What is Ontruzant? Uses, warnings & side effects

Updated May 14, 2025  •  Published Dec 30, 2020

Ontruzant overview

BRAND NAMES:

  • Ontruzant, Trazimera, Herceptin, Herzuma, Kanjinti, Ogivri, Ontruzant

Generic Names:

  • Ontruzant

Uses:

  • Treats cancer, including breast, esophagus, and stomach cancer., Treats cancer, including breast, stomach, and esophageal cancer.

Therapeutic Classes:

  • Immunological Agent, Antineoplastic Agent, Antineoplastic Agent, Immunological Agent

Forms:

  • Injectable, Injectable

How it’s taken:

  • By injection, By injection

What is Ontruzant used for?

What form(s) does Ontruzant come in?

  • Injectable

  • Injectable

What are common Ontruzant dosages?

  • Solution Reconstituted 150MG

Ontruzant images - What does Ontruzant look like?

  • Ontruzant
    150mg solution reconstituted

  • Ontruzant
    420mg solution reconstituted

How to take Ontruzant

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeYou will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.

  • Missed dose: Injection routeThis medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

  • Missed dose: Injection routeThis medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeYou will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. This medicine must be given slowly, so the needle will have to stay in place for at least 30 to 90 minutes.

  • Injection routeYou will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.

  • Missed dose: Injection routeThis medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. This medicine must be given slowly, so the needle will have to stay in place for at least 30 to 90 minutes.

  • Injection routeYou will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.

  • Missed dose: Injection routeThis medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

What to do if you miss a dose of Ontruzant

Ontruzant contraindications - Who shouldn't take Ontruzant?

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to trastuzumab, or if you are pregnant.

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to trastuzumab-dttb, or if you are pregnant.

Ontruzant warnings

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Use an effective form of birth control to prevent pregnancy while you receive this medicine and for 7 months after your treatment ends.

  • Tell your doctor if you are breastfeeding, or if you have heart disease, heart rhythm problems, high blood pressure, or lung disease.

  • This medicine may cause the following problems:Heart problemsInfusion-related reactionsLung or breathing problems

  • This medicine lowers the number of white blood cells. This weakens your immune system, so you may get infections more easily. Wash your hands often. Avoid people who are sick.

  • Injection routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

  • Injection routeCancer medicine can cause nausea or vomiting, sometimes even after you receive medicine to prevent these effects. Ask your doctor or nurse about other ways to control any nausea or vomiting that might happen.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. You may also need occasional tests of your heart function during and after treatment.

  • Injection routeIt is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Use an effective form of birth control during treatment with this medicine and for 7 months after the last dose.

  • Tell your doctor if you are breastfeeding, or if you have heart disease, lung disease, or breathing problems.

  • This medicine may cause the following problems:Heart problems, including heart rhythm problems, heart failure, or high blood pressureInfusion reactionsLung problems

  • Injection routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Ontruzant interactions & what to avoid when taking Ontruzant

  • Avoid using other cancer medicines (including anthracyclines) for up to 7 months after stopping treatment with trastuzumab-dttb.

  • Injection routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

  • Injection routeCancer medicine can cause nausea or vomiting, sometimes even after you receive medicine to prevent these effects. Ask your doctor or nurse about other ways to control any nausea or vomiting that might happen.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. You may also need occasional tests of your heart function during and after treatment.

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Use an effective form of birth control to prevent pregnancy while you receive this medicine and for 7 months after your treatment ends.

  • Tell your doctor if you are breastfeeding, or if you have heart disease, heart rhythm problems, high blood pressure, or lung disease.

  • This medicine may cause the following problems:Heart problemsInfusion-related reactionsLung or breathing problems

  • This medicine lowers the number of white blood cells. This weakens your immune system, so you may get infections more easily. Wash your hands often. Avoid people who are sick.

Ontruzant side effects - How does Ontruzant make you feel?

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Fainting, dizziness, lightheadedness

  • Fast, pounding, or uneven heartbeat

  • Fever, chills, cough, sore throat, body aches

  • Rapid weight gain, swelling in your hands, ankles, or feet

  • Trouble breathing, cold sweat, bluish-colored skin, chest pain or tightness

  • Unusual bleeding, bruising, or weakness

  • Unusual bleeding, bruising, or weakness

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Chest pain, trouble breathing, or fast, slow, or uneven heartbeat

  • Fever, chills, cough, runny or stuffy nose, sore throat, and body aches

  • Lightheadedness, dizziness, or fainting, fever, vomiting, headache

  • Rapid weight gain, swelling in your hands, ankles, or feet

Less Serious Side Effects

  • Sores or white patches on your lips, mouth, or throat

  • Diarrhea, nausea

  • Headache

  • Joint or back pain

  • Decreased weight, change in taste

  • Headache

  • Muscle pain or weakness

  • Nausea, vomiting, diarrhea

  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet

  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

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