{"id":635270,"date":"2026-03-02T09:30:50","date_gmt":"2026-03-02T14:30:50","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=635270"},"modified":"2026-02-25T11:35:52","modified_gmt":"2026-02-25T16:35:52","slug":"does-mounjaro-make-you-tired","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/does-mounjaro-make-you-tired\/","title":{"rendered":"Will Mounjaro make you tired?"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/mounjaro\"><span style=\"font-weight: 400;\">Mounjaro<\/span><\/a><span style=\"font-weight: 400;\"> (tirzepatide) is a once-weekly subcutaneous injection prescribed to help adults with Type 2 diabetes manage blood sugar, alongside diet and exercise, similar to other GLP-1 medications like semaglutide. It works by mimicking the action of two hormones, GLP-1 and GIP, which affect appetite, digestion, and glucose regulation. <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/zepbound\"><span style=\"font-weight: 400;\">Zepbound<\/span><\/a><span style=\"font-weight: 400;\"> is a weight loss medication containing the same active ingredient, which is approved for the treatment of obesity or weight-related conditions, such as obstructive sleep apnea (OSA).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Because tirzepatide affects metabolism and blood sugar levels, some people report feeling unusually tired after starting Mounjaro or increasing to higher doses. Fatigue may be linked to reduced calorie intake, shifts in blood glucose, or the body adjusting to the medication. In some cases, tiredness may also be related to an underlying medical condition rather than the drug itself.<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Mounjaro with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tMounjaro 5 mg\/0.5 mL (4 pens)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-cvs.svg\" alt=\"CVS Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$667.11<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/mounjaro#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/mounjaro#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-publix.svg\" alt=\"Publix\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$668.26<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/mounjaro#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/mounjaro#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/mounjaro#blog-cta\" class=\"coupon-see-all-btn\">See Mounjaro prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"can-mounjaro-make-you-tired\"><span style=\"font-weight: 400;\">Can Mounjaro make you tired?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u201cFatigue is a <\/span><a href=\"https:\/\/www.pdr.net\/drug-summary\/?drugLabelId=24529\"><span style=\"font-weight: 400;\">common side effect<\/span><\/a><span style=\"font-weight: 400;\"> of taking Mounjaro for diabetes and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/zepbound\"><span style=\"font-weight: 400;\">Zepbound<\/span><\/a><span style=\"font-weight: 400;\"> for weight loss,\u201d says <\/span><a href=\"https:\/\/www.memorialcare.org\/providers\/mir-b-ali\"><span style=\"font-weight: 400;\">Mir Ali<\/span><\/a><span style=\"font-weight: 400;\">, MD, bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center. The incidence and duration vary widely, but fatigue is more common among those losing weight, he says. Dr. Ali notes that fatigue or tiredness often occurs alongside weight loss, whether it is due to surgery, medication, or dietary changes.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">According to clinical trials, other common Mounjaro side effects include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea or constipation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Indigestion<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Abdominal pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Decreased appetite<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Injection site reactions<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Serious side effects that warrant immediate medical advice include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe allergic reactions<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pancreatitis (inflammation of the pancreas)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hypoglycemia (low blood sugar)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Acute kidney injury<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vision changes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gallbladder problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe stomach pain<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Although it&#8217;s not known if Mounjaro causes thyroid cancer in humans, animal studies have shown an increased risk of certain types of thyroid cancer. People with symptoms of thyroid cancer, such as trouble breathing or swallowing, a lump in the neck, or hoarseness, should seek medical attention.<\/span><\/p>\n<h3 id=\"does-mounjaro-fatigue-go-away\"><span style=\"font-weight: 400;\">Does Mounjaro fatigue go away?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u201cFatigue associated with <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/mounjaro-without-insurance\/\"><span style=\"font-weight: 400;\">Mounjaro<\/span><\/a><span style=\"font-weight: 400;\"> is often temporary and may resolve as the body adjusts to the medication,\u201d says <\/span><a href=\"https:\/\/theintracare.com\/location\/grapevine-health-center\/\"><span style=\"font-weight: 400;\">Shopana Ganpath, MD<\/span><\/a><span style=\"font-weight: 400;\">, an internist with IntraCare Health Center in Grapevine, Texas.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dr. Ganpath explains that many people report that Mounjaro side effects, including tiredness, are most pronounced during the initial weeks of treatment and gradually diminish over time.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, for some individuals, fatigue may persist, particularly when other factors, such as dietary changes or underlying health conditions, are contributing. <\/span><\/p>\n<h2 id=\"why-might-mounjaro-cause-fatigue\"><span style=\"font-weight: 400;\">Why might Mounjaro cause fatigue?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Dr. Ganpath explains that fatigue after taking Mounjaro may occur due to the following reasons:<\/span><\/p>\n<h3 id=\"blood-sugar-fluctuations\"><span style=\"font-weight: 400;\">Blood sugar fluctuations<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Mounjaro changes how your body releases insulin and glucagon (another hormone that raises blood sugar). As your body adjusts to the medication, this can sometimes cause short periods of low blood sugar, also known as hypoglycemia. When that happens, you may feel tired, lightheaded, dizzy, or weak.<\/span><\/p>\n<h3 id=\"gastrointestinal-effects\"><span style=\"font-weight: 400;\">Gastrointestinal effects<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Mounjaro makes food move more slowly through your digestive system, a process known as delayed gastric emptying. This can decrease appetite and make you want to eat less, resulting in lower energy levels from reduced calorie intake. Hydration with water and electrolytes can help manage side effects such as constipation and dehydration.<\/span><\/p>\n<h3 id=\"nutritional-deficiencies\"><span style=\"font-weight: 400;\">Nutritional deficiencies<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Dr. Ali notes that fatigue may also result from <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/anemia-treatment-and-medications\"><span style=\"font-weight: 400;\">anemia<\/span><\/a><span style=\"font-weight: 400;\"> or other nutritional deficiencies caused by Mounjaro-induced appetite loss, which may prevent adequate intake of protein, healthy fats, or whole grains.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our diabetes newsletter<\/span>\n\t\t\t<form class=\"form-wrapper\" data-newsletter-form=\"1\" data-subsource=\"Diabetes Newsletter\">\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<label for=\"dynamic-email\">Email<\/label>\n\t\t\t\t\t<input type=\"email\" id=\"dynamic-email\" class=\"email\" required>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<input class=\"submit-form-btn\" type=\"submit\" value=\"Click to sign up\">\n\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t\t<p class=\"success-message\" aria-live=\"polite\"><\/p>\n\t\t<\/div>\n\t<\/span><\/p>\n<h2 id=\"distinguishing-mounjaro-fatigue-from-other-causes\"><span style=\"font-weight: 400;\">Distinguishing Mounjaro fatigue from other causes<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">It\u2019s also possible that the fatigue you experience while on Mounjaro is not a result of the medication but rather due to other factors like lifestyle, underlying health conditions, and other treatments.<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For instance, other medical conditions like <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/insomnia-treatment-and-medications\"><span style=\"font-weight: 400;\">insomnia<\/span><\/a><span style=\"font-weight: 400;\"> and obstructive sleep apnea (OSA) can <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12720398\/\"><span style=\"font-weight: 400;\">cause you to experience fatigue,<\/span><\/a><span style=\"font-weight: 400;\"> tiredness, or low energy. If you are prescribed Mounjaro (or Zepbound, which is also FDA-approved for <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/news\/zepbound-sleep-apnea-fda-approval\/\"><span style=\"font-weight: 400;\">moderate to severe OSA<\/span><\/a><span style=\"font-weight: 400;\"> in adults with obesity), you may still occasionally experience these symptoms. Other lifestyle habits, such as sleep, diet, physical activity, and mental health, can affect your energy levels and lead to fatigue.\u00a0\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">But how can you tell if the fatigue is caused by Mounjaro or by some other factors? Dr. Ganpath provides the following tips to help you differentiate the two:<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Timing:<\/b><span style=\"font-weight: 400;\"> Mounjaro-related fatigue often occurs shortly after starting the medication or increasing the dose. If fatigue coincides with these changes, it is likely drug-related.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Associated symptoms:<\/b><span style=\"font-weight: 400;\"> Tiredness caused by Mounjaro may be accompanied by other possible side effects, including nausea, dizziness, and mild hypoglycemia. If these symptoms are present, they may point to the medication as the cause of your fatigue.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Duration:<\/b><span style=\"font-weight: 400;\"> In many cases, fatigue associated with Mounjaro resolves as the body adapts to the medication.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Lifestyle factors:<\/b><span style=\"font-weight: 400;\"> Consider whether fatigue could be related to poor sleep, stress, or dietary changes. For example, reduced caloric intake due to appetite suppression may contribute to tiredness.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Other medications:<\/b><span style=\"font-weight: 400;\"> Discuss any other medications you take with a healthcare provider, as some, such as antihistamines, are known to cause fatigue.\u00a0\u00a0<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Dr. Ganpath recommends keeping a symptom diary to help you track when fatigue occurs, its severity, and any accompanying symptoms. \u201cThis information can be invaluable for identifying patterns and determining the cause,\u201d she says.<\/span><\/p>\n<h2 id=\"managing-mounjaro-related-fatigue\"><span style=\"font-weight: 400;\">Managing Mounjaro-related fatigue<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The following recommendations may help manage this side effect:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Make dietary adjustments.<\/b><span style=\"font-weight: 400;\"> Dr. Ali advises that you first ensure that you are consuming an adequate, balanced diet, including sufficient protein. \u201cLack of protein may increase muscle loss, which can contribute to fatigue,\u201d he says.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Move your body more.<\/b><span style=\"font-weight: 400;\"> Lifestyle changes, such as exercise, may help boost energy. Dr. Ali notes that regular exercise (including walking) has the added benefit of minimizing muscle loss, another potential side effect.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Maintain a regular, healthy sleep schedule.<\/b><span style=\"font-weight: 400;\"> Ensure you get at least seven hours of sleep each night.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Focus on hydration.<\/b><span style=\"font-weight: 400;\"> Dehydration worsens fatigue and other side effects of Mounjaro.<\/span><\/li>\n<\/ul>\n<h2 id=\"when-to-be-concerned\"><span style=\"font-weight: 400;\">When to be concerned<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Fatigue may seem like a mild side effect, but it can disrupt your daily life. If you experience persistent tiredness that does not improve after a few weeks, seek medical advice from your healthcare team. You might need a dose adjustment or additional tests.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mounjaro (tirzepatide) is a once-weekly subcutaneous injection prescribed to help adults with Type 2 diabetes manage blood sugar, alongside diet and exercise, similar to other GLP-1 medications like semaglutide. It works by mimicking the action of two hormones, GLP-1 and GIP, which affect appetite, digestion, and glucose regulation. Zepbound is a weight loss medication containing [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":635427,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[10298,21067,8905,9825],"coauthors":[20970],"class_list":["post-635270","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-diabetes","tag-glp-1-drugs","tag-seasonal","tag-weight-loss","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Does Mounarjo make you tired? What the research says<\/title>\n<meta name=\"description\" content=\"Studies link Mounjaro to temporary fatigue as the body adjusts to it. 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