Spironolactone-HCTZ is a generic combination drug that reduces water in the body in patients with high blood pressure or edema, which is excess water collecting in the body's tissues. Both active ingredients are “water pills,” or diuretics, that flush the body of water and salt. As the water and salt content in the bloodstream decreases, blood pressure and swelling go down. The cost of Spironolactone-HCTZ is normally $62.42 for 30, 25-25mg tablets at full price. A SingleCare Spironolactone-HCTZ coupon reduces that price to $12.71 for 30, 25-25mg tablets of generic Spironolactone-HCTZ. You can find more information in our FAQs below.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/05/2025
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Spironolactone-HCTZ is a generic combination drug that reduces water in the body in patients with high blood pressure or edema, which is excess water collecting in the body's tissues. Both active ingredients are “water pills,” or diuretics, that flush the body of water and salt. As the water and salt content in the bloodstream decreases, blood pressure and swelling go down. The cost of Spironolactone-HCTZ is normally $62.42 for 30, 25-25mg tablets at full price. A SingleCare Spironolactone-HCTZ coupon reduces that price to $12.71 for 30, 25-25mg tablets of generic Spironolactone-HCTZ. You can find more information in our FAQs below.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Spironolactone-Hctz Retail Price | Spironolactone-Hctz SingleCare Price |
|---|---|---|
| CVS Pharmacy | $26.10 | $14.10 |
| Walmart | $27.90 | $27.00 |
| Walgreens | $26.70 | $14.40 |
| Kroger Pharmacy | $40.20 | $17.10 |
| Albertsons Pharmacy | $50.10 | $25.20 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Spironolactone-HCTZ is a generic combination drug that reduces water in the body in patients with high blood pressure or edema, which is excess water collecting in the body's tissues. Both active ingredients are “water pills,” or diuretics, that flush the body of water and salt. As the water and salt content in the bloodstream decreases, blood pressure and swelling go down. The cost of Spironolactone-HCTZ is normally $62.42 for 30, 25-25mg tablets at full price. A SingleCare Spironolactone-HCTZ coupon reduces that price to $12.71 for 30, 25-25mg tablets of generic Spironolactone-HCTZ. You can find more information in our FAQs below.
Spironolactone-HCTZ normally costs $62.42 for 30, 25-25mg tablets. That same prescription will cost $12.71 for 30, 25-25mg tablets of generic Spironolactone-HCTZ using a SingleCare savings card, which you can use at major pharmacies throughout the country, such as Walmart, Kroger, Fry's, Harris Teeter, and others.
The copay cost of Spironolactone-HCTZ will depend on your insurance plan and the dose prescribed. Consider asking your pharmacist to compare your Spironolactone-HCTZ insurance copay to your SingleCare Spironolactone-HCTZ coupon. With SingleCare, Spironolactone-HCTZ costs only $12.71 for 30, 25-25mg tablets of generic Spironolactone-HCTZ, which may save you more money than using insurance.
Spironolactone-HCTZ will often not covered for Medicare-eligible patients under Medicare Part D and Medicare Advantage. However, Medicare prescription drug plans do not cover prescriptions for Aldactazide, the brand-name version of Spironolactone-HCTZ. Patients without Medicare prescription drug coverage can save money with a SingleCare Spironolactone-HCTZ coupon – the price of Spironolactone-HCTZ with a SingleCare savings card is only $12.71 for 30, 25-25mg tablets of generic Spironolactone-HCTZ.
Spironolactone-HCTZ is a generic prescription drug manufactured by Greenstone, Sun, Mylan, Apotex, and Teva. It is also available as a more expensive brand-name drug, Aldactazide, from Pfizer. For more information about Aldactazide and valuable savings coupons, search the SingleCare website or app. SingleCare savings are welcomed at participating pharmacies nationwide.
Spironolactone-HCTZ is a blood pressure and edema combination drug that reduces water in the body. Spironolactone-HCTZ is prescribed to patients with high blood pressure or edema (excess water collecting in the body's tissues) due to liver failure, kidney failure, heart failure, or who have not responded to other diuretics.
Both active ingredients are “water pills,” or diuretics, that flush water and salts from the body.
Hydrochlorothiazide belongs to a class of diuretics called thiazides, which work by reducing the kidney's ability to reabsorb water or salt from the urine. Thiazide diuretics are a very common and safe diuretic and often the first prescribed to patients.
Spironolactone belongs to a class of diuretics called potassium-sparing diuretics. Like other diuretics, spironolactone inhibits the kidney's ability to reabsorb water and salt (sodium), but it works on a specific part of the kidney so that the kidney can still reabsorb potassium. Potassium-sparing diuretics are often prescribed as a secondary drug in treating high blood pressure, but they are not as effective as other diuretics.
By combining a thiazide diuretic with a potassium-sparing diuretic, Spironolactone-HCTZ balances the effectiveness of the thiazide while alleviating its potential to lower potassium in the bloodstream.
Spironolactone-HCTZ is taken as a tablet once a day either as a single or divided dose. The dose will vary depending on the patient's responsiveness and tolerance.
While medicines may have side effects, many people experience no side effects, or the side effects they experience are very minimal. The most common physical side effects of Spironolactone-HCTZ include lightheadedness, dizziness, drowsiness, low energy, headache, loss of appetite, stomach pain, and gas. Serious side effects include low potassium, low sodium, and dehydration. The symptoms of dehydration are dry mouth, thirst, muscle cramps, severe dizziness, and confusion, among others.
Allergic reactions are rare but may be severe, including severe skin reactions that may require hospitalization. You should seek immediate medical care if you notice signs of an allergic reaction such as hives, trouble breathing, facial swelling, fever, sore throat, skin pain, dark rash, blistering, or peeling.
This is not a complete list of side effects that may occur. Consult with your doctor or pharmacist about possible side effects before taking this medicine.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved