Tretinoin is a prescription medication available as a topical cream or gel for treating acne and other skin conditions. Tretinoin is a generic drug that belongs to a class of medications called retinoids. As a vitamin A derivative, Tretinoin is believed to speed up the skin cell life cycle and promote skin cell turnover. Tretinoin is also available as an oral capsule to treat acute promyelocytic leukemia (APL), which is a type of blood cancer. The average retail price of Tretinoin is $274.46 for 1, 45gm of 0.025% tube of cream. You can may be able to use Tretinoin coupons from SingleCare to save on the cash price of Tretinoin and pay $42.87 for 1, 45gm of 0.025% tube of cream. SingleCare free drug coupons can be redeemed at participating pharmacies.
Edit your dosage
56 capsule, 10mgEdit
Unlock members-only prices.Free signup.
You have 0.00 in available bonus savings. Bonus savings will be automatically applied to your next eligible prescription fill.
Show this free card to your pharmacist.

Save an extra $3 on any eligible prescription! Sign up for free
Members can save even more
and it's free to join
SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/05/2025
Members save the most
Tretinoin is a prescription medication available as a topical cream or gel for treating acne and other skin conditions. Tretinoin is a generic drug that belongs to a class of medications called retinoids. As a vitamin A derivative, Tretinoin is believed to speed up the skin cell life cycle and promote skin cell turnover. Tretinoin is also available as an oral capsule to treat acute promyelocytic leukemia (APL), which is a type of blood cancer. The average retail price of Tretinoin is $274.46 for 1, 45gm of 0.025% tube of cream. You can may be able to use Tretinoin coupons from SingleCare to save on the cash price of Tretinoin and pay $42.87 for 1, 45gm of 0.025% tube of cream. SingleCare free drug coupons can be redeemed at participating pharmacies.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Retin-A Retail Price | Tretinoin Retail Price | Tretinoin SingleCare Price |
|---|---|---|---|
| CVS Pharmacy | $54.45 | $72.00 | $71.29 |
| Walmart | $154.62 | $91.31 | $65.32 |
| Walgreens | $52.50 | $139.66 | $84.45 |
| Kroger Pharmacy | $44.71 | $312.40 | $53.38 |
| Albertsons Pharmacy | $75.75 | $216.75 | $64.65 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Tretinoin is a prescription medication available as a topical cream or gel for treating acne and other skin conditions. Tretinoin is a generic drug that belongs to a class of medications called retinoids. As a vitamin A derivative, Tretinoin is believed to speed up the skin cell life cycle and promote skin cell turnover. Tretinoin is also available as an oral capsule to treat acute promyelocytic leukemia (APL), which is a type of blood cancer. The average retail price of Tretinoin is $274.46 for 1, 45gm of 0.025% tube of cream. You can may be able to use Tretinoin coupons from SingleCare to save on the cash price of Tretinoin and pay $42.87 for 1, 45gm of 0.025% tube of cream. SingleCare free drug coupons can be redeemed at participating pharmacies.
Tretinoin may cost an average retail price of $274.46 or more without insurance. The price of Tretinoin without insurance can vary depending on the quantity prescribed and the pharmacy location where it is purchased. You may want to shop around at different prices for the best cash price available. SingleCare may help you save on the cash price of Tretinoin and avoid high prescription costs for all of your family's medications. Use a free Tretinoin coupon above and pay as little as $42.87 for 1, 45gm of 0.025% tube of cream on your next prescription or refill of Tretinoin.
The cost of Tretinoin with insurance varies based on the health insurance plan that you currently have, the plan’s formulary, and your coverage stage. For example, you may have higher out-of-pocket costs if you have not met your deductible. You can check with your health insurance company or pharmacist to determine your cost of Tretinoin with insurance. In some cases, paying the cash price with a SingleCare card might be lower than your cost with insurance. Have your local pharmacist compare pricing for you.
Tretinoin costs with Medicare will vary by plan, prescription, and coverage stage. Refer to your plan’s drug formulary to find out whether your Medicare Part D or Medicare Advantage plan covers Tretinoin and how much the copay or coinsurance is. If Tretinoin is not covered by Medicare or if you have not met your plan’s deductible, you may have to pay the full price of $274.46 for 1, 45gm of 0.025% tube of cream. If you use SingleCare, you may end up paying less for Tretinoin than with Medicare. Ask the pharmacist at your local pharmacy to run your SingleCare discount card to compare prices.
The topical form of Tretinoin is available under various brand names, including Atralin, Refissa, Retin-A, and Renova. The brand name of oral Tretinoin is Vesanoid, which has been discontinued in the U.S.
Tretinoin is a retinoid prescription drug available in topical and oral formulations. The topical cream or gel is used to treat acne, fine wrinkles, pimples, mottled skin discoloration, and other skin conditions. Tretinoin is a derivative of vitamin A that assists the skin in renewing itself. It works by stimulating the rapid decay and regrowth of new skin cells. Tretinoin topical cream or gel is not meant for internal use. You should avoid getting the topical form of this drug in your mouth, eyes, or vagina.
Tretinoin capsules are a type of chemotherapy. Oral Tretinoin is used to treat a certain type of cancer of the white blood cells called APL-acute promyelocytic leukemia. As an oral capsule, it is believed to work by interfering with the growth of cancer cells in the body. It may also assist in the growth of normal blood and bone marrow cells, although the exact way in which it works is unknown.
Tretinoin is available in three main forms: a topical cream, a topical gel, and an oral capsule. Dosage may vary based on the form of the drug being used, the individual’s age, skin condition, the stage of acute promyelocytic leukemia, or the current phase of chemotherapy, as applicable. Consult a healthcare professional for medical advice when determining the correct dosage for your medical condition.
The topical version of Tretinoin is available in tubes of cream or gel. It's usually applied once a day before bedtime. The oral capsule of Tretinoin is available in a strength of 10 mg, which is usually taken twice daily. Your healthcare provider will determine the dosage that is best when using either the topical or oral form of Tretinoin.
Common side effects of topical Tretinoin include stinging, peeling, redness, and unusual dryness around the area of application on the skin. If you experience severe burning, blistering, or crusting, consult your healthcare provider. Some side effects that occur may not require immediate medical attention and will eventually go away after your body adjusts to the medication.
Common side effects of oral Tretinoin include headache, fever, weakness, and fatigue. Serious side effects of oral Tretinoin may include bleeding, abdominal pain, visual disturbances, and bone inflammation.
Tretinoin is not recommended in pregnant women. Using topical or oral Tretinoin may harm an unborn baby and cause birth defects. Consult your healthcare provider if you are pregnant before using Tretinoin. Your healthcare provider may recommend you use a form of birth control during treatment with Tretinoin.
Other side effects may also occur as this is not a complete list. Check with your doctor or healthcare provider to learn more.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
...SingleCare is accepted at most national pharmacies and grocers, including the following:
Health education, drug info, wellness & more
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
© 2025 SingleCare Administrators. All rights reserved
© 2025 SingleCare Administrators. All rights reserved