{"id":9608,"date":"2020-03-12T10:06:09","date_gmt":"2020-03-12T14:06:09","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=9608"},"modified":"2026-01-30T15:39:24","modified_gmt":"2026-01-30T20:39:24","slug":"levitra-vs-cialis","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/levitra-vs-cialis\/","title":{"rendered":"Levitra vs. Cialis: Differences, similarities, and which is better for you"},"content":{"rendered":"

<\/span><\/p>\n

Erectile dysfunction (ED) can be a temporary or long-term problem for many men. <\/span>Around 24% of men<\/span><\/a> in the United States have ED, with the prevalence increasing for older men. Due to the stigma surrounding this common sexual disorder, the percentage of men with ED may be underreported. However, in today\u2019s world, ED treatment is more accessible, with several options available.\u00a0<\/span><\/p>\n

The most commonly prescribed ED medications belong to a class of drugs called phosphodiesterase (PDE5) inhibitors. <\/span>Levitra<\/span><\/a> and <\/span>Cialis<\/span><\/a> are two PDE5 inhibitors that primarily work by increasing blood flow to get and maintain an erection. While brand-name Levitra was <\/span>discontinued in 2018<\/span><\/a>, the generic version, vardenafil, remains available.<\/span><\/p>\n

Although these drugs work in similar ways, they do have some differences to be aware of when choosing the best treatment option. Your healthcare provider may recommend lifestyle changes as well as a medication like vardenafil or Cialis to help improve your sex life.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
Main differences between Levitra and Cialis<\/span><\/th>\n<\/tr>\n<\/thead>\n
<\/td>\nLevitra<\/b><\/td>\nCialis<\/b><\/td>\n<\/tr>\n
Drug class<\/span><\/td>\nPDE5 inhibitor<\/span><\/td>\nPDE5 inhibitor<\/span><\/td>\n<\/tr>\n
Brand\/generic status<\/span><\/td>\nBrand and generic available<\/span><\/td>\nBrand and generic available<\/span><\/td>\n<\/tr>\n
What is the generic name?<\/span><\/td>\nVardenafil<\/span><\/td>\nTadalafil<\/span><\/td>\n<\/tr>\n
What form(s) does the drug come in?<\/span><\/td>\nOral tablet<\/span><\/td>\nOral tablet<\/span><\/td>\n<\/tr>\n
What is the standard dosage?<\/span><\/td>\n5 to 20 mg as needed before sexual activity\u00a0<\/span><\/td>\n5 to 20 mg as needed before sexual activity or 2.5 to 5 mg once daily<\/span><\/td>\n<\/tr>\n
How long is the typical treatment?<\/span><\/td>\nThis medication is taken as needed. Long-term daily use is not recommended.<\/span><\/td>\nThis medication is taken as needed. Daily use may be appropriate for some people.<\/span><\/td>\n<\/tr>\n
Who typically uses the medication?<\/span><\/td>\nAdults 18 years of age and older<\/span><\/td>\nAdults 18 years of age and older<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

What are the main differences between Levitra and Cialis?<\/span><\/h2>\n

Vardenafil and Cialis are two different drugs. Cialis is a brand-name drug containing the active ingredient tadalafil, while vardenafil is a generic drug and the active ingredient in the now-discontinued brand-name drug Levitra.\u00a0<\/span><\/p>\n

Vardenafil can take up to an hour to start working. Once it kicks in, its effects can last <\/span>5 to 7 hours<\/span><\/a>, and in some cases, effects can last up to 12 hours. On the other hand, Cialis typically starts working faster, within 20 to <\/span>30 minutes<\/span><\/a>, and its effects can last much longer\u2014up to 36 hours.<\/span><\/p>\n

Vardenafil and Cialis can be taken with or without food, as indicated on their drug labels. However, the absorption of Levitra may be affected by a <\/span>high-fat meal<\/span><\/a>, while Cialis remains largely unaffected by food intake.<\/span><\/p>\n

Conditions treated by Levitra and Cialis<\/span><\/h2>\n

Vardenafil and Cialis are both FDA-approved to treat ED. This sexual disorder is <\/span>diagnosed<\/span><\/a> after a medical evaluation by a healthcare provider. ED can be caused by both psychological problems and physical health issues that cause a persistent inability to get or keep an erection.<\/span><\/p>\n

While PDE5 inhibitors have been studied to improve <\/span>benign prostatic hyperplasia<\/span><\/a> (BPH), Cialis is the only one that is FDA-approved to treat it. BPH is a medical condition characterized by an enlarged prostate. It can cause symptoms like an increased need to urinate, difficulty urinating, and an inability to fully empty the bladder.<\/span><\/p>\n

Off-label uses of Levitra and Cialis include treating Raynaud\u2019s phenomenon and pulmonary arterial hypertension (PAH). <\/span>Raynaud\u2019s phenomenon<\/span><\/a> is a rare condition in which the fingers or toes can become discolored or numb due to cold temperature changes. <\/span>PAH<\/span><\/a> is another rare disorder caused by high blood pressure in the lungs and can lead to shortness of breath and chest pain.\u00a0<\/span><\/p>\n

The active ingredients of Levitra and Cialis have also been <\/span>shown<\/span><\/a> to prevent and improve altitude sickness. These drugs may be useful for climbers who are at risk of experiencing high-altitude pulmonary edema (HAPE), a condition caused by fluid leakage in the lungs. This condition can be fatal if it\u2019s not treated in a timely manner.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n
Condition<\/b><\/td>\nLevitra<\/b><\/td>\nCialis<\/b><\/td>\n<\/tr>\n
Erectile dysfunction\u00a0<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Benign prostatic hyperplasia\u00a0<\/span><\/td>\nOff-label<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Raynaud\u2019s phenomenon<\/span><\/td>\nOff-label<\/span><\/td>\nOff-label<\/span><\/td>\n<\/tr>\n
Pulmonary arterial hypertension\u00a0<\/span><\/td>\nOff-label<\/span><\/td>\nOff-label<\/span><\/td>\n<\/tr>\n
Altitude sickness<\/span><\/td>\nOff-label<\/span><\/td>\nOff-label<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Is Levitra or Cialis more effective?<\/span><\/h2>\n

When taken as prescribed, vardenafil and Cialis can be effective ED treatments. However, Cialis may be preferred for its once-daily dosing option, longer duration of action, and approved use for BPH.<\/span><\/p>\n

According to a <\/span>meta-analysis<\/span><\/a>, tadalafil was found to be the most effective agent for ED, followed by vardenafil. This meta-analysis included 118 different trials and compared seven different medications. All PDE5 inhibitors in the studies were found to have similar safety profiles.\u00a0<\/span><\/p>\n

However, <\/span>one study<\/span><\/a> found that sildenafil, the active ingredient in Viagra, may be the most effective PDE5 inhibitor for ED in the general population. The study noted that while PDE5 inhibitors are generally effective and safe compared to a placebo, more high-quality studies that directly compare these medications are needed.<\/span><\/p>\n

Levitra or Cialis may be more effective, depending on your preferences and other health conditions. Your <\/span>healthcare provider<\/span><\/a> can help you decide which ED medication is best for you.\u00a0<\/span><\/p>\n

Coverage and cost comparison of Levitra vs. Cialis<\/span><\/h2>\n

Most Medicare and commercial insurance plans don\u2019t generally cover ED pills like vardenafil and Cialis. Therefore, you may have to pay out of pocket for these medications. Some health insurance plans may be more likely to cover Cialis if it\u2019s prescribed for BPH. Still, you may want to contact your pharmacist or insurance company directly about insurance coverage for ED drugs.<\/span><\/p>\n

Vardenafil is a generic medication that may be cheaper than brand-name alternatives. The average retail price may be <\/span>around $479<\/span><\/a> for 10 tablets with a strength of 20 mg. Cialis is available as a brand-name and generic drug. For 30 tablets with a strength of 5 mg, the average retail price of generic Cialis is <\/span>around $448<\/span><\/a>.\u00a0<\/span><\/p>\n

If you\u2019re looking to save on the retail cost of vardenafil or Cialis, you may want to use a <\/span>SingleCare savings card<\/span><\/a>. You may find that SingleCare helps you save up to 80% on brand-name and generic medications. Another potential alternative is to check out SingleCare\u2019s partnership with <\/span>Lemonaid Health<\/span><\/a>, where you can get Sildenafil for as little as $2 per pill.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n
\n

Levitra vs. Cialis cost and coverage<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

<\/td>\nLevitra<\/b><\/td>\nCialis<\/b><\/td>\n<\/tr>\n
Typically covered by insurance?<\/b><\/td>\nNo<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Typically covered by Medicare?<\/b><\/td>\nNo<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Quantity<\/b><\/td>\n10 tablets (20 mg)<\/span><\/td>\n90 tablets (5 mg)<\/span><\/td>\n<\/tr>\n
Typical Medicare copay<\/b><\/td>\nVaries<\/span><\/td>\nVaries<\/span><\/td>\n<\/tr>\n
SingleCare cost<\/b><\/td>\n$36 at CVS<\/span><\/a><\/td>\n$17 at Kroger<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of Jan. 30, 2026. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available.<\/span><\/i><\/small><\/small><\/p>\n

Common side effects of Levitra vs. Cialis<\/h2>\n

Vardenafil and Cialis tend to have similar side effects since they\u2019re both in the same drug class. The most frequently reported side effects include headaches, nasal congestion or a stuffy nose, indigestion, and back pain. In addition, both medications may lead to facial flushing, characterized by redness and warmth in the face.<\/span><\/p>\n

Other common side effects of vardenafil are dizziness, flu symptoms, and inflamed sinuses (sinusitis). Other common side effects of Cialis include muscle pain and pain in the arms or legs.\u00a0<\/span><\/p>\n

Most side effects with these medications are mild and go away on their own. If you experience serious side effects, such as visual changes or sudden hearing loss, seek medical attention immediately.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\nLevitra\u00a0<\/b><\/td>\nCialis<\/b><\/td>\n<\/tr>\n
Side Effect<\/span><\/td>\nApplicable?<\/span><\/td>\nFrequency<\/span><\/td>\nApplicable?<\/span><\/td>\nFrequency<\/span><\/td>\n<\/tr>\n
Headache<\/span><\/td>\nYes<\/span><\/td>\n15%<\/span><\/td>\nYes<\/span><\/td>\n11%<\/span><\/td>\n<\/tr>\n
Flushing<\/span><\/td>\nYes<\/span><\/td>\n11%<\/span><\/td>\nYes<\/span><\/td>\n3%<\/span><\/td>\n<\/tr>\n
Nasal congestion<\/span><\/td>\nYes<\/span><\/td>\n9%<\/span><\/td>\nYes<\/span><\/td>\n3%<\/span><\/td>\n<\/tr>\n
Indigestion<\/span><\/td>\nYes<\/span><\/td>\n4%<\/span><\/td>\nYes<\/span><\/td>\n8%<\/span><\/td>\n<\/tr>\n
Dizziness<\/span><\/td>\nYes<\/span><\/td>\n2%<\/span><\/td>\nNo<\/span><\/td>\n–<\/span><\/td>\n<\/tr>\n
Nausea<\/span><\/td>\nYes<\/span><\/td>\n2%<\/span><\/td>\nYes<\/span><\/td>\n*not reported<\/span><\/td>\n<\/tr>\n
Back pain<\/span><\/td>\nYes<\/span><\/td>\n2%<\/span><\/td>\nYes\u00a0<\/span><\/td>\n5%<\/span><\/td>\n<\/tr>\n
Pain in the arms or legs<\/span><\/td>\nNo<\/span><\/td>\n–<\/span><\/td>\nYes<\/span><\/td>\n3%<\/span><\/td>\n<\/tr>\n
Sinusitis<\/span><\/td>\nYes<\/span><\/td>\n3%<\/span><\/td>\nNo<\/span><\/td>\n–<\/span><\/td>\n<\/tr>\n
Flu syndrome<\/span><\/td>\nYes<\/span><\/td>\n3%<\/span><\/td>\nNo<\/span><\/td>\n–<\/span><\/td>\n<\/tr>\n
Muscle pain<\/span><\/td>\nNo<\/span><\/td>\n–<\/span><\/td>\nYes<\/span><\/td>\n4%<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

This may not be a complete list of adverse effects that can occur. Please refer to your doctor or healthcare provider to learn more.<\/span><\/i><\/p>\n

Source: DailyMed (<\/span>Levitra<\/span><\/a>), DailyMed (<\/span>Cialis<\/span><\/a>)<\/span><\/p>\n

Drug interactions of Levitra vs. Cialis<\/span><\/h2>\n

PDE5 inhibitors like vardenafil and Cialis work by relaxing and widening blood vessels. This effect can help with the intended benefits of these medications, but it can also lead to some unwanted side effects.<\/span><\/p>\n

Combining vardenafil or Cialis with nitrates, alpha-blockers, or other <\/span>blood pressure medications<\/span><\/a> (antihypertensives) can lead to a dangerous drop in blood pressure, which may be fatal in severe cases. Vardenafil and Cialis should not be used with guanylate cyclase (GC) stimulators like riociguat for this same reason.\u00a0<\/span><\/p>\n

Vardenafil and Cialis are both metabolized or processed in the liver. The doses of these drugs may need to be adjusted when taking other drugs that alter certain liver enzymes, such as the CYP3A4 enzyme. Therefore, caution is recommended when mixing vardenafil or Cialis with certain antibiotics, antifungals, and anticonvulsants (seizure medications), among others. In addition, <\/span>grapefruit juice<\/span><\/a> may increase the levels of vardenafil and Cialis in the body, which may lead to adverse effects.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n
Drug<\/b><\/td>\nDrug Class<\/b><\/td>\nLevitra<\/b><\/td>\nCialis<\/b><\/td>\n<\/tr>\n
Nitrostat (nitroglycerin)<\/span><\/p>\n

Imdur (isosorbide mononitrate)<\/span><\/p>\n

Isordil (isosorbide dinitrate)<\/span><\/p>\n

Nipride (nitroprusside)<\/span><\/td>\n

Nitrate<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Minipress (prazosin)<\/span><\/p>\n

Hytrin (terazosin)<\/span><\/p>\n

Cardura (doxazosin)<\/span><\/td>\n

Alpha-blocker<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Prinivil (lisinopril)<\/span><\/p>\n

Cozaar (losartan)<\/span><\/p>\n

Norvasc (amlodipine)<\/span><\/p>\n

Calan (verapamil)<\/span><\/p>\n

Coreg (carvedilol)<\/span><\/td>\n

Antihypertensive<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Adempas (riociguat)<\/span><\/p>\n

Verquvo (vericiguat)<\/span><\/td>\n

Guanylate cyclase (GC) stimulator<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Erythrocin (erythromycin)<\/span><\/p>\n

Biaxin (clarithromycin)<\/span><\/p>\n

Rifadin (rifampin)<\/span><\/td>\n

Antibiotic<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Nizoral (ketoconazole)<\/span><\/p>\n

Sporanox (itraconazole)<\/span><\/td>\n

Antifungal<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Tegretol (carbamazepine)<\/span><\/p>\n

Dilantin (phenytoin)<\/span><\/td>\n

Anticonvulsant<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Norvir (ritonavir)<\/span><\/p>\n

Crixivan (indinavir)<\/span><\/td>\n

Antiviral<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

This is not a complete list of drug interactions. Please consult your doctor before taking these medications.<\/span><\/i><\/p>\n

Warnings of Levitra and Cialis<\/span><\/h2>\n

Taking a drug like vardenafil or Cialis may increase the risk of heart attack, stroke, or other <\/span>heart problems<\/span><\/a> in people with heart disease. The use of vardenafil and Cialis should be avoided in people with a history of unstable angina (chest pain), uncontrolled high blood pressure, stroke, heart attack, arrhythmia, and\/or severe heart disease.<\/span><\/p>\n

PDE5 inhibitors can increase the risk of dangerously low blood pressure, particularly when combined with other blood pressure medications. It is important to monitor blood pressure regularly if you are prescribed these drugs.<\/span><\/p>\n

If you experience <\/span>priapism<\/span><\/a>, or a painful erection that lasts longer than 4 hours, seek emergency medical attention. Priapism can cause damage to the penile tissue if it\u2019s not treated promptly.<\/span><\/p>\n

Visual problems, such as sudden vision loss, are rare adverse effects of vardenafil and Cialis. Using these medications can also increase the risk of a sudden decrease or loss of hearing. Seek prompt medical attention if you experience these effects.<\/span><\/p>\n

Frequently asked questions about Levitra vs. Cialis<\/span><\/h2>\n

Are Levitra and Cialis the same?<\/span><\/h3>\n

Levitra and Cialis belong to the same class of drugs called PDE5 inhibitors, but they are not the same drugs. These drugs contain different active ingredients and can be used in different ways. Cialis is available as a once-daily pill, while Levitra is only taken as needed.<\/span><\/p>\n

Is Levitra or Cialis better?<\/span><\/h3>\n

Choosing which is better can depend on personal preferences and how often you plan to be intimate. Cialis may work faster and have effects that last longer than vardenafil. In addition, Cialis may be preferred by those who also have BPH or want a once-daily option. It’s best to consult a doctor for medical advice about the best option for you.<\/span><\/p>\n

Can I use Levitra or Cialis with alcohol?<\/span><\/h3>\n

Taking Levitra or Cialis along with alcohol may increase the chances of side effects. Since alcohol affects blood vessels in a way similar to these medications, you might experience more noticeable symptoms, like flushing and dizziness. While small amounts of alcohol might be okay, drinking too much can make these medications less effective. Talk to a doctor about how much alcohol is safe to drink while using these medicines.<\/span><\/p>\n

Which erectile dysfunction drug is best?<\/span><\/h3>\n

There is no single ED drug that is considered the best. ED treatment is highly individualized, and thus, the better choice is the one that helps you the most. Price and potential side effects should also be considered when picking an ED drug with your healthcare provider.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Erectile dysfunction (ED) can be a temporary or long-term problem for many men. Around 24% of men in the United States have ED, with the prevalence increasing for older men. Due to the stigma surrounding this common sexual disorder, the percentage of men with ED may be underreported. However, in today\u2019s world, ED treatment is […]<\/p>\n","protected":false},"author":87,"featured_media":9609,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8313],"tags":[8922],"coauthors":[8669],"class_list":["post-9608","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-vs-drug","tag-erectile-dysfunction","wpautop"],"acf":[],"yoast_head":"\nLevitra vs. Cialis: Differences, similarities, and which is better for you<\/title>\n<meta name=\"description\" content=\"Levitra and Cialis treat erectile dysfuntion but work in different ways. 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