Caplyta is used to treat schizophrenia in adults. It can also be used to treat bipolar depression. Caplyta contains the active ingredient lumateperone and was approved by the U.S. Food and Drug Administration (FDA) in 2019. The average retail price of Caplyta is $2,275.77 per 30, 42mg capsules, but you can pay just $1,564.23 for 30, 42mg capsules of Caplyta with a prescription drug discount card from SingleCare’s discount program.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/05/2025
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Caplyta is used to treat schizophrenia in adults. It can also be used to treat bipolar depression. Caplyta contains the active ingredient lumateperone and was approved by the U.S. Food and Drug Administration (FDA) in 2019. The average retail price of Caplyta is $2,275.77 per 30, 42mg capsules, but you can pay just $1,564.23 for 30, 42mg capsules of Caplyta with a prescription drug discount card from SingleCare’s discount program.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Caplyta Retail Price | Caplyta SingleCare Price |
|---|---|---|
| CVS Pharmacy | $2015.10 | $1687.19 |
| Walmart | $2052.00 | $1712.10 |
| Walgreens | $2053.20 | $1813.20 |
| Kroger Pharmacy | $2052.00 | $1588.50 |
| Albertsons Pharmacy | $2487.30 | $1818.60 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Caplyta is used to treat schizophrenia in adults. It can also be used to treat bipolar depression. Caplyta contains the active ingredient lumateperone and was approved by the U.S. Food and Drug Administration (FDA) in 2019. The average retail price of Caplyta is $2,275.77 per 30, 42mg capsules, but you can pay just $1,564.23 for 30, 42mg capsules of Caplyta with a prescription drug discount card from SingleCare’s discount program.
The standard out-of-pocket cost of Caplyta without health insurance is $2,275.77 per 30, 42mg capsules though you can save using a SingleCare Caplyta coupon to pay only $1,564.23 for 30, 42mg capsules of Caplyta. If you don’t have access to an insurance plan, you can still use SingleCare for free Caplyta savings. If you do not have insurance and you have difficulty paying for Caplyta, you can look into the Intra-Cellular Therapies Patient Assistance Program. Check the website for more information and eligibility requirements.
Most, but not all, insurance plans cover Caplyta. The cost of Caplyta with insurance coverage varies depending on your plan - check with your insurance company for specific drug coverage and copay details. You can also check the manufacturer's website to find out more about the Caplyta Savings Card. Eligible patients with commercial insurance may pay as little as $0 for the first two prescription fills, each up to 30 days. After that, the cost may be as low as $15 per prescription for up to a 90-day supply. Check the website for more information and eligibility requirements.
If your insurance does not cover Caplyta, you can use SingleCare to get discounts on Caplyta at your participating pharmacy. Additionally, you can also use SingleCare coupons if you have Medicare or Medicaid. If Medicare or Medicaid don’t cover your Caplyta prescription, you can use SingleCare instead. Go to the SingleCare website or app to compare the lowest price of Caplyta with SingleCare versus your copay with insurance or Medicare.
Most Medicare prescription plans cover Caplyta, but the cost will vary by plan, prescription, and coverage stage. Refer to your plan’s drug formulary to find out whether your Medicare Part D or Medicare Advantage plan covers Caplyta and how much the copay or coinsurance is. If Caplyta is not covered by Medicare or if you have not met your plan’s deductible, you may have to pay the full price of $2,275.77 for 30, 42mg capsules. In that case, using a SingleCare coupon for Caplyta could save you more money than Medicare. Our lowest price for Caplyta is currently $1,564.23 for 30, 42mg capsules.
Caplyta is a brand name drug made by Intra-Cellular Therapies. There is no generic version of Caplyta currently available. Use a SingleCare prescription drug discount card to pay $1,564.23 for 30, 42mg capsules.
Caplyta is part of a class of drugs known as second-generation antipsychotic drugs or atypical antipsychotics. It is used to treat schizophrenia in adults. It can also be used to treat depressive episodes associated with bipolar I or II disorder, also known as bipolar depression, in adults. For bipolar depression, Caplyta can be used alone or in combination with other medication such as lithium or divalproex.
Caplyta is made by the pharmaceutical company Intra-Cellular Therapies, Inc. Caplyta is available as a capsule that is taken by mouth and is available in 10.5 mg, 21 mg, and 42 mg doses. It is typically prescribed to be taken once a day and can be taken with or without food.
Caplyta is approved for use in adults only. Before taking Caplyta, tell your healthcare professional about all of your medical conditions, including pregnancy or breastfeeding. Caplyta use during the third trimester of pregnancy may cause withdrawal symptoms in the newborn baby, such as agitation, muscle stiffness, tremors, drowsiness, breathing problems, and feeding issues. Caplyta may also affect fertility in both males and females, so discuss any concerns about fertility with your healthcare provider.
Caplyta can cause problems with body temperature regulation, making you feel very warm and leading to overheating. To avoid overheating while taking Caplyta, stay in cool environments and wear light clothing. It's also important to stay hydrated by drinking plenty of water, as this helps manage overall body temperature.
Avoid alcohol while taking this medicine. Do not drive or operate machinery until you know how Caplyta affects you, as it may cause drowsiness.
Tell your healthcare professional about all of the medicines you take, including prescription and OTC drugs, vitamins, and supplements. You should avoid grapefruit juice and grapefruit while taking this medicine, as grapefruit can interact with Caplyta.
The most common side effects of Caplyta are nausea, dry mouth, sleepiness, and dizziness.
This medicine has a black box warning, the most serious warning required by the FDA. This warning states:
Caplyta should not be used in patients with dementia-related psychosis, as it can cause an increased risk of death in older adults with this condition.
Medications that treat depression can increase the risk of suicidal thoughts and behaviors, especially in pediatric and young adult patients. Patients of any age who take Caplyta should be closely monitored for changes in mood and behavior, as well as suicidal thoughts and behaviors.
If you have symptoms of an allergic reaction, such as hives, difficulty breathing or swallowing, or swelling of the face, lips, tongue, or throat, get emergency medical help immediately.
Other serious side effects may include, but are not limited to:
Neuroleptic malignant syndrome (NMS), a serious condition that can cause death. Symptoms may include high fever, confusion, stiff muscles, sweating, and changes in breathing, heart rate, and blood pressure. NMS requires emergency medical help.
Uncontrolled body movement problems (tardive dyskinesia), which may occur in the face, tongue, or other parts of the body
Metabolic problems including weight gain, high cholesterol, or high blood sugar and diabetes
Low white blood cell counts
Orthostatic hypotension, which is a drop in blood pressure when standing up. This can also lead to falls and fractures.
Seizures
Excess sleepiness
Difficulty thinking and performing normal activities
Problems regulating your body temperature
Swallowing problems, which can cause food or liquid to get into the lungs
All antipsychotics, including Caplyta, can lead to weight gain. The extent of weight gain varies among different antipsychotics. Caplyta is generally considered to have a lower risk of weight gain compared to some other antipsychotics. Your doctor will monitor your weight before starting Caplyta and will continue to check it regularly during your treatment.
Abilify (aripiprazole) is an atypical antipsychotic similar to Caplyta. In addition to treating schizophrenia, Abilify is FDA-approved for managing manic and mixed episodes related to bipolar I disorder. It is also used to treat Tourette syndrome and irritability associated with autism. Abilify can also be combined with other medications to treat depression. While both Caplyta and Abilify are effective for treating schizophrenia, Caplyta may have fewer side effects for some individuals. However, individual responses can vary, so it is important to consult your healthcare provider for more information and medical advice.
After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved