gm of 1% tube of cream of generic Lotrimin AF at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Lamisil\u00a0<\/span><\/p>\n

(<\/span>terbinafine<\/span><\/a>)<\/span><\/td>\n

$270 for 30, 250 mg tablets<\/span><\/td>\n$11 for 30, 250 mg tablets of generic Lamisil at Food Lion<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Miconazole<\/span><\/a><\/td>\n$16 for 1, 30 gm of 2% tube<\/span><\/td>\n$12 for 1, 30 gm of 2% tube of generic miconazole at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Ciclodan<\/span><\/a>\u00a0<\/span><\/p>\n

(<\/span>ciclopirox<\/span><\/a>)<\/span><\/td>\n

$152 for 1, 6.6 ml of 8% bottle<\/span><\/td>\n$17 for 1, 6.6ml of 8% bottle of generic Ciclodan at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of October 30, 2025. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available.<\/small><\/p>\n\t\t

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Save up to 80% on Ketoconazole with SingleCare<\/p>\n\t\t\t

Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t

\n\t\t\t\t
\n\t\t\t\t\tKetoconazole 120 mL of 2% (1 Liquid)\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
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\n\t\t\t\"Kroger\t\t\t<\/div>\n\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t$3.31\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\tGet free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\"Harris\t\t\t<\/div>\n\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t$3.31\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\tGet free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\tSee Ketoconazole prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n

Top 5 ketoconazole alternatives<\/span><\/h2>\n

The following are some of the most common alternatives to ketoconazole.<\/span><\/p>\n

1. Diflucan (fluconazole)<\/span><\/h3>\n

Ketoconazole and Diflucan are both antifungal medications. However, ketoconazole is mainly only used as a topical medication or shampoo. <\/span>Diflucan<\/span><\/a>, on the other hand, is commonly taken as an oral tablet or capsule to treat vaginal yeast infections, fungal meningitis, and other types of systemic fungal infections. While both medications work similarly to treat fungal infections, ketoconazole can interact with several more drugs than Diflucan.\u00a0<\/span><\/p>\n

2. Sporanox (itraconazole)<\/span><\/h3>\n

Sporanox is a brand-name antifungal medication that is also available as a generic called <\/span>itraconazole<\/span><\/a>. Unlike ketoconazole, <\/span>Sporanox<\/span><\/a> is most commonly used for systemic fungal infections, such as aspergillosis and histoplasmosis. However, healthcare providers may also prescribe Sporanox for fungal infections of the fingernail and toenail. Sporanox has a <\/span>boxed warning<\/span><\/a>; the most serious warning issued by the FDA regarding its risk of use in people with congestive heart failure (CHF) and its risk of drug interactions.\u00a0<\/span><\/p>\n

3. Lotrimin AF (clotrimazole)<\/span><\/h3>\n

Lotrimin AF is a popular topical antifungal medication. Unlike ketoconazole cream, <\/span>Lotrimin<\/span><\/a> cream is available OTC and is used for common skin fungal infections, such as athlete\u2019s foot and jock itch. It contains the active ingredient clotrimazole and is typically applied to the affected area twice daily, whereas <\/span>ketoconazole cream<\/span><\/a> can be used once or twice daily depending on the condition being treated.\u00a0<\/span><\/p>\n

4. Lamisil (terbinafine)<\/span><\/h3>\n

Lamisil is another OTC antifungal medication. Similar to Lotrimin, <\/span>Lamisil<\/span><\/a> is typically used to treat skin fungal infections, such as athlete\u2019s foot, ringworm, and jock itch. In contrast, topical ketoconazole is typically used to treat medical conditions such as dandruff or seborrheic dermatitis. Both medications have the potential to interact with other drugs, but ketoconazole tends to interact with more drugs than Lamisil.\u00a0<\/span><\/p>\n

5. Ciclodan (ciclopirox)<\/span><\/h3>\n

Ciclodan is a brand-name antifungal medication. Like ketoconazole, it is commonly used to treat scalp conditions such as seborrheic dermatitis, but it may also be used for skin fungal infections. The shampoo form of ciclopirox is only available by prescription, but <\/span>Nizoral<\/span><\/a> (ketoconazole) shampoo is available both OTC and with a prescription, depending on the strength.\u00a0<\/span><\/p>\n

Over-the-counter alternatives<\/span><\/h2>\n

OTC ketoconazole alternatives may be available depending on the condition being treated.<\/span><\/p>\n