{"id":6843,"date":"2019-11-08T16:51:08","date_gmt":"2019-11-08T21:51:08","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=6843"},"modified":"2026-01-28T13:39:14","modified_gmt":"2026-01-28T18:39:14","slug":"tamiflu-vs-xofluza","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/tamiflu-vs-xofluza\/","title":{"rendered":"Tamiflu vs. Xofluza: Differences, similarities, and which one is better for you"},"content":{"rendered":"<p><iframe loading=\"lazy\" title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/T_OVyM7YLgo?rel=0\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p><span style=\"font-weight: 400;\">When flu season hits, it can help to know you have potential treatment options. Along with the protection of the <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/flu-shot-101\/\"><span style=\"font-weight: 400;\">yearly flu shot<\/span><\/a><span style=\"font-weight: 400;\">, prescription medicines like Tamiflu and Xofluza can lessen symptoms and may shorten how long the illness lasts. Both <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antivirals\"><span style=\"font-weight: 400;\">antiviral medications<\/span><\/a><span style=\"font-weight: 400;\"> are approved by the U.S. Food and Drug Administration (FDA), but they differ in how they work, how they\u2019re taken, and how much they cost.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Let\u2019s compare Tamiflu vs. Xofluza so you can make an informed choice if you come down with the flu.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th colspan=\"3\">\n<h2 id=\"main-differences-between-tamiflu-vs-xofluza\"><span style=\"font-weight: 400;\">Main differences between Tamiflu vs. Xofluza<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td><span style=\"font-weight: 400;\">Tamiflu<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Xofluza<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Drug class<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Antiviral<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Neuraminidase inhibitor<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Antiviral<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Polymerase acidic (PA) endonuclease inhibitor<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Brand\/generic status<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Generic version available<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Generic version not currently available<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">What is the generic name?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Oseltamivir phosphate<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Baloxavir marboxil<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">What form(s) does the drug come in?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Oral capsule<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Powder for oral suspension<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Oral tablet<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Oral suspension bottle<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Packet for oral suspension<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">What is the standard dosage?<\/span><\/td>\n<td><b>Treatment of influenza:<\/b><\/p>\n<p><span style=\"font-weight: 400;\">13 years or older: 75 mg twice daily for 5 days<\/span><\/p>\n<p><span style=\"font-weight: 400;\">1 to 12 years old: Dosage depends on weight, twice daily for 5 days<\/span><\/p>\n<p><span style=\"font-weight: 400;\">2 weeks to less than 1 year old: 3 mg\/kg twice daily for 5 days<\/span><\/p>\n<p><b>Prevention of influenza:<\/b><\/p>\n<p><span style=\"font-weight: 400;\">13 years and older: 75 mg once daily for at least 10 days<\/span><\/p>\n<p><span style=\"font-weight: 400;\">1 to 12 years old: Dosage depends on weight, once daily for 10 days<\/span><\/td>\n<td><b>Treatment or prevention of influenza:<\/b><\/p>\n<p><span style=\"font-weight: 400;\">5 years and older with a body weight of at least 80 kg (176 lbs or more): 80 mg taken as a single dose<\/span><\/p>\n<p><span style=\"font-weight: 400;\">5 years and older with a body weight of 20 to less than 80 kg (44 to 176 lbs): 40 mg taken as a single dose<\/span><\/p>\n<p><span style=\"font-weight: 400;\">5 years and older with a body weight of less than 20 kg (44 lbs): 2 mg\/kg as a single dose (oral suspension only)<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">How long is the typical treatment?<\/span><\/td>\n<td><b>Treatment of influenza:<\/b><span style=\"font-weight: 400;\"> 5 days<\/span><\/p>\n<p><b>Prevention of influenza:<\/b><span style=\"font-weight: 400;\"> 10 days<\/span><\/p>\n<p><span style=\"font-weight: 400;\">*Preventive treatment during a community outbreak may last up to 6 weeks<\/span><\/td>\n<td><b>Treatment or prevention of influenza:<\/b><span style=\"font-weight: 400;\"> 1 day with a single dose<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Who typically uses the medication?<\/span><\/td>\n<td><b>Treatment of influenza:<\/b><span style=\"font-weight: 400;\"> Adults, children, and infants 2 weeks of age and older<\/span><\/p>\n<p><b>Prevention of influenza:<\/b><span style=\"font-weight: 400;\"> Adults and children 1 year of age and older<\/span><\/td>\n<td><b>Treatment and prevention of influenza:<\/b><span style=\"font-weight: 400;\"> Adults and children 5 years of age and older<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"what-are-the-main-differences-between-tamiflu-vs-xofluza\"><b>What are the main differences between Tamiflu vs. Xofluza?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Tamiflu<\/span><span style=\"font-weight: 400;\"> is the brand name for oseltamivir, first <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2019\/021087s071,021246s054lbl.pdf\"><span style=\"font-weight: 400;\">FDA-approved in 1999<\/span><\/a><span style=\"font-weight: 400;\">. It\u2019s a neuraminidase inhibitor (NAI) that blocks the release of the influenza virus from infected cells, limiting its spread in the body. For treatment, it\u2019s usually taken <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/tamiflu\/dosage\"><span style=\"font-weight: 400;\">twice daily for five days<\/span><\/a><span style=\"font-weight: 400;\">, while for post-exposure prevention, it\u2019s typically taken once daily for at least 10 days. Dosing is weight-based in children and often needs to be adjusted in people with kidney problems.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Xofluza is the brand name for baloxavir marboxil, which was <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2025\/210854s023,214410s008lbl.pdf\"><span style=\"font-weight: 400;\">approved in 2018<\/span><\/a><span style=\"font-weight: 400;\">. It works as a polymerase acidic (PA) endonuclease inhibitor that stops the flu virus from making copies of itself in a process known as viral replication. In this way, Xofluza works differently from other antiviral drugs like Tamiflu (oseltamivir) and Relenza (zanamivir). The drug only needs to be taken once as a single oral dose to treat or prevent the flu.<\/span><\/p>\n<h2 id=\"conditions-treated-by-tamiflu-and-xofluza\"><b>Conditions treated by Tamiflu and Xofluza<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Both Tamiflu and Xofluza were developed as antiviral treatments for <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/what-is-the-flu\/\"><span style=\"font-weight: 400;\">influenza<\/span><\/a><span style=\"font-weight: 400;\">. They are most effective when given at the first sign of symptoms and within 48 hours after symptoms appear. However, Tamiflu may also be recommended in certain hospitalized patients <\/span><a href=\"https:\/\/www.cdc.gov\/flu\/hcp\/antivirals\/summary-clinicians.html\"><span style=\"font-weight: 400;\">even after 48 hours<\/span><\/a><span style=\"font-weight: 400;\">. Xofluza isn\u2019t currently recommended for severe cases during hospitalization.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Tamiflu and Xofluza can also be used to help <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/cold-vs-flu\/\"><span style=\"font-weight: 400;\">prevent the flu<\/span><\/a><span style=\"font-weight: 400;\"> (prophylaxis) in those in close contact with an infected individual. People with a higher risk of flu complications include those living in an area with a viral outbreak or those with a compromised immune system because of underlying medical conditions.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">As <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/flu-medicine\/\"><span style=\"font-weight: 400;\">antiviral treatments<\/span><\/a><span style=\"font-weight: 400;\">, Tamiflu and Xofluza are ineffective against fungal, parasitic, or bacterial infections.\u00a0<\/span><\/p>\n<h2 id=\"is-tamiflu-or-xofluza-more-effective\"><b>Is Tamiflu or Xofluza more effective?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Tamiflu and Xofluza help people recover from the flu faster than a placebo or no treatment. In clinical trials, Xofluza generally worked slightly quicker than Tamiflu.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">In one study (<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30184455\/\"><span style=\"font-weight: 400;\">CAPSTONE-1<\/span><\/a><span style=\"font-weight: 400;\">), Xofluza shortened flu symptoms to around 54 hours, while Tamiflu worked in a similar timeframe. However, Xofluza reduced viral load (how much virus is in the body) more quickly than either placebo or Tamiflu.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">In another study with high-risk patients (<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32526195\/\"><span style=\"font-weight: 400;\">CAPSTONE-2<\/span><\/a><span style=\"font-weight: 400;\">), Xofluza improved symptoms in about 73 hours versus 81 hours with Tamiflu. This difference was not statistically significant, and the study concluded that both drugs were similarly effective in shortening the time to improved symptoms.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Other <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39804622\/\"><span style=\"font-weight: 400;\">systematic reviews<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37866622\/\"><span style=\"font-weight: 400;\">meta-analyses<\/span><\/a><span style=\"font-weight: 400;\"> suggest that Xofluza also caused fewer side effects and shortened flu symptoms more quickly than Tamiflu.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Tamiflu and Xofluza work about the same against the flu in real-world settings. The main differences are in how they\u2019re taken and other factors like cost and availability.<\/span><\/p>\n<h2 id=\"coverage-and-cost-comparison-of-tamiflu-vs-xofluza\"><b>Coverage and cost comparison of Tamiflu vs. Xofluza<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Tamiflu is typically more affordable, especially in its generic form. Xofluza is only available as a brand-name drug, which may be more expensive.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th colspan=\"3\">\n<h2 id=\"tamiflu-vs-xofluza-cost\"><span style=\"font-weight: 400;\">Tamiflu vs. Xofluza cost<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><span style=\"font-weight: 400;\">\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Tamiflu<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Xofluza<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Typically covered by insurance?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes, depending on the plan<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes, depending on the plan<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Typically covered by Medicare?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes, depending on the plan<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes, depending on the plan<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Quantity<\/span><\/td>\n<td><span style=\"font-weight: 400;\">10, 75 mg capsules<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1, 40 mg tablet<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Typical Medicare copay<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Varies<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Varies<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">SingleCare cost<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/tamiflu\"><span style=\"font-weight: 400;\">$18<\/span><span style=\"font-weight: 400;\"> at Kroger<\/span><\/a><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/xofluza\"><span style=\"font-weight: 400;\">$167<\/span><span style=\"font-weight: 400;\"> at Kroger<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&lt;small&gt;Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of October 24, 2025. The listed SingleCare price references the price of generic drugs if available.&lt;\/small&gt;<\/p>\n<h2 id=\"common-side-effects-of-tamiflu-vs-xofluza\"><b>Common side effects of Tamiflu vs. Xofluza<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Tamiflu and Xofluza can cause many of the same possible side effects, such as nausea and headache. However, the likelihood of each side effect can vary between the two medications.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The most common <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/tamiflu-side-effects\/\"><span style=\"font-weight: 400;\">side effects of Tamiflu<\/span><\/a><span style=\"font-weight: 400;\"> include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach pain (more often when used for prevention)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">The most common side effects of Xofluza include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sinusitis (inflammation of the sinuses)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bronchitis (inflammation of the lung airways)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<\/ul>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Tamiflu is generally more likely than Xofluza to cause nausea and vomiting. Both drugs can also lead to more serious side effects in rare cases, including severe skin reactions and allergic reactions.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There have also been reports of psychiatric events such as delirium, hallucinations, and abnormal behavior in those taking Tamiflu. These <\/span><a href=\"https:\/\/www.fda.gov\/drugs\/postmarket-drug-safety-information-patients-and-providers\/tamiflu-pediatric-adverse-events-questions-and-answers\"><span style=\"font-weight: 400;\">psychiatric events<\/span><\/a><span style=\"font-weight: 400;\"> have mostly been reported in children from Japan.<\/span><\/p>\n<h2 id=\"drug-interactions-of-tamiflu-and-xofluza\"><b>Drug interactions of Tamiflu and Xofluza<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Tamiflu and Xofluza can interfere with the live attenuated <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/how-to-prevent-the-flu\/\"><span style=\"font-weight: 400;\">flu vaccine<\/span><\/a><span style=\"font-weight: 400;\"> (nasal spray). Therefore, it is recommended that you avoid live flu vaccines for at least two weeks before or two days after taking one of these antivirals.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Xofluza can interact with certain supplements and foods. Minerals like calcium, iron, magnesium, and zinc, as well as dairy products, can decrease the medicine&#8217;s effectiveness. Avoid taking Xofluza with medications that contain these minerals, including certain over-the-counter <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/best-heartburn-medicine\/\"><span style=\"font-weight: 400;\">antacids<\/span><\/a><span style=\"font-weight: 400;\"> and laxatives.<\/span><\/p>\n<h2 id=\"warnings-of-tamiflu-and-xofluza\"><b>Warnings of Tamiflu and Xofluza<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Tamiflu should be used with caution in people who have kidney problems since the drug can build up in the body, leading to an increased risk of side effects. Both Tamiflu and Xofluza can cause serious allergic reactions, including severe skin reactions. If a rash or other allergic symptoms appear, stop the medication and get medical help right away.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Tamiflu has also been linked to rare <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11560017\/\"><span style=\"font-weight: 400;\">mental health side effects<\/span><\/a><span style=\"font-weight: 400;\">, such as confusion, hallucinations, or unusual behavior, mostly in children and adolescents. Xofluza isn\u2019t recommended for children under 5 because resistance to the drug can develop more easily in this age group.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There is limited data on the use of Xofluza during pregnancy. Tamiflu is generally the <\/span><a href=\"https:\/\/www.acog.org\/clinical\/clinical-guidance\/committee-statement\/articles\/2024\/02\/influenza-in-pregnancy-prevention-and-treatment\"><span style=\"font-weight: 400;\">preferred option<\/span><\/a><span style=\"font-weight: 400;\"> in pregnant women. Consult a healthcare provider for treatment options while pregnant or breastfeeding.\u00a0<\/span><\/p>\n<h2 id=\"frequently-asked-questions-about-tamiflu-vs-xofluza\"><b>Frequently asked questions about Tamiflu vs Xofluza<\/b><\/h2>\n<h3 id=\"are-tamiflu-and-xofluza-the-same\"><span style=\"font-weight: 400;\">Are Tamiflu and Xofluza the same?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Tamiflu and Xofluza are both antiviral medications. But they are not the same. Although they both improve flu symptoms, they work differently and may have different costs or side effects.<\/span><\/p>\n<h3 id=\"is-tamiflu-or-xofluza-better\"><span style=\"font-weight: 400;\">Is Tamiflu or Xofluza better?\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Tamiflu and Xofluza are both effective against the influenza virus. Xofluza is a newer drug that may help improve flu symptoms faster than Tamiflu, although studies show their overall effectiveness is similar. Xofluza only needs to be taken as a single dose, which some people may prefer. Consult healthcare provider for medical advice and more information on the best treatment.<\/span><\/p>\n<h3 id=\"who-can-use-tamiflu-and-xofluza\"><span style=\"font-weight: 400;\">Who can use Tamiflu and Xofluza?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Tamiflu and Xofluza treat uncomplicated influenza in adult and pediatric patients. Tamiflu is approved to treat the flu in adults and children aged 2 weeks and older and prevent the flu in adults and children 1 year and older. Xofluza is approved to treat or prevent the flu in adults and children 5 years and older. Both medications are generally safe in older adults 65 years and older.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Can you take Xofluza with Tamiflu?<\/span><\/p>\n<p><span style=\"font-weight: 400;\">No. It is not recommended to take Xofluza and Tamiflu together. These drugs are prescribed as separate, individual options for the flu. One drug may be preferred depending on your medical history and overall condition.<\/span><\/p>\n<h2 id=\"bottom-line\"><b>Bottom line<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Both Tamiflu and Xofluza are effective flu treatments. Xofluza may work faster and more conveniently, but it\u2019s often more expensive than Tamiflu. Tamiflu is widely available in generic form and has a longer safety record.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Talk to your healthcare provider about which flu treatment is right for you. And don\u2019t forget\u2014you can save on both medications with the<\/span><a href=\"https:\/\/www.singlecare.com\/prescription-discount-card\"> <span style=\"font-weight: 400;\">SingleCare prescription discount card<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>When flu season hits, it can help to know you have potential treatment options. Along with the protection of the yearly flu shot, prescription medicines like Tamiflu and Xofluza can lessen symptoms and may shorten how long the illness lasts. Both antiviral medications are approved by the U.S. Food and Drug Administration (FDA), but they [&hellip;]<\/p>\n","protected":false},"author":87,"featured_media":9120,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8313],"tags":[11169,20954],"coauthors":[8669],"class_list":["post-6843","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-vs-drug","tag-cold-flu","tag-infections","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Tamiflu vs. Xofluza: Which is better for the flu? | SingleCare<\/title>\n<meta name=\"description\" content=\"Tamiflu and Xofluza are antiviral drugs that treat the flu, but they work in different ways. Compare these medications to find out which one is better.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/tamiflu-vs-xofluza\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tamiflu vs. Xofluza: Which is better?\" \/>\n<meta property=\"og:description\" content=\"We compare the drugs that can help you get over the flu faster\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.singlecare.com\/blog\/tamiflu-vs-xofluza\/\" \/>\n<meta property=\"og:site_name\" content=\"The Checkup\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/singlecare\" \/>\n<meta property=\"article:published_time\" content=\"2019-11-08T21:51:08+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-01-28T18:39:14+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2019\/11\/Tamiflu-vs.-Xofluza.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Gerardo Sison, Pharm.D.\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"Tamiflu vs. Xofluza: Which is better?\" \/>\n<meta name=\"twitter:description\" content=\"We compare the drugs that can help you get over the flu faster\" \/>\n<meta name=\"twitter:creator\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:site\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Gerardo Sison, Pharm.D.\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"8 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/tamiflu-vs-xofluza\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/tamiflu-vs-xofluza\\\/\"},\"author\":{\"name\":\"Kelsey Roadruck\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/person\\\/166518d9621e8b3bf1a33e7fdaa6dd41\"},\"headline\":\"Tamiflu vs. Xofluza: Differences, similarities, and which one is better for you\",\"datePublished\":\"2019-11-08T21:51:08+00:00\",\"dateModified\":\"2026-01-28T18:39:14+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/tamiflu-vs-xofluza\\\/\"},\"wordCount\":1580,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/tamiflu-vs-xofluza\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2019\\\/11\\\/Tamiflu-vs.-Xofluza.png\",\"keywords\":[\"Cold &amp; Flu\",\"Infections\"],\"articleSection\":[\"Drug vs. Drug\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/tamiflu-vs-xofluza\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/tamiflu-vs-xofluza\\\/\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/tamiflu-vs-xofluza\\\/\",\"name\":\"Tamiflu vs. Xofluza: Which is better for the flu? | SingleCare\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/tamiflu-vs-xofluza\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/tamiflu-vs-xofluza\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2019\\\/11\\\/Tamiflu-vs.-Xofluza.png\",\"datePublished\":\"2019-11-08T21:51:08+00:00\",\"dateModified\":\"2026-01-28T18:39:14+00:00\",\"description\":\"Tamiflu and Xofluza are antiviral drugs that treat the flu, but they work in different ways. Compare these medications to find out which one is better.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/tamiflu-vs-xofluza\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/tamiflu-vs-xofluza\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/tamiflu-vs-xofluza\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2019\\\/11\\\/Tamiflu-vs.-Xofluza.png\",\"contentUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2019\\\/11\\\/Tamiflu-vs.-Xofluza.png\",\"width\":1920,\"height\":1080,\"caption\":\"Two Rx tablets: Tamiflu vs Xofluza\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/tamiflu-vs-xofluza\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Tamiflu vs. Xofluza: Differences, similarities, and which one is better for you\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#website\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\",\"name\":\"The Checkup, a health blog by SingleCare\",\"description\":\"Read the latest in prescription, wellness, and healthcare news\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\",\"name\":\"SingleCare\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2020\\\/01\\\/placeholderimage-1.jpg\",\"contentUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2020\\\/01\\\/placeholderimage-1.jpg\",\"width\":1200,\"height\":630,\"caption\":\"SingleCare\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/singlecare\",\"https:\\\/\\\/x.com\\\/SingleCare\",\"https:\\\/\\\/www.instagram.com\\\/singlecare\\\/?hl=en\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/singlecare\\\/\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UCd9kiPIjCQw95-2BHCYePKA\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/person\\\/166518d9621e8b3bf1a33e7fdaa6dd41\",\"name\":\"Kelsey Roadruck\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/3eced7f55b3640b64c71505486a60aa3456c3e45c971a6a5d5029ed3ac503e1a?s=96&d=mm&r=gb043a7d006bca3f118bc1c78fd0601df\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/3eced7f55b3640b64c71505486a60aa3456c3e45c971a6a5d5029ed3ac503e1a?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/3eced7f55b3640b64c71505486a60aa3456c3e45c971a6a5d5029ed3ac503e1a?s=96&d=mm&r=g\",\"caption\":\"Kelsey Roadruck\"},\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/author\\\/kroadruck\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Tamiflu vs. Xofluza: Which is better for the flu? | SingleCare","description":"Tamiflu and Xofluza are antiviral drugs that treat the flu, but they work in different ways. Compare these medications to find out which one is better.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.singlecare.com\/blog\/tamiflu-vs-xofluza\/","og_locale":"en_US","og_type":"article","og_title":"Tamiflu vs. Xofluza: Which is better?","og_description":"We compare the drugs that can help you get over the flu faster","og_url":"https:\/\/www.singlecare.com\/blog\/tamiflu-vs-xofluza\/","og_site_name":"The Checkup","article_publisher":"https:\/\/www.facebook.com\/singlecare","article_published_time":"2019-11-08T21:51:08+00:00","article_modified_time":"2026-01-28T18:39:14+00:00","og_image":[{"width":1920,"height":1080,"url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2019\/11\/Tamiflu-vs.-Xofluza.png","type":"image\/png"}],"author":"Gerardo Sison, Pharm.D.","twitter_card":"summary_large_image","twitter_title":"Tamiflu vs. Xofluza: Which is better?","twitter_description":"We compare the drugs that can help you get over the flu faster","twitter_creator":"@SingleCare","twitter_site":"@SingleCare","twitter_misc":{"Written by":"Gerardo Sison, Pharm.D.","Est. reading time":"8 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.singlecare.com\/blog\/tamiflu-vs-xofluza\/#article","isPartOf":{"@id":"https:\/\/www.singlecare.com\/blog\/tamiflu-vs-xofluza\/"},"author":{"name":"Kelsey Roadruck","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/person\/166518d9621e8b3bf1a33e7fdaa6dd41"},"headline":"Tamiflu vs. Xofluza: Differences, similarities, and which one is better for you","datePublished":"2019-11-08T21:51:08+00:00","dateModified":"2026-01-28T18:39:14+00:00","mainEntityOfPage":{"@id":"https:\/\/www.singlecare.com\/blog\/tamiflu-vs-xofluza\/"},"wordCount":1580,"commentCount":0,"publisher":{"@id":"https:\/\/www.singlecare.com\/blog\/#organization"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/tamiflu-vs-xofluza\/#primaryimage"},"thumbnailUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2019\/11\/Tamiflu-vs.-Xofluza.png","keywords":["Cold &amp; Flu","Infections"],"articleSection":["Drug vs. Drug"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.singlecare.com\/blog\/tamiflu-vs-xofluza\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.singlecare.com\/blog\/tamiflu-vs-xofluza\/","url":"https:\/\/www.singlecare.com\/blog\/tamiflu-vs-xofluza\/","name":"Tamiflu vs. Xofluza: Which is better for the flu? | SingleCare","isPartOf":{"@id":"https:\/\/www.singlecare.com\/blog\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.singlecare.com\/blog\/tamiflu-vs-xofluza\/#primaryimage"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/tamiflu-vs-xofluza\/#primaryimage"},"thumbnailUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2019\/11\/Tamiflu-vs.-Xofluza.png","datePublished":"2019-11-08T21:51:08+00:00","dateModified":"2026-01-28T18:39:14+00:00","description":"Tamiflu and Xofluza are antiviral drugs that treat the flu, but they work in different ways. Compare these medications to find out which one is better.","breadcrumb":{"@id":"https:\/\/www.singlecare.com\/blog\/tamiflu-vs-xofluza\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.singlecare.com\/blog\/tamiflu-vs-xofluza\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.singlecare.com\/blog\/tamiflu-vs-xofluza\/#primaryimage","url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2019\/11\/Tamiflu-vs.-Xofluza.png","contentUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2019\/11\/Tamiflu-vs.-Xofluza.png","width":1920,"height":1080,"caption":"Two Rx tablets: Tamiflu vs Xofluza"},{"@type":"BreadcrumbList","@id":"https:\/\/www.singlecare.com\/blog\/tamiflu-vs-xofluza\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.singlecare.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Tamiflu vs. Xofluza: Differences, similarities, and which one is better for you"}]},{"@type":"WebSite","@id":"https:\/\/www.singlecare.com\/blog\/#website","url":"https:\/\/www.singlecare.com\/blog\/","name":"The Checkup, a health blog by SingleCare","description":"Read the latest in prescription, wellness, and healthcare news","publisher":{"@id":"https:\/\/www.singlecare.com\/blog\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.singlecare.com\/blog\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.singlecare.com\/blog\/#organization","name":"SingleCare","url":"https:\/\/www.singlecare.com\/blog\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/logo\/image\/","url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2020\/01\/placeholderimage-1.jpg","contentUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2020\/01\/placeholderimage-1.jpg","width":1200,"height":630,"caption":"SingleCare"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/singlecare","https:\/\/x.com\/SingleCare","https:\/\/www.instagram.com\/singlecare\/?hl=en","https:\/\/www.linkedin.com\/company\/singlecare\/","https:\/\/www.youtube.com\/channel\/UCd9kiPIjCQw95-2BHCYePKA"]},{"@type":"Person","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/person\/166518d9621e8b3bf1a33e7fdaa6dd41","name":"Kelsey Roadruck","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/3eced7f55b3640b64c71505486a60aa3456c3e45c971a6a5d5029ed3ac503e1a?s=96&d=mm&r=gb043a7d006bca3f118bc1c78fd0601df","url":"https:\/\/secure.gravatar.com\/avatar\/3eced7f55b3640b64c71505486a60aa3456c3e45c971a6a5d5029ed3ac503e1a?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/3eced7f55b3640b64c71505486a60aa3456c3e45c971a6a5d5029ed3ac503e1a?s=96&d=mm&r=g","caption":"Kelsey Roadruck"},"url":"https:\/\/www.singlecare.com\/blog\/author\/kroadruck\/"}]}},"_links":{"self":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts\/6843","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/users\/87"}],"replies":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/comments?post=6843"}],"version-history":[{"count":0,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts\/6843\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/media\/9120"}],"wp:attachment":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/media?parent=6843"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/categories?post=6843"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/tags?post=6843"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/coauthors?post=6843"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}