{"id":635657,"date":"2026-03-16T16:03:37","date_gmt":"2026-03-16T20:03:37","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=635657"},"modified":"2026-03-16T16:03:37","modified_gmt":"2026-03-16T20:03:37","slug":"normal-estradiol-levels-by-age","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/normal-estradiol-levels-by-age\/","title":{"rendered":"Normal estradiol levels by age"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/estradiol\/what-is\"><span style=\"font-weight: 400;\">Estradiol<\/span><\/a><span style=\"font-weight: 400;\"> is a hormone that\u2019s instrumental in the sexual development and reproductive health of both males and females, but it\u2019s mainly associated with menstrual cycles and pregnancy. The amount of estradiol that a person produces depends on their age, sex, and life stage. Learn about what estradiol levels are normal, and save the estradiol levels chart in this article for easy reference.<\/span><\/p>\n<h2 id=\"what-is-estradiol\"><span style=\"font-weight: 400;\">What is estradiol?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Estradiol is a type of <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/estrogens\"><span style=\"font-weight: 400;\">estrogen<\/span><\/a><span style=\"font-weight: 400;\">, a hormone that\u2019s primarily produced in the ovaries, testes, fat cells, and adrenal glands. Estradiol affects sexual development and function in both men and women and helps keep your brain, heart, and bones healthy.\u00a0<\/span><\/p>\n<h3 id=\"estradiol-vs-estrogen\"><span style=\"font-weight: 400;\">Estradiol vs. estrogen<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Estrogen is an umbrella term for <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK549797\/\"><span style=\"font-weight: 400;\">four<\/span><\/a><span style=\"font-weight: 400;\"> different but closely related sex hormones:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Estrone (E1): Common in postmenopausal women<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Estradiol (E2): Common in women of reproductive age<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Estriol (E3): Common in pregnant women<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Estetrol (E4): Produced by the <\/span><a href=\"https:\/\/www.acs.org\/molecule-of-the-week\/archive\/e\/estetrol.html\"><span style=\"font-weight: 400;\">liver of a developing fetus<\/span><\/a><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">All estrogens share the same chemical structure except for some <\/span><a href=\"https:\/\/restorativemedicine.org\/journal\/estriol-good-estrogen-advances-updates-clinical-uses\/\"><span style=\"font-weight: 400;\">slight variations<\/span><\/a><span style=\"font-weight: 400;\"> in oxygen and hydrogen bonds. Of the four types of estrogen, estradiol is most common and most significant in women of reproductive age who aren\u2019t pregnant.\u00a0<\/span><\/p>\n<h2 id=\"how-estradiol-levels-change-across-life-stages\"><span style=\"font-weight: 400;\">How estradiol levels change across life stages<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Estradiol levels fluctuate throughout a woman\u2019s life but typically remain steady throughout a man\u2019s life. Here\u2019s a closer look at how estradiol levels change across life stages in both sexes.\u00a0\u00a0<\/span><\/p>\n<h3 id=\"childhood\"><span style=\"font-weight: 400;\">Childhood<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Everyone is born with elevated estradiol levels (as maternal estrogen also circulates through the fetus) that plummet a few days after birth. Then, the body produces small amounts of estradiol to grow healthy bones, brains, cardiovascular tissue, and much more.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Normal estradiol levels in children who haven\u2019t started puberty tend to be <\/span><a href=\"https:\/\/www.mayocliniclabs.com\/test-catalog\/overview\/81816#clinical-and-interpretive\"><span style=\"font-weight: 400;\">20 picograms per milliliter<\/span><\/a><span style=\"font-weight: 400;\"> (pg\/mL) or less for girls and 13 pg\/mL for boys. Sometimes, children\u2019s estradiol levels are so low that they\u2019re undetectable. This is also normal.\u00a0\u00a0<\/span><\/p>\n<h3 id=\"puberty\"><span style=\"font-weight: 400;\">Puberty<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">When puberty begins, estradiol production ramps up significantly in girls and moderately in boys. Although it\u2019s commonly called a female sex hormone, estradiol plays a <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4854098\/\"><span style=\"font-weight: 400;\">critical role<\/span><\/a><span style=\"font-weight: 400;\"> in the reproductive development of both sexes.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In females, high levels of estradiol trigger developmental changes like enlarged breasts and the onset of menstruation. In males, a moderate increase in estradiol helps improve sperm production, erectile health, and libido.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The increase in estradiol happens gradually over several years. According to the Mayo Clinic, girls typically start puberty around the age of 10.5. By the time they\u2019re about two years into puberty, girls\u2019 estradiol levels tend to be 15\u201385 pg\/mL.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Boys start puberty a little later than girls, at about 11.5 years old. After about two years of puberty, boys\u2019 estradiol levels can be as high as 26 pg\/mL, but it\u2019s also normal for boys to still have undetectable estradiol levels at this age.\u00a0<\/span><\/p>\n<h3 id=\"reproductive-years\"><span style=\"font-weight: 400;\">Reproductive years<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Males produce 10\u201340 pg\/mL of estradiol by the age of 18. Unless a medical condition causes a hormonal imbalance, they\u2019ll continue to produce about the same level of estradiol for the rest of their lives.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It\u2019s a very different scenario for females, who will experience estradiol fluctuations until they reach menopause in their 50s.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Women of reproductive age typically produce 15 to 350 pg\/mL of estradiol <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK279054\/\"><span style=\"font-weight: 400;\">depending on the stage<\/span><\/a><span style=\"font-weight: 400;\"> of their menstrual cycle. Estradiol levels are lowest in the early follicular phase and highest just before ovulation (which is mid-cycle and when an egg is usually released from an ovary).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Estradiol levels rise significantly during pregnancy, sometimes to 10 or 100 times the normal non-pregnant levels. According to the <\/span><a href=\"https:\/\/www.perinatology.com\/Reference\/Reference%20Ranges\/Estradiol.htm\"><span style=\"font-weight: 400;\">Roche Diagnostics<\/span><\/a><span style=\"font-weight: 400;\"> reference range, the following estradiol levels are typical for each trimester of pregnancy:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>First trimester:<\/b><span style=\"font-weight: 400;\"> 154\u20133,243 pg\/mL\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Second trimester: <\/b><span style=\"font-weight: 400;\">1,561\u201321,280 pg\/mL<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Third trimester: <\/b><span style=\"font-weight: 400;\">8,525\u201330,000 pg\/mL\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u201cEstradiol increases during pregnancy due to the placenta producing large amounts of estradiol,\u201d says <\/span><a href=\"https:\/\/manhattancardiology.com\/team\/dr-randy-gould\/\"><span style=\"font-weight: 400;\">Randy Gould<\/span><\/a><span style=\"font-weight: 400;\">, MD, a cardiologist based in New York City. \u201cThis is important to support fetal growth, to increase blood flow to the uterus to support uterine muscle growth for the developing baby, and to prepare the mammary glands for breastfeeding.\u201d\u00a0<\/span><\/p>\n<h3 id=\"perimenopause\"><span style=\"font-weight: 400;\">Perimenopause<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/what-is-perimenopause\/\"><span style=\"font-weight: 400;\">Perimenopause<\/span><\/a><span style=\"font-weight: 400;\"> occurs when the female body transitions to menopause, or the end of the menstrual cycle. During this time, estradiol levels don\u2019t follow the predictable pattern associated with a normal menstrual cycle.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cDuring perimenopause, estradiol levels fluctuate between very high and very low levels. These unpredictable changes can lead to mood swings, hot flashes, and irregular periods,\u201d Dr. Gould says.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In fact, estradiol levels can be so erratic during perimenopause that researchers haven\u2019t agreed on what a \u201cnormal\u201d or healthy estradiol range looks like during this life stage. Perimenopause symptoms can vary depending on whether estradiol is high or low at any given time. Perimenopause is not about estrogen disappearing overnight. It\u2019s about uneven flow, like a gas tank when it\u2019s near empty. Understanding this can help explain why symptoms come and go\u2014and why patience and support matter during this transition.<\/span><\/p>\n<h3 id=\"menopause-and-postmenopause\"><span style=\"font-weight: 400;\">Menopause and postmenopause<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Once a woman\u2019s periods have disappeared for 12 months in a row, she has reached the definition of \u201cmenopause.\u201d By this stage, estradiol levels will have dropped to less than 10 pg\/mL. They\u2019ll stay that low for the rest of a woman\u2019s life.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Perimenopausal symptoms typically ease up once menopause occurs, but some women experience persistent mood changes, vaginal dryness, night sweats, hot flashes, or other symptoms due to low estradiol levels. Low estradiol increases the risk of certain health conditions like <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/osteoporosis-treatment-and-medications\"><span style=\"font-weight: 400;\">osteoporosis<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<table class=\" singlecare-table\" role=\"table\">\n<thead>\n<tr>\n<th class=\"title\" role=\"columnheader\" scope=\"col\">\n<h2 id=\"normal-estradiol-levels-chart-female\"><span class=\"title\">\u00a0 \u00a0Normal estradiol levels chart: Female<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><b>Children (pre-puberty)<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Undetectable to 20 picograms (pg) per milliliter (mL)<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Puberty<\/b><\/td>\n<td><span style=\"font-weight: 400;\">15\u201385 pg\/mL<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Reproductive years<\/b><\/td>\n<td><span style=\"font-weight: 400;\">15\u2013350 pg\/mL<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Pregnancy<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Up to 30,000 pg\/mL, depending on trimester<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Perimenopause<\/b><\/td>\n<td><span style=\"font-weight: 400;\">No standard range<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Postmenopause<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Up to 10 pg\/mL<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<table class=\" singlecare-table\" role=\"table\">\n<thead>\n<tr>\n<th class=\"title\" role=\"columnheader\" scope=\"col\">\n<h2 id=\"normal-estradiol-levels-chart-male\"><span class=\"title\">\u00a0 Normal estradiol levels chart: Male<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><b>Children (pre-puberty)<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Undetectable to 13 pg\/mL<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Puberty\u00a0<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Undetectable to 26 pg\/mL<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Adulthood and beyond<\/b><\/td>\n<td><span style=\"font-weight: 400;\">10\u201340 pg\/mL<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"symptoms-of-low-estradiol-in-women\"><span style=\"font-weight: 400;\">Symptoms of low estradiol in women<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Women with low estradiol levels may notice a variety of sexual, physical, and mental or emotional symptoms, such as the following:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sore or tender breasts<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/vaginal-dryness-treatment\/\"><span style=\"font-weight: 400;\">Vaginal dryness<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Painful sex<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Low libido<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Poor sleep<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Irregular or absent periods<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weight gain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fatigue<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hot flashes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headaches or migraines<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Frequent <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/uti-causes\"><span style=\"font-weight: 400;\">urinary tract infections<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Urinary incontinence<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry skin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hair loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Poor concentration<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Joint pains<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Memory problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Irritability<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mood swings<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Depression<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Some symptoms of low estradiol may be more subtle. For example, low estradiol can cause a weakening of the bones known as osteoporosis, which normally goes unnoticed until a fracture occurs. Low estradiol also <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36210243\/\"><span style=\"font-weight: 400;\">increases the risk of cardiovascular disease<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cLow estradiol levels in women can be caused by aging, poor nutrition, extreme exercise, or thyroid disorders,\u201d Dr. Gould says.<\/span><\/p>\n<h2 id=\"symptoms-of-low-estradiol-in-men\"><span style=\"font-weight: 400;\">Symptoms of low estradiol in men<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Adult males who produce less than 20 pg\/mL of estradiol may experience symptoms <\/span><a href=\"https:\/\/www.baptisthealth.com\/care-services\/conditions-treatments\/low-estrogen\"><span style=\"font-weight: 400;\">such as<\/span><\/a><span style=\"font-weight: 400;\">:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Low libido<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fertility problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weight gain, especially around the abdomen<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Migraines<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry skin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle weakness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Poor stamina<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">As with women, low estradiol levels in men can also increase the risk of bone fractures and heart disease. \u201cLow estradiol in men can be caused by <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/low-testosterone-symptoms\"><span style=\"font-weight: 400;\">low testosterone<\/span><\/a><span style=\"font-weight: 400;\"> (hypogonadism), excess body fat, or high stress levels,\u201d Dr. Gould says.\u00a0<\/span><\/p>\n<h2 id=\"how-to-test-estradiol-levels\"><span style=\"font-weight: 400;\">How to test estradiol levels<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Estradiol levels are typically analyzed through a blood test. Sometimes healthcare providers perform a urine or saliva test instead.\u00a0<\/span><\/p>\n<h3 id=\"does-insurance-cover-hormone-testing\"><span style=\"font-weight: 400;\">Does insurance cover hormone testing?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Insurance coverage for hormone testing varies by plan. Health insurance companies tend to cover estradiol blood tests that are performed for women with specific symptoms to rule out certain diagnoses. Estradiol tests are less likely to be covered for evaluating fertility, perimenopause, or general wellness.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Talk to your health insurance company to understand your coverage benefits and to estimate any out-of-pocket expenses associated with estradiol testing.<\/span><\/p>\n<h2 id=\"how-to-treat-low-estradiol\"><span style=\"font-weight: 400;\">How to treat low estradiol<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If you have low estradiol, your healthcare provider may recommend making certain lifestyle changes to boost your body\u2019s natural estradiol production. <\/span><a href=\"https:\/\/my.clevelandclinic.org\/health\/diseases\/22354-low-estrogen#management-and-treatment\"><span style=\"font-weight: 400;\">Common recommendations<\/span><\/a><span style=\"font-weight: 400;\"> include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increasing your body weight if it\u2019s considered low (BMI less than 20)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dialing back on exercise if you work out intensely<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increasing physical activity if you\u2019re mostly sedentary<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reducing stress levels<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aiming for 7\u20139 hours of restful sleep nightly<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Low estradiol can be treated with hormone replacement therapy. Usually, this means you take synthetic estrogen and progesterone at the same time. Progesterone is a hormone that helps to balance the effects of estrogens like estradiol. Without progesterone, estrogen can cause the lining of the uterus to thicken too much, which can ultimately lead to uterine cancer. Your healthcare provider may recommend estrogen-only therapy if you don\u2019t have a uterus. Otherwise, a combination of estrogen and progesterone is the safer option.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Unfortunately, there are other risks associated with menopausal hormonal therapy. Upon starting to take estrogen and progesterone, there\u2019s an increased risk of breast cancer, stroke, and blood clots. The risk of blood clots is lessened if the route of estrogen therapy is non-oral (an estrogen patch or gel). If menopausal hormonal therapy is started 10 years after menopause or before age 60, there is no increased risk of heart attack. It\u2019s important to talk to a healthcare provider about whether hormone replacement therapy is right for you and how you can minimize its risks. Systemic estrogen is discouraged in people who have experienced menopause more than 10 years earlier and have not been on systemic estrogen.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Estrogen and progesterone treatments are available in several formats, including skin patches, skin creams, vaginal creams, oral pills, injections, and vaginal rings. Estradiol is available in generic, trademark generic, and brand-name products. Common brand names include:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/dotti\"><span style=\"font-weight: 400;\">Dotti<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/estradiol\"><span style=\"font-weight: 400;\">Estrogel<\/span><\/a><span style=\"font-weight: 400;\"> (estradiol skin creams)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/estring\"><span style=\"font-weight: 400;\">Estring<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/femring\"><span style=\"font-weight: 400;\">Femring<\/span><\/a><span style=\"font-weight: 400;\"> (estradiol vaginal rings)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/estrace\"><span style=\"font-weight: 400;\">Estrace<\/span><\/a><span style=\"font-weight: 400;\"> (estradiol vaginal cream)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/activella\"><span style=\"font-weight: 400;\">Activella<\/span><\/a><span style=\"font-weight: 400;\"> (estradiol-norethindrone tablets)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/combipatch\"><span style=\"font-weight: 400;\">Combipatch<\/span><\/a><span style=\"font-weight: 400;\"> (estradiol-norethindrone skin patch)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/bijuva\"><span style=\"font-weight: 400;\">Bijuva<\/span><\/a><span style=\"font-weight: 400;\"> (estradiol-progesterone capsules)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Because estradiol generics are widely available, you typically don\u2019t need to pay full price for a brand-name hormone replacement therapy. A SingleCare prescription discount card can also help lower the price of any prescription. For example, you could pay $33 for one tube of <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/estradiol\"><span style=\"font-weight: 400;\">generic estradiol cream<\/span><\/a><span style=\"font-weight: 400;\"> with a free SingleCare coupon. Prices vary by product, dosage, location, and pharmacy.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><b>Read more: <\/b><a href=\"https:\/\/www.singlecare.com\/resources\/estrogen\"><b>Estrogen Costs &amp; Coupons<\/b><\/a><\/p>\n<h2 id=\"bottom-line\"><span style=\"font-weight: 400;\">Bottom line<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">It\u2019s normal for estradiol levels to fluctuate in women who have started puberty but aren\u2019t yet in menopause. Estradiol levels in men are more stable, but they can still fluctuate within a narrower range. Talk to a healthcare provider if you notice symptoms of low estradiol, such as hot flashes, night sweats, sleep disturbance, and painful sex. Low estradiol is treatable, and increasing your estradiol levels can help ward off chronic conditions like osteoporosis.\u00a0<\/span><\/p>\n<p><small><i><span style=\"font-weight: 400;\">The SingleCare prices in this article are the most accurate at the time of publishing in ZIP code 23666 as of <\/span><\/i><i><span style=\"font-weight: 400;\">March 13, 2026. <\/span><\/i><i><span style=\"font-weight: 400;\">Prices vary by pharmacy.\u00a0\u00a0<\/span><\/i><small><\/small><\/small><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Estradiol is a hormone that\u2019s instrumental in the sexual development and reproductive health of both males and females, but it\u2019s mainly associated with menstrual cycles and pregnancy. The amount of estradiol that a person produces depends on their age, sex, and life stage. Learn about what estradiol levels are normal, and save the estradiol levels [&hellip;]<\/p>\n","protected":false},"author":149,"featured_media":635658,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8029],"tags":[8670],"coauthors":[21074],"class_list":["post-635657","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-education","tag-womens-health","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Normal estradiol levels by age: Chart and ranges<\/title>\n<meta name=\"description\" content=\"Estradiol levels vary by age. 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