{"id":634249,"date":"2025-11-07T12:04:32","date_gmt":"2025-11-07T17:04:32","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=634249"},"modified":"2026-02-02T16:36:01","modified_gmt":"2026-02-02T21:36:01","slug":"does-eliquis-cause-depression-or-anxiety","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/does-eliquis-cause-depression-or-anxiety\/","title":{"rendered":"Does Eliquis cause depression or anxiety?"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/eliquis\"><span style=\"font-weight: 400;\">Eliquis<\/span><\/a><span style=\"font-weight: 400;\"> (apixaban) is a prescription blood thinner, or anticoagulant, approved by the Food and Drug Administration for the treatment of two of the most serious types of blood clots: <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/deep-vein-thrombosis-treatment-and-medications\"><span style=\"font-weight: 400;\">deep vein thrombosis<\/span><\/a><span style=\"font-weight: 400;\"> (DVT) and <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/pulmonary-embolism-symptoms\"><span style=\"font-weight: 400;\">pulmonary embolism<\/span><\/a><span style=\"font-weight: 400;\"> (PE). It\u2019s also used to prevent blood clots and stroke in people with atrial fibrillation and people recovering from certain types of surgery.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Even though Eliquis isn\u2019t a psychiatric medication or used to treat conditions related to mental health, some people report mood changes while taking Eliquis\u2014particularly, an increase in anxiety and depression symptoms. Even if they\u2019re not direct side effects, it\u2019s worth understanding why you might notice mental health changes when using Eliquis.\u00a0\u00a0<\/span><\/p>\n<h2 id=\"can-eliquis-cause-depression-or-anxiety-what-evidence-says\"><span style=\"font-weight: 400;\">Can Eliquis cause depression or anxiety? What evidence says<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Anxiety and depression are not considered common side effects of Eliquis. In fact, they aren\u2019t included in any of the drug\u2019s <\/span><a href=\"https:\/\/packageinserts.bms.com\/pi\/pi_eliquis.pdf\"><span style=\"font-weight: 400;\">prescribing information<\/span><\/a><span style=\"font-weight: 400;\"> or noted in relevant clinical trials or research studies. This means those symptoms occur or are reported so infrequently that they can\u2019t be measured.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Although these symptoms aren\u2019t listed as official side effects, some people do notice mood changes after <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/eliquis-starter-pack-directions\/\"><span style=\"font-weight: 400;\">starting the medication<\/span><\/a><span style=\"font-weight: 400;\">, according to <\/span><a href=\"https:\/\/www.medstarhealth.org\/doctors\/gurpreet-kaur-saini-md\"><span style=\"font-weight: 400;\">Gurpreet Saini<\/span><\/a><span style=\"font-weight: 400;\">, MD, an internal medicine physician at MedStar Health in Maryland. There are some reasons why people taking Eliquis might experience <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/symptoms-of-depression-and-anxiety\/\"><span style=\"font-weight: 400;\">new or worsening anxiety or depression<\/span><\/a><span style=\"font-weight: 400;\"> (more on that below), but the evidence we have doesn\u2019t really suggest that the medication is the cause.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Eliquis with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tEliquis 5 mg (28 Tablets)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$331.83<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"#\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"#\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-harristeeter.svg\" alt=\"Harris Teeter Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$331.83<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"#\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"#\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"#\" class=\"coupon-see-all-btn\">See Eliquis prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t<\/span><\/p>\n<h2 id=\"indirect-links-between-eliquis-and-anxiety-or-depression\"><span style=\"font-weight: 400;\">Indirect links between Eliquis and anxiety or depression<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If some people taking Eliquis develop symptoms of anxiety or depression, but the drug itself doesn\u2019t cause those symptoms, then what <\/span><i><span style=\"font-weight: 400;\">is <\/span><\/i><span style=\"font-weight: 400;\">the connection?\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Per <\/span><a href=\"https:\/\/kambilihealth.com\/about\/\"><span style=\"font-weight: 400;\">Cynthia Odogwu<\/span><\/a><span style=\"font-weight: 400;\">, MD, family and lifestyle medicine physician and founder of Kambili Health, mental health changes on Eliquis are more likely related to whatever health condition you have that\u2019s requiring you to take this medication in the first place. They could also be secondary to some of the other more common side effects of Eliquis.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some indirect causes of depression or anxiety on Eliquis include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Related health conditions:<\/b><span style=\"font-weight: 400;\"> Having had a recent PE or DVT can be stressful and scary, and may make you more prone to anxiety about your health and future. It can also be challenging to live with chronic conditions like atrial fibrillation or a blood-clotting disorder, or to know that you now have a higher risk for a blood clot or stroke than you did previously. <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7384626\/\"><span style=\"font-weight: 400;\">Health anxiety is a real mental health condition<\/span><\/a><span style=\"font-weight: 400;\">, sometimes fueled by serious illnesses you\u2019ve experienced. It makes sense that major health complications, like a life-threatening blood clot or stroke, might trigger feelings of anxiety and depression.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Medication concerns:<\/b> <a href=\"https:\/\/www.singlecare.com\/drug-classes\/anticoagulants\"><span style=\"font-weight: 400;\">Blood thinners<\/span><\/a><span style=\"font-weight: 400;\"> increase your risk of excessive bleeding because they prevent your blood from forming clots when you\u2019re injured. People taking Eliquis are often warned to avoid alcohol, certain medications, supplements, foods, and risky activities like contact sports. These warnings can create a fear of excessive bleeding, per Dr. Odogwu, which can raise your overall level of anxiety or increase feelings of depression, especially if you have to change your lifestyle to accommodate your medication.\u00a0\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Other side effects:<\/b><span style=\"font-weight: 400;\"> In addition to excess bleeding, another common side effect of Eliquis is <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/can-stress-cause-anemia\/\"><span style=\"font-weight: 400;\">anemia<\/span><\/a><span style=\"font-weight: 400;\">. \u201cAnemia can lead to dizziness and fatigue,\u201d says Dr. Odogwu, \u201c[which] can indirectly make you feel depressed or anxious.\u201d For example, feeling dizzy might trigger ongoing worries about fainting, especially in public places. Daily fatigue can cause you to miss out on social activities or hobbies, which could develop into feelings of depression over time.<\/span><\/li>\n<\/ul>\n<h2 id=\"known-side-effects-of-eliquis\"><span style=\"font-weight: 400;\">Known side effects of Eliquis<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Like all medications, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/eliquis-side-effects\/\"><span style=\"font-weight: 400;\">Eliquis can cause side effects<\/span><\/a><span style=\"font-weight: 400;\">. The most common include an increased risk of excessive bruising or bleeding, anemia, nausea, dizziness, fatigue, weakness, and headaches.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you\u2019re taking Eliquis and experience bleeding that doesn\u2019t stop, persistent nosebleeds, signs of blood in your urine, stool, or vomit, fainting, or shortness of breath, contact your healthcare provider or seek emergency medical care right away.<\/span><\/p>\n<h2 id=\"what-to-do-about-anxiety-or-depression-on-eliquis\"><span style=\"font-weight: 400;\">What to do about anxiety or depression on Eliquis<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If you\u2019ve been put on Eliquis, it\u2019s because you have a high risk of a blood clot or stroke\u2014both potentially life-threatening conditions. You should never stop taking Eliquis without talking to your healthcare provider first.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cRemember, there is a reason to start [taking a] blood thinner, and you can\u2019t risk having another blood clot,\u201d Dr. Saini says. She adds that she wouldn\u2019t typically adjust an Eliquis dose for mood symptoms alone\u2014only if there were signs of other side effects, or if it became clear that the medication was playing a more direct role in mental health changes.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, Dr. Saini adds that you shouldn\u2019t ignore new or worsening feelings of anxiety or depression, especially if they\u2019re affecting your daily life. Instead, reach out to your healthcare provider to talk about what you\u2019re experiencing. They can help you take a \u201cbig picture\u201d look at your day-to-day life to see if other factors could be causing your symptoms. Per Dr. Saini, this could include major changes or stressors in your life, your mental health history, sleep habits, appetite, energy level, and other medications (some drugs, like <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/dopamine-agonists\"><span style=\"font-weight: 400;\">dopamine agonists<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/corticosteroids\"><span style=\"font-weight: 400;\">steroids<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3181628\/\"><span style=\"font-weight: 400;\">are known to contribute to feelings of anxiety and depression<\/span><\/a><span style=\"font-weight: 400;\">).\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It can also be helpful to take a proactive role in managing your health. Dr. Saini says, \u201cUnderstanding the \u2018why\u2019 behind your medication can reduce fear, [and asking] about practical safety tips for bleeding prevention can help you feel more in control.\u201d<\/span><\/p>\n<p><a href=\"https:\/\/www.wilkes.edu\/campus-directory\/dana.manning.aspx\"><span style=\"font-weight: 400;\">Dana Manning<\/span><\/a><span style=\"font-weight: 400;\">, Pharm.D., RD, LDN, associate professor of pharmacy practice at Wilkes University in Pennsylvania, agrees that patient empowerment plays a huge part in reducing feelings of anxiety and depression related to medical treatment. She adds that talking with your healthcare provider or pharmacist so you\u2019re educated about how your medication benefits you\u2014and the potential risks of going without it\u2014can make it easier to work through some of the side effects it causes.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ultimately, if you are struggling with feelings of anxiety and depression, make an appointment with a mental health provider. They can provide ongoing counseling, recommend local or online support groups, or prescribe medications to treat your anxiety or depression, if needed. Just make sure your mental health provider knows you are taking Eliquis. According to Dr. Manning, <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8566746\/\"><span style=\"font-weight: 400;\">some antidepressants further increase the risk for bleeding<\/span><\/a><span style=\"font-weight: 400;\">, so that\u2019s something your provider would need to consider carefully before prescribing anything new.<\/span><\/p>\n<h2 id=\"bottom-line\"><span style=\"font-weight: 400;\">Bottom line<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Eliquis is not known to directly cause symptoms of <\/span><a href=\"https:\/\/www.singlecare.com\/resources\/anxiety\"><span style=\"font-weight: 400;\">anxiety<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/resources\/antidepressants\"><span style=\"font-weight: 400;\">depression<\/span><\/a><span style=\"font-weight: 400;\">, but some people taking this medication report changes to their mood or mental health. This is most likely because the reasons for taking Eliquis\u2014such as a recent surgery, blood clot, or stroke, or major changes to their overall health\u2014are stressful and scary, and can trigger anxiety and depression as you try to navigate your new reality. Sometimes, other symptoms of Eliquis, like excessive bleeding and anemia, can lead to fear, worry, or depression over restrictions on someone\u2019s lifestyle or usual activities.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Whatever the reason, you should never stop Eliquis <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/stopping-eliquis-side-effects\/\"><span style=\"font-weight: 400;\">without talking to your healthcare provider<\/span><\/a><span style=\"font-weight: 400;\"> or ignore new or worsening symptoms of anxiety or depression. If your provider thinks Eliquis is causing your symptoms, they will work with you to find another medication, but most often, treating your anxiety symptoms with minor lifestyle changes, counseling, or mental health medications is the better approach.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Eliquis (apixaban) is a prescription blood thinner, or anticoagulant, approved by the Food and Drug Administration for the treatment of two of the most serious types of blood clots: deep vein thrombosis (DVT) and pulmonary embolism (PE). It\u2019s also used to prevent blood clots and stroke in people with atrial fibrillation and people recovering from [&hellip;]<\/p>\n","protected":false},"author":149,"featured_media":634250,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[9777,451,12752],"coauthors":[8860],"class_list":["post-634249","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-anxiety","tag-depression","tag-medication-side-effects","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Does Eliquis cause depression or anxiety?<\/title>\n<meta name=\"description\" content=\"Eliquis doesn\u2019t directly cause depression and anxiety, but you shouldn\u2019t ignore symptoms if they occur. 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