What is Ifosfamide: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Ifosfamide overview

BRAND NAMES:

  • Ifex, Ifosfamide Novaplus

Generic Names:

  • Ifosfamide

Uses:

  • Treats cancer.

Therapeutic Classes:

  • Antineoplastic Agent

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Ifosfamide used for?

Ifex is a cancer medication that comes in the form of an intravenous powder for injection. It is used to treat testicular cancer. Ifex works by interfering with the growth and spread of cancer cells in the body.

What form(s) does Ifosfamide come in

  • Injectable

What are common Ifosfamide doses?

  • Solution Reconstituted 1GM

Common Ifosfamide prescriptions

  • Ifosfamide
    3gm solution reconstituted

  • Ifosfamide
    20ml of 1gm/20ml vial

  • Ifosfamide
    60ml of 3gm/60ml vial

How to take Ifosfamide

  • Injection routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeYou will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.

  • Drink extra fluids so you will urinate more often and help prevent kidney problems.

  • Missed dose: Injection routeThis medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Missed dose: Injection routeThis medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

  • Injection routeYou will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.

  • Drink extra fluids so you will urinate more often and help prevent kidney problems.

  • Injection routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

What to do if you miss a dose of Ifosfamide

Ifosfamide contraindications

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to ifosfamide, or if you have trouble urinating. You should not receive this medicine if you are pregnant or breastfeeding.

Ifosfamide warnings

  • Injection routeThis medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. Use effective birth control during the time you are being treated. Men should keep using birth control for 6 months after treatment ends.

  • Do not breastfeed during the time you are being treated.

  • Tell your doctor if you have kidney disease, liver disease, bone marrow problems, or heart disease. Tell your doctor if you have a weak immune system or an infection.

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

  • This medicine may cause the following problems:Increased risk for other types of cancersDamage to the nervous system, bladder, kidneys, heart, lungs, or liverSlow wound healingSlow or delayed growth in children

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Injection routeThis medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children. Women might stopping having menstrual periods or experience early menopause.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Injection routeCancer medicine can cause nausea or vomiting, sometimes even after you receive medicine to prevent these effects. Ask your doctor or nurse about other ways to control any nausea or vomiting that might happen.

  • Unusual bleeding, bruising, or weakness

  • Vision changes, drowsiness, uncontrolled body movements, seizures

Ifosfamide interactions

  • Some medicines and foods can affect how ifosfamide works. Tell your doctor if you have received other cancer drugs or radiation treatments. Also tell your doctor if you are using any of the following:Aprepitant, fosaprepitant, rifampin, sorafenib, or St John's wortCarbamazepine, fosphenytoin, phenobarbital, phenytoinFluconazole, itraconazole, ketoconazole

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

  • Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

  • This medicine may cause the following problems:Increased risk for other types of cancersDamage to the nervous system, bladder, kidneys, heart, lungs, or liverSlow wound healingSlow or delayed growth in children

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Injection routeThis medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children. Women might stopping having menstrual periods or experience early menopause.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Injection routeCancer medicine can cause nausea or vomiting, sometimes even after you receive medicine to prevent these effects. Ask your doctor or nurse about other ways to control any nausea or vomiting that might happen.

Ifosfamide side effects

Serious Side Effects

  • Lightheadedness, dizziness, fainting

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blistering, peeling, or red skin rash

  • Change in how much or how often you urinate, red or dark brown urine, painful or burning urination

  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet

  • Fast, pounding, or uneven heartbeat

  • Vision changes, drowsiness, uncontrolled body movements, seizures

  • Fever, chills, cough, sore throat, body aches

  • Trouble breathing, chest pain

  • Unusual bleeding, bruising, or weakness

  • Confusion, hallucinations, or other unusual behavior

Less Serious Side Effects

  • Pain, itching, swelling, or a lump under your skin where the needle is placed

  • Hair loss

  • Nausea or vomiting

Subscribe to our savings newsletter

Health education, drug info, wellness & more

By clicking 'Subscribe', I agree to SingleCare's Terms & Conditions.