What is Hydrocodone-Ibuprofen: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Hydrocodone-Ibuprofen overview

BRAND NAMES:

  • Ibudone, Vicoprofen, Xylon 10, Xylon 10

Generic Names:

  • Hydrocodone-Ibuprofen

Uses:

  • Treats pain. This medicine contains a narcotic and an NSAID.

Therapeutic Classes:

  • Opioid/NSAID Combination, Central Nervous System Agent, Analgesic

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Hydrocodone-Ibuprofen used for?

Hydrocodone-Ibuprofen is used for a short term to help relieve moderate to severe pain. It contains an opioid pain reliever and a nonsteroidal anti-inflammatory drug that works in the brain to change how your body feels and responds to pain reduces pain and fever.

What form(s) does Hydrocodone-Ibuprofen come in

  • Tablet

What are common Hydrocodone-Ibuprofen doses?

  • Tablet 7.5-200MG

  • Tablet 5-200MG

  • Tablet 10-200MG

Common Hydrocodone-Ibuprofen prescriptions

  • HYDROcodone-Ibuprofen
    10-200mg tablet

  • HYDROcodone-Ibuprofen
    2.5-200mg tablet

  • HYDROcodone-Ibuprofen
    5-200mg tablet

  • HYDROcodone-Ibuprofen
    7.5-200mg tablet

How to take Hydrocodone-Ibuprofen

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store the medicine in a safe and secure place. Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Check your local drug store and clinics for take-back locations. You can also check the DEA web site for locations. Here is the link to the FDA safe disposal of medicines website: www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/ensuringsafeuseofmedicine/safedisposalofmedicines/ucm186187.htm

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Drink plenty of liquids to help avoid constipation.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Drink plenty of liquids to help avoid constipation.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store the medicine in a safe and secure place. Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Check your local drug store and clinics for take-back locations. You can also check the DEA web site for locations. Here is the link to the FDA safe disposal of medicines website: www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/ensuringsafeuseofmedicine/safedisposalofmedicines/ucm186187.htm

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

What to do if you miss a dose of Hydrocodone-Ibuprofen

Hydrocodone-Ibuprofen contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to hydrocodone, ibuprofen, aspirin, or similar pain medicines, or if you have heart surgery (including CABG), serious lung or breathing problems (including asthma, respiratory depression), or stomach or bowel blockage (including paralytic ileus).

Hydrocodone-Ibuprofen warnings

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.

  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.

  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

  • This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Lightheadedness, dizziness, fainting

  • Numbness or weakness in one side of your body, sudden or severe headache, problems with vision, speech, or walking

  • Rapid weight gain, swelling in your hands, ankles, or feet

  • Severe stomach pain, vomiting blood, bloody or black, tarry stools

  • Unusual bleeding, bruising, or weakness

  • Tell your doctor if you have kidney disease, liver disease, anemia, lung disease, bleeding problems, high blood pressure, heart failure or other heart problems, lupus, Addison disease or other thyroid problems, trouble urinating, prostate disorder, or a history of head injury, brain tumor, or digestive problems.

  • This medicine might cause the following problems:High risk of overdose, which can lead to deathRespiratory depression (serious breathing problem that can be life-threatening)Sleep-related breathing problems (including sleep apnea, sleep-related hypoxemia)Serotonin syndrome (when used with certain medicines)Higher risk of heart attack or strokeStomach bleeding and ulcersHigh blood pressureKidney or liver damageAseptic meningitisSerotonin syndrome (when used with certain medicines)

  • Tell your doctor if you are pregnant or breastfeeding. Do not use this medicine during the later part of your pregnancy.

Hydrocodone-Ibuprofen interactions

  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone. An overdose in a child could cause death.

  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.

  • Too much of this medicine can cause death. Symptoms of an overdose include extreme dizziness or weakness, trouble breathing, slow heartbeat, seizure, and cold, clammy skin.

  • Do not drink alcohol while you are using this medicine.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol. Tell your doctor if you are using buprenorphine, butorphanol, nalbuphine, pentazocine, or a muscle relaxer (including cyclobenzaprine, metaxalone).

  • Avoid using this medicine and an MAO inhibitor (including phenelzine, tranylcypromine, linezolid) within 14 days of each other.

  • Some medicines can affect how ibuprofen/hydrocodone works. Tell your doctor if you are using any of the following: Aspirin, carbamazepine, cyclosporine, diflunisal, digoxin, erythromycin, ketoconazole, lithium, methotrexate, mirtazapine, pemetrexed, phenytoin, rifampin, ritonavir, salsalate, tramadol, or trazodoneBlood pressure medicineBlood thinner (including warfarin)Diuretic (water pill)Medicine to treat depression, anxiety, or mental health problemsPhenothiazine medicineSteroid medicineTriptan medicine to treat migraine headaches

Hydrocodone-Ibuprofen side effects

Serious Side Effects

  • Chest pain, trouble breathing, or coughing up blood

  • Severe constipation, stomach pain, vomiting blood, bloody or black, tarry stools

  • Blistering, peeling, red skin rash

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there

  • Fever, neck pain or stiff neck

  • Rapid weight gain, swelling in your hands, ankles, or feet

  • Numbness or weakness in one side of your body, sudden or severe headache, problems with vision, speech, or walking

  • Chest pain that may spread, trouble breathing, nausea, unusual sweating, fainting

  • Extreme dizziness or weakness, shallow breathing, slow or uneven heartbeat, sweating, cold or clammy skin, seizures

  • Unusual bleeding, bruising, or weakness

  • Change in how much or how often you urinate

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, yellow skin or eyes

  • Lightheadedness, dizziness, fainting

Less Serious Side Effects

  • Blurred vision, changes in vision

  • Mild drowsiness and sleepiness

  • Mild constipation, diarrhea, heartburn, stomach upset

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