{"id":634192,"date":"2025-11-04T15:27:45","date_gmt":"2025-11-04T20:27:45","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=634192"},"modified":"2026-01-23T15:17:01","modified_gmt":"2026-01-23T20:17:01","slug":"can-you-take-eliquis-less-than-12-hours-apart","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/can-you-take-eliquis-less-than-12-hours-apart\/","title":{"rendered":"Can you take Eliquis less than 12 hours apart?"},"content":{"rendered":"

Eliquis<\/span><\/a> (apixaban) is a commonly prescribed anticoagulant, or blood thinner. It\u2019s used to reduce the risk of stroke and blood clots in people with atrial fibrillation (<\/span>AFib<\/span><\/a>), deep vein thrombosis (<\/span>DVT<\/span><\/a>), or pulmonary embolism (<\/span>PE<\/span><\/a>). Eliquis is also commonly prescribed after hip or knee replacement surgeries to prevent blood clots. Like other anticoagulants, the timing of each dose of Eliquis matters. Taking the medication too close together or too far apart affects how it works and increases your risk of side effects. Learn why consistency is important when taking Eliquis and what the experts say about how to take this medication safely.<\/span><\/p>\n

Standard Eliquis dosage guidelines<\/span><\/h2>\n

The standard dosing schedule of Eliquis is typically one pill taken orally twice a day, 12 hours apart. Following the dosage guidelines carefully helps to keep a consistent level of medication in the blood. Taking too much Eliquis increases the risk of uncontrolled bleeding, and too little increases the risk of blood clots.\u00a0<\/span><\/p>\n

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\n\t\t\t\t
\n\t\t\t\t\tEliquis 5 mg (28 Tablet)\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t
\n\t\t\t\"Kroger\t\t\t<\/div>\n\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t$155.92\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\tGet free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\"Harris\t\t\t<\/div>\n\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t$155.92\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\tGet free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\tSee Eliquis prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t<\/span><\/p>\n

Can you take Eliquis less than 12 hours apart?<\/span><\/h2>\n

It\u2019s not recommended to take Eliquis pills less than 12 hours apart. Taking your dose of Eliquis sooner than 12 hours can increase the risk of bleeding.\u00a0<\/span><\/p>\n

There\u2019s a risk of serious, uncontrolled, and potentially fatal bleeding with taking Eliquis, especially if someone is taking other medications that increase the risk of bleeding. Examples include <\/span>aspirin<\/span><\/a>, nonsteroidal anti-inflammatory drugs (NSAIDS, such as ibuprofen), selective serotonin reuptake inhibitors (SSRIs, such as <\/span>fluoxetine<\/span><\/a>), and other blood thinners (e.g., <\/span>warfarin<\/span><\/a>).\u00a0<\/span><\/p>\n

If you overdose on <\/span>Eliquis<\/span><\/a>, contact your healthcare provider or hematologist. There are ways to <\/span>reverse the effects of taking too much Eliquis<\/span><\/a>. For example, <\/span>Andexxa<\/span><\/a> (andexanet alfa) is a drug used to reverse the effects of medications like Eliquis, and activated charcoal can also be used to interfere with the absorption of the drug.\u00a0<\/span><\/p>\n

Why timing matters with Eliquis<\/span><\/h2>\n

Timing is important when taking Eliquis because it can mean the difference between effectively decreasing the risk of blood clots and stroke or experiencing side effects of the medication.\u00a0<\/span><\/p>\n

The half-life of Eliquis is about 12 hours. This means that after 12 hours, half the initial amount of Eliquis is still in the blood. Skipping doses or <\/span>stopping Eliquis suddenly<\/span><\/a> decreases the amount of drug in the blood, which increases the risk of stroke and blood clots.\u00a0<\/span><\/p>\n

Taking Eliquis less than 12 hours from the last dose can cause higher than intended levels of the drug in the blood, which can increase the risk of bleeding. Bleeding can happen in the brain, causing a hemorrhagic stroke, or in the gastrointestinal system, causing blood in the stool. It\u2019s important to recognize these serious <\/span>side effects of Eliquis<\/span><\/a>:<\/span><\/p>\n