Brixadi (Weekly) is a Opioid Partial Agonists class medication produced by Braeburn Pharmaceutical. Brixadi (Weekly) is a brand-name extended-release injection that contains the ingredient buprenorphine, which is classified as a partial opioid agonist. It is approved by the U.S. Food and Drug Administration (FDA) to treat moderate to severe opioid use disorder in adult patients who have started treatment with a single dose of a transmucosal buprenorphine product or who are already taking buprenorphine. Brixadi (Weekly) is used as part of a treatment plan that includes other measures such as counseling and psychosocial support. There are both weekly and monthly forms of this medication. They are different formulations with different dosing. Brixadi (Weekly) is administered by a healthcare provider.
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Prices updated: 12/20/2025
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Brixadi (Weekly) is a Opioid Partial Agonists class medication produced by Braeburn Pharmaceutical. Brixadi (Weekly) is a brand-name extended-release injection that contains the ingredient buprenorphine, which is classified as a partial opioid agonist. It is approved by the U.S. Food and Drug Administration (FDA) to treat moderate to severe opioid use disorder in adult patients who have started treatment with a single dose of a transmucosal buprenorphine product or who are already taking buprenorphine. Brixadi (Weekly) is used as part of a treatment plan that includes other measures such as counseling and psychosocial support. There are both weekly and monthly forms of this medication. They are different formulations with different dosing. Brixadi (Weekly) is administered by a healthcare provider.
Brixadi (Weekly) is a Opioid Partial Agonists class medication produced by Braeburn Pharmaceutical. Brixadi (Weekly) is a brand-name extended-release injection that contains the ingredient buprenorphine, which is classified as a partial opioid agonist. It is approved by the U.S. Food and Drug Administration (FDA) to treat moderate to severe opioid use disorder in adult patients who have started treatment with a single dose of a transmucosal buprenorphine product or who are already taking buprenorphine. Brixadi (Weekly) is used as part of a treatment plan that includes other measures such as counseling and psychosocial support. There are both weekly and monthly forms of this medication. They are different formulations with different dosing. Brixadi (Weekly) is administered by a healthcare provider.
The standard out-of-pocket cost of Brixadi (Weekly) without health insurance is $639.95 per 1, 0.64ml of 32mg/0.64ml syringe though you can save using a SingleCare Brixadi (Weekly) coupon to pay only $450.79 for 1, 0.64ml of 32mg/0.64ml syringe of Brixadi (Weekly). If you don’t have access to an insurance plan, you can still use SingleCare for free Brixadi (Weekly) savings.
Each insurance formulary is different and may or may not cover Brixadi (Weekly). The cost of Brixadi (Weekly) with insurance coverage varies depending on your plan - check with your insurance provider for specific drug coverage and copay details. If your insurance does not cover Brixadi (Weekly), you can use SingleCare to get discounts on Brixadi (Weekly) at your participating pharmacy. Additionally, you can also use SingleCare coupons if you have Medicare or Medicaid. If Medicare or Medicaid don’t cover your Brixadi (Weekly) prescription, you can use SingleCare instead. Go to the SingleCare website or app to compare the lowest price of Brixadi (Weekly) with SingleCare versus your copay with insurance or Medicare.
Brixadi (Weekly) costs with Medicare will vary by plan, prescription, and coverage stage. Refer to your plan’s drug formulary to find out whether your Medicare Part D or Medicare Advantage plan covers Brixadi (Weekly) and how much the copay or coinsurance is. If Brixadi (Weekly) is not covered by Medicare or if you have not met your plan’s deductible, you may have to pay the full price of $639.95 for 1, 0.64ml of 32mg/0.64ml syringe. In that case, using a SingleCare coupon for Brixadi (Weekly) could save you more money than Medicare. Our lowest price for Brixadi (Weekly) is currently $450.79 for 1, 0.64ml of 32mg/0.64ml syringe.
Brixadi (Weekly) is a brand name drug made by Braeburn Pharmaceutical. There is no generic version of Brixadi (Weekly) at this time.
Brixadi (Weekly) contains the ingredient buprenorphine, which is classified as a partial opioid agonist. It is FDA-approved to treat moderate to severe opioid use disorder in individuals who have started treatment with one dose of a transmucosal buprenorphine medication or who are already taking buprenorphine. Brixadi (Weekly) is used as part of a treatment plan that includes other measures such as counseling and psychosocial support.
This medication is prepared and injected by a healthcare provider. Brixadi (Weekly) is injected subcutaneously (under the skin). It should never be given by intravenous injection. Brixada is only available through a restricted program called Brixadi (Weekly) REMS. Healthcare facilities and pharmacies must be certified in the program to order and dispense this medication.
Individuals who take Brixadi (Weekly) should also have naloxone (such as Narcan nasal spray) on hand in case of an opioid overdose. People who are being treated for opioid use disorder are at risk of relapse and opioid overdose. Your healthcare provider or pharmacist can show you how to use naloxone. Make sure your family, caregivers, and close friends know where it is and how to use it on you in case of an opioid overdose.
The most common side effects of Brixadi (Weekly) are:
Pain, redness, and itching at the injection site
Headache
Constipation
Nausea
Insomnia
Urinary tract infection
Serious side effects may include sleep apnea, slowed or stopped breathing, liver problems, seizures, and others. Allergic reactions are rare. Individuals who experience hives, trouble breathing, or swelling of the face, lips, tongue, or throat should get emergency medical help.
The half-life of Brixadi (Weekly) weekly injection can last up to 5 days, which is the time it takes for half of the drug to be cleared from the body. Since it takes about 5 half-lives for a drug to mostly clear the body, the drug can stay in your system for up to approximately 25 days.
The half-life of the monthly formulation can last up to 26 days, which means it can take over 4 months to leave the body.
Before taking Brixadi (Weekly), be sure to tell your healthcare provider about all the medications you take, including prescription and OTC drugs, vitamins, and supplements. Examples of interactions include, but are not limited to:
Alcohol
Drugs that cause central nervous system (CNS) depression, such as opioid drugs, anxiety medications, sleep medications, and muscle relaxants
Drugs that act on certain enzymes, such as Nizoral (ketoconazole), erythromycin, protease inhibitors (such as ritonavir), rifampin, Dilantin (phenytoin), and Tegretol (carbamazepine)
Certain antiretrovirals
Drugs that increase serotonin levels, such as monoamine oxidase inhibitors (MAOIs), SSRI or SNRI antidepressants, tricyclic antidepressants, triptans for migraine, lithium, buspirone, St. John’s wort, muscle relaxants, and others
Diuretics
Talk to your healthcare provider about drug interactions and how they may affect you.
Brixadi (Weekly) is not safe for everyone. You should not take Brixadi (Weekly) if you are allergic to buprenorphine or any ingredients in the medication.
Brixadi (Weekly) and Sublocade both contain the active ingredient buprenorphine, and both are used to treat opioid use disorder. Brixadi (Weekly) and Sublocade can be given once per month. Brixadi (Weekly) can also be given once per week using the weekly formulation. Talk to your doctor for additional information and medical advice to determine which medication is appropriate for you.
After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.
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