{"id":637213,"date":"2026-09-17T09:00:28","date_gmt":"2026-09-17T13:00:28","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=637213"},"modified":"2026-09-10T20:59:50","modified_gmt":"2026-09-11T00:59:50","slug":"digoxin-toxicity","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/digoxin-toxicity\/","title":{"rendered":"What to know about digoxin toxicity"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/digoxin\">Digoxin<\/a> (brand names <a href=\"https:\/\/www.singlecare.com\/prescription\/lanoxin\">Lanoxin<\/a> and Digitek) is a cardiac glycoside medication extracted from the foxglove plant that treats heart failure and irregular heart rhythms like atrial fibrillation. The drug has a narrow therapeutic index, which means the difference between a working dose and a harmful dose is small. If you take too much, it can cause digoxin toxicity, a scary-sounding condition that is possible, but avoidable.<\/p>\n<p>It can occur even if you\u2019ve been taking the medication safely for years. Fortunately, digoxin toxicity is manageable if you catch it early. Here\u2019s a look at what causes it, what to look for, and how to lower your risk of developing it.<\/p>\n<h2 id=\"what-is-digoxin-toxicity\">What is digoxin toxicity?<\/h2>\n<p>Digoxin toxicity is a condition that occurs if too much digoxin accumulates in your body. \u201cThis can happen if someone accidentally takes more than the prescribed dose, but it&#8217;s also common in people whose kidneys aren&#8217;t clearing the medication as well as they should, since digoxin is primarily eliminated through the kidneys,\u201d says <a href=\"https:\/\/www.sirishavadali.com\/\">Sirisha Vadali, MD<\/a>, a board-certified cardiologist in Phoenix, Arizona.<\/p>\n<p>Digoxin toxicity can occur after starting a new prescription, but it is also possible to develop the condition after years of using the drug safely. Because the therapeutic index for the drug is so narrow, even relatively small changes in the amount of digoxin in your body can increase the risk of adverse effects.<\/p>\n<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10599802\/\">Chronic toxicity<\/a> may occur if a change in your body affects how it processes the medication. For example, if your kidney function starts to decline as you get older, it\u2019s possible your body may no longer process the same dose of the medication like it once could.<\/p>\n<h2 id=\"what-are-the-symptoms-of-digoxin-toxicity\">What are the symptoms of digoxin toxicity?<\/h2>\n<p>There are four main categories of symptoms: gastrointestinal, neurological, visual changes, and heart-related symptoms. Some signs may be subtle, while others can be life-threatening.<\/p>\n<h3 id=\"gastrointestinal-and-neurological-signs\">Gastrointestinal and neurological signs<\/h3>\n<p>Some of the early warning signs of <a href=\"https:\/\/www.mayoclinic.org\/drugs-supplements\/digoxin-intramuscular-route-intravenous-route\/description\/drg-20072679\">digoxin toxicity<\/a> involve effects on the digestive and nervous systems, such as:<\/p>\n<ul>\n<li>Nausea<\/li>\n<li>Anorexia (loss of appetite)<\/li>\n<li>Diarrhea<\/li>\n<li>Abdominal pain<\/li>\n<li>Vomiting<\/li>\n<li>Headache<\/li>\n<li>Tiredness and weakness<\/li>\n<li>Confusion, delirium, and dizziness<\/li>\n<\/ul>\n<p>Some of these symptoms, such as nausea, are also side effects of digoxin. Therefore, just because you notice these doesn\u2019t mean you have digoxin toxicity.<\/p>\n<p>However, you should always alert your healthcare provider if you experience any side effects, particularly if more than one symptom appears or worsens. In older adults, confusion, lethargy, or unusual weakness may occur and become especially noticeable.<\/p>\n<h3 id=\"visual-changes\">Visual changes<\/h3>\n<p><a href=\"https:\/\/medlineplus.gov\/ency\/article\/000165.htm\">Changes in vision<\/a>, or visual disturbances, may by symptoms of digoxin toxicity, including:<\/p>\n<ul>\n<li>Blurred vision<\/li>\n<li>Blind spots<\/li>\n<li>Seeing spots<\/li>\n<li>Changes in the way colors look<\/li>\n<\/ul>\n<p>If you experience any of these, contact your healthcare provider right away.<\/p>\n<h3 id=\"cardiac-symptoms\">Cardiac symptoms<\/h3>\n<p>The most dangerous effects of digoxin toxicity are heart-related. The condition is linked to several abnormal heart rhythms, including:<\/p>\n<ul>\n<li>An unusually slow heartbeat (bradycardia or bradyarrhythmia)<\/li>\n<li>An unusually fast heartbeat (tachyarrhythmia)<\/li>\n<li>Irregular heartbeats (arrhythmia)<\/li>\n<\/ul>\n<p>A new or significant change in your heart rate requires prompt attention if you\u2019re taking digoxin. Severe toxicity can lead to conditions like ventricular tachycardia and ventricular fibrillation, which are both life-threatening.<\/p>\n<p>If you experience chest pain, fainting, severe dizziness, vomiting, or irregular heart rhythms, seek emergency care. If your symptoms seem mild but are worsening, speak to your healthcare provider immediately.<\/p>\n<h2 id=\"what-causes-digoxin-toxicity\">What causes digoxin toxicity?<\/h2>\n<p>\u201cTaking too high of a dose or accidentally doubling the dose, or starting a new medication that has a drug interaction can all increase digoxin levels,\u201d warns <a href=\"https:\/\/www.mytoolboxgenomics.com\/about-us\/erika-gray\/\">Erika Gray, Pharm.D.<\/a>, founder and chief medical officer at ToolBox Genomics.com. The most common cause of digoxin toxicity is taking too much of the medication.<\/p>\n<p>Several other factors could also increase your risk of developing digoxin toxicity, Dr. Gray explains:<\/p>\n<ul>\n<li><b>Electrolyte imbalances:<\/b> If you have low potassium, low magnesium, or high calcium (often caused by taking prescription diuretics), digoxin may have an increased harmful effect on your heart.<\/li>\n<li><b>Older age:<\/b> Older adults are at a higher risk due to their susceptibility to changes in kidney function.<\/li>\n<li><b>Impaired renal function:<\/b> Anyone with kidney disease, acute kidney injury, or reduced kidney function (renal impairment) are at a higher risk because the kidneys are responsible for eliminating the drug from the body.<\/li>\n<li><b>Dehydration:<\/b> If you are dehydrated, your kidneys\u2019 ability to clear the drug may lessen, increasing the risk of toxicity.<\/li>\n<li><b>Certain medical conditions:<\/b> Some conditions, like <a href=\"https:\/\/www.singlecare.com\/blog\/hypothyroidism-vs-hyperthyroidism\/\">hypothyroidism<\/a> (an underactive thyroid), can predispose you to digoxin toxicity.<\/li>\n<li><b>Drug interactions:<\/b> <a href=\"https:\/\/www.singlecare.com\/blog\/digoxin-interactions\/\">Digoxin interactions<\/a> include medications like amiodarone, quinidine, verapamil, spironolactone, and certain antibiotics like clarithromycin and erythromycin, which may raise digoxin levels.<\/li>\n<\/ul>\n<p>Always alert your provider and pharmacist to any medications or dietary supplements that you\u2019re currently taking before starting digoxin and during ongoing treatment with the drug.<\/p>\n<h2 id=\"how-is-digoxin-toxicity-treated\">How is digoxin toxicity treated?<\/h2>\n<p>The treatments for chronic and acute digoxin toxicity depend on the severity of the case.<\/p>\n<p>When the condition is life-threatening, such as instances of <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10599802\/#sec3\">ventricular tachycardia or fibrillation<\/a>, medical professionals may use an antidote called <a href=\"https:\/\/www.singlecare.com\/prescription\/digifab\">digoxin immune Fab<\/a> (brand names DigiFab or Digibind) that binds to digoxin and enables the kidneys to clear it from the body. Even if the condition is not life-threatening, patients may still be treated with DigiFab.<\/p>\n<p>In certain cases, healthcare providers may:<\/p>\n<ul>\n<li>Advise patients to temporarily stop the medication or reduce the dosage.<\/li>\n<li>Try to correct electrolyte abnormalities, such as in cases of severe hypokalemia (low potassium), hyperkalemia (high potassium), or hypomagnesemia (low magnesium).<\/li>\n<li>Use medications like activated charcoal in cases of acute overdose to shorten the elimination half-life of the drug, or atropine when a dangerously slow heart rate is present.<\/li>\n<\/ul>\n<p>It\u2019s critical not to try to treat digoxin toxicity on your own. A healthcare provider must assess your symptoms. Stopping the medication abruptly has its own risks and should only be done under medical guidance.<\/p>\n<h2 id=\"how-can-you-prevent-digoxin-toxicity\">How can you prevent digoxin toxicity?<\/h2>\n<p>\u201cThe best way to prevent digoxin toxicity is to take the medication exactly as prescribed and avoid adjusting your dose without speaking with your healthcare provider,\u201d says Dr. Vadali.<\/p>\n<p>Dr. Vadali notes that if you currently take digoxin or are considering starting it, you should also follow these steps:<\/p>\n<ul>\n<li>Tell your healthcare team about prescriptions, over-the-counter drugs, and supplements you are taking.<\/li>\n<li>Get blood tests as recommended by your healthcare provider to monitor kidney function, electrolyte levels, and serum digoxin concentration levels.<\/li>\n<li>Stay well-hydrated, especially during illnesses.<\/li>\n<li>Take digoxin at the same time every day to maintain a steady amount in your bloodstream.<\/li>\n<\/ul>\n<p>\u201cDigoxin remains an effective and important medication for the right patients, but like many cardiac medications, it requires careful monitoring,\u201d Dr. Vadali says.<\/p>\n<h2 id=\"how-much-does-digoxin-cost\">How much does digoxin cost?<\/h2>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/digoxin\">Digoxin<\/a> is a relatively inexpensive generic, and the amount you pay depends on your dosage, insurance, and which pharmacy you use. The average price without insurance is about $75 for 30, 125 mcg tablets. A <a href=\"https:\/\/www.singlecare.com\/prescription-discount-card\">SingleCare coupon<\/a> can lower the self-pay price to as little as $9 for the same amount. <a href=\"https:\/\/www.singlecare.com\/prescription\/lanoxin\">Lanoxin<\/a>, the brand name version of digoxin, is a pricier alternative.<\/p>\n<p>The <a href=\"https:\/\/www.singlecare.com\/prescription-discount-card\">SingleCare discount card<\/a> is free. You can use it at participating pharmacies that include Walgreens, Kroger, Walmart, and CVS Pharmacy. Just search for your medication and dosage, select the pharmacy where you want to use, and click the coupon button. You can print the coupon, save it to your phone, or download the <a href=\"https:\/\/www.singlecare.com\/blog\/use-singlecare-app\/\">SingleCare app<\/a>. Then, show it to the pharmacist when you pick up your prescription. Always compare that cost with your insurance copay to decide whether to use insurance or the coupon to get the best deal.<\/p>\n<h2 id=\"expert-takeaway\">Expert takeaway<\/h2>\n<p>\u201cIn the past, digoxin was a commonly used medication for congestive heart failure and atrial fibrillation,\u201d recalls Chad Shaffer, MD, a member of the SingleCare Medical Board. \u201cBut, over the past 20 years, it has become a rarely used option thanks to the development of alternative medications and fears of digoxin toxicity.\u201d<\/p>\n<h2 id=\"frequently-asked-questions\">Frequently asked questions<\/h2>\n<h3 id=\"what-are-the-first-signs-of-digoxin-toxicity\">What are the first signs of digoxin toxicity?<\/h3>\n<p>Early symptoms of digoxin toxicity include nausea, vomiting, unusual tiredness or weakness, loss of appetite, and confusion. Changes to vision, like blurred vision or seeing spots, are another significant warning sign.<\/p>\n<h3 id=\"who-is-most-at-risk-for-digoxin-toxicity\">Who is most at risk for digoxin toxicity?<\/h3>\n<p>Older adults and people with reduced kidney function are at the highest risk of developing digoxin toxicity. People who have electrolyte imbalances, or those who are dehydrated, are also at an increased risk.<\/p>\n<h3 id=\"can-digoxin-toxicity-be-prevented\">Can digoxin toxicity be prevented?<\/h3>\n<p>Yes, you can help to prevent digoxin toxicity by taking the medication exactly as it\u2019s prescribed, keeping your healthcare provider and pharmacist updated on all changes to your medications and medical conditions, and avoiding any changes to the dosage without consulting a medical professional. Always report side effects to your provider immediately.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Digoxin (brand names Lanoxin and Digitek) is a cardiac glycoside medication extracted from the foxglove plant that treats heart failure and irregular heart rhythms like atrial fibrillation. The drug has a narrow therapeutic index, which means the difference between a working dose and a harmful dose is small. If you take too much, it can [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":637127,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[737,12752,8905],"coauthors":[21080],"class_list":["post-637213","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-heart-health","tag-medication-side-effects","tag-seasonal","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Digoxin toxicity: Signs, causes, and what to do<\/title>\n<meta name=\"description\" content=\"Digoxin toxicity can cause symptoms from mild nausea to serious heart problems. Learn the signs, causes, and treatments, plus how to lower your risk.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/digoxin-toxicity\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What is digoxin toxicity?\" \/>\n<meta property=\"og:description\" content=\"Signs to look out for\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.singlecare.com\/blog\/digoxin-toxicity\/\" \/>\n<meta property=\"og:site_name\" content=\"The Checkup\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/singlecare\" \/>\n<meta property=\"article:published_time\" content=\"2026-09-17T13:00:28+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2026\/08\/Blog_Digoxin-toxicity-copy.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"Kate Meier\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"What is digoxin toxicity?\" \/>\n<meta name=\"twitter:description\" content=\"Signs to look out for\" \/>\n<meta name=\"twitter:creator\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:site\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Kate Meier\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/digoxin-toxicity\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/digoxin-toxicity\\\/\"},\"author\":{\"name\":\"Heidi Borst\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/person\\\/fda93df2f5d09af0d250b59dfb4b46f2\"},\"headline\":\"What to know about digoxin toxicity\",\"datePublished\":\"2026-09-17T13:00:28+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/digoxin-toxicity\\\/\"},\"wordCount\":1453,\"publisher\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/digoxin-toxicity\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2026\\\/08\\\/Blog_Digoxin-toxicity-copy.webp\",\"keywords\":[\"Heart health\",\"Medication side effects\",\"Seasonal\"],\"articleSection\":[\"Drug Info\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/digoxin-toxicity\\\/\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/digoxin-toxicity\\\/\",\"name\":\"Digoxin toxicity: Signs, causes, and what to do\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/digoxin-toxicity\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/digoxin-toxicity\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2026\\\/08\\\/Blog_Digoxin-toxicity-copy.webp\",\"datePublished\":\"2026-09-17T13:00:28+00:00\",\"description\":\"Digoxin toxicity can cause symptoms from mild nausea to serious heart problems. 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