{"id":634166,"date":"2025-11-04T10:52:32","date_gmt":"2025-11-04T15:52:32","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=634166"},"modified":"2026-06-04T17:29:11","modified_gmt":"2026-06-04T21:29:11","slug":"anti-inflammatory-with-eliquis","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/anti-inflammatory-with-eliquis\/","title":{"rendered":"Is there an anti-inflammatory that can be taken with Eliquis?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Blood clots are a serious medical concern that can cause many other conditions, including heart attack, stroke, deep vein thrombosis, and more. So for people who have had heart disease, blood vessel conditions, certain cancers, and major surgeries, prescription anticoagulants like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/eliquis\"><span style=\"font-weight: 400;\">Eliquis<\/span><\/a><span style=\"font-weight: 400;\"> (apixaban) might be necessary. Taking Eliquis with some common anti-inflammatory drugs increases the risk of bleeding\u2014but certain combinations are safer than others. Below, we\u2019ll outline which anti-inflammatories are safe, which to avoid, and safer alternatives.<\/span><\/p>\n<h2 id=\"what-anti-inflammatory-drugs-can-you-take-with-eliquis\"><span style=\"font-weight: 400;\">What anti-inflammatory drugs can you take with Eliquis?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Some anti-inflammatory medications can <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6971311\/\"><span style=\"font-weight: 400;\">affect the way blood platelets work<\/span><\/a><span style=\"font-weight: 400;\">, and when you combine that with the anti-clotting effects of a blood thinner like Eliquis, it can increase the risk of internal bleeding. However, some anti-inflammatories are safer than others, and might be fine to take with blood thinners.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">You should consult a healthcare provider before combining <\/span><i><span style=\"font-weight: 400;\">any <\/span><\/i><span style=\"font-weight: 400;\">drug with Eliquis. They\u2019ll be able to provide medical advice on the safest choices for anti-inflammatory treatment. That said, here are a few over-the-counter and prescription drugs that are typically safer options for Eliquis patients.\u00a0<\/span><\/p>\n<h3 id=\"otcs-safe-to-take-with-eliquis\"><span style=\"font-weight: 400;\">OTCs safe to take with Eliquis<\/span><\/h3>\n<ul>\n<li aria-level=\"1\"><b>COX-2 inhibitors: <\/b><span style=\"font-weight: 400;\">\u201cIf anti-inflammatory treatment is absolutely necessary, I advise taking short courses of selective COX-2 inhibitors, such as celecoxib (Celebrex), under close supervision,\u201d says <\/span><a href=\"https:\/\/www.linkedin.com\/in\/rohitvuppuluri\/\"><span style=\"font-weight: 400;\">Dr. Rohit Vuppuluri, DO<\/span><\/a><span style=\"font-weight: 400;\">, interventional and vascular cardiologist at <\/span><a href=\"https:\/\/chicagoheartvascular.com\"><span style=\"font-weight: 400;\">Chicago Heart &amp; Vascular Specialists<\/span><\/a><span style=\"font-weight: 400;\">. \u201cThese tend to have a lower risk of stomach bleeding compared to older NSAIDs, though the bleeding risk is still present.\u201d<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-level=\"1\"><b>Topical diclofenac: <\/b><span style=\"font-weight: 400;\">This is technically a non-steroidal anti-inflammatory drug (NSAID), which is usually unsafe to take with Eliquis. However, as a topical NSAID, its systemic absorption and risk of internal bleeding is <\/span><a href=\"https:\/\/journals.lww.com\/ebp\/citation\/2024\/02000\/does_topical_nsaid_use_in_adults_increase_the_risk.31.aspx\"><span style=\"font-weight: 400;\">lower than its oral counterparts<\/span><\/a><span style=\"font-weight: 400;\">. It still poses some risk, though, so it should only be taken under medical supervision.\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-level=\"1\"><b>Hydrocortisone cream: <\/b><span style=\"font-weight: 400;\">Like topical diclofenac, these corticosteroid creams (Cortizone-10, etc.) are less likely to affect blood platelets. But you should still ask a doctor before using them.\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-level=\"1\"><b>Antihistamines: <\/b><span style=\"font-weight: 400;\">Drugs like diphenhydramine (Benadryl), loratadine (Claritin), and cetirizine (Zyrtec) aren\u2019t technically anti-inflammatories, but if your inflammation is allergy-related, they can help. They\u2019re <\/span><a href=\"https:\/\/www.researchgate.net\/publication\/11818628_Co-administration_of_histamine_H1_antagonist_and_oral_anticoagulants\"><span style=\"font-weight: 400;\">not known to interact with anticoagulants<\/span><\/a><span style=\"font-weight: 400;\"> or cause an increased risk of bleeding.\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-level=\"1\"><b>Acetaminophen (Tylenol): <\/b><span style=\"font-weight: 400;\">This drug doesn\u2019t work on inflammation, but inflammation is often associated with pain, and it\u2019s an extremely common pain reliever\u2014one that\u2019s generally safe to take with blood thinners, per Dr. Vuppuluri.\u00a0<\/span><\/li>\n<\/ul>\n<h3 id=\"prescription-medications-you-can-take-with-eliquis\"><span style=\"font-weight: 400;\">Prescription medications you can take with Eliquis<\/span><\/h3>\n<ul>\n<li aria-level=\"1\"><b>Some corticosteroids: <\/b><span style=\"font-weight: 400;\">These drugs, like prednisone or dexamethasone, are powerful anti-inflammatory drugs that <\/span><a href=\"https:\/\/www.mayoclinic.org\/tests-procedures\/cortisone-shots\/in-depth\/steroids\/art-20045692\"><span style=\"font-weight: 400;\">work by suppressing the immune system<\/span><\/a><span style=\"font-weight: 400;\">. They might make Eliquis slightly less effective or cause an even higher risk of bleeding, but for some people, they\u2019re the best option.\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-level=\"1\"><b>Non-acetylated salicylate drugs: <\/b><span style=\"font-weight: 400;\">Medications like salsalate and choline magnesium trisalicylate are similar to NSAIDs, but have fewer antiplatelet effects and a <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2662587\/\"><span style=\"font-weight: 400;\">lower risk of bleeding<\/span><\/a><span style=\"font-weight: 400;\">. Yet Eliquis patients should still use them with caution and under the care of a healthcare provider.\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-level=\"1\"><b>Disease-Modifying Antirheumatic Drugs (DMARDs): <\/b><span style=\"font-weight: 400;\">Typically prescribed for rheumatoid arthritis and other autoimmune or inflammatory conditions, drugs like methotrexate and leflunomide aren\u2019t contraindicated for people taking blood thinners. However, certain ones\u2014specifically JAK inhibitors\u2014may <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8850698\/\"><span style=\"font-weight: 400;\">increase the risk of venous thromboembolic events (VTEs)<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/li>\n<\/ul>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Eliquis with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tEliquis 5 mg (28 Tablets)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$155.92<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"#\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"#\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-harristeeter.svg\" alt=\"Harris Teeter Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$155.92<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"#\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"#\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"#\" class=\"coupon-see-all-btn\">See Eliquis prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"anti-inflammatory-medications-to-avoid-while-taking-eliquis\"><span style=\"font-weight: 400;\">Anti-inflammatory medications to avoid while taking Eliquis?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The medicines to avoid are <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/nsaids\"><span style=\"font-weight: 400;\">NSAIDS<\/span><\/a><span style=\"font-weight: 400;\"> like ibuprofen, aspirin, or naproxen. <\/span><a href=\"https:\/\/doi.org\/10.1093\/eurheartj\/ehae736\"><span style=\"font-weight: 400;\">A study of over 50,000 venous thromboembolic event patients<\/span><\/a><span style=\"font-weight: 400;\"> found that taking NSAIDs alongside an oral anticoagulant doubles the risk of bleeding. This is because NSAIDs inhibit cyclooxygenase (COX) enzymes, which help produce prostaglandins\u2014compounds that contribute to clotting in the stomach lining.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">When prostaglandins aren\u2019t available to <\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/036192308090297X\"><span style=\"font-weight: 400;\">protect the stomach<\/span><\/a><span style=\"font-weight: 400;\">, the risk of gastrointestinal bleeding increases. Combine that with the existing bleeding risk that Eliquis poses, and it can cause <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/eliquis-interactions\/\"><span style=\"font-weight: 400;\">a dangerous interaction<\/span><\/a><span style=\"font-weight: 400;\">, especially for people who are already prone to bleeding.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cIf an oral NSAID is absolutely necessary, I recommend keeping the dose as low as possible and to be used for the shortest amount of time, with protection from a proton pump inhibitor and close monitoring of symptoms for bleeding signs such as dark stools, bruising, or fatigue,\u201d says <\/span><a href=\"https:\/\/www.linkedin.com\/in\/elizabeth-rubin-ribak-27254338\"><span style=\"font-weight: 400;\">Dr. Elizabeth Rubin Ribak, MD<\/span><\/a><span style=\"font-weight: 400;\">, clinical advisor at <\/span><a href=\"https:\/\/emberstreatmentcenter.com\/\"><span style=\"font-weight: 400;\">Embers Recovery<\/span><\/a><span style=\"font-weight: 400;\">. \u201cI also recommend taking extra caution with elderly patients and those with kidney disease, anemia, or previous GI bleeding.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Here are several NSAIDs to avoid while taking Eliquis or other anticoagulant drugs:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ibuprofen (Advil, Motrin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Naproxen (Aleve)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Meloxicam (Mobic)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diclofenac (oral)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Indomethacin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ketorolac<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u201cGenerally, the safest approach is to avoid systemic NSAIDs, rely on acetaminophen and topical treatments, and support overall inflammation control with hydration, movement, and nutrition,\u201d Dr. Rubin Ribak says. \u201cUltimately, I believe that inflammation management in patients who require anticoagulants should focus on minimizing systemic drug exposure while preserving comfort and function.\u201d<\/span><\/p>\n<h2 id=\"alternatives-to-manage-inflammation-while-on-eliquis\"><span style=\"font-weight: 400;\">Alternatives to manage inflammation while on Eliquis<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Medications are an extremely common and effective way to deal with inflammation, but there are alternative methods that can also help, and an informed healthcare provider can help you choose ones that might work for you. Some treatment options include:<\/span><\/p>\n<ul>\n<li><b>Joint injections:<\/b><span style=\"font-weight: 400;\"> An authorized healthcare professional can administer certain types of injections to treat joint inflammation caused by arthritis or other medical conditions. <\/span><a href=\"https:\/\/www.arthritis.org\/health-wellness\/treatment\/treatment-plan\/disease-management\/joint-injections-for-arthritis-pain\"><span style=\"font-weight: 400;\">These injections can include<\/span><\/a><span style=\"font-weight: 400;\"> corticosteroids, hyaluronic acid, Platelet-rich plasma, stem cells, and more.\u00a0<\/span><\/li>\n<li><b>Tropical remedies: <\/b><span style=\"font-weight: 400;\">We\u2019ve already covered topical medications, but <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3834722\/\"><span style=\"font-weight: 400;\">research has suggested<\/span><\/a><span style=\"font-weight: 400;\"> that the external use of aloe vera, comfrey, witch hazel, marshmallow root, and other herbs may help specifically with skin inflammation. Turmeric, capsaicin, and menthol rubs may also help.\u00a0<\/span><\/li>\n<li><b>Ice: <\/b><span style=\"font-weight: 400;\">It\u2019s part of the classic RICE (rest, ice, compression, elevation) therapy for injuries because it doesn\u2019t just reduce pain, it also decreases inflammation.\u00a0<\/span><\/li>\n<li><b>Dietary changes: <\/b><span style=\"font-weight: 400;\">For people with chronic inflammation or inflammatory conditions, a diet rich in anti-inflammatory foods can help. Per Dr. Vuppuluri, <\/span><a href=\"https:\/\/www.health.harvard.edu\/staying-healthy\/foods-that-fight-inflammation\"><span style=\"font-weight: 400;\">foods that can help fight inflammation<\/span><\/a><span style=\"font-weight: 400;\"> include \u201cfruits, vegetables, omega-3 fatty acids, and whole grains.\u201d\u00a0<\/span><\/li>\n<li><b>Physical therapy: <\/b><span style=\"font-weight: 400;\">Primarily for injury recovery and chronic pain, physical therapy uses a variety of techniques like exercise, heat\/ice, massage therapy, and electrical stimulation to reduce pain and swelling.\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Some people swear by certain over-the-counter remedies, but according to Dr. Vuppuluri, \u201cpatients on blood thinners need to be careful when taking over-the-counter \u2018natural\u2019 anti-inflammatories, like ginkgo biloba, garlic, and turmeric supplements in high doses, which can also thin the blood and compound the bleeding risk.\u201d<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Blood clots are a serious medical concern that can cause many other conditions, including heart attack, stroke, deep vein thrombosis, and more. So for people who have had heart disease, blood vessel conditions, certain cancers, and major surgeries, prescription anticoagulants like Eliquis (apixaban) might be necessary. Taking Eliquis with some common anti-inflammatory drugs increases the [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":634167,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[788,737,12752],"coauthors":[21095],"class_list":["post-634166","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-drug-safety","tag-heart-health","tag-medication-side-effects","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.8 (Yoast SEO v27.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Is there an anti-inflammatory that can be taken with Eliquis?<\/title>\n<meta name=\"description\" content=\"Taking anti-inflammatory drugs with Eliquis can increase bleeding risk. 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