{"id":634958,"date":"2026-01-15T09:30:41","date_gmt":"2026-01-15T14:30:41","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=634958"},"modified":"2026-01-07T16:10:46","modified_gmt":"2026-01-07T21:10:46","slug":"can-entresto-be-cut-in-half","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/can-entresto-be-cut-in-half\/","title":{"rendered":"Can Entresto be cut in half?"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/entresto\"><span style=\"font-weight: 400;\">Entresto<\/span><\/a><span style=\"font-weight: 400;\"> is a prescription medication used to treat chronic heart failure in adults\u2014a condition in which the heart can\u2019t pump blood as efficiently as it should. Because it plays a key role in managing symptoms and reducing the risk of hospitalization, taking it correctly is essential.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Entresto comes as a film-coated oral tablet and as a capsule containing oral pellets known as Entresto Sprinkle. Unlike some medications, Entresto tablets are not designed to be split, crushed, or chewed. In fact, the manufacturer (Novartis Pharmaceuticals Corporation) and the Food and Drug Administration (FDA) recommend taking the tablet whole.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For people who are good candidates, healthcare providers may prescribe Entresto alongside other standard heart-failure treatments, such as <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/beta-blockers\"><span style=\"font-weight: 400;\">beta blockers<\/span><\/a><span style=\"font-weight: 400;\"> like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/carvedilol\"><span style=\"font-weight: 400;\">carvedilol<\/span><\/a><span style=\"font-weight: 400;\">. If you have questions about dosing, side effects, cost, or whether your medication can be altered, it\u2019s important to talk with your healthcare provider before making any changes.<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Entresto with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tEntresto 24-26 mg (60 Tablets)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-cvs.svg\" alt=\"CVS Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$34.83<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/entresto#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/entresto#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-publix.svg\" alt=\"Publix\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$55.55<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/entresto#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/entresto#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/entresto#blog-cta\" class=\"coupon-see-all-btn\">See Entresto prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"can-you-split-entresto-tablets\"><span style=\"font-weight: 400;\">Can you split Entresto tablets?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u201cEntresto tablets are not designed to be split, and doing so is generally not recommended unless specifically instructed by a provider or pharmacist,\u201d says <\/span><a href=\"https:\/\/dreugenelipov.com\/about\/\"><span style=\"font-weight: 400;\">Eugene Lipov<\/span><\/a><span style=\"font-weight: 400;\">, MD, chief medical officer at <\/span><a href=\"https:\/\/stellamentalhealth.com\/\"><span style=\"font-weight: 400;\">Stella<\/span><\/a><span style=\"font-weight: 400;\">, a mental healthcare institute.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dr. Lipov explains that splitting Entresto may not be ideal in many cases because:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The tablet does not have a score line to ensure accurate dosing.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Splitting may lead to an uneven distribution of the two active ingredients.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Inconsistent dosing can reduce effectiveness or increase side effects.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u201cWith heart failure medications, dose accuracy matters. Even small variations can affect blood pressure, kidney function, and potassium levels,\u201d he says.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Common side effects of Entresto include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hypotension (low blood pressure)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hyperkalemia (high potassium levels)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cough<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Changes in kidney function<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Serious side effects include:<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Angioedema (severe allergic reaction)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Worsening kidney problems or kidney failure<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Entresto also has a boxed warning for the potential to cause fetal harm and should be avoided by pregnant and breastfeeding individuals.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Entresto should be avoided by individuals taking the following medications due to potential drug interactions:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aliskiren<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Other ACE Inhibitors, such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/lisinopril\"><span style=\"font-weight: 400;\">lisinopril<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/enalapril-maleate\"><span style=\"font-weight: 400;\">enalapril<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Potassium-sparing diuretics, such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/spironolactone\"><span style=\"font-weight: 400;\">spironolactone<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDs)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/lithium\"><span style=\"font-weight: 400;\">Lithium<\/span><\/a><\/li>\n<\/ul>\n<h2 id=\"understanding-entresto\"><span style=\"font-weight: 400;\">Understanding Entresto<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Entresto belongs to a class of medications known as <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/angiotensin-receptor-neprilysin-inhibitors\"><span style=\"font-weight: 400;\">angiotensin receptor neprilysin inhibitors (ARNIs)<\/span><\/a><span style=\"font-weight: 400;\">, which are designed to help the heart work more efficiently while reducing strain on the cardiovascular system.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The drug was initially approved to treat heart failure with reduced ejection fraction (HFrEF), sometimes called systolic heart failure, a condition in which the heart\u2019s left ventricle becomes enlarged and can\u2019t pump blood effectively. In <\/span><a href=\"https:\/\/www.ajmc.com\/view\/entresto-wins-first-fda-nod-in-hard-to-treat-type-of-heart-failure\"><span style=\"font-weight: 400;\">2021<\/span><\/a><span style=\"font-weight: 400;\">, the Food and Drug Administration (FDA) expanded Entresto\u2019s approval to include cardiology patients with heart failure with preserved ejection fraction (HFpEF), a form of heart failure in which the left ventricle is stiff and unable to relax enough to fill properly, despite having normal pumping strength.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Entresto contains two active ingredients that work together:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Sacubitril<\/b><span style=\"font-weight: 400;\">, which helps relax blood vessels and reduce fluid buildup<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Valsartan<\/b><span style=\"font-weight: 400;\">, an angiotensin II receptor blocker (ARB) that lowers blood pressure and decreases stress on the heart<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u201cTogether, these medications improve blood flow and reduce the workload on the heart,\u201d says Dr. Lipov. Entresto is typically prescribed <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK507904\/\"><span style=\"font-weight: 400;\">in place<\/span><\/a><span style=\"font-weight: 400;\"> of an ARB or an <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/ace-inhibitors\"><span style=\"font-weight: 400;\">angiotensin-converting enzyme inhibitor (ACE inhibitor)<\/span><\/a><span style=\"font-weight: 400;\"> for high blood pressure, not alongside them.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our heart health newsletter<\/span>\n\t\t\t<form class=\"form-wrapper\" data-newsletter-form=\"1\" data-subsource=\"Heart Health Newsletter\">\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<label for=\"dynamic-email\">Email<\/label>\n\t\t\t\t\t<input type=\"email\" id=\"dynamic-email\" class=\"email\" required>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<input class=\"submit-form-btn\" type=\"submit\" value=\"Click to sign up\">\n\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t\t<p class=\"success-message\" aria-live=\"polite\"><\/p>\n\t\t<\/div>\n\t<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Entresto tablets are available in three fixed-dose combinations:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>24\/26 mg<\/b><span style=\"font-weight: 400;\"> tablets (24 mg sacubitril + 26 mg valsartan), also referred to as the 50 mg dose<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>49\/51 mg<\/b><span style=\"font-weight: 400;\"> tablets (49 mg sacubitril + 51 mg valsartan), also called the 100 mg dose<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>97\/103 mg<\/b><span style=\"font-weight: 400;\"> tablets (97 mg sacubitril + 103 mg valsartan), also known as the 200 mg dose<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Your healthcare provider selects the recommended dose based on your condition, prior treatment, and how well you tolerate the medication. In case of a missed dose, take Entresto as soon as you remember, unless it\u2019s closer to the time for your next dose.<\/span><\/p>\n<h2 id=\"why-pill-splitting-can-be-risky-and-what-to-do-instead\"><span style=\"font-weight: 400;\">Why pill splitting can be risky, and what to do instead<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">While some medications are designed to be split (often indicated by a <\/span><a href=\"https:\/\/www.mdpi.com\/2076-3417\/9\/15\/3066\"><span style=\"font-weight: 400;\">score line<\/span><\/a><span style=\"font-weight: 400;\">), others, like Entresto, are not. Splitting tablets that aren\u2019t intended to be cut can lead to several potential problems that affect <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9680753\/\"><span style=\"font-weight: 400;\">safety and effectiveness<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<ul>\n<li aria-level=\"1\"><b>Uneven dosing: <\/b><span style=\"font-weight: 400;\">When a tablet isn\u2019t scored, it\u2019s difficult to divide it into equal halves. This can result in taking too much or too little medication, which may increase the risk of side effects such as low blood pressure, kidney problems, or reduced treatment effectiveness.<\/span><\/li>\n<li aria-level=\"1\"><b>Compromised stability and absorption: <\/b><span style=\"font-weight: 400;\">Cutting a tablet exposes its interior to air and moisture, which may cause the drug to degrade more quickly or absorb differently in the body. For tablets with special coatings, such as enteric coatings designed to protect the stomach or control where the drug dissolves, splitting can cause the medication to break down too early, altering how and when it works.<\/span><\/li>\n<li aria-level=\"1\"><b>Physical damage and waste: <\/b><span style=\"font-weight: 400;\">Tablets can crumble or shatter when split by hand, leading to lost medication and inconsistent dosing, especially without a proper pill splitter.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">These risks stem from how tablets are designed and manufactured. During <\/span><a href=\"https:\/\/www.researchgate.net\/publication\/387659191_Formulation_Of_The_Tablets\"><span style=\"font-weight: 400;\">formulation<\/span><\/a><span style=\"font-weight: 400;\">, drug makers carefully combine active ingredients with inactive ones to ensure the medication remains stable, is absorbed properly, and delivers the intended dose. Some tablets are engineered to release medication slowly over time or dissolve only after reaching a specific part of the digestive tract. Altering the tablet by splitting it can disrupt these mechanisms, leading to unintended effects.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For these reasons, even tablets that appear suitable for splitting may not be safe to cut unless a healthcare provider or pharmacist confirms it\u2019s appropriate.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you\u2019re taking a medication like Entresto, there are several reasons you might consider splitting a pill, such as:<\/span><\/p>\n<h3 id=\"ease-of-swallowing\"><span style=\"font-weight: 400;\">Ease of swallowing<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Difficulty swallowing pills is common, especially among older adults and people with certain medical conditions such as dysphagia. If swallowing tablets is challenging for you, you\u2019re not alone, and you don\u2019t need to split your medication to manage it.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For patients who can\u2019t swallow tablets, the manufacturer offers Entresto Sprinkle, an alternative form of the medication. Entresto Sprinkle contains oral pellets inside a capsule that can be opened and sprinkled onto 1 to 2 teaspoonfuls of soft food, such as applesauce, and taken immediately. Because the dosing differs from the tablet form, your healthcare provider will need to adjust the dose accordingly.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In some cases, a pharmacist may also be able to prepare Entresto as a liquid oral suspension, providing another option for those who have difficulty swallowing pills.<\/span><\/p>\n<h3 id=\"dosage-adjustment\"><span style=\"font-weight: 400;\">Dosage adjustment<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Some people consider splitting tablets to start on a lower dose or gradually increase their medication. However, dose titrations should never be made without seeking medical advice from a healthcare professional. Your provider can determine whether a different strength, formulation, or medication is more appropriate and ensure the dose is both safe and effective.<\/span><\/p>\n<h3 id=\"reduce-cost\"><span style=\"font-weight: 400;\">Reduce cost<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Cost is another common reason people consider splitting their medication. Because tablets of different strengths are often priced similarly, some people attempt to stretch a higher-dose tablet by cutting it in half.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If the cost of Entresto is a concern, safer alternatives are available. You may be able to lower your out-of-pocket costs by using prescription discount cards like SingleCare, exploring manufacturer copay programs, or switching to mail-order or bulk pharmacy refills. Your healthcare provider can also help you explore more affordable treatment options that still meet your medical needs.<\/span><\/p>\n<h2 id=\"alternatives-to-tablet-splitting\"><span style=\"font-weight: 400;\">Alternatives to tablet splitting\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If your prescribed dose of Entresto feels too strong or difficult to tolerate, the safest option is to discuss this with your healthcare provider, rather than splitting the tablet. Your provider may adjust your dose, switch you to a different formulation, recommend a pharmacy-compounded liquid, or evaluate other heart failure treatments if side effects are a concern.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Patients should never adjust heart failure medication on their own, says Dr. Lipov. Dose changes should always be supervised.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If cost is the main reason you\u2019re considering tablet splitting, there are other options to explore. Prescription discount programs, such as SingleCare, and manufacturer copay cards may significantly reduce monthly costs, sometimes to as little as $10 per month for eligible patients.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, these programs typically apply only to people with commercial insurance. \u201cPatients on Medicare are not eligible for manufacturer copay cards, and there is currently no patient assistance program for Entresto,\u201d explains <\/span><a href=\"https:\/\/www.linkedin.com\/in\/william-fryfogle-pharmd-bcps-bcacp-57a504223\/\"><span style=\"font-weight: 400;\">William Fryfogle<\/span><\/a><span style=\"font-weight: 400;\">, Pharm.D., a clinical pharmacy specialist at University Hospitals in Cleveland, Ohio.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For Medicare beneficiaries taking multiple high-cost medications, Dr. Fryfogle notes that enrolling in the Medicare prescription payment plan through a Part D plan may help spread out copays over the year. This option is most helpful for individuals who anticipate exceeding the annual out-of-pocket maximum, which is $2,100 in 2026.<\/span><\/p>\n<h2 id=\"the-bottom-line\"><span style=\"font-weight: 400;\">The bottom line<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Entresto is an <\/span><a href=\"https:\/\/www.novartis.com\/us-en\/sites\/novartis_us\/files\/entresto.pdf\"><span style=\"font-weight: 400;\">unscored film-coated tablet<\/span><\/a><span style=\"font-weight: 400;\"> that is not designed to be split. While it may be physically possible to cut the tablet, doing so can lead to dosing inaccuracies and potential safety concerns. If you\u2019re considering splitting Entresto because of side effects, swallowing difficulties, or cost, talk with your healthcare provider first. They can help identify safer and more effective alternatives, ensuring you receive the full benefit of your treatment.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Entresto is a prescription medication used to treat chronic heart failure in adults\u2014a condition in which the heart can\u2019t pump blood as efficiently as it should. Because it plays a key role in managing symptoms and reducing the risk of hospitalization, taking it correctly is essential. Entresto comes as a film-coated oral tablet and as [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":634961,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[788,737,8905],"coauthors":[20970],"class_list":["post-634958","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-drug-safety","tag-heart-health","tag-seasonal","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Can Entresto be cut in half? What patients need to know<\/title>\n<meta name=\"description\" content=\"Cutting Entresto in half can lead to risks from uneven dosing. Here\u2019s why you should ask your doctor first or consider safer alternatives to splitting Entresto.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/can-entresto-be-cut-in-half\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Can you split Entresto?\" \/>\n<meta property=\"og:description\" content=\"Here\u2019s what experts want you to know\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.singlecare.com\/blog\/can-entresto-be-cut-in-half\/\" \/>\n<meta property=\"og:site_name\" content=\"The Checkup\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/singlecare\" \/>\n<meta property=\"article:published_time\" content=\"2026-01-15T14:30:41+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2026\/01\/Blog_011526_Can_Entresto_be_cut_in_half-copy.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"Joy Emeh\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"Can you split Entresto?\" \/>\n<meta name=\"twitter:description\" content=\"Here\u2019s what experts want you to know\" \/>\n<meta name=\"twitter:creator\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:site\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Joy Emeh\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/can-entresto-be-cut-in-half\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/can-entresto-be-cut-in-half\\\/\"},\"author\":{\"name\":\"Heidi Borst\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/person\\\/fda93df2f5d09af0d250b59dfb4b46f2\"},\"headline\":\"Can Entresto be cut in half?\",\"datePublished\":\"2026-01-15T14:30:41+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/can-entresto-be-cut-in-half\\\/\"},\"wordCount\":1555,\"publisher\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/can-entresto-be-cut-in-half\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/Blog_011526_Can_Entresto_be_cut_in_half-copy.webp\",\"keywords\":[\"Drug safety\",\"Heart health\",\"Seasonal\"],\"articleSection\":[\"Drug Info\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/can-entresto-be-cut-in-half\\\/\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/can-entresto-be-cut-in-half\\\/\",\"name\":\"Can Entresto be cut in half? 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