What is Atripla? Uses, warnings & side effects

Updated May 14, 2025  •  Published Dec 30, 2020

Atripla overview

BRAND NAMES:

  • Atripla

Generic Names:

  • Efavirenz-Emtricitab-Tenofovir

Uses:

  • Treats HIV infection. HIV causes AIDS. This medicine does not cure HIV or AIDS, but combinations of drugs may slow the progress of the disease.

Therapeutic Classes:

  • Antiretroviral Agent

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Atripla used for?

What form(s) does Atripla come in?

  • Tablet

What are common Atripla dosages?

  • Tablet 600-200-300MG

Atripla images - What does Atripla look like?

  • Atripla
    30 tablets bottle

  • Atripla
    600-200-300mg tablet

How to take Atripla

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep the bottle tightly closed. Keep the medicine in the original bottle that you were given at the pharmacy.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Take this medicine at the same time each day, preferably at bedtime.

  • Do not stop using this medicine without checking first with your doctor. If you stop the medicine even briefly, the virus may become harder to treat. Contact your doctor or pharmacist when your supply is running low so you do not run out.

  • Oral routeIt is best to take this medicine on an empty stomach.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Do not stop using this medicine without checking first with your doctor. If you stop the medicine even briefly, the virus may become harder to treat. Contact your doctor or pharmacist when your supply is running low so you do not run out.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Take this medicine at the same time each day, preferably at bedtime.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Oral routeIt is best to take this medicine on an empty stomach.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep the bottle tightly closed. Keep the medicine in the original bottle that you were given at the pharmacy.

What to do if you miss a dose of Atripla

Atripla contraindications - Who shouldn't take Atripla?

  • This medicine is not right for everyone. Do not use if you had an allergic reaction to efavirenz, emtricitabine, or tenofovir, or if you are pregnant.

Atripla warnings

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • This medicine will not keep you from giving HIV to others. Always practice safe sex, even if your partner also has HIV. Do not share needles or other items that may have blood or body fluids on them.

  • Do not breastfeed. You can spread HIV or AIDS to your baby through your breast milk.

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Birth control pills may not work as well to prevent pregnancy when used with this medicine. Use 2 effective forms of birth control (including condoms or spermicide) along with your pills during treatment with this medicine and for at least 12 weeks after your last dose.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Your immune system may get stronger when you start taking HIV medicines. This could cause a hidden infection in your body to become active. Tell your doctor right away if you notice any changes in your health.

  • This medicine may cause the following problems:Worsening of hepatitis B infection (if the medicine is stopped)Serious skin reactionsLiver problemsQT prolongation (heart rhythm problem)Changes in mood or behaviorKidney problemsLower bone mineral densitySeizuresLactic acidosis (too much acid in the blood)

  • Tell your doctor if you have kidney disease, liver disease (including hepatitis B or C), bone problems (including osteoporosis), heart rhythm problems, mental health problems, or a history of seizures or drug or alcohol use. Tell your doctor if you drink alcohol.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Atripla interactions & what to avoid when taking Atripla

  • Do not breastfeed. You can spread HIV or AIDS to your baby through your breast milk.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Your immune system may get stronger when you start taking HIV medicines. This could cause a hidden infection in your body to become active. Tell your doctor right away if you notice any changes in your health.

  • There are many other drugs that can interact with Atripla. Make sure your doctor knows about all other medicines you are using.

  • Do not use this medicine together with elbasvir/grazoprevir or voriconazole.

  • There are many drugs that can interact with this medicine. Make sure your doctor knows about all other medicines you are using, especially the following:Acyclovir, adefovir, atazanavir, artemether/lumefantrine, atovaquone/proguanil, boceprevir, bupropion, carbamazepine, cidofovir, clarithromycin, cyclosporine, darunavir/ritonavir, didanosine, fosamprenavir/ritonavir, ganciclovir, itraconazole, ketoconazole, ledipasvir/sofosbuvir, lopinavir/ritonavir, maraviroc, methadone, phenobarbital, phenytoin, posaconazole, rifabutin, rifampin, ritonavir, saquinavir, sertraline, simeprevir, sirolimus, sofosbuvir/velpatasvir, tacrolimus, valacyclovir, valganciclovirAminoglycoside antibiotic (including gentamicin)Birth control pillsBlood pressure medicineBlood thinner (including warfarin)NSAID pain or arthritis medicine (including aspirin, celecoxib, diclofenac, ibuprofen, naproxen)Statin medicine

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • This medicine will not keep you from giving HIV to others. Always practice safe sex, even if your partner also has HIV. Do not share needles or other items that may have blood or body fluids on them.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Atripla side effects - How does Atripla make you feel?

Serious Side Effects

  • Fast breathing, trouble breathing, lightheadedness, severe weakness, tiredness, or confusion

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Behavior or mood changes , paranoid or manic behavior

  • Anxiety, anger, aggression, severe depression, seeing or hearing things that are not there, or thoughts of hurting yourself or others

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Bone, joint, or muscle pain

  • Blistering, peeling, red skin rash

  • Change in how much or how often you urinate

  • Fast, pounding, or uneven heartbeat

  • Severe sleepiness, decreased awareness or responsiveness

  • Seizures

Less Serious Side Effects

  • Headache, dizziness

  • Diarrhea

  • Weight gain around your neck, upper back, breast, or waist

  • Mild skin rash, change in skin color

  • Cough, runny or stuffy nose, sore throat