{"id":7954,"date":"2020-01-10T13:00:44","date_gmt":"2020-01-10T18:00:44","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=7954"},"modified":"2025-06-30T18:50:47","modified_gmt":"2025-06-30T22:50:47","slug":"non-drowsy-benadryl","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/non-drowsy-benadryl\/","title":{"rendered":"What are non-drowsy Benadryl options?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Antihistamines, like Benadryl, are one of the best treatments when it comes to alleviating the symptoms of <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/allergy-treatment-and-medications\/\"><span style=\"font-weight: 400;\">allergies<\/span><\/a><span style=\"font-weight: 400;\"> and colds. However, sometimes the side effect of drowsiness can be just as bad as the symptoms they are treating. Drowsiness from antihistamines can cause reduced coordination and reaction speed, making driving and operating machinery more dangerous. Due to the severity of drowsiness, some people take Benadryl as a sleep aid, which may lead to <\/span><span style=\"font-weight: 400;\">sleepwalking<\/span><span style=\"font-weight: 400;\">. Antihistamines that cause drowsiness can <\/span><span style=\"font-weight: 400;\">increase the risk of falls<\/span><span style=\"font-weight: 400;\"> for people over the age of 65. Luckily for those wanting to avoid drowsiness, there are a variety of non-drowsy alternatives.\u00a0<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Benadryl with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tBenadryl 1 bottle (100 Tablets)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23663 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-food-lion.svg\" alt=\"Food Lion\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$9.16<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/benadryl-allergy#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/benadryl-allergy#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$9.94<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/benadryl-allergy#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/benadryl-allergy#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/benadryl-allergy#blog-cta\" class=\"coupon-see-all-btn\">See Benadryl prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"what-are-antihistamines\"><span style=\"font-weight: 400;\">What are antihistamines?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Allergies happen when allergens\u2014such as pollen, pet dander, peanuts, mosquito bites, or ragweed\u2014trigger chemicals in the body called histamines. When produced, histamines cause an allergic reaction with symptoms including stuffy nose; hives and skin rashes; or itchiness of the throat, eyes, or nose.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Antihistamines are medicines that are typically cheap and available over the counter. They reduce or block the histamines, preventing allergic reaction symptoms. Antihistamines help reduce allergy symptoms caused by environmental, seasonal, or <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/food-allergies-at-school\/\"><span style=\"font-weight: 400;\">food allergies<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<h3 id=\"first-generation-antihistamines\"><span style=\"font-weight: 400;\">First-generation antihistamines<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">First-generation antihistamines (developed more than 60 years ago) commonly cause sleepiness. First-generation antihistamines include:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/benadryl-allergy\"><span style=\"font-weight: 400;\">Benadryl<\/span><\/a><span style=\"font-weight: 400;\"> (diphenhydramine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/unisom-sleepmelts\"><span style=\"font-weight: 400;\">Unisom<\/span><\/a><span style=\"font-weight: 400;\"> (doxylamine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dayhist (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/clemastine-fumarate\"><span style=\"font-weight: 400;\">clemastine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/chlor-trimeton\"><span style=\"font-weight: 400;\">Chlor-Trimeton<\/span><\/a><span style=\"font-weight: 400;\"> (chlorpheniramine)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">First-generation antihistamines are in many over-the-counter (OTC) flu and cold medicines, such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vicks-nyquil-cough\"><span style=\"font-weight: 400;\">Nyquil<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/advil-pm\"><span style=\"font-weight: 400;\">Advil PM<\/span><\/a><span style=\"font-weight: 400;\">. These are some of the <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15992014\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">most widely used<\/span><\/a><span style=\"font-weight: 400;\"> drugs in the world.<\/span><\/p>\n<p><strong>RELATED: <a href=\"https:\/\/www.singlecare.com\/blog\/benadryl-allergy-medicine-and-alcohol\/\">Is it safe to drink alcohol while taking allergy medicine?<\/a><\/strong><\/p>\n<h3 id=\"second-and-third-generation-antihistamines\"><span style=\"font-weight: 400;\">Second- and third-generation antihistamines<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Second-generation and third-generation antihistamines were created more recently. These antihistamines cause less drowsiness and need to be taken less frequently throughout the day to be effective. These antihistamines are \u201cnon-sedating.\u201d\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Second-generation antihistamines, first introduced in <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15992014\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">1981<\/span><\/a><span style=\"font-weight: 400;\">, include <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/claritin\"><span style=\"font-weight: 400;\">Claritin<\/span><\/a><span style=\"font-weight: 400;\"> (loratadine) and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/zyrtec-allergy\"><span style=\"font-weight: 400;\">Zyrtec<\/span><\/a><span style=\"font-weight: 400;\"> (cetirizine). Third-generation antihistamines, which are newest on the market, include<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/allegra-allergy\"><span style=\"font-weight: 400;\"> Allegra<\/span><\/a><span style=\"font-weight: 400;\"> (fexofenadine).\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Second- and third-generation antihistamines may also have variations that contain pseudoephedrine (the active ingredient in <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/sudafed\"><span style=\"font-weight: 400;\">Sudafed<\/span><\/a><span style=\"font-weight: 400;\">). These antihistamines include <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/allegra-d-allergy-congestion\"><span style=\"font-weight: 400;\">Allegra-D<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/claritin-d-12-hour\"><span style=\"font-weight: 400;\">Claritin-D<\/span><\/a><span style=\"font-weight: 400;\">, or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/zyrtec-d-allergy-congestion\"><span style=\"font-weight: 400;\">Zyrtec-D<\/span><\/a><span style=\"font-weight: 400;\">. The combination of pseudoephedrine and antihistamine helps with nasal congestion in addition to allergy relief.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our allergies newsletter<\/span>\n\t\t\t<form class=\"form-wrapper\" data-newsletter-form=\"1\" data-subsource=\"Allergies Newsletter\">\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<label for=\"dynamic-email\">Email<\/label>\n\t\t\t\t\t<input type=\"email\" id=\"dynamic-email\" class=\"email\" required>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<input class=\"submit-form-btn\" type=\"submit\" value=\"Click to sign up\">\n\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t\t<p class=\"success-message\" aria-live=\"polite\"><\/p>\n\t\t<\/div>\n\t<\/span><\/p>\n<h2 id=\"is-benadryl-drowsy-or-non-drowsy\"><span style=\"font-weight: 400;\">Is Benadryl drowsy or non-drowsy?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Drowsiness is the main side effect of Benadryl and a common side effect in all first-generation antihistamines.\u00a0 Diphenhydramine is the active ingredient in Benadryl as well as OTC sleep aids.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While Benadryl does not have a non-drowsy product, there are non-sedating antihistamines, such as Zyrtec or Allegra. Restlessness is one side effect of Zyrtec, though, so it may not be the best option to take before bedtime.<\/span><\/p>\n<h2 id=\"is-there-a-non-drowsy-antihistamine\"><span style=\"font-weight: 400;\">Is there a non-drowsy antihistamine?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Second- and third-generation antihistamines, like Claritin and Allegra, are advertised as non-drowsy antihistamines. Studies have found that while second- and third-generation antihistamines can have <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17883909\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">some sedation<\/span><\/a><span style=\"font-weight: 400;\"> effects on individuals, it is to a <\/span><a href=\"https:\/\/www.medscape.org\/viewarticle\/461718_5\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">lesser extent<\/span><\/a><span style=\"font-weight: 400;\"> than the first-generation antihistamines.\u00a0<\/span><\/p>\n<h2 id=\"what-is-the-best-allergy-medicine-that-is-non-drowsy\"><span style=\"font-weight: 400;\">What is the best allergy medicine that is non-drowsy?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Several non-drowsy allergy medicines can treat allergies. These include non-drowsy medication, such as:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Claritin (loratadine)<\/b><span style=\"font-weight: 400;\">: This second-generation antihistamine reduces the effects of histamines and stops the triggers that lead to sneezing, runny nose, itching, and watery eyes. Side effects include stomach pain, headache, and tiredness. The standard dosage of Claritin is one 10 mg tablet once per day. Children\u2019s Claritin is also available in the form of chewable tablets and liquid solution.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Zyrtec (cetirizine)<\/b><span style=\"font-weight: 400;\">: This second-generation antihistamine reduces the effects of histamines, stopping the triggers that lead to sneezing, runny nose, itching, watery eyes, and hives. Side effects include headache, irregular heartbeat, weakness, and restlessness. The standard dosage of Zyrtec is 5 to 10 mg tablet orally once per day. Children\u2019s Zyrtec is available in dissolvable tablets and syrup.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Allegra (fexofenadine)<\/b><span style=\"font-weight: 400;\">: This third-generation antihistamine reduces the effects of seasonal allergies. It treats sneezing, runny nose, itchy, and watery eyes. Side effects include headache, nausea, menstrual cramps, and drowsiness. The standard dosage of Allegra is one 60 mg tablet twice daily, with approved dosing up to 180 mg per day. Children\u2019s Allegra is available as a flavored liquid and dissolvable tablets.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Always consult a healthcare professional\u2014like your pharmacist\u2014if you\u2019re unsure of the best allergy medicine for you. A pharmacist can offer medical advice regarding which <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/allergy-medicine-while-pregnant\/\"><span style=\"font-weight: 400;\">allergy medicine to take while pregnant<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/mixing-allergy-medicine\/\"><span style=\"font-weight: 400;\">how to combine allergy medicine<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Antihistamines, like Benadryl, are one of the best treatments when it comes to alleviating the symptoms of allergies and colds. However, sometimes the side effect of drowsiness can be just as bad as the symptoms they are treating. Drowsiness from antihistamines can cause reduced coordination and reaction speed, making driving and operating machinery more dangerous. [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":57389,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[554],"coauthors":[15090],"class_list":["post-7954","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-allergies","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Non-drowsy Benadryl: What are your options?<\/title>\n<meta name=\"description\" content=\"Non-drowsy Benadryl (diphenhydramine) isn&#039;t available but second-generation antihistamines cause less drowsiness. 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