{"id":637310,"date":"2026-10-12T09:00:34","date_gmt":"2026-10-12T13:00:34","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=637310"},"modified":"2026-09-29T11:27:18","modified_gmt":"2026-09-29T15:27:18","slug":"auvelity-cost-without-insurance","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/auvelity-cost-without-insurance\/","title":{"rendered":"How much does Auvelity cost without insurance?"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/auvelity\">Auvelity<\/a> is a fast-acting antidepressant medication used to treat major depressive disorder (MDD) in adults and agitation in people with Alzheimer\u2019s disease. It contains a combination of two active ingredients: <a href=\"https:\/\/www.singlecare.com\/prescription\/dextromethorphan-hbr-monohyd\">dextromethorphan<\/a> and <a href=\"https:\/\/www.singlecare.com\/prescription\/bupropion-hcl?q=Bupropion%20Hcl&amp;isHomeSearch=false\">bupropion<\/a>.<\/p>\n<p>Because it\u2019s a relatively new drug,\u00a0 approved by the U.S. Food and Drug Administration (FDA) in 2022, Auvelity still has an extremely high retail price: about <a href=\"https:\/\/www.singlecare.com\/prescription\/auvelity\">$1,750 for a 30-day supply<\/a>. There\u2019s no generic for Auvelity yet, so if you need to take this medication and don\u2019t have insurance coverage, your approach to saving money is going to look different than it does for most other drugs. Here\u2019s what you can expect Auvelity to cost without insurance, why it\u2019s so expensive, and suggestions for lowering your out-of-pocket costs.<\/p>\n<h2 id=\"how-much-does-auvelity-cost-without-insurance\">How much does Auvelity cost without insurance?<\/h2>\n<p>Currently, the <a href=\"https:\/\/www.singlecare.com\/prescription\/auvelity#coupon-prices\">average retail price of Auvelity is $1,752<\/a> for 60 extended-release tablets containing 45 mg of dextromethorphan and 105 mg of bupropion. Adults on a <a href=\"https:\/\/www.dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=dcefda7c-9a68-278e-e053-2995a90aec79\">maintenance dose<\/a> of Auvelity typically take 2 tablets per day, so this is a standard 30-day supply for most people. However, keep in mind that the exact retail price will vary by pharmacy, so this is only an estimate.<\/p>\n<table class=\" singlecare-table\" role=\"table\">\n<thead>\n<tr>\n<th colspan=\"3\">\n<h3 id=\"auvelity-cost-without-insurance-approximate\" style=\"text-align: center;\">Auvelity cost without insurance (approximate<\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><b>Supply<\/b><\/td>\n<td><b>Retail price without insurance<\/b><\/td>\n<td><b>With SingleCare coupon<\/b><\/td>\n<\/tr>\n<tr>\n<td>60, 45 mg\/105 mg extended-release tablets (30-day supply)<\/td>\n<td>$1,752<\/td>\n<td>$1,173<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"why-is-auvelity-so-expensive\">Why is Auvelity so expensive?<\/h2>\n<p>Auvelity was approved by the FDA in 2022, so it\u2019s still fairly new to the market. That means it\u2019s <a href=\"https:\/\/www.fda.gov\/drugs\/development-approval-process-drugs\/frequently-asked-questions-patents-and-exclusivity#howlongpatentterm\">protected by patent and exclusivity rights<\/a> restricting other manufacturers from making a generic version.<\/p>\n<p>\u201cWhile Auvelity is \u2026 composed of two drugs that have been available as generics for years, this patented combination is not yet available as a generic,\u201d says <a href=\"https:\/\/www.linkedin.com\/in\/cooper-stone-a476b6373\/\">Cooper Stone, DO<\/a>, clinical assistant professor of psychiatry at the University of Pennsylvania. \u201cNew drugs that are not yet off patent always come at a premium.\u201d<\/p>\n<p>Auvelity is also the only oral rapid-acting antidepressant on the market, so it doesn\u2019t have to be priced competitively. What\u2019s more, its combination formula makes it particularly effective, with both drugs working together as a team, says <a href=\"https:\/\/www.drkrishnataneja.com\/\">Krishna Taneja<\/a>, MD, an integrative psychiatrist practicing in Indiana.<\/p>\n<p>Per Dr. Taneja:<\/p>\n<ul>\n<li>Dextromethorphan is the main active ingredient in Auvelity, relieving depression relatively quickly by increasing the amount of a neurotransmitter called glutamate in the brain. However, the liver breaks dextromethorphan down too quickly for it to maintain its therapeutic effect.<\/li>\n<li>Bupropion acts as a shield, stopping the body&#8217;s liver enzymes from destroying the dextromethorphan and allowing it to stay in the bloodstream at therapeutic levels. Meanwhile, bupropion also adds its own independent antidepressant benefits.<\/li>\n<\/ul>\n<p>This carefully engineered combination results in a fast-acting and effective medication without many of the typical antidepressant side effects like weight gain and sexual dysfunction, says Dr. Taneja. A drug like that, without any competition from generic versions, is going to be priced high.<\/p>\n<h2 id=\"how-to-lower-the-cost-of-auvelity\">How to lower the cost of Auvelity<\/h2>\n<p>There are a few ways to save money on Auvelity with or without insurance, but the exact methods change based on your coverage. The only option that works regardless of your insurance status is the SingleCare prescription discount coupon.<\/p>\n<h3 id=\"use-a-singlecare-prescription-discount-coupon\">Use a SingleCare prescription discount coupon<\/h3>\n<p>If you use a free <a href=\"https:\/\/www.singlecare.com\/prescription-discount-card\">SingleCare prescription discount card<\/a>, you may be able to save more than $600 on your prescription. At participating pharmacies, your cash price could drop from $1,752 for a 30-day supply to around $1,173. However, you can\u2019t use a SingleCare coupon and any type of insurance coverage at the same time. You\u2019ll need to choose one or the other. You can compare pharmacy prices for Auvelity <a href=\"https:\/\/www.singlecare.com\/prescription\/auvelity\">here<\/a> to find the lowest cost in your area.<\/p>\n\t\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t\t<p id=\"headline\">Save up to 80% on Auvelity with SingleCare<\/p>\n\t\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t\t<div class=\"details-wrap\">\n\t\t\t\t\t<div class=\"details\">\n\t\t\t\t\t\tAuvelity 45-105 mg (60 extended release tablet)\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"address\">\n\t\t\t\t\t\t23666 - Hampton, VA\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$1173.37<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/auvelity#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/auvelity#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-harristeeter.svg\" alt=\"Harris Teeter Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$1173.37<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/auvelity#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/auvelity#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/auvelity#blog-cta\" class=\"coupon-see-all-btn\">See Auvelity prices at all pharmacies<\/a>\n\t\t\t<\/div>\n\t\t\n<h3 id=\"axsome-s-auvelity-savings-card\">Axsome&#8217;s Auvelity savings card<\/h3>\n<p>If you have private or commercial insurance, you may be eligible for an Auvelity savings card through the Auvelity OnMySide program. The card can help you pay as little as a $10 copay per prescription fill, including supplies up to 90 days. But the Auvelity savings card is only for people with commercial insurance that covers some of the cost of the drug, and it can\u2019t be used if you have Medicare or Medicaid (or no insurance coverage at all).<\/p>\n<h3 id=\"axsome-patient-assistance-program\">Axsome patient assistance program<\/h3>\n<p>The manufacturer of Auvelity, Axsome Therapeutics, runs a <a href=\"https:\/\/www.singlecare.com\/blog\/patient-assistance-programs\/\">patient assistance program<\/a> to make the drug accessible to uninsured people. If you are a U.S. resident who meets the income eligibility requirements, you may be able to receive free or reduced-cost Auvelity. You will need to submit an application that includes proof of income.<\/p>\n<h2 id=\"are-there-cheaper-alternatives-to-auvelity\">Are there cheaper alternatives to Auvelity?<\/h2>\n<p>Even though you can\u2019t save money on Auvelity by opting for a generic over the brand name, there may be other alternatives available that are cheaper. Several medications, including <a href=\"https:\/\/www.singlecare.com\/drug-classes\/atypical-antidepressants\">atypical antidepressants<\/a> like <a href=\"https:\/\/www.singlecare.com\/prescription\/trintellix\">Trintellix (vortioxetine)<\/a>, <a href=\"https:\/\/www.singlecare.com\/drug-classes\/ssris\">selective serotonin reuptake inhibitors (SSRIs)<\/a> like <a href=\"https:\/\/www.singlecare.com\/prescription\/fluoxetine-hcl#coupons\">Prozac (fluoxetine)<\/a>, and <a href=\"https:\/\/www.singlecare.com\/drug-classes\/snris\">serotonin-norepinephrine reuptake inhibitors (SNRIs)<\/a> like <a href=\"https:\/\/www.singlecare.com\/prescription\/effexor-xr?q=Effexor%20Xr%20(Venlafaxine%20HCl%20ER)&amp;isHomeSearch=false\">Effexor XR (venlafaxine)<\/a>, are approved for use in treating MDD. Many of these drugs are available as cost-saving generics.<\/p>\n<p>Finding a cheaper alternative to Auvelity for agitation associated with Alzheimer\u2019s is more challenging. According to Dr. Stone, very few other drugs are approved for this use, and the most common one, <a href=\"https:\/\/www.singlecare.com\/prescription\/rexulti?q=Rexulti&amp;isHomeSearch=false\">Rexulti (brexpiprazole)<\/a>, is also expensive.<\/p>\n<p>For some people, generic bupropion on its own, without the dextromethorphan component, may be an option for treating symptoms, but it\u2019s <i>not<\/i> a substitute for Auvelity, says <a href=\"https:\/\/drgailsaltz.com\/\">Gail Saltz<\/a>, MD, associate professor of psychiatry at the NY Presbyterian Hospital Weill-Cornell School of Medicine and host of the <i>How Can I Help?<\/i> podcast.<\/p>\n<p>\u201cGeneric bupropion is used to treat MDD, but it has its own mechanism of action and, according to studies, it has a slower mechanism of action when taken alone,\u201d says Dr. Saltz.<\/p>\n<p>In addition to working differently and more slowly, bupropion may not be quite as effective when used alone. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35582785\/\">Clinical trial data<\/a> has shown that the combined formulation is superior to bupropion by itself, says Dr. Taneja, resulting in significantly greater symptom improvement, a faster onset of action, and a much higher week-six remission rate.<\/p>\n<p>But what about taking generic bupropion and generic dextromethorphan individually\u2014can that serve as a workaround to paying for brand-name Auvelity? Possibly, says Dr. Stone, and it would certainly save you money. However, Dr. Taneja says this isn\u2019t the easy fix it seems to be: \u201cAuvelity contains a specific patented extended-release ratio [of dextromethorphan and bupropion] to ensure the dextromethorphan levels remain at therapeutic levels in the brain.\u201d<\/p>\n<p>In other words, there\u2019s no direct substitute for Auvelity for people with MDD, though there are alternative <a href=\"https:\/\/www.singlecare.com\/conditions\/depression-treatment-and-medications\">depression medications<\/a> that could still help to alleviate your symptoms. It\u2019s important to always discuss these other options with your healthcare provider; never make medication swaps or changes on your own. Your provider knows your full medical history and is the best person to advise you on appropriate treatments.<\/p>\n<h2 id=\"expert-takeaway\">Expert takeaway<\/h2>\n<p>\u201cAuvelity has not been compared in head-to-head trials to first-line, inexpensive SSRIs and SNRIs for depression,\u201d cautions Chad Shaffer, MD, a member of the SingleCare Medical Board, \u201cbut its claim to act more rapidly, while also avoiding some common side effects, could make it appealing in some circumstances despite a higher cost.\u201d<\/p>\n<h2 id=\"frequently-asked-questions\">Frequently asked questions<\/h2>\n<h3 id=\"is-there-a-generic-version-of-auvelity\">Is there a generic version of Auvelity?<\/h3>\n<p>No. Auvelity was approved by the FDA in 2022 and is still protected by patent and exclusivity rights. There is no generic version of its unique combination of drugs.<\/p>\n<h3 id=\"does-medicare-cover-auvelity\">Does Medicare cover Auvelity?<\/h3>\n<p>Yes, Auvelity is typically covered by Medicare Part D plans, though some may require prior authorizations. It\u2019s important to check the details of your specific plan before filling your prescription.<\/p>\n<h3 id=\"can-you-use-a-singlecare-coupon-and-the-auvelity-savings-card-at-the-same-time\">Can you use a SingleCare coupon and the Auvelity savings card at the same time?<\/h3>\n<p>No. You need to pick either the SingleCare coupon or the Auvelity savings card.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Auvelity is a fast-acting antidepressant medication used to treat major depressive disorder (MDD) in adults and agitation in people with Alzheimer\u2019s disease. It contains a combination of two active ingredients: dextromethorphan and bupropion. Because it\u2019s a relatively new drug,\u00a0 approved by the U.S. Food and Drug Administration (FDA) in 2022, Auvelity still has an extremely [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":637138,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[451,450,4350,8905],"coauthors":[8860],"class_list":["post-637310","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-depression","tag-mental-health","tag-prescription-savings","tag-seasonal","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.6 (Yoast SEO v28.6) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Auvelity cost without insurance: What you&#039;ll pay &amp; how to save<\/title>\n<meta name=\"description\" content=\"Auvelity costs about $1,750 a month without insurance. 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