What is Combivir: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Combivir overview

BRAND NAMES:

  • Combivir

Generic Names:

  • Lamivudine-Zidovudine

Uses:

  • Treats HIV infection. HIV causes AIDS. This medicine does not cure HIV or AIDS, but combinations of drugs may slow the progress of the disease.

Therapeutic Classes:

  • Antiretroviral Agent

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Combivir used for?

Lamivudine-Zidovudine works to decrease the amount of HIV in your body so your immune system can function better. It is used together with other antiretrovirals to prevent HIV from multiplying in the body.

What form(s) does Combivir come in

  • Tablet

What are common Combivir doses?

  • Tablet 150-300MG

Common Combivir prescriptions

  • Combivir
    150-300mg tablet

How to take Combivir

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Do not stop using this medicine without checking first with your doctor. If you stop the medicine even for a short time, the virus may become harder to treat. Contact your doctor or pharmacist when your supply is running low so you do not run out.

  • Your doctor may give you an oral liquid if your child has trouble swallowing tablets.

  • Your doctor may give you an oral liquid if your child has trouble swallowing tablets.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Do not stop using this medicine without checking first with your doctor. If you stop the medicine even for a short time, the virus may become harder to treat. Contact your doctor or pharmacist when your supply is running low so you do not run out.

What to do if you miss a dose of Combivir

  • Oral routeAsk your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

Combivir contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to lamivudine or zidovudine.

Combivir warnings

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. You may need tests for several months after you stop using this medicine if you also have hepatitis.

  • Tell your doctor if you are pregnant, or if you have kidney disease, liver disease (including hepatitis B or C), muscle problems, or a history of pancreas problems.

  • Do not breastfeed. You can spread HIV or AIDS to your baby through your breast milk.

  • This medicine may cause the following problems:Myopathy (muscle weakness)Lactic acidosis (too much acid in the blood)Severe liver problemsPancreatitis (swelling of the pancreas)Changes in body fat

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

  • Your immune system may get stronger when you start taking HIV medicines. This could cause a hidden infection in your body to become active. Tell your doctor right away if you notice any changes in your health.

  • This medicine will not keep you from giving HIV to others. Always practice safe sex, even if your partner also has HIV. Do not share needles or other items that may have blood or body fluids on them.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • This medicine will not keep you from giving HIV to others. Always practice safe sex, even if your partner also has HIV. Do not share needles or other items that may have blood or body fluids on them.

Combivir interactions

  • Some medicines can affect how this medicine works. Tell your doctor if you are using any of the following:Doxorubicin, ganciclovir, interferon-alfa, ribavirin, sorbitol, stavudine, or zalcitabineSteroid or cancer treatment

  • Tell your doctor if you use doxorubicin (Adriamycin®), ganciclovir (Cytovene®), interferon-alfa (Intron®-A, Roferon®-A), ribavirin (Virazole®), stavudine (Zerit®), or zalcitabine (Hivid®). Make sure your doctor knows if you use medicines that weaken your immune system, such as a steroid or cancer treatment.

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

  • This medicine may cause a muscle disease called myopathy. Check with your doctor if you have muscle pain, swelling, tenderness, wasting, or weakness while you use this medicine.

  • Lactic acidosis (too much acid in the blood) and liver toxicity are rare but serious reactions to this medicine. These are more common if you are female, obese, or have been taking anti-HIV medicines for a long time. Call your doctor right away if you have more than one of these symptoms: stomach pain; dark urine; decreased appetite; diarrhea; general feeling of discomfort; light-colored stools; muscle pain; nausea; unusual tiredness or weakness; trouble breathing; vomiting; or yellow eyes or skin.

  • Pancreatitis may occur while you use this medicine. Check with your doctor right away if you have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness.

  • Your immune system may get stronger when you start taking HIV medicines. Tell your doctor right away if you notice any changes in your health. Sometimes the immune system will start to fight infections that were hidden in your body, such as pneumonia, herpes, or tuberculosis.

  • This medicine may cause changes to your body fat. Tell your doctor right away if you notice changes in your body shape, such as more fat in your neck or upper back or around your chest or stomach area. You may also lose fat from your legs, arms, or face.

  • This medicine will not keep you from giving HIV to others. Always practice safe sex, even if your partner also has HIV. Do not share needles or other items that may have blood or body fluids on them.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. You may need tests for several months after you stop using this medicine if you also have hepatitis.

Combivir side effects

Serious Side Effects

  • Unusual bleeding, bruising, tiredness, or weakness

  • Trouble breathing

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blistering, peeling, red skin rash

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Decrease or loss of body fat, especially in the face, arms, legs, or buttocks

  • Fever, chills, cough, sore throat, body aches

  • Muscle pain or weakness

  • Yellowing of your skin or the whites of your eyes

Less Serious Side Effects

  • Mild tiredness

  • Weight gain around your neck, upper back, breast, face, or waist

  • Stuffy or runny nose

  • Headache

  • Stuffy or runny nose