What is Dyazide: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Dyazide overview

BRAND NAMES:

  • Dyazide, Maxzide, Maxzide-25

Generic Names:

  • Triamterene-Hctz

Uses:

  • Treats fluid retention (edema) and high blood pressure. This medicine is a combination of two types of diuretic (water pill).

Therapeutic Classes:

  • Diuretic, Potassium Sparing/Thiazide Combination

Forms:

  • Capsule, Tablet

How it’s taken:

  • By mouth

What is Dyazide used for?

Triamterene-HCTZ is used to treat patients who have fluid retention (edema). It is also used to treat high blood pressure. It is a combination drug that works by ridding the body of excess fluids by increasing urine production. It is indicated for use by adults and is available as a capsule.

What form(s) does Dyazide come in

  • Capsule

  • Tablet

What are common Dyazide doses?

  • Capsule 37.5-25MG

Common Dyazide prescriptions

  • Dyazide
    30 capsules bottle

  • Dyazide
    37.5-25mg capsule

How to take Dyazide

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Swallow the capsule whole. Do not break, crush, or chew it.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Swallow the capsule whole. Do not break, crush, or chew it.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

What to do if you miss a dose of Dyazide

Dyazide contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to triamterene, hydrochlorothiazide, or a sulfa drug. Do not use this medicine if you are not able to urinate, or if you have severe kidney disease or high potassium levels.

Dyazide warnings

  • This medicine may cause the following problems: Kidney problems, including kidney stonesNew or worsening lupusHigh or low levels of calcium, magnesium, potassium, or sodiumEye or vision problems, including glaucoma, myopiaNew or worsening goutIncreased risk for skin cancer

  • Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease (including cirrhosis), diabetes, gout, lupus, heart rhythm problems, heart failure, or a history of kidney stones.

  • This medicine could lower your blood pressure too much and cause you to feel dizzy or lightheaded. Sit or lie down if you feel dizzy. Stand up carefully.

  • Do not stop using this medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help keep it in the normal range. You may have to take blood pressure medicine for the rest of your life.

  • Drink plenty of fluids if you exercise, sweat more than usual, or have diarrhea or vomiting while you are using this medicine.

  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Sudden and severe stomach pain, nausea, vomiting, fever, lightheadedness

  • Unusual bleeding, bruising, or weakness

  • Yellow skin or eyes

Dyazide interactions

  • Do not use this medicine together with amiloride, spironolactone, or other products containing triamterene.

  • Some medicines can affect how this medicine works. Tell your doctor if you are also using the following: Amphotericin B, digoxin, lithium, methenamineBlood pressure medicine (including ACE inhibitors)Blood thinnerDiabetes medicine (including chlorpropamide)LaxativesNSAIDs (including indomethacin)Steroid medicine

  • Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine. Tell your doctor if you drink alcohol or use pain relievers or sleeping pills.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

Dyazide side effects

Serious Side Effects

  • Yellow skin or eyes

  • Blistering, peeling, red skin rash

  • Unusual bleeding, bruising, or weakness

  • Confusion, weakness, uneven heartbeat, trouble breathing, numbness or tingling in your hands, feet, or lips

  • Fever, chills, cough, sore throat, and body aches

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Sudden and severe stomach pain, nausea, vomiting, fever, lightheadedness

  • Change in how much or how often you urinate, problems urinating, pain in your side or lower back

  • Blurred vision, eye pain, changes in vision

  • Dry mouth, increased thirst, muscle cramps

  • Lightheadedness, dizziness, or fainting

  • Fast, pounding, or uneven heartbeat

  • Sores, reddish patch or irritated area, shiny bump, pink growth, or white, yellow or waxy scar-like area on the skin

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