What is Glyset: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Glyset overview

BRAND NAMES:

  • Glyset

Generic Names:

  • Miglitol

Uses:

  • Helps control blood sugar in patients who have diabetes mellitus.

Therapeutic Classes:

  • Hypoglycemic

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Glyset used for?

Miglitol is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes. It works by slowing the breakdown and absorption of carbohydrates in your intestines. This helps to decrease the rise of your blood sugar level after a meal.

What form(s) does Glyset come in

  • Tablet

What are common Glyset doses?

  • Tablet 25MG

Common Glyset prescriptions

  • Glyset
    100mg tablet

  • Glyset
    25mg tablet

  • Glyset
    50mg tablet

How to take Glyset

  • Your doctor will tell you how much of this medicine to use and how often.

  • Take the tablet at the start (with the first bite) of your main meals.

  • Your doctor will tell you how much of this medicine to use and how often.

  • Take the tablet at the start (with the first bite) of your main meals.

What to do if you miss a dose of Glyset

  • If you remember the dose while you are still eating or right after you finished your meal, take the dose right away. Otherwise, wait until your next main meal to use your medicine.

  • You should not use two doses at the same time.

Glyset contraindications

  • You should not use this medicine if you have had an allergic reaction to miglitol or if you have a bowel disorder such as colitis, Crohn's disease, or a blockage in your bowels.

Glyset warnings

  • You may need to keep a supply of glucose tablets or gel with you to treat low blood sugar. Regular table sugar may not work as well for low blood sugar, because miglitol keeps your body from absorbing regular sugar quickly.

  • Make sure you know what to do if your blood sugar gets too low. Teach your friends, co-workers, or family members what they can do to help you if you have low blood sugar.

  • To keep your diabetes under control, follow the diet that your doctor ordered, exercise regularly, and test your urine or blood for sugar as your doctor ordered.

  • Talk to your doctor before using this medicine if you are pregnant or breastfeeding.

  • Because of the way miglitol works, it is likely to cause gas. This is normal and should get better over time.

  • Tell your doctor if you start to have more problems than usual with low blood sugar.

  • If your blood sugar gets too low, you may feel weak, drowsy, confused, or very hungry. You may also sweat, shake, or have blurred vision, a fast heartbeat, trouble concentrating, or a headache that won't go away.

  • Tell your doctor if you have kidney disease or any problems with digestion or your bowels.

  • Miglitol by itself does not cause low blood sugar the way some other medicines to treat diabetes can. But, if you also use other anti-diabetes medicine, miglitol can work with these other medicines to make your blood sugar even lower.

Glyset interactions

  • Certain drugs can increase the level of sugar in your blood and make it harder for you to control your diabetes. Some of these drugs are diuretics (water pills such as Lasix® or Dyazide®), steroids (such as Prednisone®), Dilantin®, estrogen, birth control pills, niacin, and some cold and allergy drugs. Make sure your doctor knows if you are using any of these drugs.

  • Medicines used to help digest food (such as Donnazyme®, Pancrease®, or Creon®) should not be taken at the same time as miglitol.

  • Make sure your doctor knows if you are using any other medicines, especially those for your heart, stomach, blood pressure, or to treat your diabetes.

  • To keep your diabetes under control, follow the diet that your doctor ordered, exercise regularly, and test your urine or blood for sugar as your doctor ordered.

  • Miglitol by itself does not cause low blood sugar the way some other medicines to treat diabetes can. But, if you also use other anti-diabetes medicine, miglitol can work with these other medicines to make your blood sugar even lower.

  • If your blood sugar gets too low, you may feel weak, drowsy, confused, or very hungry. You may also sweat, shake, or have blurred vision, a fast heartbeat, trouble concentrating, or a headache that won't go away.

  • Make sure you know what to do if your blood sugar gets too low. Teach your friends, co-workers, or family members what they can do to help you if you have low blood sugar.

  • You may need to keep a supply of glucose tablets or gel with you to treat low blood sugar. Regular table sugar may not work as well for low blood sugar, because miglitol keeps your body from absorbing regular sugar quickly.

  • Tell your doctor if you start to have more problems than usual with low blood sugar.

Glyset side effects

Serious Side Effects

  • Gas, diarrhea, or stomach discomfort

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