{"id":634480,"date":"2025-12-15T09:30:11","date_gmt":"2025-12-15T14:30:11","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=634480"},"modified":"2025-12-09T16:37:10","modified_gmt":"2025-12-09T21:37:10","slug":"medications-that-cause-cold-intolerance","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/medications-that-cause-cold-intolerance\/","title":{"rendered":"5 medications that cause cold intolerance"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">If you\u2019re one of those people who \u201cruns cold,\u201d always layering on sweaters, bundling under blankets, or cranking up the thermostat, there could be a good reason: You might be taking a medication that makes you more intolerant to the cold. These medications\u2014which include common drugs like beta blockers, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/ssris-vs-snris\/\"><span style=\"font-weight: 400;\">antidepressants<\/span><\/a><span style=\"font-weight: 400;\">, and diuretics\u2014change the way your body regulates heat, leaving you susceptible to feeling chilly even when everyone else around you is comfortable. Here are the six most common types of medications that cause cold intolerance, along with tips on how to manage this side effect.<\/span><\/p>\n<h2 id=\"what-is-cold-intolerance\"><span style=\"font-weight: 400;\">What is cold intolerance?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Cold intolerance is a hypersensitivity to cold temperatures that affects your day-to-day life. Obviously, some environments are genuinely cold, and it\u2019s normal for your body to respond by trying to get warm, but if you\u2019re regularly the only person who feels cold when others around you don\u2019t, you may be unusually sensitive or intolerant to cold.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Sometimes cold intolerance makes it difficult for you to warm up after becoming cold, for example, or leaves you shivering even when the temperature is mild. Other common symptoms of cold intolerance target your extremities, causing <\/span><a href=\"https:\/\/www.rheumres.org\/article_199463_c8d102c736e8515bbebcfe708dedff39.pdf\"><span style=\"font-weight: 400;\">numbness, pain, tingling, stiffness, and skin changes like discoloration or swelling<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Cold intolerance is fairly common, potentially <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9613912\/#:~:text=Introduction,and%20non%2Dtraumatic%20pathologies6.\"><span style=\"font-weight: 400;\">affecting more than 40% of the population<\/span><\/a><span style=\"font-weight: 400;\">, with some people more likely than others to experience it. This includes women, people with certain health conditions, and people with a history of hand injury or corrective surgery.\u00a0\u00a0<\/span><\/p>\n<h2 id=\"the-surprising-link-between-your-meds-and-feeling-chilly\"><span style=\"font-weight: 400;\">The surprising link between your meds and feeling chilly<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If you\u2019re constantly cold and wondering why, it might never have crossed your mind to consider your medications, but they can have an impact on your body temperature.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cSome medications can affect the systems that regulate your internal heat,\u201d says <\/span><a href=\"https:\/\/richamittalmd.com\/about\"><span style=\"font-weight: 400;\">Richa Mittal<\/span><\/a><span style=\"font-weight: 400;\">, MD, internist, obesity and lifestyle medicine expert, and founder of Radiant Health Dallas in Texas. \u201cThe body works like a thermostat, and some meds can nudge the thermostat up or down.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">How exactly do these medications alter your body\u2019s thermostat? Per Dr. Mittal, they can:<\/span><b><\/b><\/p>\n<ul>\n<li aria-level=\"1\"><b>Slow down metabolism:<\/b><span style=\"font-weight: 400;\"> Drugs that decrease your metabolic rate can cause your body to generate less heat overall.<\/span><\/li>\n<li aria-level=\"1\"><b>Restrict blood flow:<\/b><span style=\"font-weight: 400;\"> By narrowing blood vessels and restricting blood flow, some medications can reduce the amount of warmth that reaches your skin, hands, and feet.\u00a0<\/span><\/li>\n<li aria-level=\"1\"><b>Cause loss of appetite:<\/b><span style=\"font-weight: 400;\"> A lower caloric intake due to side effects like nausea or loss of appetite can cause a medication to make you feel cold, since your body needs the right amount of calories from food to stay warm.\u00a0\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Finally, <\/span><a href=\"https:\/\/psychiatryconnection.com\/about\/#sid\"><span style=\"font-weight: 400;\">Sid Khurana<\/span><\/a><span style=\"font-weight: 400;\">, MD, a psychiatrist and co-founder of Psychiatry Connection, notes that medications can also alter your heart rate, body\u2019s fight-or-flight response, or sweating, all of which can impact how your body regulates temperature.<\/span><\/p>\n<h2 id=\"5-classes-of-medications-that-can-cause-cold-intolerance\"><span style=\"font-weight: 400;\">5 classes of medications that can cause cold intolerance<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">These types of prescriptions are most likely to alter your reaction to cold temperatures.<\/span><\/p>\n<h3 id=\"1-beta-blockers\"><span style=\"font-weight: 400;\">1. Beta blockers<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Blood pressure medications, such as beta blockers, have a reputation for causing sensitivity to cold. <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/beta-blockers\"><span style=\"font-weight: 400;\">Beta blockers<\/span><\/a><span style=\"font-weight: 400;\"> lower your heart rate and allow the heart to work less hard to pump blood; common beta blockers include <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/coreg#coupons\"><span style=\"font-weight: 400;\">Coreg<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/propranolol-hcl\"><span style=\"font-weight: 400;\">propranolol<\/span><\/a><span style=\"font-weight: 400;\">, and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/toprol-xl#coupons\"><span style=\"font-weight: 400;\">Toprol XL<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, <\/span><a href=\"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.12980\"><span style=\"font-weight: 400;\">beta blockers also cause peripheral vasoconstriction<\/span><\/a><span style=\"font-weight: 400;\">, which is the narrowing of smaller blood vessels. This can reduce blood flow, especially to your extremities, causing cold hands and feet.<\/span><\/p>\n<h3 id=\"2-antidepressants\"><span style=\"font-weight: 400;\">2. Antidepressants<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">According to Dr. Khurana, most antidepressants raise the levels of serotonin and norepinephrine in your brain, which can indirectly affect your hypothalamus. Selective serotonin reuptake inhibitors (SSRIs), such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/zoloft\"><span style=\"font-weight: 400;\">Zoloft<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/paxil\"><span style=\"font-weight: 400;\">Paxil<\/span><\/a><span style=\"font-weight: 400;\">, work on serotonin levels, while selective serotonin and norepinephrine reuptake inhibitors (SNRIs), like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/effexor-xr?q=Effexor%20Xr%20(Venlafaxine%20HCl%20ER)&amp;isHomeSearch=false\"><span style=\"font-weight: 400;\">Effexor<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/duloxetine-hcl#coupons\"><span style=\"font-weight: 400;\">Cymbalta<\/span><\/a><span style=\"font-weight: 400;\">, work on both.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Why does this matter? Because the hypothalamus regulates your body temperature. Taking antidepressants can mess with the previously established settings of your body\u2019s internal thermostat, Dr. Khurana says, triggering changes in sweating, heart rate, and metabolic rate.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our wellness newsletter<\/span>\n\t\t\t<form class=\"form-wrapper\" data-newsletter-form=\"1\" data-subsource=\"Wellness Newsletter\">\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<label for=\"dynamic-email\">Email<\/label>\n\t\t\t\t\t<input type=\"email\" id=\"dynamic-email\" class=\"email\" required>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<input class=\"submit-form-btn\" type=\"submit\" value=\"Click to sign up\">\n\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t\t<p class=\"success-message\" aria-live=\"polite\"><\/p>\n\t\t<\/div>\n\t<\/span><\/p>\n<h3 id=\"3-diuretics\"><span style=\"font-weight: 400;\">3. Diuretics<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Diuretics <\/span><a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/high-blood-pressure\/in-depth\/diuretics\/art-20048129#:~:text=Diuretics%20are%20medicines%20that%20help,through%20the%20veins%20and%20arteries.\"><span style=\"font-weight: 400;\">increase urination by helping your kidneys flush out extra sodium and water<\/span><\/a><span style=\"font-weight: 400;\">, but this can lead to dehydration if you\u2019re not replenishing your fluids. When you\u2019re dehydrated, you have lower blood volume, which can reduce circulation and make you feel cold, says Dr. Mittal. Common diuretic medications include <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/chlorthalidone\"><span style=\"font-weight: 400;\">chlorthalidone<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/furosemide?q=Furosemide%20(Lasix)&amp;isHomeSearch=false\"><span style=\"font-weight: 400;\">furosemide<\/span><\/a><span style=\"font-weight: 400;\">, and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/amiloride-hcl?q=Amiloride%20Hcl&amp;isHomeSearch=false\"><span style=\"font-weight: 400;\">amiloride<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3 id=\"4-adhd-medications\"><span style=\"font-weight: 400;\">4. ADHD medications<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Stimulant medications, which are often used to treat attention-deficit hyperactivity disorder (ADHD), can constrict blood vessels or reduce circulation, particularly to the extremities. Not only can this make you feel cold, but it could potentially <\/span><a href=\"https:\/\/www.mayoclinic.org\/drugs-supplements\/dexmethylphenidate-oral-route\/description\/drg-20067099\"><span style=\"font-weight: 400;\">trigger a condition called Raynaud&#8217;s phenomenon<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">People with Raynaud&#8217;s phenomenon experience coldness, numbness, and discoloration in their fingers and toes. Medications like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ritalin?q=Ritalin%20(Methylphenidate%20HCl)&amp;isHomeSearch=false\"><span style=\"font-weight: 400;\">Ritalin<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ritalin?q=Ritalin%20(Methylphenidate%20HCl)&amp;isHomeSearch=false\"><span style=\"font-weight: 400;\">Adderall<\/span><\/a><span style=\"font-weight: 400;\"> are commonly associated with Raynaud\u2019s phenomenon, though <\/span><a href=\"https:\/\/www.mayoclinic.org\/drugs-supplements\/lisdexamfetamine-dimesylate-oral-route\/description\/drg-20070888\"><span style=\"font-weight: 400;\">Vyvanse can also cause it<\/span><\/a><span style=\"font-weight: 400;\">. In these cases, Raynaud\u2019s phenomenon <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39875750\/#:~:text=Implicated%20medications%20included%20methylphenidate%2C%20(dex,RS%2C%20controlling%20for%20confounding%20factors.\"><span style=\"font-weight: 400;\">tends to be temporary, resolving after the medication is discontinued<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3 id=\"5-chemotherapy-treatments\"><span style=\"font-weight: 400;\">5. Chemotherapy treatments<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Cold intolerance or sensitivity is a <\/span><a href=\"https:\/\/www.mdanderson.org\/cancerwise\/how-to-cope-with-cold-sensitivity-during-chemotherapy-oxaliplatin-drug.h00-159460056.html#:~:text=BY%20Molly%20Adams,this%20sensation%20can%20be%20painful.\"><span style=\"font-weight: 400;\">common side effect of chemotherapy medications<\/span><\/a><span style=\"font-weight: 400;\"> used to treat cancer, like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/oxaliplatin?q=Oxaliplatin&amp;isHomeSearch=false\"><span style=\"font-weight: 400;\">oxaliplatin<\/span><\/a><span style=\"font-weight: 400;\">. Oxaliplatin can <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3377073\/#:~:text=Abstract,treatment%20for%20oxaliplatin%2Dinduced%20neuropathy.\"><span style=\"font-weight: 400;\">overexcite your nerves or even cause neuropathy<\/span><\/a><span style=\"font-weight: 400;\">, making coming into contact with cold environments or objects painful. Some cancer treatments can also cause <\/span><a href=\"https:\/\/www.cityofhope.org\/locations\/chicago\/midwest-winter-and-cancer\"><span style=\"font-weight: 400;\">side effects like anemia and dehydration<\/span><\/a><span style=\"font-weight: 400;\"> (due to vomiting or loss of appetite), both of which can leave people feeling cold. Finally, some chemotherapy treatments cause <\/span><a href=\"https:\/\/www.ons.org\/publications-research\/cjon\/11\/1\/supplement-february-2007-b-cell-disorders\/cytokine-release-syndrome#:~:text=Cytokine%2Drelease%20syndrome%20is%20a,safely%20care%20for%20such%20patients.\"><span style=\"font-weight: 400;\">cytokine-release syndrome<\/span><\/a><span style=\"font-weight: 400;\">, or a reaction to the infusion of drugs; this can lead to flu-like symptoms, including chills or feeling cold.<\/span><\/p>\n<h2 id=\"other-factors-influencing-cold-sensitivity\"><span style=\"font-weight: 400;\">Other factors influencing cold sensitivity<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">While medications are a common cause of cold intolerance, an underlying health condition or even an individual characteristic, such as low body weight, may be to blame. Here are some other factors that can increase your sensitivity to cold.\u00a0<\/span><\/p>\n<h3 id=\"health-conditions\"><span style=\"font-weight: 400;\">Health conditions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">There are many <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9613912\/\"><span style=\"font-weight: 400;\">health conditions that can trigger cold sensitivity<\/span><\/a><span style=\"font-weight: 400;\">, including fibromyalgia, anemia, atherosclerosis, and Raynaud\u2019s disease. According to Dr. Mittal, low thyroid function and low estrogen (which is common in perimenopause and menopause) can affect temperature stability, as well as poor circulation, chronic inflammation, and autoimmune diseases.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Another possible cause? Low muscle mass. Dr. Khurana says the less muscle you have, the less heat you\u2019ll produce, and the colder you get.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cWhen someone has low muscle mass, they get cold easily [because] muscle tissue is one of the main powerhouses of heat production,\u201d he explains. Being inactive can cause low muscle mass, but some <\/span><a href=\"https:\/\/my.clevelandclinic.org\/health\/diseases\/23167-sarcopenia\"><span style=\"font-weight: 400;\">chronic medical conditions<\/span><\/a><span style=\"font-weight: 400;\"> can cause it, too, like obesity, diabetes, cancer, and rheumatoid arthritis.<\/span><\/p>\n<h3 id=\"nutrient-deficiencies\"><span style=\"font-weight: 400;\">Nutrient deficiencies<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Per Dr. Mittal, two nutrient deficiencies can contribute toward cold intolerance by causing anemia: iron and B12. Both nutrients support blood health, with <\/span><a href=\"https:\/\/www.nhlbi.nih.gov\/health\/anemia\/vitamin-b12-deficiency-anemia\"><span style=\"font-weight: 400;\">B12 helping to make red blood cells<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/medlineplus.gov\/iron.html#:~:text=What%20is%20iron?,iron%20to%20make%20some%20hormones.\"><span style=\"font-weight: 400;\">iron producing a protein called hemoglobin that red blood cells need in order to carry oxygen<\/span><\/a><span style=\"font-weight: 400;\"> to other parts of your body. People with anemia often experience poor circulation, particularly in their extremities, which can lead to cold hands and feet.<\/span><\/p>\n<h3 id=\"lifestyle-reasons\"><span style=\"font-weight: 400;\">Lifestyle reasons\u00a0\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Your cold intolerance may not be caused by any medication, health condition, or deficiency. It could simply be a symptom of a temporary issue or a normal part of your body composition.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Lack of sleep:<\/b><span style=\"font-weight: 400;\"> Losing sleep can interfere with your body\u2019s internal thermostat, says Dr. Khurana. It can make your body <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3490360\/\"><span style=\"font-weight: 400;\">lose more heat<\/span><\/a><span style=\"font-weight: 400;\"> than if you got a good night\u2019s sleep.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Low body fat:<\/b><span style=\"font-weight: 400;\"> Body fat is insulating, says Dr. Khurana, so you may feel cold often if you have a low percentage of body fat. Recent weight loss applies here, too. Dr. Mittal says this not only reduces your fat-insulating reserves but also your resting metabolic rate.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Hunger or loss of appetite:<\/b><span style=\"font-weight: 400;\"> When you\u2019re hungry or have a low appetite, says Dr. Khurana, your body shifts into energy conservation mode, which can make you feel chilly.<\/span><\/li>\n<\/ul>\n<h2 id=\"managing-medication-induced-cold-intolerance\"><span style=\"font-weight: 400;\">Managing medication-induced cold intolerance<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If your health provider has prescribed one of these medications to you, there\u2019s a good reason. We don\u2019t recommend stopping any medication without consulting your provider first, even if it\u2019s causing an uncomfortable side effect, such as feeling cold.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, there are some lifestyle changes you can make to manage medication-induced cold intolerance:<\/span><b><\/b><\/p>\n<ul>\n<li aria-level=\"1\"><b>Stay hydrated<\/b><span style=\"font-weight: 400;\"> to maintain a healthy blood volume, including sipping on warm beverages like tea if it helps, says Dr. Mittal.<\/span><\/li>\n<li aria-level=\"1\"><b>Get enough sleep<\/b><span style=\"font-weight: 400;\"> so your body can retain heat.<\/span><\/li>\n<li aria-level=\"1\"><b>Dress in warm layers<\/b><span style=\"font-weight: 400;\"> during the day and at night so you\u2019re prepared in case your medication makes you cold or hot, suggests Dr. Khurana.<\/span><\/li>\n<li aria-level=\"1\"><b>Eat a healthy diet,<\/b><span style=\"font-weight: 400;\"> prioritizing nutrient-dense foods; per Dr. Mittal, it\u2019s important to get enough calories, vitamins, and minerals if you\u2019re on a medication that suppresses appetite.<\/span><\/li>\n<li aria-level=\"1\"><b>Practice strength and resistance training<\/b><span style=\"font-weight: 400;\"> if you\u2019re in danger of losing muscle mass, says Dr. Mittal.\u00a0\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If medication-induced cold intolerance is making it hard for you to take part in your normal activities, talk to your healthcare provider. They may be able to switch you to a different drug within the same class that is less likely to trigger sensitivity. If not, they can work with you to manage your symptoms.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>If you\u2019re one of those people who \u201cruns cold,\u201d always layering on sweaters, bundling under blankets, or cranking up the thermostat, there could be a good reason: You might be taking a medication that makes you more intolerant to the cold. These medications\u2014which include common drugs like beta blockers, antidepressants, and diuretics\u2014change the way your [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":634553,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[12752],"coauthors":[8860],"class_list":["post-634480","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-medication-side-effects","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Which medications make you more sensitive to cold?<\/title>\n<meta name=\"description\" content=\"Medications that cause cold intolerance may include beta blockers, diuretics, and antidepressants, but there are ways to treat medication-induced 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