Tri-Luma is a brand-name prescription cream used for short-term treatment of facial melasma, a skin pigmentation condition characterized by brown or gray patches on the face. The active ingredients in Tri-Luma are a corticosteroid (fluocinolone), a pigment-reducing drug (hydroquinone), and a vitamin A derivative (tretinoin) that helps repair damaged skin. The pharmacy price of Tri-Luma is $334.35, but with SingleCare's Tri-Luma coupon, it costs only $241.91 for 1, 30gm of 0.01-4-0.05% tube of cream. Find out more about Tri-Luma in our FAQs below: what it is, how it works, how much it costs, and how to save money on your prescription.
Edit your dosage
0.5 tube of cream, 30gm of 0.01-4-0.05%Edit
Unlock members-only prices.Free signup.
You have 0.00 in available bonus savings. Bonus savings will be automatically applied to your next eligible prescription fill.
Show this free card to your pharmacist.

Save an extra $3 on any eligible prescription! Sign up for free
Members can save even more
and it's free to join
SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/19/2025
Members save the most
Tri-Luma is a brand-name prescription cream used for short-term treatment of facial melasma, a skin pigmentation condition characterized by brown or gray patches on the face. The active ingredients in Tri-Luma are a corticosteroid (fluocinolone), a pigment-reducing drug (hydroquinone), and a vitamin A derivative (tretinoin) that helps repair damaged skin. The pharmacy price of Tri-Luma is $334.35, but with SingleCare's Tri-Luma coupon, it costs only $241.91 for 1, 30gm of 0.01-4-0.05% tube of cream. Find out more about Tri-Luma in our FAQs below: what it is, how it works, how much it costs, and how to save money on your prescription.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Tri-Luma Retail Price | Tri-Luma SingleCare Price |
|---|---|---|
| CVS Pharmacy | $291.90 | $275.10 |
| Walmart | $294.30 | $263.10 |
| Walgreens | $300.00 | $262.20 |
| Kroger Pharmacy | $309.90 | $244.80 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Tri-Luma is a brand-name prescription cream used for short-term treatment of facial melasma, a skin pigmentation condition characterized by brown or gray patches on the face. The active ingredients in Tri-Luma are a corticosteroid (fluocinolone), a pigment-reducing drug (hydroquinone), and a vitamin A derivative (tretinoin) that helps repair damaged skin. The pharmacy price of Tri-Luma is $334.35, but with SingleCare's Tri-Luma coupon, it costs only $241.91 for 1, 30gm of 0.01-4-0.05% tube of cream. Find out more about Tri-Luma in our FAQs below: what it is, how it works, how much it costs, and how to save money on your prescription.
Uninsured customers will pay $334.35, but Tri-Luma prices can vary. Visit any participating pharmacy and pay only $241.91 for 1, 30gm of 0.01-4-0.05% tube of cream with a SingleCare Tri-Luma coupon. Your SingleCare prescription discount card can reduce your prescription drug prices by up to 80%.
Tri-Luma is not always covered by insurance plans. If your insurance does provide coverage for Tri-Luma, your copay with insurance will vary. Ask your pharmacist to compare your insurance copay to SingleCare. You may find a SingleCare discount card saves you more money than insurance–with SingleCare, Tri-Luma costs only $241.91 for 1, 30gm of 0.01-4-0.05% tube of cream.
Tri-Luma is usually not covered by Medicare Advantage and Medicare Part D prescription drug plans. Patients with Medicare can rely on a SingleCare Tri-Luma coupon for significant savings on Tri-Luma at major pharmacies around the country, such as CVS, Walmart, Walgreens, Longs Drugs, Duane Reade, and many others.
Tri-Luma is a brand-name prescription skin cream with fluocinolone, hydroquinone, and tretinoin. There are no other brand-name or generic alternatives available at this time with these three active ingredients.
Tri-Luma is a brand-name prescription cream that treats facial melasma, a skin pigmentation condition characterized by brown or gray patches on the face. Melasma is usually caused by a sensitivity to female sex hormones, estrogens and progesterones. Pregnancy, birth control pills, and hormone therapy are common causes, but stress and thyroid conditions can also cause melasma. Whatever the cause, exposure to the sun greatly increases the problem, so Tri-Luma therapy also involves sun avoidance and use of sunscreen.
The active ingredients in Tri-Luma are a corticosteroid (fluocinolone) to reduce swelling, a pigment-reducing drug (hydroquinone) to block melanin production, and a retinoid (tretinoin or “synthetic vitamin A”) that helps repair skin damaged by the sun.
Tri-Luma is applied as a thin layer over the affected skin area 30 minutes before bedtime once daily. The cream should be gently rubbed into the skin. The cream should be applied to the affected area as well as the ½ inch of normally-pigmented skin surrounding the affected area. Patients should avoid sunlight, wear protective clothing, and use sunscreen of at least SPF 30 when exposed to sunlight. Tri-Luma is discontinued when the underlying condition is under control. Tri-Luma is for short-term treatment, not long-term maintenance. However, when Tri-Luma is discontinued, melasma often returns, so your healthcare professional may prescribe a different treatment.
The side effects of Tri-Luma are very common and many are temporary site reactions to Tri-Luma, such as redness, burning, peeling, dryness, itching, and tingling (paresthesia). Other common side effects of Tri-Luma include acne and pigment changes. More serious but very rare side effects are the result of one of the active ingredients, fluocinolone, being absorbed into the bloodstream. Symptoms include thinning skin, hair loss, weakness, tiredness, loss of appetite, depression, anxiety, and irritability.
Allergic reactions are rare. If you experience an allergic reaction, such as facial swelling, trouble breathing, or rash, discontinue use of Tri-Luma and get emergency medical attention.
After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.
...SingleCare is accepted at most national pharmacies and grocers, including the following:
Health education, drug info, wellness & more
SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
© 2025 SingleCare Administrators. All rights reserved
© 2025 SingleCare Administrators. All rights reserved