{"id":9771,"date":"2020-04-15T10:00:14","date_gmt":"2020-04-15T14:00:14","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=9771"},"modified":"2025-10-08T14:21:07","modified_gmt":"2025-10-08T18:21:07","slug":"medications-that-cause-false-positive-drug-test","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/medications-that-cause-false-positive-drug-test\/","title":{"rendered":"What can cause a false positive on a drug test?"},"content":{"rendered":"

There are several instances where you may be asked to complete a drug test\u2014employers may require one when you\u2019re applying for a new job or if you are a student or an athlete. Urine drug screens are the most common test (although other body fluids may be analyzed). The test, an immunoassay that uses antibodies to detect drugs and their metabolites, is simple and painless and only requires a urine sample. It can feel a little unnerving to be asked to take a drug test, and it is important to know that there are some medications and other substances that could cause a false positive drug test result.<\/span><\/p>\n

What can drug tests detect?<\/b><\/h2>\n

Drug tests can identify various substances commonly associated with abuse or misuse, including drugs like marijuana (THC), crystal methamphetamine, cocaine, PCP, and heroin. They can also detect prescription medications, such as benzodiazepines, barbiturates, amphetamines, methadone, and opioids.<\/span><\/p>\n

Drug tests are generally reliable. Still, certain factors, including specific medications, can produce false positive results.<\/span><\/p>\n

What is a false positive drug test?<\/b><\/h2>\n

A \u201cfalse positive\u201d result occurs when the analytical drug detection method recognizes some of the molecules in the body as illegal drugs when you haven\u2019t ingested any illegal substances. Drugs that are typically screened for include amphetamines, methamphetamines, benzodiazepines, barbiturates, marijuana, cocaine, PCP, methadone, MDMA, and opioids. Some of the above, such as benzodiazepines, barbiturates, and prescription opioids like oxycodone, fentanyl<\/a>, and codeine, may be legally or illegally obtained. Other examples, such as cocaine and PCP, are illicit substances.<\/span><\/p>\n

Research<\/span><\/a> conducted at Boston Medical Center shows that drug tests produce false positives in 5% to 10% of cases. Although this is not a high percentage, the consequences of failing a drug test could jeopardize your career, education, or job prospects. Several common prescriptions, over-the-counter medications, herbs, vitamins, and even some foods could trigger a false positive drug test. According to one <\/span>study<\/span><\/a>, false positive drug tests are most commonly reported for amphetamine and methamphetamine. That\u2019s because common <\/span>over-the-counter<\/span><\/a> medications can result in false positives for these substances.<\/span><\/p>\n

When it comes to prescriptions, \u201c<\/span>warnings are available, but usually only if you look for them,\u201d s<\/span>ays <\/span>Brent McFadden, Pharm.D., the owner of <\/span>Brent’s Pharmacy & Diabetes Care<\/span><\/a> in St. George, Utah. <\/span>\u201cIt is usually in the fine print, and most people, in my experience, don’t read the material given to them by the pharmacist.<\/span>\u201d<\/span><\/p>\n

Research<\/span><\/a> suggests that 10% to 15% of drug tests yield false negative results. While urine drug tests are most commonly used, their accuracy depends on several <\/span>factors<\/span><\/a>, including the frequency of drug use and how fast the drug is metabolized by the body. It\u2019s important to note that no drug test is 100% accurate.<\/span><\/p>\n

13 medications that cause false positive drug tests<\/b><\/h2>\n

So, if you are like most people who don\u2019t take the time to study the fine print, here is a list of prescriptions and over-the-counter medications that could cause a false positive drug test.<\/span><\/p>\n

1. Analgesics\/ NSAIDS<\/b><\/h3>\n

The medication <\/span>Daypro<\/span><\/a> (<\/span>oxaprozin), which is prescribed for types of arthritis, may result in a false positive test for benzodiazepines. The pain medication <\/span>tramadol<\/span><\/a> could trigger a <\/span>false positive result for PCP<\/span><\/a>. In rare cases, common over-the-counter anti-inflammatory pain medications such as <\/span>Advil<\/span><\/a> (ibuprofen) <\/span>and <\/span>Aleve<\/span><\/a> (naproxen) <\/span>could make you test positive for barbiturates and THC (marijuana\/cannabinoids). Ibuprofen can also make you <\/span>test positive for PCP<\/span><\/a>.<\/span><\/p>\n

2. Antibiotics<\/b><\/h3>\n

Quinolone antibiotics are commonly prescribed for certain infections (urinary tract, sinus, etc.). <\/span>Levofloxacin<\/span><\/a> may trigger a false positive urine result for <\/span>opiates<\/span><\/a>. <\/span>Avelox (moxifloxacin)<\/span><\/a> may trigger a false positive for amphetamines. Rifampin, an antibiotic used to treat tuberculosis, can also lead to a false positive <\/span>result for opiates<\/span><\/a>.<\/span><\/p>\n

3. Antidepressants<\/b><\/h3>\n

According to <\/span>research<\/span><\/a>, certain antidepressants can cause false positive drug test results. For example, selective serotonin reuptake inhibitors (SSRIs) like Zoloft (sertraline)<\/span> and <\/span>Prozac<\/span><\/a> (<\/span>fluoxetine<\/span><\/a>) can <\/span>cause false-positive results for benzodiazepines and lysergic acid diethylamide (LSD) or for LSD and amphetamines, respectively.<\/span><\/p>\n

 <\/p>\n

The antidepressants <\/span>Wellbutrin<\/span><\/a> (<\/span>bupropion<\/span><\/a>) and <\/span>trazodone<\/span><\/a> can <\/span>cause a false positive result for amphetamines or LSD. A false positive result for <\/span>PCP<\/span><\/a> can occur in individuals taking the serotonin and norepinephrine reuptake inhibitors (SNRIs), <\/span>Pristiq<\/span><\/a> (<\/span>desvenlafaxine<\/span><\/a>), or<\/span> Effexor XR (<\/span><\/a>venlafaxine)<\/span><\/a>.<\/span><\/p>\n

4. Antihistamines<\/b><\/h3>\n

Antihistamines and some sleep aids containing <\/span>diphenhydramine (like <\/span>Benadryl<\/span><\/a>) could cause a false positive result for <\/span>methadone<\/span><\/a> or, rarely, PCP. <\/span>Doxylamine<\/span><\/a> (the active ingredient in Unisom) may also trigger a positive drug result for methadone, opiates, and PCP.<\/span><\/p>\n

5. Central nervous system (CNS) stimulants<\/b><\/h3>\n

Ritalin<\/span><\/a> (<\/span>methylphenidate<\/span><\/a>) and <\/span>Adderall<\/span><\/a> are used to treat <\/span>ADHD<\/span><\/a> and are well known to cause a positive test result for amphetamines and methamphetamines, so tell the lab that you take this medication before your appointment.<\/span><\/p>\n

6. Cough suppressant<\/b><\/h3>\n

Dextromethorphan, the active ingredient in <\/span>Robitussin-DM<\/span><\/a>, <\/span>Delsym<\/span><\/a>, and other over-the-counter and prescription cough suppressants or combination cold and flu products, may cause a drug screen to be positive for <\/span>opiates or PCP<\/span><\/a>.<\/span><\/p>\n

RELATED: <\/b>Learn the dangers of a cough syrup addiction<\/b><\/a><\/p>\n

7. Decongestants<\/b><\/h3>\n

The active ingredient in <\/span>Sudafed<\/span><\/a> (pseudoephedrine) is also the main ingredient in the illicit making of <\/span>methamphetamine, also known as crystal meth. Taking Sudafed can result in a false positive for <\/span>amphetamine or methamphetamine<\/span><\/a>.<\/span><\/p>\n

8. Proton pump inhibitors<\/b><\/h3>\n

Prilosec<\/span><\/a> (<\/span>omeprazole<\/span><\/a>), <\/span>Nexium<\/span><\/a> (<\/span>esomeprazole<\/span><\/a>), <\/span>Protonix (pantoprazole)<\/span><\/a>, and <\/span>Prevacid<\/span><\/a> (<\/span>lansoprazole<\/span><\/a>) are used to treat <\/span>gastroesophageal reflux disease<\/span> (<\/span>GERD<\/span><\/a>) or <\/span>peptic ulcer disease<\/span> (PUD)<\/span> and can cause a false positive for <\/span>THC<\/span><\/a>.<\/span><\/p>\n

9. Weight loss pills<\/b><\/h3>\n

The weight loss drug <\/span>phentermine<\/span><\/a> may produce a false positive drug test. That\u2019s because the chemical structure of phentermine is similar to that of amphetamine, so if you\u2019re taking the drug, it is likely to appear as a positive result on a 5-panel urinalysis.<\/span><\/p>\n

10. HIV medication<\/b><\/h3>\n

People taking the HIV medication <\/span>efavirenz<\/span><\/a> may obtain false positive drug test results. In one <\/span>study<\/span><\/a>, 49 out of 50 patients taking the drug tested positive for benzodiazepines. As well, false positive urine tests for <\/span>cannabinoids<\/span><\/a> have been reported among those taking efavirenz.<\/span><\/p>\n

11. Blood pressure medications<\/b><\/h3>\n

Common medications like <\/span>labetalol<\/span><\/a>, <\/span>a beta-blocker<\/span><\/a> used to treat hypertension, and <\/span>Cardizem<\/span><\/a> (<\/span>diltiazem<\/span><\/a>), a <\/span>calcium channel blocker<\/span><\/a> used to treat hypertension and chest pain, may result in false positive drug test results for <\/span>LSD<\/span><\/a>. Labetalol can also cause a false positive for amphetamine or methamphetamine because a labetalol metabolite is structurally similar to amphetamine.<\/span><\/p>\n

12. Metformin<\/b><\/h3>\n

Metformin<\/span><\/a> is a drug commonly used to reduce the blood sugar of patients with diabetes. The drug has been linked to false-positive drug test results for <\/span>amphetamine<\/span><\/a>.<\/span><\/p>\n

13. Prednisone<\/b><\/h3>\n

Prednisone is a corticosteroid that is <\/span>detectable in your urine<\/span><\/a>, so if you are taking the drug, you may test positive for steroids.<\/span><\/p>\n

\u201c<\/span>My recommendation to anyone taking these medicines who might be drug tested is, first and foremost, to be honest with the tester,\u201d says Dr. McFadden. \u201cKnow if the meds you are taking might cause a false positive and notify the administrator of the test. If it is prescribed, make sure you have the label from the pharmacy, which will show that the medication was prescribed to you. If it is an OTC product, have some kind of documentation (the container it was in, a note from your physician, etc.) that you have taken it.\u201d<\/span><\/p>\n

What substances can cause a false positive?<\/b><\/h2>\n

In addition to prescription medications, these other common substances can lead to a false positive drug test.<\/span><\/p>\n

1. CBD (<\/b>cannabidiol)<\/b><\/h3>\n

CBD<\/span><\/a> is the non-psychoactive portion of the marijuana plant that has become a very popular remedy for everything from pain control to promoting sleep to helping relieve anxiety. Urine drug testing screens for the presence of THC, the psychoactive component of marijuana, but a problem could arise due to the fact that these products are not very well-regulated, and cross-contamination can occur.<\/span><\/p>\n

\u201c<\/span>With CBD available in everything from drink powders to weight loss formulations, to tinctures of all types, false positive urine screenings for <\/span>THC<\/span><\/a> will become more and more common,\u201d warns Dr. McFadden.<\/span><\/p>\n

2. Secondhand marijuana smoke<\/b><\/h3>\n

According to <\/span>research<\/span><\/a>, it\u2019s highly unlikely that secondhand smoke will cause a false positive test for marijuana. In rare cases, a false positive might occur, but it will be most likely within several hours of exposure.<\/span><\/p>\n

3. Poppy seeds<\/b><\/h3>\n

Can poppy seeds make you fail a drug test? Ingestion in large quantities (such as in a poppy seed bagel or muffin), the tiny black seeds might cause a false positive drug result for <\/span>opioids<\/span><\/a>. Poppy seeds come from the seedpod of the opium poppy, and while the seeds are cleaned before consumption, they may still contain trace amounts of opium residue. In 1998, the federal government raised the <\/span>threshold on opiates<\/span><\/a> from 0.3 micrograms to 2 micrograms per milliliter, but some drug testing facilities still go by the old standard (which would increase the likelihood of a false positive result).<\/span><\/p>\n

4. Mouthwash<\/b><\/h3>\n

Alcohol in hand sanitizer (from heavy or frequent use), certain liquid medications, and mouthwash or other breath-cleaning products containing alcohol could potentially cause you to test positive for drinking alcohol.<\/span><\/p>\n

5. Tonic water<\/b><\/h3>\n

Tonic water contains <\/span>quinine, and when consumed in large amounts, could lead to <\/span>false positive results for illicit drug use<\/span><\/a>.<\/span><\/p>\n

6. Coca tea<\/b><\/h3>\n

Coca tea is made from coca leaves, which are part of the coca plant from which <\/span>cocaine<\/span><\/a> is derived. <\/span>Coca leaves are illegal<\/span><\/a> in the United States, but if you consume the tea in another country like Bolivia or Peru, you may receive a positive test result for cocaine.<\/span><\/p>\n

Can you fight a false positive drug test?<\/b><\/h2>\n

If you believe you have a failed drug test due to taking a prescription drug or consuming one of these products, you do have options<\/span>, such as seeking<\/span> confirmatory testing from a healthcare provider or clinician.<\/span><\/p>\n

\u201c<\/span>I would counsel [anyone who received a false-positive test to ask] the administrator to do a more specific test,\u201d says Dr. McFadden, who recommends samples be sent away to labs to have a more specific mass spectroscopy assay done. \u201cFurthermore, if they can prove they are taking a medicine that can produce a false positive (by producing a legitimate prescription), the administrator may schedule another test 30 to 60 days later. If, under their physicians\u2019 approval, the person can be off the medicine for that length of time, a negative test should result.\u201d<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

There are several instances where you may be asked to complete a drug test\u2014employers may require one when you\u2019re applying for a new job or if you are a student or an athlete. Urine drug screens are the most common test (although other body fluids may be analyzed). The test, an immunoassay that uses antibodies […]<\/p>\n","protected":false},"author":93,"featured_media":10072,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[814],"coauthors":[12545],"class_list":["post-9771","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-drug-interactions","wpautop"],"acf":[],"yoast_head":"\nFalse positive drug tests - medicines that cause It<\/title>\n<meta name=\"description\" content=\"Certain foods, meds, and supplements can trigger a false positive drug test result. 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