What is Daptomycin: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Daptomycin overview

BRAND NAMES:

  • PremierPro Rx Cubicin RF, PremierPro Rx Cubicin RF, Cubicin, Cubicin RF

Generic Names:

  • Daptomycin

Uses:

  • Treats infections. This medicine is an antibiotic.

Therapeutic Classes:

  • Antibiotic

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Daptomycin used for?

What form(s) does Daptomycin come in

  • Injectable

What are common Daptomycin doses?

  • Solution Reconstituted 350MG

  • Solution Reconstituted 500MG

Common Daptomycin prescriptions

  • DAPTOmycin
    350mg solution reconstituted

  • DAPTOmycin
    500mg solution reconstituted

How to take Daptomycin

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. This medicine is given slowly, so the needle will remain in place for about 30 minutes.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Missed dose: Injection routeCall your doctor or pharmacist for instructions.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. This medicine is given slowly, so the needle will remain in place for about 30 minutes.

  • Missed dose: Injection routeCall your doctor or pharmacist for instructions.

What to do if you miss a dose of Daptomycin

Daptomycin contraindications

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to daptomycin.

Daptomycin warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, lung or breathing problems (including pneumonia), muscle problems, nerve problems, or if you are on dialysis.

  • This medicine may cause the following problems: Severe diarrheaEosinophilic pneumoniaDrug reaction with eosinophilia and systemic symptoms (DRESS), which can damage organs, including the liver, kidney, or heartKidney problems (including tubulointerstitial nephritis)Peripheral neuropathyMuscle problems that can lead to kidney problems

  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine. Diarrhea may occur 2 months or more after your treatment ends.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Call your doctor if your symptoms do not improve or if they get worse.

  • Unusual tiredness or weakness

Daptomycin interactions

  • Some medicines can affect how daptomycin works. Tell your doctor if you are using medicine to lower cholesterol.

  • This medicine may cause the following problems: Severe diarrheaEosinophilic pneumoniaPeripheral neuropathyMuscle problems that can lead to kidney problems

  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine. Diarrhea may occur 2 months or more after your treatment ends.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Call your doctor if your symptoms do not improve or if they get worse.

Daptomycin side effects

Serious Side Effects

  • Unusual tiredness or weakness

  • Decrease in how often or how much you urinate

  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blistering, peeling, red skin rash

  • Chest pain, cough, fever, trouble breathing

  • Muscle pain, tenderness, or cramping

Less Serious Side Effects

  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

  • Mild diarrhea

  • Sore throat

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