What is Actos: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Actos overview

BRAND NAMES:

  • Pioglitazone Hydrochloride, Actos

Generic Names:

  • Pioglitazone Hcl

Uses:

  • Treats type 2 diabetes.

Therapeutic Classes:

  • Hypoglycemic

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Actos used for?

What form(s) does Actos come in

  • Tablet

What are common Actos doses?

  • Tablet 15MG

  • Tablet 30MG

  • Tablet 45MG

Common Actos prescriptions

  • Actos
    15mg tablet

  • Actos
    30mg tablet

  • Actos
    45mg tablet

How to take Actos

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

What to do if you miss a dose of Actos

Actos contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to pioglitazone.

Actos warnings

  • Tell your doctor if you are pregnant or breastfeeding. If you had problems ovulating or have irregular periods, this medicine may cause you to ovulate, which could lead to pregnancy if you are sexually active. Talk to your doctor about effective birth control while you are using this medicine.

  • Tell your doctor if you have kidney disease, liver disease, heart disease, heart failure, macular edema (swelling of the back of the eye), or a history of bladder cancer.

  • This medicine may cause the following problems:Congestive heart failureLow blood sugar levelsLiver problemsIncreased risk of broken bones, especially in womenIncreased risk of bladder cancer, if you use this medicine for a long time

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Rapid weight gain, swelling in your hands, ankles, or feet, trouble breathing

  • Unusual tiredness or weakness

Actos interactions

  • Some medicines can affect how pioglitazone works. Tell your doctor if you are using gemfibrozil or rifampin.

  • This medicine may cause the following problems:Low blood sugarLiver damageCongestive heart failureBroken bones, especially in womenBladder cancer, if taken for more than 12 monthsMacular edema (swelling behind the eye)

  • Women: This medicine can cause you to ovulate if you did not ovulate regularly before. This means you could get pregnant. Talk with your doctor about birth control if this is a concern for you.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Actos side effects

Serious Side Effects

  • Shaking, trembling, sweating, fast or pounding heartbeat, faintness, hunger, confusion

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Blurred vision or changes in vision

  • Rapid weight gain, swelling in your hands, ankles, or feet, trouble breathing

  • Severe joint pain

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Change in how often or how much you urinate, painful urination, lower back or side pain, blood in your urine

Less Serious Side Effects

  • Cough, runny or stuffy nose, sneezing, or sore throat

  • Headache

  • Bloated or full feeling, gas