{"id":9232,"date":"2020-02-25T09:44:47","date_gmt":"2020-02-25T14:44:47","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=9232"},"modified":"2026-01-28T13:40:33","modified_gmt":"2026-01-28T18:40:33","slug":"vitamin-d-vs-d3","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/vitamin-d-vs-d3\/","title":{"rendered":"Vitamin D vs. D3: Differences, similarities, and which is better for you"},"content":{"rendered":"<p><iframe loading=\"lazy\" title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/Zb_tJuORr3Y?rel=0\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p><span style=\"font-weight: 400;\">The D vitamins are fat-soluble vitamins that play an important role in calcium absorption and bone health, as well as immune function. Our skin produces vitamin D when exposed to sunlight, but due to the risk of skin cancer from UV radiation, many people avoid sun exposure or use sunscreen, which prevents the human body from producing vitamin D. Many types of milk and dairy products, along with orange juice, are also fortified with vitamin D. Even with all of the available sources of vitamin D, many of us do not get enough of this essential nutrient and need to take a supplement. There are two forms of vitamin D dietary supplements: <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vitamin-d2\"><span style=\"font-weight: 400;\">vitamin D2<\/span><\/a><span style=\"font-weight: 400;\"> (ergocalciferol) and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vitamin-d3\"><span style=\"font-weight: 400;\">vitamin D3<\/span><\/a><span style=\"font-weight: 400;\"> (cholecalciferol), and it is important to understand their differences when choosing which vitamin D supplement to take.<\/span><\/p>\n<h2 id=\"what-are-the-main-differences-between-vitamin-d-and-d3\"><span style=\"font-weight: 400;\">What are the main differences between vitamin D and D3?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The term vitamin D is kind of a misnomer because you will not find anything labeled simply as \u201cvitamin D\u201d in a pharmacy vitamin aisle. Rather, your choices will be <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vitamin-d2\/what-is\"><span style=\"font-weight: 400;\">vitamin D2<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vitamin-d3\/what-is\"><span style=\"font-weight: 400;\">vitamin D3<\/span><\/a><span style=\"font-weight: 400;\">. The names can be confusing because patients often go into the pharmacy looking for vitamin D and are surprised that there is a D2 and a D3.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Vitamin D (D2) comes from plant sources, such as wild mushrooms, and fortified foods, such as milk or cereal products. Its strength is typically measured in international units, which is abbreviated as \u201cIU\u201d on labeling. The 50,000 IU capsules are prescription only, while lower strengths are available over-the-counter (OTC). Vitamin D2 is less expensive to produce and, therefore, is the form most commonly found in fortified food products.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Vitamin D3 mainly comes from animal sources, such as fish oil, cod liver oil, fatty fish, liver, and egg yolks. When your skin is exposed to sunlight, it produces vitamin D3. For this reason, it is sometimes referred to as the sunshine vitamin. Its strength is also measured in international units. All forms of vitamin D3 are available OTC.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th><span class=\"title\">Main differences between vitamin D2 and D3<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td><b>Vitamin D2<\/b><\/td>\n<td><b>Vitamin D3<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Drug class<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Vitamin D Analog<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Vitamin D Analog<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Brand\/generic status<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Brand and generic available<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Brand and generic available<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">What is the generic name?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Ergocalciferol or vitamin D, or vitamin D2<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Cholecalciferol, vitamin D, or vitamin D3<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">What is the brand name?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Drisdol, Calcidol, Calciferol<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Decara, Dialyvite D3 Max<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">What form(s) does the drug come in?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Oral tablets and capsules, oral liquid solution<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Oral tablets and capsules, oral liquid solution, sublingual liquid solution<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">What is the standard dosage?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1,000 IU to 2,000 IU daily for vitamin D supplementation<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1,000 IU to 2,000 IU daily for vitamin D supplementation<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">How long is the typical treatment?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Indefinite<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Indefinite<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Who typically uses the medication?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Infants, children, adolescents, and adults<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Infants, children, adolescents, and adults<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"similarities-between-vitamin-d-and-d3\"><span style=\"font-weight: 400;\">Similarities between vitamin D and D3<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Vitamin D and D3 are metabolized to their active metabolite form, calcitriol. From <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21796828\/\"><span style=\"font-weight: 400;\">calcitriol<\/span><\/a><span style=\"font-weight: 400;\"> comes the important end results of a healthy level of vitamin D in your body. Calcitriol promotes renal absorption of calcium, increases intestinal absorption of both calcium and phosphorus, and increases the mobilization of calcium from bone to plasma. Calcitriol has even been shown to inhibit cancer cell growth. Ultimately both vitamin D2 and D3 provide your body with the critical metabolite, calcitriol, and play a vital role in overall health.\u00a0<\/span><\/p>\n<h2 id=\"conditions-treated-by-vitamin-d2-and-d3\"><span style=\"font-weight: 400;\">Conditions treated by vitamin D2 and D3<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Vitamin D2, as a prescription, is used to treat hypoparathyroidism (decreased parathyroid hormone secretion), vitamin D resistant rickets, and hypophosphatemia (low levels of phosphorus in the blood). It is commonly used for vitamin D insufficiency in its prescription and OTC formulations. The FDA does not approve treatment claims for OTC vitamin supplements, so even though this use is very common, it is considered off-label.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">All forms of vitamin D3 supplements are available OTC and, therefore, are not FDA-approved to make treatment claims. However, vitamin D3 is commonly used off-label to treat hypoparathyroidism and vitamin D deficiency and to prevent osteoporosis.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Both Vitamin D2 and D3 are used to supplement diet as well. In summary, conditions treated by vitamin D2 and D3, both FDA-approved and off-label, include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hypoparathyroidism<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Refractory rickets<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hypophosphatemia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dietary supplementation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vitamin D insufficiency\/deficiency<\/span><\/li>\n<\/ul>\n<h2 id=\"is-vitamin-d-or-d3-more-effective\"><span style=\"font-weight: 400;\">Is vitamin D or D3 more effective?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Vitamin D2 and D3 are absorbed into the bloodstream, where they are metabolized by the liver into 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3, otherwise collectively known as 25D or calcifediol. Calcifediol is the vitamin D complex circulating in your blood, and its levels directly reflect your body\u2019s stores of vitamin D. Calcifediol is commonly referred to as the active form of vitamin D. When your healthcare provider orders lab tests to check your vitamin D levels, they are measuring your calcifediol (25D) levels. Calcifediol is the precursor to calcitriol, the ultimate active metabolite of vitamin D2 and D3.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There have been several studies comparing whether supplementation with vitamin D2 or D3 produces a higher blood level of calcifediol. A <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18492750\"><span style=\"font-weight: 400;\">study<\/span><\/a><span style=\"font-weight: 400;\"> was conducted on older adults, post-menopausal women who had been identified as being vitamin D deficient. It compared the effects of receiving a single high dose of vitamin D2 or vitamin D3 on calcifediol levels. The study concluded that vitamin D3 produced about twice the amount of circulating calcifediol in this patient population versus that of vitamin D.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In a separate <\/span><a href=\"https:\/\/doi.org\/10.1210\/jc.2016-1871\"><span style=\"font-weight: 400;\">clinical trial<\/span><\/a><span style=\"font-weight: 400;\"> comparing a five-week regimen of twice weekly 50,000 IU dosing of both vitamin D2 and vitamin D3, followed by a five-week equilibrium period, in demographically matched groups, vitamin D3 was also found to be superior in producing higher levels of 25D, or calcifediol. <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9372493\/\"><span style=\"font-weight: 400;\">Retrospective research<\/span><\/a><span style=\"font-weight: 400;\"> shows that an injectable form of vitamin D3 worked better to restore severe vitamin D deficiency than an injectable form of vitamin D2, even though vitamin D2 was double the strength of vitamin D3.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In terms of the lab tests that measure blood vitamin D levels, your healthcare provider may evaluate total 25D, free 25D, or both. Controversy remains on which lab test is the best measure of your body\u2019s vitamin D stores, but these studies showed that vitamin D3 was superior in raising both levels.<\/span><\/p>\n<h2 id=\"coverage-and-cost-comparison-of-vitamin-d-vs-d3\"><span style=\"font-weight: 400;\">Coverage and cost comparison of vitamin D vs. D3<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Vitamin D2 in prescription form is commonly covered by most commercial insurance plans, but the OTC formulations are typically not covered. The price can vary greatly depending on dosage. The average cost of the 50,000 IU dose for 12 weeks of therapy is $29. With a <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vitamin-d-ergocalciferol?q=Vitamin%20D%20(Ergocalciferol)%20(Drisdol)\"><span style=\"font-weight: 400;\">coupon from SingleCare<\/span><\/a><span style=\"font-weight: 400;\">, this price can drop to as low as $3.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Vitamin D3 is available OTC and, therefore, is typically not covered by insurance plans, but some plans may cover it. The price varies depending on the dose. Vitamin D3 can cost as much as $50 per month, but if your healthcare provider prescribes the medication, you can get it for as low as $8 with a <\/span><a href=\"https:\/\/www.singlecare.com\/prescription-discount-card\"><span style=\"font-weight: 400;\">SingleCare discount coupon<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><a href=\"https:\/\/www.medicareinteractive.org\/get-answers\/medicare-prescription-drug-coverage-part-d\/medicare-part-d-coverage\/drugs-excluded-from-part-d-coverage\"><span style=\"font-weight: 400;\">Medicare<\/span><\/a><span style=\"font-weight: 400;\"> does not typically cover vitamin D2 or D3. Some commercial insurance plans may cover them, but it depends on their formularies.<\/span><\/p>\n<table class=\" singlecare-table\">\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td><b>Vitamin D<\/b><\/td>\n<td><b>Vitamin D3<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Typically covered by insurance?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes, at prescription dosing<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Typically covered by Medicare?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Standard dosage<\/span><\/td>\n<td><span style=\"font-weight: 400;\">12, 50,000 IU capsules<\/span><\/td>\n<td><span style=\"font-weight: 400;\">12, 50,000 IU capsules<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">SingleCare cost<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$3-$22<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$8<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"common-side-effects-of-vitamin-d-vs-d3\"><span style=\"font-weight: 400;\">Common side effects of vitamin D vs. D3<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There are no common side effects to therapy with either vitamin D2 or D3. Side effects related to vitamin D result from hypervitaminosis D. This extremely rare condition occurs when you take in too much vitamin D. This is sometimes seen in patients who take megadoses of vitamin D, leading to vitamin D toxicity. The result is a buildup of dangerously high levels of calcium in the blood, which can lead to nausea, vomiting, constipation, and frequent urination. If left untreated, irreversible renal failure and calcification of organs and soft tissues can occur.<\/span><\/p>\n<p><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=acb61678-d23d-405d-8c14-1a16cfd3a776\"><span style=\"font-weight: 400;\">Side effects<\/span><\/a><span style=\"font-weight: 400;\"> related to hypervitaminosis D include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Polyuria<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nocturia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Renal failure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Organ or soft tissue calcification<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Soft tissue<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anemia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weight loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bone demineralization<\/span><\/li>\n<\/ul>\n<h2 id=\"drug-interactions-of-vitamin-d-and-d3\"><span style=\"font-weight: 400;\">Drug interactions of vitamin D and D3<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Vitamin D2 and D3 each are metabolized by the liver to 25D, and, therefore, the potential drug interactions are similar for both forms. Vitamin D may increase the serum levels of aluminum when taken with aluminum hydroxide, a common antacid, and, therefore, the combination should be avoided. Thiazide diuretics, such as hydrochlorothiazide, may increase the chance of vitamin D raising calcium levels in the blood to a dangerously high level. Patients on both thiazide diuretics and vitamin D supplementation should be monitored for this effect by their healthcare provider. Some drugs may decrease the absorption and effectiveness of vitamin D. Bile acid sequestrants, such as cholestyramine, will impair vitamin D absorption, and they should not be taken at the same time as vitamin D.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The following list does not include all possible drug interactions with vitamin D2 and D3, so please consult your pharmacist or healthcare provider for more information. Some common drug interactions with vitamin D2 and D3 include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antacids, such as aluminum hydroxide<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bile acid sequestrants, such as cholestyramine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hormones, such as danazol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">FGFR kinase inhibitors (cancer treatment), such as erdafitinib<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Laxatives, such as mineral oil<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lipase inhibitors, such as orlistat<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mucosal coating agents, such as sucralfate<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Thiazide diuretics, such as <\/span><span style=\"font-weight: 400;\">chlorthalidone, hydrochlorothiazide, indapamide, and metolazone<\/span><\/li>\n<\/ul>\n<h2 id=\"warnings-of-vitamin-d-or-d3\"><span style=\"font-weight: 400;\">Warnings of vitamin D or D3<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Vitamin D toxicity may occur with excessively high doses. Symptoms could include nausea, vomiting, loss of appetite, constipation, dehydration, fatigue, and confusion. Since vitamin D is a fat-soluble drug, the effects of vitamin D can last 2 months or more after therapy is discontinued. It is also important to know the vitamin D content of other supplements you may be taking, such as a daily multivitamin. You should not take high doses of vitamin D supplements without your healthcare provider\u2019s instruction.<\/span><\/p>\n<h2 id=\"frequently-asked-questions-about-vitamin-d2-and-d3\"><span style=\"font-weight: 400;\">Frequently asked questions about vitamin D2 and D3<\/span><\/h2>\n<h3 id=\"what-is-vitamin-d2\"><span style=\"font-weight: 400;\">What is vitamin D2?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Vitamin D2 (ergocalciferol) is a vitamin D supplement available in both prescription and OTC formulations. It is available as oral tablets, capsules, and an oral solution. Vitamin D2 comes from plant sources and is the most common form of vitamin D found in fortified foods.<\/span><\/p>\n<h3 id=\"what-is-vitamin-d3\"><span style=\"font-weight: 400;\">What is vitamin D3?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Vitamin D3 (cholecalciferol) is an OTC vitamin D supplement available in a variety of strengths. It is available as oral tablets, capsules, and oral and sublingual solutions.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Vitamin D3 comes from animal sources, such as fish oil, fatty fish, liver, and egg yolks.<\/span><\/p>\n<h3 id=\"are-vitamin-d-or-d3-the-same\"><span style=\"font-weight: 400;\">Are vitamin D or D3 the same?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Vitamin D2 and D3 are both widely used vitamin D supplements, but they are not the same. Vitamin D2 is ergocalciferol and comes from plant-based sources. Vitamin D3 is cholecalciferol and comes from animal-based sources. Both supplements are processed in the body by the liver to 25D, though vitamin D3 is thought to provide higher levels of 25D. Some formulations of vitamin D2 are prescription only, while all formulations of vitamin D3 are OTC.<\/span><\/p>\n<h3 id=\"is-vitamin-d2-or-d3-better\"><span style=\"font-weight: 400;\">Is vitamin D2 or D3 better?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Vitamin D2 and D3 are each processed in the body by the liver to 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3, both known as 25D. Studies have shown that taking vitamin D3 leads to higher 25D levels, leading to a higher contribution to the body\u2019s vitamin D stores.<\/span><\/p>\n<h3 id=\"can-i-use-vitamin-d-or-d3-while-pregnant\"><span style=\"font-weight: 400;\">Can I use vitamin D or D3 while pregnant?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Vitamin D2 and D3 are safe to take when pregnant and monitored by a healthcare provider. Your healthcare provider may recommend a daily supplement dose and should monitor for signs of vitamin D toxicity, which is rare.<\/span><\/p>\n<h3 id=\"can-i-use-vitamin-d-or-d3-with-alcohol\"><span style=\"font-weight: 400;\">Can I use vitamin D or D3 with alcohol?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Vitamin D2 and D3 are safe to take if you consume alcohol. Both substances are metabolized primarily by the liver, so liver function should be monitored by a healthcare professional.<\/span><\/p>\n<h3 id=\"should-i-take-vitamin-d2-or-d3\"><span style=\"font-weight: 400;\">Should I take vitamin D2 or D3?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Vitamin D2 and D3 are both effective vitamin D supplements. Vitamin D2 is approved for treating hypoparathyroidism, vitamin D resistant rickets, and hypophosphatemia. Both supplements are commonly used for vitamin D supplementation.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Studies have shown that vitamin D3 supplements may be superior in raising the body\u2019s vitamin D stores. There are many health benefits to vitamin D supplementation, but your healthcare provider should use lab tests to recommend the amount of vitamin D you should take and which form.<\/span><\/p>\n<h3 id=\"what-is-vitamin-d3-good-for\"><span style=\"font-weight: 400;\">What is vitamin D3 good for?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Vitamin D3 is most commonly used as a dietary supplement of vitamin D. It aids in the absorption of calcium and may be helpful in the prevention of osteoporosis and osteomalacia.<\/span><\/p>\n<h3 id=\"why-do-healthcare-providers-prescribe-vitamin-d2-instead-of-d3\"><span style=\"font-weight: 400;\">Why do healthcare providers prescribe vitamin D2 instead of D3?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Your healthcare provider may determine your vitamin D recommendation based on lab work. Some health professionals may perceive that vitamin D2 is more effective because it is available by prescription only, even though studies have shown this is not necessarily true. Vitamin D2 may also be a lower cost to the patient, especially when covered in part or full by their insurance.<\/span><\/p>\n<h3 id=\"does-vitamin-d3-give-you-energy\"><span style=\"font-weight: 400;\">Does vitamin D3 give you energy?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Increasing vitamin D intake is thought to improve energy. A <\/span><a href=\"https:\/\/academic.oup.com\/jcem\/article\/98\/3\/E509\/2536948\"><span style=\"font-weight: 400;\">clinical trial<\/span><\/a><span style=\"font-weight: 400;\"> was done examining fatigue levels in patients who were identified as vitamin D deficient. These patients were given vitamin D3 supplementation to increase blood levels of vitamin D, and the results showed a significant improvement in fatigue levels. Scientists have shown this may be due to vitamin D\u2019s effect at the cellular level, where it augments mitochondrial oxidative phosphorylation in skeletal muscle. This decreases muscle fatigue.<\/span><\/p>\n<h3 id=\"should-seniors-take-vitamin-d2-or-vitamin-d3\"><span style=\"font-weight: 400;\">Should seniors take vitamin D2 or Vitamin D3?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Yes, vitamin D is an important vitamin for the senior population as it supports the immune system and plays an essential role in calcium absorption. Vitamin D is one of several vital <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/best-vitamins-for-seniors\/\"><span style=\"font-weight: 400;\">vitamins for seniors<\/span><\/a><span style=\"font-weight: 400;\">. The recommendations for supplemental dosing increase with age, so you should check with your healthcare provider to get the recommended dose for your age and health status.<\/span><\/p>\n<h3 id=\"can-i-take-vitamin-d-every-day-and-how-much-vitamin-d-should-i-take\"><span style=\"font-weight: 400;\">Can I take vitamin D every day? And how much vitamin D should I take?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Yes, you can take daily vitamin D supplements. Some dosages are designed for once-weekly or once-monthly dosing, so it is important to go over this with your healthcare professional. Many people in the United States are vitamin D deficient, but the question is <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/how-much-vitamin-d-should-i-take\/\"><span style=\"font-weight: 400;\">should we all be taking the same amount<\/span><\/a><span style=\"font-weight: 400;\">? The answer is no. The appropriate dose for your supplementation will depend on your health status, sun exposure, whether or not you are pregnant, and age, just to name a few factors. Consult your healthcare provider or pharmacist for a recommendation.\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/es\/recursos\/vitamina-d-vs-d3\"><span style=\"font-weight: 400;\">Lea este art\u00edculo en espa\u00f1ol aqu\u00ed.<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The D vitamins are fat-soluble vitamins that play an important role in calcium absorption and bone health, as well as immune function. Our skin produces vitamin D when exposed to sunlight, but due to the risk of skin cancer from UV radiation, many people avoid sun exposure or use sunscreen, which prevents the human body [&hellip;]<\/p>\n","protected":false},"author":87,"featured_media":10185,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8313],"tags":[812],"coauthors":[10437],"class_list":["post-9232","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-vs-drug","tag-supplements","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Comparing Vitamin D and D3: Differences, dosages, and effectiveness<\/title>\n<meta name=\"description\" content=\"Vitamin D vs. D3: Learn how these supplements differ in benefits, absorption, and effectiveness to support bone and immune health.New short dek: Vitamin D and D3 have unique benefits.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/vitamin-d-vs-d3\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What\u2019s the difference between vitamin D and D3?\" \/>\n<meta property=\"og:description\" content=\"See which supplement is better for you\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.singlecare.com\/blog\/vitamin-d-vs-d3\/\" \/>\n<meta property=\"og:site_name\" content=\"The Checkup\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/singlecare\" \/>\n<meta property=\"article:published_time\" content=\"2020-02-25T14:44:47+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-01-28T18:40:33+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2020\/04\/Blog_022520_Vitamin-D-vs-D3-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Kristi C. 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