Can you take ibuprofen while on Eliquis?

Medically reviewed by Anne Jacobson, MD, MPH

Board-Certified Family Physician

Contributor

Updated Oct 23, 2025 • Published Oct 23, 2025

Fact Checked

It’s generally not recommended to take ibuprofen while on Eliquis since the combination increases the risk of bleeding. Eliquis interacts with NSAIDs, including ibuprofen, aspirin, and naproxen, interfering with a key enzyme called platelet cyclooxygenase. This results in slower blood clotting and a higher risk of bleeding. However, healthcare providers may recommend low doses of ibuprofen for short-term instances of inflammation.

Medically reviewed by Anne Jacobson, MD, MPH

Board-Certified Family Physician

Anne Jacobson, MD, MPH, is a board-certified family physician, writer, editor, teacher, and consultant. She is a graduate of University of Wisconsin School of Medicine and Public Health, and trained at West Suburban Family Medicine in Oak Park, Illinois. She later completed a fellowship in community medicine at PCC Community Wellness and a master's in Public Health at the University of Illinois-Chicago. She lives with her family near Chicago.

Written by Vanessa Ling, ND, CNS

Contributor

Vanessa Ling, ND, CNS, is a naturopathic doctor, certified nutrition specialist, and health and medical writer. Her goal is to make health information accessible and understandable so readers can make the best choices for their well-being. She focuses on sharing evidence-based research and clinical best practices on a variety of health topics.

Can you take ibuprofen while on Eliquis?

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