{"id":635650,"date":"2026-03-16T15:24:52","date_gmt":"2026-03-16T19:24:52","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=635650"},"modified":"2026-03-16T15:26:05","modified_gmt":"2026-03-16T19:26:05","slug":"depakote-generic","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/depakote-generic\/","title":{"rendered":"Depakote generic availability, cost, and how to save"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/depakote\"><span style=\"font-weight: 400;\">Depakote<\/span><\/a><span style=\"font-weight: 400;\"> (divalproex sodium) is a brand-name prescription medication that\u2019s approved by the Food and Drug Administration (FDA) to prevent migraine headaches, to treat symptoms of bipolar disorder, and to lower the risk of seizures in people with <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/epilepsy-treatment-and-medications\"><span style=\"font-weight: 400;\">epilepsy<\/span><\/a><span style=\"font-weight: 400;\">. It can also be used off-label for several conditions, including nerve pain caused by infections or diabetes. <\/span><span style=\"font-weight: 400;\">A generic version of Depakote, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/divalproex-sodium\"><span style=\"font-weight: 400;\">divalproex sodium<\/span><\/a><span style=\"font-weight: 400;\">, has been available since 2008 from multiple drug manufacturers.\u00a0<\/span><\/p>\n<table class=\" singlecare-table\" role=\"table\">\n<thead>\n<tr>\n<th colspan=\"2\">\n<h2 id=\"depakote-generic-availability\"><span style=\"font-weight: 400;\">\u00a0 \u00a0Depakote generic availability<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><b>Generic name<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Divalproex sodium<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>FDA approval date of the generic version<\/b><\/td>\n<td><span style=\"font-weight: 400;\"> July 29, 2008<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Is there a generic available for sale in the U.S.?\u00a0<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"what-are-depakote-and-divalproex-sodium-used-for\"><span style=\"font-weight: 400;\">What are Depakote and divalproex sodium used for?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Depakote and divalproex sodium are approved by the FDA to treat the same indications:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Manic episodes in people with <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/bipolar-disorder-treatment-and-medications\"><span style=\"font-weight: 400;\">bipolar disorder<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Simple absence, complex partial, and complex absence seizures in people over 10 years old with epilepsy<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Prevention (not treatment) of <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/migraine-treatment-and-medications\"><span style=\"font-weight: 400;\">migraine headaches<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Both the generic and brand-name versions of the drugs may also be used off-label for emergency treatment of <\/span><a href=\"https:\/\/www.epilepsy.com\/complications-risks\/emergencies\/status-epilepticus\"><span style=\"font-weight: 400;\">status epilepticus<\/span><\/a><span style=\"font-weight: 400;\"> (long or uncontrolled seizures), diabetic peripheral neuropathy, nerve pain due to shingles infection, and symptoms of impulsivity, agitation, and aggression.\u00a0<\/span><\/p>\n<h2 id=\"what-s-the-difference-between-depakote-and-divalproex-sodium\"><span style=\"font-weight: 400;\">What\u2019s the difference between Depakote and divalproex sodium?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Depakote and divalproex sodium contain the same active ingredient and come in the same dosages and forms. However, there are some slight differences, including how the pills look, the inactive ingredients, and the price.<\/span><\/p>\n<h3 id=\"appearance\"><span style=\"font-weight: 400;\">Appearance<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Depakote and its generic forms both come in tablet or capsule form, but differ in color and imprint. Brand-name Depakote tablets are either salmon pink, peach, or lavender and have imprints with an \u201cA\u201d logo and either \u201cNT,\u201d \u201cNR,\u201d or \u201cNS,\u201d depending on the dose. Generic divalproex sodium tablets can be white, gray, blue, or pink in color and have different imprints based on the manufacturer or dosage. Capsules may also differ in appearance.<\/span><\/p>\n<h3 id=\"dosage-and-forms\"><span style=\"font-weight: 400;\">Dosage and forms<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Both Depakote and generic divalproex are available as delayed-release tablets in 125 mg, 250 mg, and 500 mg <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/depakote\/dosage\"><span style=\"font-weight: 400;\">doses<\/span><\/a><span style=\"font-weight: 400;\">. Most formulations are either <\/span><a href=\"https:\/\/jppt.kglmeridian.com\/view\/journals\/jppt\/23\/4\/article-p277.xml\"><span style=\"font-weight: 400;\">delayed-release or extended-release drugs<\/span><\/a><span style=\"font-weight: 400;\">, meaning the drug doesn\u2019t get absorbed into the blood right away or enters the bloodstream gradually over time. Extended-release versions of the drug are available in 250 mg and 500 mg.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Depakote is also available in a \u201c<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/depakote\/dosage\"><span style=\"font-weight: 400;\">sprinkles<\/span><\/a><span style=\"font-weight: 400;\">\u201d form, which is a capsule with 125 mg of Depakote that can be opened up and mixed into soft food for people who have trouble swallowing the whole tablets or capsules.\u00a0<\/span><\/p>\n<h3 id=\"risks-and-side-effects\"><span style=\"font-weight: 400;\">Risks and side effects\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The brand-name and generic versions of Depakote both carry the same side-effect risks. They also share the same <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/black-box-warning\/\"><span style=\"font-weight: 400;\">boxed (black box) warning<\/span><\/a><span style=\"font-weight: 400;\"> about its potential for liver damage when starting the drug and the potential to cause congenital disabilities in a fetus when taken by a pregnant person. For this reason, people who are able to get pregnant may be recommended birth control while on divalproex sodium. The drug also carries a risk of pancreatitis, which can lead to medical emergencies or death.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Common <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/depakote-side-effects\/\"><span style=\"font-weight: 400;\">side effects of Depakote<\/span><\/a><span style=\"font-weight: 400;\"> and generic divalproex sodium include headache, abdominal pain, dizziness, tiredness, drowsiness, nausea, weight gain, weight loss, nervousness, hair loss, and insomnia. Serious side effects may include liver problems, psychosis, suicidal thoughts, allergic reactions, bleeding, blood cell abnormalities, and hallucinations.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It\u2019s important not to stop taking the drug suddenly, especially when taking it for seizures. A drop in blood levels can cause withdrawal seizures.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you\u2019ve started Depakote or divalproex sodium and are concerned about new or continuing symptoms, seek medical advice from your healthcare professional to manage side effects.\u00a0<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/depakote-and-alcohol\/\"><b>Depakote and alcohol<\/b><\/a><b> \u2502 <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/foods-to-avoid-while-on-depakote\/\"><b>Foods to avoid while on Depakote<\/b><\/a><\/p>\n<h3 id=\"cost\"><span style=\"font-weight: 400;\">Cost\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">One of the biggest differences between brand-name Depakote and generic divalproex sodium is its cost. <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/depakote-without-insurance\/\"><span style=\"font-weight: 400;\">Depakote costs<\/span><\/a><span style=\"font-weight: 400;\"> an average of $801 for 90, 500 mg delayed-release tablets without insurance or discounts. Generic divalproex costs on average $176 for 60, 500 mg delayed-release tablets without insurance.\u00a0<\/span><\/p>\n<table class=\" singlecare-table\" role=\"table\">\n<thead>\n<tr>\n<th class=\"title\" role=\"columnheader\" colspan=\"2\" scope=\"col\">\n<h3 id=\"depakote-divalproex-sodium-cost-at-a-glance\"><span style=\"font-weight: 400;\">\u00a0 \u00a0Depakote (divalproex sodium) cost at a glance<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><b>Average cost without insurance<\/b><\/td>\n<td><span style=\"font-weight: 400;\"> $801 for 90, 500 mg tablets of brand-name Depakote<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>SingleCare cost<\/b><\/td>\n<td><span style=\"font-weight: 400;\">$25 for 90, 500 mg tablets of generic divalproex sodium at Walgreens<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>How to save<\/b><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/depakote\"><span style=\"font-weight: 400;\">Get coupon<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><small><i>Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of <\/i><i>Feb. 11, 2026. <\/i><i>The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available.<\/i><small><\/small><\/small><\/p>\n<h2 id=\"can-you-switch-between-depakote-and-divalproex-sodium\"><span style=\"font-weight: 400;\">Can you switch between Depakote and divalproex sodium?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Yes, but with caution, and only under a healthcare provider\u2019s guidance. Divalproex sodium is a <\/span><a href=\"https:\/\/www.fda.gov\/media\/162779\/download\"><span style=\"font-weight: 400;\">Narrow Therapeutic Index (NTI) drug<\/span><\/a><span style=\"font-weight: 400;\">. NTI drugs require cautious dosing and monitoring, since minor differences in dosages can lead to toxic blood concentrations in the body.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cThe FDA generally allows generic drugs to have a bioavailability range relative to the brand-name drug,\u201d says Ryan Sultan, MD, a dual board-certified adult and child psychiatrist and research and medical director at <\/span><a href=\"https:\/\/www.integrative-psych.org\/\"><span style=\"font-weight: 400;\">Integrative Psych<\/span><\/a><span style=\"font-weight: 400;\">. \u201cFor most drugs, this variation is negligible. However, for an NTI drug like Depakote, a variation that is technically \u2018allowable\u2019 by regulatory standards can sometimes be enough to push a patient&#8217;s blood levels out of the therapeutic range and into toxicity or seizure breakthrough,\u201d he says. This is why switching medications under your healthcare provider\u2019s guidance is the safest approach.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cA switch typically necessitates re-checking blood levels (valproic acid levels) one to two weeks after the change to ensure they remain in the therapeutic range,\u201d Dr. Sultan says.<\/span><\/p>\n<h2 id=\"how-to-save-on-generic-divalproex-sodium\"><span style=\"font-weight: 400;\">How to save on generic divalproex sodium<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Switching from brand-name Depakote to generic divalproex sodium can save a significant amount on your prescription costs, but there are ways to save even more.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Using a SingleCare coupon or your <\/span><a href=\"https:\/\/www.singlecare.com\/prescription-discount-card\"><span style=\"font-weight: 400;\">prescription discount card<\/span><\/a><span style=\"font-weight: 400;\"> can save you up to 89% on the cost of generic divalproex sodium without insurance. While 60, 500 mg tablets of the generic drug can cost $176, using a SingleCare coupon can reduce that cost to $19 for the same prescription. A <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/divalproex-sodium#coupons\"><span style=\"font-weight: 400;\">SingleCare coupon for divalproex sodium<\/span><\/a><span style=\"font-weight: 400;\"> is free, easy to use, and can be used at most pharmacies.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">To get a SingleCare coupon, search for your prescribed medication through the <\/span><a href=\"https:\/\/www.singlecare.com\/\"><span style=\"font-weight: 400;\">SingleCare website<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/use-singlecare-app\/\"><span style=\"font-weight: 400;\">SingleCare app<\/span><\/a><span style=\"font-weight: 400;\">. Then, select the pharmacy with the lowest price near you. Simply show your card or coupon to pharmacy staff when you\u2019re ready to pay for your prescription.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Another way to save on generic divalproex sodium is to check your insurance coverage. Generally, insurance plans are more likely to cover generic medications in their drug formulary. Most insurance plans cover divalproex sodium but not Depakote. It\u2019s best to check with your specific plan details and plan administrator to find out whether your prescription is covered.\u00a0<\/span><\/p>\n<h2 id=\"frequently-asked-questions-about-depakote-generic\"><span style=\"font-weight: 400;\">Frequently asked questions about Depakote generic<\/span><\/h2>\n<h3 id=\"is-generic-divalproex-sodium-as-safe-as-depakote\"><span style=\"font-weight: 400;\">Is generic divalproex sodium as safe as Depakote?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Yes, generic divalproex sodium is as safe as brand-name Depakote. They both have the same active ingredient and carry the same risks.\u00a0<\/span><\/p>\n<h3 id=\"can-you-switch-from-depakote-to-generic-divalproex-sodium\"><span style=\"font-weight: 400;\">Can you switch from Depakote to generic divalproex sodium?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Yes, you can switch from Depakote to generic divalproex sodium, but it is important to only switch under the guidance of your healthcare provider, since they\u2019re NTI drugs that require cautious dosing and monitoring.\u00a0<\/span><\/p>\n<h3 id=\"does-insurance-cover-generic-depakote\"><span style=\"font-weight: 400;\">Does insurance cover generic Depakote?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Most insurance plans cover generic Depakote, divalproex sodium. However, it\u2019s best to check with your individual plan or contact your plan administrator to find out specific coverage details.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Depakote (divalproex sodium) is a brand-name prescription medication that\u2019s approved by the Food and Drug Administration (FDA) to prevent migraine headaches, to treat symptoms of bipolar disorder, and to lower the risk of seizures in people with epilepsy. It can also be used off-label for several conditions, including nerve pain caused by infections or diabetes. [&hellip;]<\/p>\n","protected":false},"author":149,"featured_media":635651,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[3418,20802],"coauthors":[21072],"class_list":["post-635650","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-generic-drugs","tag-seizures","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Depakote generic availability, cost, and how to save<\/title>\n<meta name=\"description\" content=\"A Depakote generic has been available since 2008. 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