{"id":636961,"date":"2026-08-03T09:00:26","date_gmt":"2026-08-03T13:00:26","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=636961"},"modified":"2026-07-21T21:05:15","modified_gmt":"2026-07-22T01:05:15","slug":"lexapro-and-caffeine","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/lexapro-and-caffeine\/","title":{"rendered":"Why coffee hits different on Lexapro"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/lexapro\">Lexapro (escitalopram)<\/a> is a <a href=\"https:\/\/www.singlecare.com\/drug-classes\/ssris\/\">selective serotonin reuptake inhibitor (SSRI)<\/a> antidepressant. It\u2019s prescribed to treat generalized anxiety disorder and major depressive disorder. Lexapro is also prescribed <a href=\"https:\/\/www.singlecare.com\/blog\/off-label-ssri-uses\/\">off-label<\/a> to treat panic disorder, PTSD, social anxiety disorder, OCD, premenstrual dysphoric disorder, and vasomotor symptoms associated with menopause.<\/p>\n<p>If you are taking Lexapro, you may want to know: Can you drink coffee while taking Lexapro? There are <a href=\"https:\/\/www.singlecare.com\/blog\/escitalopram-interactions\/\">no known interactions between Lexapro and caffeine<\/a>. However, some people experience jitteriness and anxiety when consuming caffeine. This can decrease the benefits of Lexapro, especially if you are taking it to treat anxiety.<\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Levothyroxine with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tLevothyroxine 75 mcg (90 Tablets)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart-nbh-market.svg\" alt=\"Walmart Neighborhood Market\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$10.00<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/levothyroxine-sodium#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/levothyroxine-sodium#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart.svg\" alt=\"Walmart Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$10.00<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/levothyroxine-sodium#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/levothyroxine-sodium#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/levothyroxine-sodium#blog-cta\" class=\"coupon-see-all-btn\">See Levothyroxine prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"can-you-drink-coffee-while-taking-lexapro\">Can you drink coffee while taking Lexapro?<\/h2>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/coffee-benefits\/\">Coffee<\/a> is a staple for many of us, and the good news is that you should be able to continue your daily coffee routine with no issues if you are taking Lexapro.<\/p>\n<p>\u201cIn my clinical experience, there&#8217;s no direct interaction between coffee and Lexapro, and for most of my patients, the morning cup is perfectly fine,\u201d says Ritu Goel, MD, psychiatrist at<a href=\"https:\/\/www.mindclaire.com\/\"> Mindclaire Psychiatry<\/a>. \u201cThere are no clear contraindications or negative effects with Lexapro.\u201d<\/p>\n<p>However, as Dr. Goel notes, many patients are taking Lexapro to manage anxiety disorder and other mental illnesses that can be negatively impacted by caffeine. \u201cI watch for any negative effects from caffeine, especially when dealing with anxiety or sleep issues,\u201d she says.<\/p>\n<p>While caffeine and Lexapro do not have a severe, direct interaction, the caffeine in coffee may <a href=\"https:\/\/my.clevelandclinic.org\/health\/diseases\/caffeine-sensitivity\">exacerbate anxiety<\/a> in sensitive individuals, which can counteract the calming effects of Lexapro.<\/p>\n<h3 id=\"does-drinking-coffee-with-lexapro-cause-serotonin-syndrome\">Does drinking coffee with Lexapro cause serotonin syndrome?<\/h3>\n<p>You may also wonder if drinking coffee might impact your levels of serotonin, or <a href=\"https:\/\/www.singlecare.com\/blog\/serotonin-syndrome-symptoms\/\">trigger serotonin syndrome<\/a>, a potentially life-threatening condition caused by too much serotonin building up in your system. While moderate consumption is likely safe, overloading on caffeine consumption while on Lexapro may trigger serotonin syndrome in <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35345760\/\">rare cases<\/a>.<\/p>\n<h3 id=\"does-lexapro-make-you-more-sensitive-to-caffeine\">Does Lexapro make you more sensitive to caffeine?<\/h3>\n<p>Some folks also wonder whether Lexapro makes you more sensitive to caffeine in general. While increased caffeine sensitivity may occur, it typically resolves within the first few weeks of starting Lexapro.<\/p>\n\t\t<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our mental health newsletter<\/span>\n\t\t\t<form class=\"form-wrapper\" data-newsletter-form=\"1\" data-subsource=\"Mental Health Newsletter\">\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<label for=\"dynamic-email\">Email<\/label>\n\t\t\t\t\t<input type=\"email\" id=\"dynamic-email\" class=\"email\" required>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<input class=\"submit-form-btn\" type=\"submit\" value=\"Click to sign up\">\n\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t\t<p class=\"success-message\" role=\"status\" aria-live=\"polite\"><\/p>\n\t\t<\/div>\n\t\n<p>\u201cBoth caffeine and SSRIs can cause jitteriness, anxiety, a faster heart rate, and trouble sleeping,\u201d says<a href=\"https:\/\/www.northwell.edu\/find-care\/find-a-doctor\/dr-rashi-aggarwal-md-1154514909\"> Rashi Aggarwal, MD,<\/a> chair of the department of psychiatry and behavioral sciences at Northwell\u2019s Staten Island University Hospital. \u201cSo, a few cups of coffee on top of a new SSRI can amplify those effects, especially in the first few weeks after starting or adjusting a dose, when the body is still adapting.\u201d<\/p>\n<h3 id=\"does-coffee-interact-with-other-antidepressants\">Does coffee interact with other antidepressants?<\/h3>\n<p>Several antidepressants are in the same family as Lexapro.<a href=\"https:\/\/www.singlecare.com\/prescription\/zoloft\"> For example, Zoloft (sertraline)<\/a> and<a href=\"https:\/\/www.singlecare.com\/prescription\/fluoxetine-hcl\"> Prozac (Fluoxetine)<\/a> are two SSRIs that are potential alternatives to Lexapro for the treatment of depression and anxiety disorders.<\/p>\n<p>Both of these medications are similar to Lexapro in that they don\u2019t typically interact with coffee. But, similar to Lexapro, caffeine can increase anxiety, which may blunt the effects of the medication.<\/p>\n<p>Although most antidepressants aren\u2019t a problem for coffee drinkers, there\u2019s one exception:<a href=\"https:\/\/www.singlecare.com\/prescription\/fluvoxamine-maleate\"> Luvox (fluvoxamine)<\/a>. According to Dr. Goel,<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16678550\/\"> Luvox inhibits the liver enzyme CYP1A2<\/a>, which breaks down caffeine. As a result, \u201cfluvoxamine slows caffeine clearance, so people can feel more wired than usual on the same amount of coffee,\u201d Dr. Goel explains.<\/p>\n<h2 id=\"tips-on-taking-lexapro-to-avoid-caffeine-side-effects\">Tips on taking Lexapro to avoid caffeine side effects<\/h2>\n<p><b>\u00a0<\/b>It makes sense to consider your caffeine intake when starting any medication. For most people, mixing caffeine with Lexapro shouldn\u2019t be an issue, and there\u2019s nothing you have to change in your daily coffee routine.<\/p>\n<p>In most cases, you don\u2019t need to time your coffee or Lexapro in any particular order, such as spacing the two apart. \u201cTiming doesn&#8217;t matter much here,\u201d Dr. Aggarwal explains. \u201cThis isn&#8217;t an absorption-based interaction, so spacing coffee and the medication apart doesn&#8217;t change anything.\u201d<\/p>\n<p>Still, there are some tips you should keep in mind, especially if you are particularly sensitive to caffeine, or if you end up having side effects as your body adjusts to Lexapro.<\/p>\n<p>Here are some expert tips.<b>\u00a0<\/b><\/p>\n<h3 id=\"time-your-coffee-intake-around-your-sleep-schedule\">Time your coffee intake around your sleep schedule<\/h3>\n<p>Most people taking Lexapro are looking to decrease mood issues and <a href=\"https:\/\/www.singlecare.com\/conditions\/anxiety-treatment-and-medications\">anxiety<\/a> symptoms. Caffeine can make those symptoms worse, especially when consumed close to bedtime. \u201cI tell patients to keep coffee in the morning and avoid it in the late afternoon and evening, because disrupted sleep worsens both mood and anxiety,\u201d Dr. Goel suggests.<\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/does-lexapro-make-you-tired\/\"><b>Does Lexapro make you tired?<\/b><\/a><\/p>\n<h3 id=\"consider-cutting-back-in-the-first-few-weeks\">Consider cutting back in the first few weeks<\/h3>\n<p>Although most people don\u2019t have issues with caffeine, some people find that they are more sensitive to it when first starting Lexapro. \u201cYou don&#8217;t need to give up coffee when starting Lexapro, but the first couple of weeks are when activation and jitteriness tend to peak, so that&#8217;s a sensible time to cut back a bit if you&#8217;re feeling on edge,\u201d Dr. Goel recommends.<\/p>\n<h3 id=\"consider-limiting-if-you-are-a-heavy-coffee-drinker\">Consider limiting if you are a heavy coffee drinker<\/h3>\n<p>It might make sense to cut back on excessive caffeine intake. \u201cThe recommended safe amount of coffee per day is about two to three regular ( eight-ounce cups) while on Lexapro,\u201d says<a href=\"https:\/\/facultyprofiles.tufts.edu\/michelle-diblasi\"> Michelle DiBlasi, DO<\/a>, chief of inpatient psychiatry at Tufts Medical Center. As such, heavy coffee drinkers (over three cups a day) may want to decrease their consumption if they are noticing side effects. The upper daily limit for caffeine consumption is <a href=\"https:\/\/www.fda.gov\/consumers\/consumer-updates\/spilling-beans-how-much-caffeine-too-much\">400 milligrams daily<\/a>, per the U.S. Food and Drug Administration (FDA).<\/p>\n<h3 id=\"take-precautions-if-you-have-a-sensitive-stomach\">Take precautions if you have a sensitive stomach<\/h3>\n<p>Both Lexapro and coffee can cause gastrointestinal (GI) effects, like loose stools and nausea. Some simple precautions can help, though. \u201cFor patients whose GI symptoms flare on Lexapro, I&#8217;d also suggest skipping coffee on an empty stomach, since both can irritate the stomach independently,\u201d Dr. Aggarwal recommends.<\/p>\n<h2 id=\"when-to-talk-to-your-healthcare-provider\">When to talk to your healthcare provider<\/h2>\n<p>There is no one-size-fits-all advice when it comes to Lexapro and caffeine.<\/p>\n<p>\u201cEveryone is different and may respond differently to drinking coffee while taking Lexapro,\u201d Dr. DiBlasi says. It\u2019s important not to compare yourself to others and to take action if you experience any concerning symptoms when combining Lexapro and coffee.<\/p>\n<p>Here are a few general tips:<\/p>\n<ul>\n<li>Wean off coffee to see if unwanted symptoms resolve. Symptoms may include anxiety, jitteriness, nausea, or trouble sleeping.<\/li>\n<li>Cut back slowly to avoid caffeine withdrawal symptoms like excess drowsiness.<\/li>\n<li>If symptoms linger or you have other questions\/concerns about <a href=\"https:\/\/www.singlecare.com\/blog\/lexapro-side-effects\/\">Lexapro side effects<\/a>, seek medical advice from a healthcare professional. They can help you determine whether your symptoms are from the coffee, the Lexapro, or something else, and whether any adjustments are needed.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Lexapro (escitalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It\u2019s prescribed to treat generalized anxiety disorder and major depressive disorder. Lexapro is also prescribed off-label to treat panic disorder, PTSD, social anxiety disorder, OCD, premenstrual dysphoric disorder, and vasomotor symptoms associated with menopause. If you are taking Lexapro, you may want to know: Can [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":636972,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[9777,451,12752,8905],"coauthors":[20899],"class_list":["post-636961","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-anxiety","tag-depression","tag-medication-side-effects","tag-seasonal","franchise-the-jolt","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Can you drink coffee while taking Lexapro?<\/title>\n<meta name=\"description\" content=\"There are no known interactions, but coffee may blunt the effects of Lexapro\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/lexapro-and-caffeine\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Can you drink coffee on Lexapro?\" \/>\n<meta property=\"og:description\" content=\"You may be more sensitive to caffeine\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.singlecare.com\/blog\/lexapro-and-caffeine\/\" \/>\n<meta property=\"og:site_name\" content=\"The Checkup\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/singlecare\" \/>\n<meta property=\"article:published_time\" content=\"2026-08-03T13:00:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2026\/07\/Blog_072026_Why-coffee-hits-different-on-Lexapro-copy.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta 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