Estrogel is a clear, colorless gel used to reduce certain symptoms of menopause. These symptoms include hot flashes, vaginal dryness, burning, and irritation. The average cost of Estrogel is about $235.02 for 1, 37.5gm of 0.75 mg/1.25 gm(0.06%) bottle. You can, however, save significantly on your Estrogel prices by using a free copay card and Estrogel coupons from SingleCare. Use these discounts at any of our participating pharmacies to pay as little as $74.89 for 1, 37.5gm of 0.75 mg/1.25 gm(0.06%) bottle for your next Estrogel prescription. Participating pharmacies include CVS Pharmacy, Walmart, Kroger, and Walgreens.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/20/2025
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Estrogel is a clear, colorless gel used to reduce certain symptoms of menopause. These symptoms include hot flashes, vaginal dryness, burning, and irritation. The average cost of Estrogel is about $235.02 for 1, 37.5gm of 0.75 mg/1.25 gm(0.06%) bottle. You can, however, save significantly on your Estrogel prices by using a free copay card and Estrogel coupons from SingleCare. Use these discounts at any of our participating pharmacies to pay as little as $74.89 for 1, 37.5gm of 0.75 mg/1.25 gm(0.06%) bottle for your next Estrogel prescription. Participating pharmacies include CVS Pharmacy, Walmart, Kroger, and Walgreens.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Estrogel Retail Price | Estradiol Retail Price | Estradiol SingleCare Price |
|---|---|---|---|
| CVS Pharmacy | $202.12 | $159.00 | $114.56 |
| Walmart | - | $132.37 | $132.37 |
| Walgreens | $247.88 | $112.50 | $112.50 |
| Kroger Pharmacy | $176.63 | $174.38 | $134.62 |
| Albertsons Pharmacy | - | $188.63 | $139.88 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Estrogel is a clear, colorless gel used to reduce certain symptoms of menopause. These symptoms include hot flashes, vaginal dryness, burning, and irritation. The average cost of Estrogel is about $235.02 for 1, 37.5gm of 0.75 mg/1.25 gm(0.06%) bottle. You can, however, save significantly on your Estrogel prices by using a free copay card and Estrogel coupons from SingleCare. Use these discounts at any of our participating pharmacies to pay as little as $74.89 for 1, 37.5gm of 0.75 mg/1.25 gm(0.06%) bottle for your next Estrogel prescription. Participating pharmacies include CVS Pharmacy, Walmart, Kroger, and Walgreens.
Typically, Estrogel can cost around $235.02 for 1, 37.5gm of 0.75 mg/1.25 gm(0.06%) bottle without insurance. With SingleCare, you can save significantly on the cost of your prescription drugs. SingleCare offers a free discount card and Estrogel coupons which can help you reduce your out-of-pocket cost to as little as $74.89 for 1, 37.5gm of 0.75 mg/1.25 gm(0.06%) bottle. You can use these discounts at any of our participating pharmacies. These include CVS Pharmacy, Walmart, and Walgreens.
Estrogel is covered by most insurance plans. You can receive discounts for your Estrogel prescription refill when you use SingleCare. With SingleCare, you could owe as little as $74.89 for 1, 37.5gm of 0.75 mg/1.25 gm(0.06%) bottle. You can ask your local pharmacy to apply your savings card and compare prices for Estrogel so you can find the best price for you.
Medicare does not generally cover Estrogel. You can still save money when you use SingleCare. SingleCare offers a copay card along with Estrogel coupons which can reduce your cost to as little as $74.89 for 1, 37.5gm of 0.75 mg/1.25 gm(0.06%) bottle. This may be a cheaper alternative to insurance. You can ask your pharmacist to enter your discount card ID to compare discounts.
Estrogel is a brand-name drug manufactured by Ascend Therapeutics, Inc. There is no generic version of Estrogel currently available on the U.S. market.
Estrogel is a clear, colorless gel used to reduce specific symptoms of menopause. These symptoms include hot flashes, and vaginal symptoms such as dryness, burning, and irritation. Estrogel is an FDA-approved bioidentical estrogen therapy derived from a plant source. It contains an estrogen hormone called estradiol. This is absorbed through the skin and enters into the bloodstream to provide the body with needed estrogen.
When using Estrogel, do not allow the medication to come into contact with others, especially children. You should not use Estrogel if you have a history of heart attack, stroke, blood clot, a bleeding or blood-clotting disorder, breast cancer, liver disease, or abnormal vaginal bleeding. Do not use Estrogel if you are pregnant or breastfeeding. Using estrogens such as Estrogel may also increase your chances of getting heart attacks, strokes, blood clots, breast cancer, or dementia. There is also an increased risk of endometrial cancer in women with a uterus. It is recommended that you talk to your healthcare provider before using Estrogel to find out if it may be right for you.
Common side effects of Estrogel include, but are not limited to headache, breast pain, stomach or abdominal cramps, bloating, nausea, vomiting, hair loss, fluid retention, and vaginal yeast infection.
Other less common but serious side effects may include heart attack, stroke, blood clots, dementia, and breast cancer. Contact your doctor immediately for medical advice if you think you may have one or more of these side effects.
You should also let your doctor know if you are allergic to any of the active or inactive ingredients in Estrogel. Signs of an allergic reaction may include rash, itching or swelling of the face, tongue, or throat, severe dizziness, and difficulty breathing. Get emergency medical attention if you have an allergic reaction to Estrogel. Talk to your doctor about these and other side effects because this is not a complete list.
After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved